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WO1998038210A3 - Methods and compositions for modulation of vesicular release - Google Patents

Methods and compositions for modulation of vesicular release Download PDF

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Publication number
WO1998038210A3
WO1998038210A3 PCT/US1998/003789 US9803789W WO9838210A3 WO 1998038210 A3 WO1998038210 A3 WO 1998038210A3 US 9803789 W US9803789 W US 9803789W WO 9838210 A3 WO9838210 A3 WO 9838210A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
modulation
compositions
vesicular release
release
Prior art date
Application number
PCT/US1998/003789
Other languages
French (fr)
Other versions
WO1998038210A2 (en
Inventor
Andrew J Bean
Richard H Scheller
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Priority to AU64407/98A priority Critical patent/AU6440798A/en
Publication of WO1998038210A2 publication Critical patent/WO1998038210A2/en
Publication of WO1998038210A3 publication Critical patent/WO1998038210A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Hrs-2 polynucleotides and polypeptides are disclosed. Also disclosed are methods of identifying a compound capable of modulating calcium-regulated secretion of secretory vesicles, such as the release of neurotransmitter-containing synaptic vesicles.
PCT/US1998/003789 1997-02-26 1998-02-26 Methods and compositions for modulation of vesicular release WO1998038210A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64407/98A AU6440798A (en) 1997-02-26 1998-02-26 Methods and compositions for modulation of vesicular release

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3915997P 1997-02-26 1997-02-26
US60/039,159 1997-02-26

Publications (2)

Publication Number Publication Date
WO1998038210A2 WO1998038210A2 (en) 1998-09-03
WO1998038210A3 true WO1998038210A3 (en) 1998-10-08

Family

ID=21903978

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/003789 WO1998038210A2 (en) 1997-02-26 1998-02-26 Methods and compositions for modulation of vesicular release

Country Status (2)

Country Link
AU (1) AU6440798A (en)
WO (1) WO1998038210A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132977A (en) * 1998-03-13 2000-10-17 University Of New Mexico Measurement of a CNS protein in cerebrospinal or amniotic fluid
FR2857098B1 (en) * 2003-07-04 2006-05-05 Inst Nat Sante Rech Med METHOD FOR THE EVIDENCE OF A MOLECULAR EVENT IN A CELL USING FLUORESCENT MARKER PROTEINS
US7998970B2 (en) 2004-12-03 2011-08-16 Proteosys Ag Use of finasteride, dutasteride and related compounds for the prevention or treatment of neurologically-associated disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015149A2 (en) * 1994-11-10 1996-05-23 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
WO1998021333A2 (en) * 1996-11-15 1998-05-22 Cedars-Sinai Medical Center Nucleic acid encoding schwannomin-binding-proteins and products related thereto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996015149A2 (en) * 1994-11-10 1996-05-23 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
WO1998021333A2 (en) * 1996-11-15 1998-05-22 Cedars-Sinai Medical Center Nucleic acid encoding schwannomin-binding-proteins and products related thereto

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BEAN A.J. ET AL.: "Hrs-2 is an ATPase implicated in calcium-regulated secretion", NATURE, vol. 385, 27 February 1997 (1997-02-27), pages 826 - 829, XP002073824 *
DATABASE EMBL SEQUENCES EMBL, Heidelberg, FRG; 8 January 1998 (1998-01-08), LU L. ET AL,: "Human Hrs", XP002073825 *
DEBELLO W.M. ET AL.: "SNAP-mediated protein-protein interactions essential for neurotransmitter release", NATURE, vol. 373, 16 February 1995 (1995-02-16), pages 626 - 630, XP002073821 *
KOMADA M. & KITAMURA N.: "Growth Factor-induced tyrosine phosphorylation of Hrs, a novel 115-kDa protein with a structurally conserved putative zinc finger domain", MOL. CELL BIOL., vol. 15, November 1995 (1995-11-01), pages 6213 - 6221, XP002073820 *
SCHIAVO G. ET AL.: "Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses", PROC. NATL. ACAD- SCI. USA, vol. 94, 4 February 1997 (1997-02-04), pages 997 - 1001, XP002073822 *
SHENG Z.H. ET AL.: "Calcium-dependent interaction of N-type calcium channels with the synaptic core complex", NATURE, vol. 379, 1 February 1995 (1995-02-01), pages 451 - 454, XP002073823 *

Also Published As

Publication number Publication date
WO1998038210A2 (en) 1998-09-03
AU6440798A (en) 1998-09-18

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