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WO1999044588A3 - Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant - Google Patents

Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant Download PDF

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Publication number
WO1999044588A3
WO1999044588A3 PCT/EP1999/001271 EP9901271W WO9944588A3 WO 1999044588 A3 WO1999044588 A3 WO 1999044588A3 EP 9901271 W EP9901271 W EP 9901271W WO 9944588 A3 WO9944588 A3 WO 9944588A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical active
forms containing
producing solid
active agents
spherical forms
Prior art date
Application number
PCT/EP1999/001271
Other languages
German (de)
English (en)
Other versions
WO1999044588A2 (fr
Inventor
Andreas Kleinke
Thomas Kessler
Joerg Rosenberg
Harald Krull
Gunther Berndl
Werner Maier
Joerg Breitenbach
Original Assignee
Basf Ag
Andreas Kleinke
Thomas Kessler
Joerg Rosenberg
Harald Krull
Gunther Berndl
Werner Maier
Joerg Breitenbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Andreas Kleinke, Thomas Kessler, Joerg Rosenberg, Harald Krull, Gunther Berndl, Werner Maier, Joerg Breitenbach filed Critical Basf Ag
Priority to CA002322629A priority Critical patent/CA2322629A1/fr
Priority to EP99911718A priority patent/EP1059914A2/fr
Publication of WO1999044588A2 publication Critical patent/WO1999044588A2/fr
Publication of WO1999044588A3 publication Critical patent/WO1999044588A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un procédé de production de corps moulés sphériques solides contenant au moins un principe actif pharmaceutique homogène en dispersion dans une matrice constituée d'un produit auxiliaire. Selon ce procédé, on mélange les composants pour obtenir une masse en fusion puis on façonne cette masse. Ce procédé est caractérisé en ce que l'on transforme au moins un principe actif pharmaceutique comprenant au moins un produit auxiliaire-matrice thermoplastiquement transformable en une masse en fusion homogène d'une viscosité inférieure à 5000 mPas et en ce que l'on transforme cette masse en fusion en gouttes à l'aide d'un cylindre perceur rotatif. Ces gouttes sont ensuite solidifiées par refroidissement.
PCT/EP1999/001271 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant WO1999044588A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002322629A CA2322629A1 (fr) 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant
EP99911718A EP1059914A2 (fr) 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998109242 DE19809242A1 (de) 1998-03-05 1998-03-05 Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix
DE19809242.3 1998-03-05

Publications (2)

Publication Number Publication Date
WO1999044588A2 WO1999044588A2 (fr) 1999-09-10
WO1999044588A3 true WO1999044588A3 (fr) 1999-10-28

Family

ID=7859688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/001271 WO1999044588A2 (fr) 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant

Country Status (4)

Country Link
EP (1) EP1059914A2 (fr)
CA (1) CA2322629A1 (fr)
DE (1) DE19809242A1 (fr)
WO (1) WO1999044588A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19943501A1 (de) * 1999-09-10 2001-03-15 Basf Ag Unterwassergranulation wirkstoffhaltiger Schmelzen
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
CN101091695B (zh) 2003-02-03 2011-01-19 诺瓦提斯公司 药物制剂
AU2005271035B2 (en) * 2004-08-12 2009-09-17 Reckitt Benckiser Healthcare (Uk) Limited Granules comprising a NSAID and a sugar alcohol made by melt extrusion
DE102007061408A1 (de) 2007-12-11 2009-06-18 Sandvik Materials Technology Deutschland Gmbh Verfahren und Tropfenformer zum Herstellen von Pastillen sowie Verfahren zum Herstellen eines schwefelhaltigen Düngers

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3139920A1 (de) * 1981-10-08 1983-04-28 Nittner, Erich, Dr., 8280 Kreuzlingen "mittel in granulatform auf basis von polysaccharid-gummen, verfahren zu seiner herstellung und verwendung"
US5013498A (en) * 1988-04-23 1991-05-07 Santrade Ltd. Method and apparatus for producing pastilles
WO1993025074A1 (fr) * 1992-06-16 1993-12-23 E.I. Du Pont De Nemours And Company Compositions agricoles granuleuses se dispersant dans l'eau
EP0582186A1 (fr) * 1992-08-04 1994-02-09 MERZ + CO. GmbH & Co. Procédé de préparation de formes pharmaceutiques solides à libération prolongée en deux étapes
WO1997012603A1 (fr) * 1995-09-29 1997-04-10 Basf Aktiengesellschaft Formes medicamenteuses solides obtenues par extrusion d'une masse fondue de substance active polymere contenant de l'isomalt
EP0922462A2 (fr) * 1997-12-01 1999-06-16 Basf Aktiengesellschaft Procédé de préparation de formes solides de dosage

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3139920A1 (de) * 1981-10-08 1983-04-28 Nittner, Erich, Dr., 8280 Kreuzlingen "mittel in granulatform auf basis von polysaccharid-gummen, verfahren zu seiner herstellung und verwendung"
US5013498A (en) * 1988-04-23 1991-05-07 Santrade Ltd. Method and apparatus for producing pastilles
WO1993025074A1 (fr) * 1992-06-16 1993-12-23 E.I. Du Pont De Nemours And Company Compositions agricoles granuleuses se dispersant dans l'eau
EP0582186A1 (fr) * 1992-08-04 1994-02-09 MERZ + CO. GmbH & Co. Procédé de préparation de formes pharmaceutiques solides à libération prolongée en deux étapes
WO1997012603A1 (fr) * 1995-09-29 1997-04-10 Basf Aktiengesellschaft Formes medicamenteuses solides obtenues par extrusion d'une masse fondue de substance active polymere contenant de l'isomalt
EP0922462A2 (fr) * 1997-12-01 1999-06-16 Basf Aktiengesellschaft Procédé de préparation de formes solides de dosage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHAK J.A.: "Pelletizing, prilling or pastillating", PROC.-INST. BRIQUET. AGGLOM. , BIENN. CONF., vol. 2, 1991, pages 143 - 149, XP002113494 *

Also Published As

Publication number Publication date
WO1999044588A2 (fr) 1999-09-10
CA2322629A1 (fr) 1999-09-10
EP1059914A2 (fr) 2000-12-20
DE19809242A1 (de) 1999-09-09

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