WO1999043335A1 - Extraits de plante et methodes anticancereuses dans lesquels ils sont utilises - Google Patents
Extraits de plante et methodes anticancereuses dans lesquels ils sont utilises Download PDFInfo
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- WO1999043335A1 WO1999043335A1 PCT/AU1999/000111 AU9900111W WO9943335A1 WO 1999043335 A1 WO1999043335 A1 WO 1999043335A1 AU 9900111 W AU9900111 W AU 9900111W WO 9943335 A1 WO9943335 A1 WO 9943335A1
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- WIPO (PCT)
- Prior art keywords
- cancer
- extract
- clover
- organic solvent
- daidzein
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
Definitions
- daidzein H genistein
- R OH the structure of biochanin is the same as for genistein but with a 4'-methoxy group, and similarly formononetin has the same structure as daidzein, but with a 4'-methoxy group.
- Chemotherapy for the treatment of cancer is harsh, often generally being cytotoxic and affecting fast growing cells such as those of the intestinal region, and hair cells. Unpleasant side effects often include nausea, loss of taste, lethargy, hair loss, loss of libido, and the like. Anti-cancer therapeutic agents are generally costly and in some cases may only be administered by intravenous infusion.
- Suitable carriers may be fillers, such as sugars, for example lactose, saccharose, mannitol or sorbitol, cellulose preparations and/or calcium phosphates, for example tricalcium phosphate or calcium hydrogen phosphate, and also binders, such as starch pastes using, for example, corn, wheat, rice or potato starch, gelatin, tragacanth, methylceullose and/or polyvinylpyrrolidone, and, if desired, disintegrators, such as the above-mentioned starches, also carboxymethyl starch, cross linked polyvinyl pyrrolidone, agar or alginic acid or a salt thereof, such as sodium alginate.
- fillers such as sugars, for example lactose, saccharose, mannitol or sorbitol, cellulose preparations and/or calcium phosphates, for example tricalcium phosphate or calcium hydrogen phosphate
- binders such as starch pastes using,
- compositions suitable for topical administration to the skin preferably take the form of an ointment, cream, lotion, paste, gel, spray, aerosol, or oil.
- Carriers which may be used include petroleum jelly, lanoline, polyethylene glycols, alcohols, and a combination of two or more thereof.
- the extract is generally present at a concentration of from 0.1 % to 30% weight/weight, for example from 0.5% to 10% weight/weight.
- the compositions of the present invention induce one or more effects of inhibition of cell proliferation, induction of cell differentiation, induction of apoptosis (programmed cell death), DNA fragmentation or cell cycle blocking which all represent anti-cancer activity.
- the compositions of the present invention have wide ranging activity against cancer cells and are accordingly effective in the treatment, prophylaxis, amelioration, defence against and/or prevention of cancers including benign prostatic hypertrophy, prostatic cancer, breast cancer, uterine cancer, leukaemia, ovarian cancer, endometrial cancer, cervical cancer, colon (large bowel) cancer, testicular cancer, Hodgkin's disease, lymphoma, rhabdo sarcoma, neuroblastoma, pancreatic cancer, lung cancer, brain tumour, skin cancer, stomach (gastric) cancer, oral cancer, liver cancer, laryngeal cancer, bladder cancer, thyroid cancer, and nasopharyngeal carcinoma.
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Composition constituées d'un extrait de trèfle à base d'eau/solvant organique, duquel on a enlevé les composés contenant le chromophore aromatique, comprenant des isoflavones, telles que la génistéine, la daidzénine, la formononétine et la biochanine et/ou leurs glycosides. Ledit extrait a une activité anti-cancéreuse contre une ou plusieurs des lignées cellulaires HLK60, K562, LNCaP ou HT29, éventuellement en association avec un ou plusieurs, excipients, auxiliaires et/ou diluants et vecteurs pharmaceutiquement acceptables. L'invention concerne aussi des procédés de production desdites compositions, des méthodes de traitement, d'atténuation du cancer, de prophylaxie ou de défense contre le cancer.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU28189/99A AU2818999A (en) | 1998-02-25 | 1999-02-25 | Plant extracts and anti-cancer modalities involving the same |
| EP19990908672 EP1056463A4 (fr) | 1998-02-25 | 1999-02-25 | Extraits de plante et methodes anticancereuses dans lesquels ils sont utilises |
| CA002320777A CA2320777A1 (fr) | 1998-02-25 | 1999-02-25 | Extraits de plante et methodes anticancereuses dans lesquels ils sont utilises |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP1987A AUPP198798A0 (en) | 1998-02-25 | 1998-02-25 | Compositions comprising extracts of isoflavone-containing plants and anti-cancer modalities involving the same |
| AUPP1987 | 1998-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1999043335A1 true WO1999043335A1 (fr) | 1999-09-02 |
Family
ID=3806255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AU1999/000111 WO1999043335A1 (fr) | 1998-02-25 | 1999-02-25 | Extraits de plante et methodes anticancereuses dans lesquels ils sont utilises |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1056463A4 (fr) |
| AU (1) | AUPP198798A0 (fr) |
| CA (1) | CA2320777A1 (fr) |
| WO (1) | WO1999043335A1 (fr) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1174144A1 (fr) * | 2000-07-20 | 2002-01-23 | Linnea S.A. | Extrait sec riche en isoflavones et procédé de préparation |
| WO2002053152A1 (fr) * | 2001-01-08 | 2002-07-11 | Imperial College Of Science, Technology & Medicine | Compositions contenant des flavonoides pour le traitement de troubles cerebraux |
| US6987098B2 (en) | 1992-05-19 | 2006-01-17 | Novogen Research Pty. Ltd. | Health supplement |
| US7033621B1 (en) | 1997-04-28 | 2006-04-25 | Novogen, Inc. | Isoflavone compositions produced from legumes |
| US7202273B2 (en) | 1996-08-30 | 2007-04-10 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
| WO2007073908A1 (fr) | 2005-12-29 | 2007-07-05 | Evultis S.A. | Procede d’isolement de principes pharmacologiquement actifs d’origine vegetale et animale |
| EP1842541A1 (fr) | 2006-03-29 | 2007-10-10 | G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg | Composé et extraits de plantes et leur utilisation |
| US7312344B2 (en) | 2001-03-08 | 2007-12-25 | Novogen Research Pty Limited | Dimeric isoflavones |
| US7488494B2 (en) | 1999-09-06 | 2009-02-10 | Novogen Research Pty Ltd. | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| CN106153808A (zh) * | 2015-03-30 | 2016-11-23 | 贵州百灵企业集团和仁堂药业有限公司 | 一种康妇灵胶囊的检测方法 |
| CN113845549A (zh) * | 2021-09-26 | 2021-12-28 | 广州鲁比生物科技有限公司 | 一种芒柄花黄素衍生物及其制备方法和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140805A (en) * | 1977-03-11 | 1979-02-20 | Edwards George W | Process of producing useful materials from plants |
| GB2136812A (en) * | 1983-03-23 | 1984-09-26 | Osaka Chem Lab | A method of isolating soya saponins |
| WO1993023069A1 (fr) * | 1992-05-19 | 1993-11-25 | Graham Edmund Kelly | Complements benefiques pour la sante, contenant des phyto-×strogenes, des analogues ou des metabolites de ceux-ci |
| AU4003497A (en) * | 1996-08-30 | 1998-03-19 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857325A (en) * | 1985-04-24 | 1989-08-15 | Bar-Ilan University | Antioxidant compositions and methods |
-
1998
- 1998-02-25 AU AUPP1987A patent/AUPP198798A0/en not_active Abandoned
-
1999
- 1999-02-25 WO PCT/AU1999/000111 patent/WO1999043335A1/fr not_active Application Discontinuation
- 1999-02-25 EP EP19990908672 patent/EP1056463A4/fr not_active Withdrawn
- 1999-02-25 CA CA002320777A patent/CA2320777A1/fr not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140805A (en) * | 1977-03-11 | 1979-02-20 | Edwards George W | Process of producing useful materials from plants |
| GB2136812A (en) * | 1983-03-23 | 1984-09-26 | Osaka Chem Lab | A method of isolating soya saponins |
| WO1993023069A1 (fr) * | 1992-05-19 | 1993-11-25 | Graham Edmund Kelly | Complements benefiques pour la sante, contenant des phyto-×strogenes, des analogues ou des metabolites de ceux-ci |
| AU4003497A (en) * | 1996-08-30 | 1998-03-19 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
Non-Patent Citations (6)
| Title |
|---|
| DATABASE WPI WORLD PATENT INF 1 January 1900 (1900-01-01), ARTYUKH M A, BATOVA R S, PETERSONE E Y U: "Surface active polysaccharide cpds. - extracted from leguminous plant leaves and stems with water and alcohol for use as emulsifiers in dr mfr.", XP002905385, Database accession no. 1982-19629E * |
| DATABASE WPI WORLD PATENT INF 1 January 1900 (1900-01-01), KAZAKOV A L, KOMPANTSEV V A, LYKYANOV M S: "Preparation having anti-sclerotic and cholagogic effects - by treating red clover with specific amount of ethanol in rotational extractor, then extracting cake with solvent", XP002905386, Database accession no. 1997-279357 * |
| PATENT ABSTRACTS OF JAPAN, (C-265), page 15; & JP 59175496 A (OOSAKA YAKUHIN KENKYUSHO KK) 4 October 1984. * |
| PATENT ABSTRACTS OF JAPAN, (C-442), page 66; & JP 62063581 A (COSMO CO LTD) 20 March 1987. * |
| PATENT ABSTRACTS OF JAPAN, (C-447), page 60; & JP 62083848 A (RIYOUSHIYOKU KENKYUKAI) 17 April 1987. * |
| See also references of EP1056463A4 * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6987098B2 (en) | 1992-05-19 | 2006-01-17 | Novogen Research Pty. Ltd. | Health supplement |
| US7045155B2 (en) | 1992-05-19 | 2006-05-16 | Novogen Research Pty Ltd. | Dietary supplements comprising soy hypocotyls containing at least one isoflavone |
| US7202273B2 (en) | 1996-08-30 | 2007-04-10 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
| US7033621B1 (en) | 1997-04-28 | 2006-04-25 | Novogen, Inc. | Isoflavone compositions produced from legumes |
| US7488494B2 (en) | 1999-09-06 | 2009-02-10 | Novogen Research Pty Ltd. | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| US6500965B2 (en) | 2000-07-20 | 2002-12-31 | Linnea Sa | Dry extract which is rich in isoflavones in the form of aglycones and process for preparing the same |
| EP1174144A1 (fr) * | 2000-07-20 | 2002-01-23 | Linnea S.A. | Extrait sec riche en isoflavones et procédé de préparation |
| WO2002053152A1 (fr) * | 2001-01-08 | 2002-07-11 | Imperial College Of Science, Technology & Medicine | Compositions contenant des flavonoides pour le traitement de troubles cerebraux |
| US7312344B2 (en) | 2001-03-08 | 2007-12-25 | Novogen Research Pty Limited | Dimeric isoflavones |
| WO2007073908A1 (fr) | 2005-12-29 | 2007-07-05 | Evultis S.A. | Procede d’isolement de principes pharmacologiquement actifs d’origine vegetale et animale |
| EP1842541A1 (fr) | 2006-03-29 | 2007-10-10 | G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg | Composé et extraits de plantes et leur utilisation |
| CN106153808A (zh) * | 2015-03-30 | 2016-11-23 | 贵州百灵企业集团和仁堂药业有限公司 | 一种康妇灵胶囊的检测方法 |
| CN113845549A (zh) * | 2021-09-26 | 2021-12-28 | 广州鲁比生物科技有限公司 | 一种芒柄花黄素衍生物及其制备方法和应用 |
| CN113845549B (zh) * | 2021-09-26 | 2023-09-19 | 广州鲁比生物科技有限公司 | 一种芒柄花黄素衍生物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AUPP198798A0 (en) | 1998-03-19 |
| CA2320777A1 (fr) | 1999-09-02 |
| EP1056463A4 (fr) | 2002-11-05 |
| EP1056463A1 (fr) | 2000-12-06 |
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