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WO1998035032A3 - Procedes permettant de provoquer une stase de cycle cellulaire - Google Patents

Procedes permettant de provoquer une stase de cycle cellulaire Download PDF

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Publication number
WO1998035032A3
WO1998035032A3 PCT/US1998/003390 US9803390W WO9835032A3 WO 1998035032 A3 WO1998035032 A3 WO 1998035032A3 US 9803390 W US9803390 W US 9803390W WO 9835032 A3 WO9835032 A3 WO 9835032A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cell cycle
inducing cell
stasis
vpr protein
Prior art date
Application number
PCT/US1998/003390
Other languages
English (en)
Other versions
WO1998035032A2 (fr
WO1998035032A9 (fr
Inventor
Irvin S Y Chen
Jeremy B M Jowett
Elizabeth Withers-Ward
Shelia A Stewart
Betty Pogh
Juli Feigon
Thorsten Dieckmann
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Priority to AU63335/98A priority Critical patent/AU6333598A/en
Publication of WO1998035032A2 publication Critical patent/WO1998035032A2/fr
Publication of WO1998035032A9 publication Critical patent/WO1998035032A9/fr
Publication of WO1998035032A3 publication Critical patent/WO1998035032A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention se fonde sur l'observation selon laquelle la protéine Vpr des lentivirus, en particulier la protéine Vpr du VIH, produit une stase et une mort cellulaires lorsqu'on la met en contact avec une cellule. Se fondant sur ces observations, la présente invention concerne des procédés permettant de provoquer une stase et une mort cellulaires, qui consistent à mettre une cellule en contact avec une protéine Vpr ou un analogue d'une protéine Vpr.
PCT/US1998/003390 1997-02-11 1998-02-11 Procedes permettant de provoquer une stase de cycle cellulaire WO1998035032A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU63335/98A AU6333598A (en) 1997-02-11 1998-02-11 Methods of inducing cell cycle stasis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79859797A 1997-02-11 1997-02-11
US08/798,597 1997-02-11
US95927997A 1997-10-24 1997-10-24
US08/959,279 1997-10-24

Publications (3)

Publication Number Publication Date
WO1998035032A2 WO1998035032A2 (fr) 1998-08-13
WO1998035032A9 WO1998035032A9 (fr) 1999-01-07
WO1998035032A3 true WO1998035032A3 (fr) 1999-02-11

Family

ID=27122014

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/003390 WO1998035032A2 (fr) 1997-02-11 1998-02-11 Procedes permettant de provoquer une stase de cycle cellulaire

Country Status (2)

Country Link
AU (1) AU6333598A (fr)
WO (1) WO1998035032A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537972B1 (en) * 1997-06-02 2003-03-25 Subsidiary No. 3., Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
US6664040B2 (en) 2000-05-23 2003-12-16 The Regents Of The University Of California Compositions and methods for delivery of a molecule into a cell
ES2312595T3 (es) * 2001-05-23 2009-03-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Piruvato-quinasa como nueva molecula diana.
CN113289001A (zh) * 2020-12-24 2021-08-24 上海市闵行区中心医院 一种调控肿瘤细胞凋亡的Vpr蛋白N端氨基酸多肽在制备抗肿瘤药物中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008970A1 (fr) * 1994-09-21 1996-03-28 The Trustees Of The University Of Pennsylvania COMPOSITIONS ET PROCEDES PERMETTANT D'INTERROMPRE UNE PROLIFERATION CELLULAIRE A L'AIDE DE LA PROTEINE Vpr DU VIH
WO1996011696A1 (fr) * 1994-10-13 1996-04-25 The Regents Of The University Of California Methode de criblage de medicaments anti-vih

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008970A1 (fr) * 1994-09-21 1996-03-28 The Trustees Of The University Of Pennsylvania COMPOSITIONS ET PROCEDES PERMETTANT D'INTERROMPRE UNE PROLIFERATION CELLULAIRE A L'AIDE DE LA PROTEINE Vpr DU VIH
WO1996011696A1 (fr) * 1994-10-13 1996-04-25 The Regents Of The University Of California Methode de criblage de medicaments anti-vih

Also Published As

Publication number Publication date
WO1998035032A2 (fr) 1998-08-13
AU6333598A (en) 1998-08-26

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