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WO1999048469A1 - Composition conçue pour degager un arome - Google Patents

Composition conçue pour degager un arome Download PDF

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Publication number
WO1999048469A1
WO1999048469A1 PCT/US1998/005581 US9805581W WO9948469A1 WO 1999048469 A1 WO1999048469 A1 WO 1999048469A1 US 9805581 W US9805581 W US 9805581W WO 9948469 A1 WO9948469 A1 WO 9948469A1
Authority
WO
WIPO (PCT)
Prior art keywords
ingredient
composition
aromatic
aroma
exothermic
Prior art date
Application number
PCT/US1998/005581
Other languages
English (en)
Inventor
Chetan Kantilal Yagnik
Anuradha Jayachandran
Venkatraman Narayanaswamy Iyer
Tushar Pandurang Sankhe
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to BR9815747-7A priority Critical patent/BR9815747A/pt
Priority to AU65758/98A priority patent/AU6575898A/en
Priority to CN98813911.1A priority patent/CN1286625A/zh
Priority to PCT/US1998/005581 priority patent/WO1999048469A1/fr
Priority to JP53605499A priority patent/JP2001506533A/ja
Priority to EP98911913A priority patent/EP1063960A1/fr
Priority to CA002325037A priority patent/CA2325037A1/fr
Publication of WO1999048469A1 publication Critical patent/WO1999048469A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/05—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating specially adapted to be released by contact with a liquid, e.g. for toilets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/02—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air by heating or combustion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/242—Exothermic; Self-heating; Heating sensation

Definitions

  • the present invention relates generally to a composition for delivering aroma. More particularly, the present invention relates to a composition for aroma delivery that is generated by an exothermic reaction.
  • Aromatic volatile components have been widely used in variety of products, including pharmaceutical products.
  • Certain types of aromatic volatile components e.g., menthol, eucalyptus oil, camphor, thymol
  • menthol eucalyptus oil
  • camphor eucalyptus oil
  • thymol eucalyptus oil
  • These pharmaceutical products are commonly used by inhaling aroma vapours along with water vapours to relieve blocked nose, cough, and other cold or allergy symptoms.
  • the vapours are generated by using hot water or steam.
  • aromatic volatile components have become increasingly popular. Consumers with mental stress often prefer to be in perfumed environments as a way to decrease stress. Due to their ability to induce relaxation and relief of mental stress, certain aromatic volatile components have become popular for treatment and therapy of such stress. These aromatic volatile components (e.g., cineol, jasmine, lavender oil) are known for providing fragranced environments in aroma therapy, as aromatic fragrance components.
  • aromatic volatile components e.g., cineol, jasmine, lavender oil
  • aroma therapy refers to a therapy which is for mental treatment, getting away from or releasing stress and, inducing relaxation, especially to ease mental stress.
  • a conventional aroma therapy is by an inhalation of aroma vapours.
  • Aroma is generated from the aromatic fragrance components by using hot water in combination with aromatic actives, or by heating a vessel, for example a pot or a plate, in which aromatic fragrance ingredients and water are placed. Consumers, however, tend to become frustrated with such methods of use, i.e., heating water for aroma vapours andfor steam inhalation, and with cleaning messy vessels due to oily or waxy bases used for aroma generation after the inhalation of aroma vapours.
  • exothermic reactions have been previously used for the purpose of generating heat or increasing temperature.
  • a variety of products using exothermic reactions are known, for example, in food products (e.g., self-heating meal modules, see Taub et al. U.S. Patent 5,517,981), pharmaceutical products (e.g., body warmers, see Sahara, U.S. Patent 5,220,909), or smoking articles (e.g., cigarette, see Potter et al. U.S. Patent 4,955,399).
  • the present invention is directed to a composition for aroma delivery comprising: (a) an aromatic ingredient; (b) an exothermic ingredient; and (c) a pH adjusting agent; wherein the aroma is delivered when water is added to the composition.
  • the present invention further relates to a composition for aroma delivery comprising: (a) an aromatic ingredient selected from the group consisting of an aromatic active, an aromatic fragrance ingredient, and mixtures thereof; (b) first granules comprising an exothermic ingredient and a first carrier; and (c) a second granules comprising a pH adjusting agent and a second carrier; wherein the aroma is delivered when water is added to the composition.
  • the present invention relates to a composition for aroma delivery comprising: (a) an aromatic ingredient; (b) an exothermic ingredient; and (c) a pH adjusting agent; wherein the aroma is delivered when water is added to the composition.
  • the temperature generated by the reaction of the exothermic ingredients with water is in the range of from about 40°C to about 100°C, more preferably from about 40°C to about 70°C.
  • the specified temperature generated is achieved by the combination of the exothermic ingredients and water. Without being bound by theory, it is believed that such temperature range is suitable for volatilizing aromatic ingredients including an aromatic active compound, and an aromatic fragrance compound.
  • the composition can deliver aroma by steam which may be generated by the temperature increase resulting from on the exothermic reaction with water.
  • aromatic ingredient
  • composition of the present invention comprises an aromatic ingredient.
  • Aromaatic ingredient herein refers to an ingredient which volatilizes due to the temperature generated by the reaction of the exothermic ingredients with water, and delivers aroma to the user.
  • aromatic ingredients useful in the present invention include an aromatic active ingredient, an aromatic fragrance ingredient, and mixtures thereof.
  • the aromatic ingredient may be provided in any form, for example as an oil or as a water-oil emulsion.
  • a kit product using the method of the present invention has two chambers, wherein one chamber contains an aromatic ingredient in emulsion, and another chamber contains an exothermic ingredient and a pH adjusting agent.
  • Aromatic active ingredient herein means an ingredient which is specially used for a medical therapy.
  • the aromatic active ingredient can include any ingredients which are conventionally used as actives for medical treatment, for example, various aromatic actives which may be volatile and useful for treatment of colds, allergy symptoms, and blocked nose in various over-the-counter products. These aromatic actives can be in solid or liquid form.
  • Nonlimiting examples of the aromatic active ingredient include menthol, eucalyptus oil, camphor, thymol, turpentine oil, l-desoxyephedrine, bornyl acetate, and mixtures thereof.
  • Aromaatic fragrance ingredient herein means an ingredient useful in aroma therapy for mental relaxation.
  • aromatic fragrance ingredients of the present invention include peppermint oil, spearmint oil, lavender oil, citronella oil, lemon oil, orange oil, sandalwood oil, and mixtures thereof.
  • the aromatic active ingredient may further provide preferable fragrance in addition to the vapours for medical treatment purpose.
  • Exothermic ingredients The composition of the present invention comprises an exothermic ingredient. "Exothermic ingredient” herein means an ingredient which is used for a reaction, called an exothermic reaction, to generate heat on reaction with water.
  • the exothermic ingredients useful in the present invention can be any ingredients which are conventionally used for generating heat on reaction with water, and are available for use in pharmaceutical areas.
  • the exothermic ingredients useful herein include a metal or a metal oxide.
  • the metals of the present invention include, for example, magnesium and sodium, preferably magnesium.
  • the preferred metal oxides herein are calcium oxide.
  • Mechanisms of the exothermic reaction using metals differ from the reaction using metal oxides. Theoretically, the exothermic reaction of metal with water requires the presence of an acidic medium. The mechanism of the metal based exothermic reaction is that one mole of metal reacts with two moles of water in the presence of hydrogen ion, thereby one mole of metal hydroxide is derived, with the heat generation enabling volatilization of the aromatic ingredients.
  • the following is an example of the exothermic reaction of the present invention using metal as the exothermic ingredient.
  • the exothermic reaction (I) using metal with water derives a metal hydroxide with evolution of hydrogen gas.
  • the hydrogen gas is evolved as bubbles and tends to give effervescence, leading to improve aesthetics. It is believed that the hydrogen gas may help the delivery of aroma and give a signal to the user as to the progress of the reaction of the exothermic ingredients with water.
  • the amount of bubbles evolved decreases.
  • the quantity of water added based on the exothermic reaction (I) is from about 1 :20 to about 1 :100, preferably 1 :20 to 1 :50 to the ratio of metal by weight for generating the temperature appropriate to volatilize the aromatic ingredients.
  • a composition for delivering aroma including about 0.1 gm of metal is prepared and by adding about 5 ml (mgs) of water, a maximum temperature of about 68 degC. is generated for volatilizing the aromatic ingredients.
  • the metal is of a high purity, and particularly when the aroma delivery in limited to occur using a large scale exothermic reaction (e.g., four times the amounts of metal and of water shown in the examples herein, as may be useful for providing aroma delivery in a room). It is believed that large scale exothermic reactions, particularly the reaction using magnesium, may cause off- odor or less odor reaction when the metal is of insufficient purity.
  • a large scale exothermic reaction e.g., four times the amounts of metal and of water shown in the examples herein, as may be useful for providing aroma delivery in a room. It is believed that large scale exothermic reactions, particularly the reaction using magnesium, may cause off- odor or less odor reaction when the metal is of insufficient purity.
  • metal oxide is the choice for the exothermic reaction to deliver aroma in the present invention
  • one mole of water is needed for the reaction with one mole of the metal oxide.
  • acids such as hydrogen ion for the exothermic reaction.
  • one mole of a metal hydroxide is derived, with the appropriate temperature generation to volatilize the aromatic ingredients.
  • the following is an example of the exothermic reaction using metal oxide.
  • the exothermic reaction using metal oxide may include an effervescent agent.
  • the quantity of metal oxide to water based on the exothermic reaction (II) is at least from about 1 :2 to about 1 :15 by weight, preferably from about 1 :2 to about 1:5, for generating the temperature for volatilization of the aromatic ingredients.
  • a composition for delivering aroma including about 1gms of metal oxide is prepared and by adding about 5 ml (mgs) of water, a maximum temperature of about 67 degC. is generated for volatizing the aromatic ingredients.
  • pH adjusting agent means a component which is useful for neutralization of the metal hydroxide derived by the exothermic reaction of the present invention described by reactions (I) and (II).
  • the pH adjusting agent useful herein includes any of the acids used for conventional neutralizations.
  • Exemplary of the pH adjusting agent herein are citric acid, oxalic acid, and tartaric acid.
  • the pH adjusting agent can be added such that the conditions of the composition after aroma delivery are slightly acidic, preferably a pH of from about 3 to about 7.
  • Total amount of the pH adjusting agent to the exothermic ingredients herein may be in the ratio from about 1 : 3 to about 1 : 6 by weight of the composition.
  • the weight ratio of the metal to the pH adjusting agent is preferably at least about 1 : 6.
  • the pH adjusting agent is at least about 1 : 3 by weight ratio.
  • composition of the present invention can further comprise additional ingredients selected from the group consisting of a carrier, a effervescent agent, a binding agent, a coloring agent, a tableting aid, and mixtures thereof.
  • additional ingredients selected from the group consisting of a carrier, a effervescent agent, a binding agent, a coloring agent, a tableting aid, and mixtures thereof.
  • the additional ingredients are preferably in a solid form to facilitate operating flowability and product stability.
  • the additional ingredients must be of sufficiently high purity and of sufficiently low toxicity to obtain the desirable quality for aroma delivery.
  • Additional ingredients other than described below that are useful for the present invention further include, for example, diluents such as glucose, mannitol and directly compressible sugar; stabilizing agents such as agar, pectin, gums and starches; antioxidants such as ascorbic acid and BHA; preservatives such as potassium sorbate and sodium benzoate, and the like; as well as other non-toxic compatible substances used in pharmaceutical formulation.
  • diluents such as glucose, mannitol and directly compressible sugar
  • stabilizing agents such as agar, pectin, gums and starches
  • antioxidants such as ascorbic acid and BHA
  • preservatives such as potassium sorbate and sodium benzoate, and the like
  • Effervescent agent The composition of the present invention, especially those using the exothermic reaction (I) to vaporize aromatic ingredients, can evolve gases as discussed above. However reaction (II) does not provide bubbles, but sometimes it may be desirable to have bubbles, for example, for aesthetic purposes.
  • Effective agent herein means any carbonate salt that provides bubbles when reacted with acid.
  • the effervescence is evolved by the reaction of a carbonate source with an acidic source, for example, in the combination of a carbonate salt and a carboxylic acid. Any ingredients which would be useful conventionally as an effervescent agent in the pharmaceutical area may be acceptable herein.
  • the effervescent agent of the present invention can be selected depending upon compatibility with other components, particularly the pH adjusting agent which reacts with the effervescent agent.
  • the preferred effervescent agent herein is sodium hydrogencarbonate. The following is one embodiment of the reaction using sodium hydrogencarbonate with citric acids as acidic sources.
  • compositions of the present invention may include a carrier.
  • the carrier useful for the compositions herein can be any which is available and conventionally used in pharmaceutical compositions.
  • the carrier can be selected depending upon the compatibility with all of the ingredients included as well as the desired characteristic of the composition.
  • the carrier suitable herein is sugar.
  • the carrier may be added in a variety of forms depending on the form of the composition, preferably the carrier in solid form.
  • the carrier may be mixed with other ingredients such as the exothermic ingredient and the pH adjusting ingredient during granulation.
  • the carrier is present at an effective level, preferably at a level of from about 10% to about 70% by weight of the composition.
  • the carrier may be added to each of main ingredients such as the exothermic ingredient and the pH adjusting agent separately for making granules to facilitate the process of tableting (e.g., granules containing the exothermic ingredient and the carrier; granules containing the pH adjusting agent and the carrier.)
  • the ratio of such ingredients to the carrier is about 50:50.
  • compositions for the present invention may also include a binding agent.
  • a binding agent is particularly useful to bind the components used for tablet forms of the composition. It is believed that insufficiencies in binding ability tend to cause compositions in tablet form, and especially those having a disc type shape, to break off into two pieces along the diameter during the manufacturing process. This splitting of the tablet is commonly referred to as "capping.”
  • the levels and types of binding agent are selected depending upon compatibility with other components, and desired characteristic of the final product.
  • binding agents examples include sugar, sugar alcohols, starches such as starch paste and pregelatinized starch, polyvinylpyrrolidone, cellulose derivatives, gelatin, gums, and mixtures thereof.
  • the binding agent and the carrier may be made of the same material.
  • the binding agent and the carrier may be altogether different. It is believed that the binding agent contributes to stability of the granules when added in the process of making granules.
  • the binding agents may be present in an effective amount, preferably from about 0.1% to about 10% by weight, more preferably from about 0.5% to about 3%.
  • composition including the method of the present invention may further include a coloring agent.
  • the coloring agent may be present at an effective level, preferably from about 10 ppm to about 500 ppm, more preferably from about 20 ppm to about 250 ppm by weight.
  • tableting aids can be added in order to facilitate forming the tablets.
  • tablette aids refers to an ingredient that is added to the granules in small quantities to improve flowability to the granules, to reduce friction, and/or to ease removal of the tablets from the tableting machine.
  • the tableting aids useful herein include, for example, magnesium stearate, stearic acid, aerosol, talc, and mixtures thereof.
  • the tableting aid of the compositions of the present invention is preferably present in an amount sufficient to prevent the tablet from breaking into two pieces, preferably from about 0.1% to about 8%, by weight of the tablet. E. Granulation
  • the composition of the present invention can be provided as a mixture of granules, especially the compositions in tablet form.
  • Such compositions prepared from the granules and compressed the granules into tablet tend to generate suitable temperature for aroma delivery, thereby provide pleasant aromatic vapours.
  • granules can be handled readily during manufacturing. For example, granules provide an uniform mixture and distribution of ingredients into the composition, and facilitate the compression of ingredients into tablets. Due to the uniform distribution of ingredients, the composition herein produced by granules tends to contact with water effectively for causing the exothermic reaction to generate the desirable temperature and deliver the aromatic ingredient. 10
  • composition of the present invention can comprise mixtures of granules. Especially useful are mixtures of granules comprising a carrier with the exothermic ingredient or a carrier with the pH adjusting agent.
  • First granules are obtained from the exothermic ingredients combined with a first carrier.
  • the ratio of the first carrier to the exothermic ingredient is from about 30:70 to about 70:30, preferably 50:50 by the weight of the first granules.
  • Second granules are prepared by combining the pH adjusting agent with a second carrier.
  • the ratio of the second carrier to the pH adjusting agent is from about 30:70 to about 70:30, preferably 50:50 by the weight of the second granules.
  • the first carrier and the second carrier which are used for the first and the second granules, can be the same carrier or different carriers.
  • the carrier may be proportionally included in the first granules and in the second granules.
  • each carrier may be separately added to the first and the second granules, or may be premixed and then proportionally included in each of the first and the second granules.
  • the granules herein may further include a binding agent.
  • the binding agent can be the same as those discussed above or may be different ingredients. It is believed that inclusion of certain binding agents may cause the temperature generated by the reaction to be somewhat lower, because of slow dissolution of the composition.
  • the levels and types of the binding agent are selected depending upon the character of the carriers, compatibility with other components, and desirable characteristic of the final products.
  • compositions of the present invention can be produced by any method useful for forming compositions, e.g., tea bag, powder, or tablets, in pharmaceutical or food industries known in the art.
  • Such conventional methods for making powder, granules, or tablets include direct compression of ingredients and a preparation of granules before compression when the products is in tablets form.
  • the granulating methods useful herein include wet and dry granulating method, preferably wet granulating.
  • ingredients e.g., active ingredients, carriers, flavors, coloring agents, and the 11
  • the tablet forms of the compositions of the present invention also can be made by any method which is conventionally used for tableting.
  • the tableting method includes preparation of granules by the wet granulating method as described above. See, for example, Palermo, et al., U.S. Patent 3,384,546. Direct compression may also be chosen for the present composition, as long as producing tablets does not cause capping.
  • composition of the present invention can be used for a variety of products in different areas, including pharmaceutical products. These products are, for example, pharmaceuticals for medical treatment of physical injuries and as aroma therapy products for inducing relaxation and stress release by being in perfumed environments. The perfumed conditions provided are also useful for skin treatment.
  • the composition of the present invention may further be used for pest control, by generating a certain toxin.
  • the compositions are particularly useful for readily inhalation of aromatic actives and fragrance compounds for treatment of symptoms such as cold, blocked nose, and the like.
  • composition of the present invention may further be suitable for products designed for body warming, including for example, heating or warming pads to warm the body to enable it to release pain.
  • the composition herein may useful to lessen the stress caused by such pains, at the time of treating the injury by warming the painful areas of the body.
  • the composition of the present invention may further be suitable for a kit product, for example, a kit comprising two chambers wherein one chamber contains water and the other contains the composition.
  • a kit product for example, a kit comprising two chambers wherein one chamber contains water and the other contains the composition.
  • a kit is used by removing a separator located between two chambers which keeps the composition from reacting with water until the kit is used.
  • a kit including a bag into which the composition is packed may be provided, the bag being made from a water-impermeable material such as polymer.
  • a kit is 12
  • any form of the composition may be provided in the kit.
  • kits comprises an effective amount of an aromatic ingredient in a first chamber, an exothermic ingredient and a pH adjusting agent in a second chamber, and water in a third chamber, wherein the second chamber is next to the third chamber, such that, upon combining the second chamber and the third chamber, an exothermic reaction is generated and aroma is delivered.
  • kits are also useful as products mentioned above.
  • the composition of the present invention take a variety of forms depending on its usage. These formations can include tablet, powder or granules, and those suitable for packed into bags or containing into kits. Preferably, the form is tablet.
  • Tablet is a typical pharmaceutical form which is easy and convenient to use.
  • the composition of the present invention can be compressed into the tablet form.
  • the tablet is used as follows: put the tablet in a cup into which water is contained so that the exothermic reaction proceeds and the aroma is delivered. Without being bound by theory, it is believed that due to the limited surface areas of the tablet form, the rate of the exothermic reaction tends to be slow at first, probably until the tablet is dissolved, after which the time the exothermic reaction proceeds more efficiently and generation of aroma suddenly becomes harder than previous. Prior to that time, most of the reaction may occur only on the surface of the tablet.
  • the tablet composition in tablet form tends to provide a peak temperature, about 2 minutes after contact with water, although that time depends on the diameter, thickness, and/or hardness of the tablet.
  • the heat generation by the exothermic reaction is decreased, then the temperature cools down. It is believed that the most of the surface of the tablet start disintegrating, the rate of reaction becomes faster than before, resulting in sudden increase of the heat generation leading to a peak temperature. Generally, at temperatures of less than about 40 degC, the aroma delivery may not be generated or there may be a lesser generation of aroma.
  • Powder or granules are another embodiment of the composition.
  • the use of the powder form composition or granules is same as the tablet; put the powder or granules into a cup in which water is contained or added later, thereby the aroma is delivered. It is believed that due to the higher surface area of the 13
  • the rate of reaction is faster than that of the tablet composition and can deliver aroma more uniformly, i.e., the temperature versus time profile is flat with no peak.
  • the temperature generated by the reaction of the powder form composition or granules may be lower than the that of tablet form.
  • Example I A tea bag composition 1
  • Citric acid as a pH adjusting agent, 3.1 gm of menthol as an aromatic active and
  • spearmint oil as an aromatic fragrance are mixed in a V cone blender about 30 min at 30 RPM. 5 gm of the mixture I is packed in a tea bag made from paper (tea bag 1).
  • Example II A tea bag composition 2
  • Example M A powder composition 1
  • Example V A tablet composition 1
  • the mixture of aerosil, menthol and spearmint oil is added to a Kalweka (made by Cadmac, India) in which the Sugar - Citric acid granules, Magnesium - Citric acid granules are then mixed for 20 minutes at 30 RPM.
  • the resulting granules are compressed on single punch machine (made by Cadmac, India) into a tablet having a diameter of 19mm. (wt%)
  • Example I Example ! Example I Example IV Example V product type tea bag 1 tea bag 2 powder 1 powder 2 tablet 1 calcium oxide 23.54 - 23.54 - - magnesium - 13.06 - 13.06 -
  • Mg-granules containing 1 :1 of magnesium and sugar Citric-granules containing 1 :1 of citric acid and sugar. 15

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Abstract

L'invention se rapporte à une composition conçue pour dégager un arôme, qui comporte (a) un agent aromatique; (b) un ingrédient exothermique et (c) un correcteur d'acidité. Cette composition dégage un arôme lorsqu'elle est additionnée d'eau.
PCT/US1998/005581 1998-03-20 1998-03-20 Composition conçue pour degager un arome WO1999048469A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR9815747-7A BR9815747A (pt) 1998-03-20 1998-03-20 Composição para liberação de aroma
AU65758/98A AU6575898A (en) 1998-03-20 1998-03-20 Composition for aroma delivery
CN98813911.1A CN1286625A (zh) 1998-03-20 1998-03-20 释放香味的组合物
PCT/US1998/005581 WO1999048469A1 (fr) 1998-03-20 1998-03-20 Composition conçue pour degager un arome
JP53605499A JP2001506533A (ja) 1998-03-20 1998-03-20 芳香放出のための組成物
EP98911913A EP1063960A1 (fr) 1998-03-20 1998-03-20 Composition con ue pour degager un arome
CA002325037A CA2325037A1 (fr) 1998-03-20 1998-03-20 Composition concue pour degager un arome

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/005581 WO1999048469A1 (fr) 1998-03-20 1998-03-20 Composition conçue pour degager un arome

Publications (1)

Publication Number Publication Date
WO1999048469A1 true WO1999048469A1 (fr) 1999-09-30

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Application Number Title Priority Date Filing Date
PCT/US1998/005581 WO1999048469A1 (fr) 1998-03-20 1998-03-20 Composition conçue pour degager un arome

Country Status (7)

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EP (1) EP1063960A1 (fr)
JP (1) JP2001506533A (fr)
CN (1) CN1286625A (fr)
AU (1) AU6575898A (fr)
BR (1) BR9815747A (fr)
CA (1) CA2325037A1 (fr)
WO (1) WO1999048469A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1205193A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil facilement activable auto-chauffant pour délivrer des matériaux volatils
EP1205194A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil auto-chauffant pour la délivrance prolongée de matériaux volatils
EP1205192A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil efficace auto-chauffant pour délivrer des matériaux volatils
EP1205195A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil auto-chauffant pour délivrer des matériaux volatils activable de manière regulable
WO2002038194A1 (fr) * 2000-11-07 2002-05-16 The Procter & Gamble Company Dispositifs autochauffants de diffusion de matieres volatiles actives par commande
WO2002068005A1 (fr) * 2001-02-26 2002-09-06 The Procter & Gamble Company Composition conçue pour degager un arome, a stabilite ameliore et a moussage reduit
US6451331B1 (en) 2000-01-31 2002-09-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Pleated cosmetic effervescent cleansing pillow
US6506713B1 (en) 2000-01-31 2003-01-14 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic effervescent cleansing compositions
WO2003053410A1 (fr) * 2001-12-20 2003-07-03 Alpex Pharma Sa Compositions particulaires
US6812258B2 (en) 1998-12-07 2004-11-02 Ecosmart Technologies, Inc. Cancer treatment composition and method using natural plant essential oils
WO2005020951A1 (fr) 2003-08-21 2005-03-10 The Procter & Gamble Company Article nettoyant effervescent
US6901609B2 (en) 2001-01-15 2005-06-07 The Procter & Gamble Company Method of dispensing volatile and soluble substances and a device for use therein
EP1627647A1 (fr) * 2004-08-19 2006-02-22 Bell Flavours & Fragrances Limited Dispositif de traitement d'air et paquet de remplissage
US7081211B2 (en) 2000-07-13 2006-07-25 The Procter & Gamble Company Multi-layer reaction mixtures and apparatuses for delivering a volatile component via a controlled exothermic reaction
US7235187B2 (en) 2000-07-13 2007-06-26 The Procter & Gamble Company Methods and apparatuses for delivering a volatile component via a controlled exothermic reaction
EP1661973A4 (fr) * 2003-09-05 2010-02-17 Shiseido Co Ltd Composition de parfum pour le controle de sensibilite a la temperature, article de controle de sensibilite, procede de controle de sensibilite et carte de parfums
US20110256209A1 (en) * 2005-02-17 2011-10-20 Yon Doo Ough Skin patch for improving menstrual
US9913924B2 (en) 2016-05-25 2018-03-13 S. C. Johnson & Son, Inc. Dispensing device

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JP4647736B2 (ja) * 1999-09-30 2011-03-09 小林製薬株式会社 薬剤発散具
DE102006056249A1 (de) 2006-11-27 2008-05-29 Henkel Kgaa Reinigungs- oder Pflegeprodukt
US8685379B2 (en) * 2008-01-29 2014-04-01 International Art And Science Group, Inc. Functional material and delivery gel composition and method for manufacturing
CA3040130C (fr) 2012-06-18 2021-09-14 Gripmetal Limited Procede de fabrication d'une feuille stratifiee
JP6377389B2 (ja) * 2014-03-31 2018-08-22 小林製薬株式会社 発泡剤
US10315382B2 (en) 2016-12-22 2019-06-11 Gripmetal Limited Process for manufacturing textured laminate sheet
CN111840621A (zh) * 2020-08-04 2020-10-30 安徽克菱保健科技有限公司 一种遇水自发热香薰沐浴片

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EP1137426B1 (fr) * 1998-12-07 2005-10-26 Ecosmart Technologies, Inc. Utilisation d'huiles essentielles vegetales naturelles pour le traitement du cancer du sein
US6812258B2 (en) 1998-12-07 2004-11-02 Ecosmart Technologies, Inc. Cancer treatment composition and method using natural plant essential oils
US6451331B1 (en) 2000-01-31 2002-09-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Pleated cosmetic effervescent cleansing pillow
US6506713B1 (en) 2000-01-31 2003-01-14 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic effervescent cleansing compositions
US7235187B2 (en) 2000-07-13 2007-06-26 The Procter & Gamble Company Methods and apparatuses for delivering a volatile component via a controlled exothermic reaction
US7081211B2 (en) 2000-07-13 2006-07-25 The Procter & Gamble Company Multi-layer reaction mixtures and apparatuses for delivering a volatile component via a controlled exothermic reaction
WO2002038194A1 (fr) * 2000-11-07 2002-05-16 The Procter & Gamble Company Dispositifs autochauffants de diffusion de matieres volatiles actives par commande
EP1205195A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil auto-chauffant pour délivrer des matériaux volatils activable de manière regulable
EP1205193A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil facilement activable auto-chauffant pour délivrer des matériaux volatils
WO2002038193A1 (fr) * 2000-11-07 2002-05-16 The Procter & Gamble Company Dispositif autochauffant de diffusion prolongee de matieres volatiles
WO2002038192A1 (fr) * 2000-11-07 2002-05-16 The Procter & Gamble Company Dispositif autochauffant de diffusion de matieres volatiles pouvant etre facilement active
WO2002038195A1 (fr) * 2000-11-07 2002-05-16 The Procter & Gamble Company Dispositif auto-chauffant efficace pour distribuer des matieres volatiles
EP1205194A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil auto-chauffant pour la délivrance prolongée de matériaux volatils
EP1205192A1 (fr) * 2000-11-07 2002-05-15 The Procter & Gamble Company Appareil efficace auto-chauffant pour délivrer des matériaux volatils
US6901609B2 (en) 2001-01-15 2005-06-07 The Procter & Gamble Company Method of dispensing volatile and soluble substances and a device for use therein
US6944889B2 (en) 2001-01-15 2005-09-20 The Procter & Gamble Company Method of dispensing volatile and soluble substances and a device for use therein
WO2002068005A1 (fr) * 2001-02-26 2002-09-06 The Procter & Gamble Company Composition conçue pour degager un arome, a stabilite ameliore et a moussage reduit
WO2003053410A1 (fr) * 2001-12-20 2003-07-03 Alpex Pharma Sa Compositions particulaires
JP2005516944A (ja) * 2001-12-20 2005-06-09 アルペックス ファーマ ソシエテ アノニム 微粒子組成物
WO2005020951A1 (fr) 2003-08-21 2005-03-10 The Procter & Gamble Company Article nettoyant effervescent
EP1661973A4 (fr) * 2003-09-05 2010-02-17 Shiseido Co Ltd Composition de parfum pour le controle de sensibilite a la temperature, article de controle de sensibilite, procede de controle de sensibilite et carte de parfums
EP1627647A1 (fr) * 2004-08-19 2006-02-22 Bell Flavours & Fragrances Limited Dispositif de traitement d'air et paquet de remplissage
US7548684B2 (en) 2004-08-19 2009-06-16 Bell Flavours & Fragrances Limitd Air treatment apparatus and refill pack
US20110256209A1 (en) * 2005-02-17 2011-10-20 Yon Doo Ough Skin patch for improving menstrual
US9913924B2 (en) 2016-05-25 2018-03-13 S. C. Johnson & Son, Inc. Dispensing device

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CA2325037A1 (fr) 1999-09-30
CN1286625A (zh) 2001-03-07
BR9815747A (pt) 2000-11-14
JP2001506533A (ja) 2001-05-22
EP1063960A1 (fr) 2001-01-03

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