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WO1999045112A3 - Gene chd1 de susceptibilite aux maladies coronariennes lie au chromosome 11 - Google Patents

Gene chd1 de susceptibilite aux maladies coronariennes lie au chromosome 11 Download PDF

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Publication number
WO1999045112A3
WO1999045112A3 PCT/US1999/004682 US9904682W WO9945112A3 WO 1999045112 A3 WO1999045112 A3 WO 1999045112A3 US 9904682 W US9904682 W US 9904682W WO 9945112 A3 WO9945112 A3 WO 9945112A3
Authority
WO
WIPO (PCT)
Prior art keywords
chd1
heart disease
coronary heart
gene
therapy
Prior art date
Application number
PCT/US1999/004682
Other languages
English (en)
Other versions
WO1999045112A2 (fr
Inventor
Dennis G Ballinger
Wei Ding
Susanne Wagner
Mark A Hess
Original Assignee
Myriad Genetics Inc
Dennis G Ballinger
Wei Ding
Susanne Wagner
Mark A Hess
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myriad Genetics Inc, Dennis G Ballinger, Wei Ding, Susanne Wagner, Mark A Hess filed Critical Myriad Genetics Inc
Priority to AU30680/99A priority Critical patent/AU3068099A/en
Publication of WO1999045112A2 publication Critical patent/WO1999045112A2/fr
Publication of WO1999045112A3 publication Critical patent/WO1999045112A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention porte sur le gène (CHD1) humain de susceptibilité aux maladies coronariennes dont certains allèles sont en relation avec ladite susceptibilité, sur des mutations des lignées germinales du gène CHD1 et leur utilisation dans le diagnostic de la prédisposition aux maladies coronariennes et des troubles du métabolisme, dont l'hypoalphalipoprotéinémie, l'hyperlipidémie familiale combinée, le syndrome X de résistance à l'insuline, ou les troubles multiples du métabolisme, l'obésité, le diabète et l'hypertension dyslipidémique, sur la thérapie présymptomatique d'individus porteurs d'allèles délétères (dont la thérapie génique, la thérapie par remplacement de protéines ou l'administration de protéines mimétiques et d'inhibiteurs), et sur le criblage de médicaments de thérapie des dyslipidémies.
PCT/US1999/004682 1998-03-04 1999-03-04 Gene chd1 de susceptibilite aux maladies coronariennes lie au chromosome 11 WO1999045112A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30680/99A AU3068099A (en) 1998-03-04 1999-03-04 Chromosome 11-linked coronary heart disease susceptibility gene chd1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3494198A 1998-03-04 1998-03-04
US09/034,941 1998-03-04
US8093498P 1998-04-06 1998-04-06
US60/080,934 1998-04-06

Publications (2)

Publication Number Publication Date
WO1999045112A2 WO1999045112A2 (fr) 1999-09-10
WO1999045112A3 true WO1999045112A3 (fr) 1999-11-04

Family

ID=26711582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004682 WO1999045112A2 (fr) 1998-03-04 1999-03-04 Gene chd1 de susceptibilite aux maladies coronariennes lie au chromosome 11

Country Status (2)

Country Link
AU (1) AU3068099A (fr)
WO (1) WO1999045112A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104050344A (zh) * 2013-09-30 2014-09-17 西安时代基因健康科技有限公司 冠心病的表征参数的获取方法
CN116144753A (zh) * 2022-12-27 2023-05-23 湖南家辉生物技术有限公司 一种致病基因chd1突变位点的应用及检测试剂

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
HILLIER ET AL.: "The WashU-Merck EST Project", EMBL SEQUENCE DATABASE, 7 June 1996 (1996-06-07), HEIDELBERG DE, XP002114882 *
HILLIER ET AL.: "WashU-merck EST Project 1997", EMBL SEQUENCE DATABASE, 25 April 1997 (1997-04-25), HEIDELBERG DE, XP002114883 *
LEE ET AL., GENOMICS, vol. 43, 1997, pages 191 - 201 *
LEE ET AL.: "Zinc finger protein", EMBL SEQUENCE DATABASE, 1 November 1996 (1996-11-01), HEIDELBERG DE, XP002114884 *
MONACO ET AL., GENOMICS, vol. 52, 1998, pages 358 - 362, XP002114888 *
MONACO ET AL.: "Homo sapiens ZNF202 beta (ZNF202) mRNA, complete cds", EMBL SEQUENCE DATABASE, 16 November 1998 (1998-11-16), HEIDELBERG DE, XP002114887 *
STOKES ET AL.: "DNA.binding and chromatin localization properties of CHD1", MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 5, May 1995 (1995-05-01), pages 2745 - 2753, XP002114885 *
WOODAGE ET AL.: "Characterization of the CHD family of proteins", PROC NATL ACAD SCI USA, vol. 94, October 1997 (1997-10-01), pages 11472 - 11477, XP002114886 *

Also Published As

Publication number Publication date
WO1999045112A2 (fr) 1999-09-10
AU3068099A (en) 1999-09-20

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