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WO1998035027A3 - Promoteurs de l'exon 1 et de l'exon 3 du facteur humain de croissance du tissu nerveux - Google Patents

Promoteurs de l'exon 1 et de l'exon 3 du facteur humain de croissance du tissu nerveux Download PDF

Info

Publication number
WO1998035027A3
WO1998035027A3 PCT/US1998/000396 US9800396W WO9835027A3 WO 1998035027 A3 WO1998035027 A3 WO 1998035027A3 US 9800396 W US9800396 W US 9800396W WO 9835027 A3 WO9835027 A3 WO 9835027A3
Authority
WO
WIPO (PCT)
Prior art keywords
exon
promoters
growth factor
nerve growth
human nerve
Prior art date
Application number
PCT/US1998/000396
Other languages
English (en)
Other versions
WO1998035027A2 (fr
Inventor
Matthew D Linnik
Margaret M Racke
Joan M Krakowsky
Arun Subramaniam
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Priority to AU57342/98A priority Critical patent/AU5734298A/en
Priority to JP53444698A priority patent/JP2001521375A/ja
Priority to CA002280211A priority patent/CA2280211A1/fr
Priority to EP98901211A priority patent/EP0977778A2/fr
Publication of WO1998035027A2 publication Critical patent/WO1998035027A2/fr
Publication of WO1998035027A3 publication Critical patent/WO1998035027A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un nouveau promoteur de l'exon 1 du facteur humain de croissance du tissu nerveux, un promoteur de l'exon 3 de ce facteur, des fragments de ce promoteur ainsi que des formes modifiées de celui-ci. L'invention concerne également des vecteurs contenant de tels promoteurs, des cellules transformées à l'aide de ceux-ci, notamment des modèles animaux et des animaux transgéniques contenant une telle séquence, ainsi que des procédés de dosage effectués au moyen de ces promoteurs.
PCT/US1998/000396 1997-02-06 1998-01-12 Promoteurs de l'exon 1 et de l'exon 3 du facteur humain de croissance du tissu nerveux WO1998035027A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU57342/98A AU5734298A (en) 1997-02-06 1998-01-12 Human nerve growth factor exon 1 and exon 3 promoters
JP53444698A JP2001521375A (ja) 1997-02-06 1998-01-12 ヒト神経成長因子エクソン１およびエクソン３プロモーター
CA002280211A CA2280211A1 (fr) 1997-02-06 1998-01-12 Promoteurs de l'exon 1 et de l'exon 3 du facteur humain de croissance du tissu nerveux
EP98901211A EP0977778A2 (fr) 1997-02-06 1998-01-12 Promoteurs de l'exon 1 et de l'exon 3 du facteur humain de croissance du tissu nerveux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3821297P 1997-02-06 1997-02-06
US60/038,212 1997-02-06

Publications (2)

Publication Number Publication Date
WO1998035027A2 WO1998035027A2 (fr) 1998-08-13
WO1998035027A3 true WO1998035027A3 (fr) 1998-12-03

Family

ID=21898668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000396 WO1998035027A2 (fr) 1997-02-06 1998-01-12 Promoteurs de l'exon 1 et de l'exon 3 du facteur humain de croissance du tissu nerveux

Country Status (5)

Country Link
EP (1) EP0977778A2 (fr)
JP (1) JP2001521375A (fr)
AU (1) AU5734298A (fr)
CA (1) CA2280211A1 (fr)
WO (1) WO1998035027A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009095403A1 (fr) * 2008-01-29 2009-08-06 Tecnogen S.P.A. Système d'expression et ses utilisations pour la production de pentraxine 3 longue humaine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121338A1 (fr) * 1983-03-03 1984-10-10 Genentech, Inc. Facteur de croissance des nerfs humains préparé biosynthétiquement, procédé pour sa production, compositions contenant ledit facteur, séquence d'ADN codant pour ce facteur, vecteurs contenant cette séquence et cellules d'hôtes transformées par ce moyen
WO1987003304A1 (fr) * 1985-12-02 1987-06-04 The Regents Of The University Of California Isolement de sequences d'adn codant une activite de luciferase, et leurs applications
WO1990004037A1 (fr) * 1988-10-03 1990-04-19 Genlux Forschungsgesellschaft Für Biologische Verfahren Mbh PROCEDE POUR DECELER ET IDENTIFIER DES SUBSTANCES TOXIQUES A l'AIDE DE MICROORGANISMES CLONES
WO1994014956A1 (fr) * 1992-12-23 1994-07-07 Iowa State University Research Foundation, Inc. Agent lumineux moleculaire
WO1994019461A1 (fr) * 1993-02-17 1994-09-01 Cephalon, Inc. PROCEDE POUR IDENTIFIER DES COMPOSES INDUISANT UN NIVEAU ACCRU D'ARNm DU FACTEUR DE CROISSANCE NERVEUSE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121338A1 (fr) * 1983-03-03 1984-10-10 Genentech, Inc. Facteur de croissance des nerfs humains préparé biosynthétiquement, procédé pour sa production, compositions contenant ledit facteur, séquence d'ADN codant pour ce facteur, vecteurs contenant cette séquence et cellules d'hôtes transformées par ce moyen
WO1987003304A1 (fr) * 1985-12-02 1987-06-04 The Regents Of The University Of California Isolement de sequences d'adn codant une activite de luciferase, et leurs applications
WO1990004037A1 (fr) * 1988-10-03 1990-04-19 Genlux Forschungsgesellschaft Für Biologische Verfahren Mbh PROCEDE POUR DECELER ET IDENTIFIER DES SUBSTANCES TOXIQUES A l'AIDE DE MICROORGANISMES CLONES
WO1994014956A1 (fr) * 1992-12-23 1994-07-07 Iowa State University Research Foundation, Inc. Agent lumineux moleculaire
WO1994019461A1 (fr) * 1993-02-17 1994-09-01 Cephalon, Inc. PROCEDE POUR IDENTIFIER DES COMPOSES INDUISANT UN NIVEAU ACCRU D'ARNm DU FACTEUR DE CROISSANCE NERVEUSE

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARTWRIGHT M ET AL: "The human nerve growth factor gene: structure of the promoter region and expression in L929 fibroblasts", MOLECULAR BRAIN RESEARCH, vol. 15, no. 1-2, 1992, AMSTERDAM NL, pages 67 - 75, XP002063940 *
DE MARTIN R ET AL: "A new luciferase promoter insertion vector for the analysis of weak transcriptional activities - Promoter-probe plasmid pUBT-luc construction with a reporter gene", GENE., vol. 124, no. 1, 1993, AMSTERDAM NL, pages 137 - 138, XP002078045 *
RACKE M M ET AL: "Demonstration of a second pharmacologically active promoter region in the NGF gene that induces transcription at exon 3", MOLECULAR BRAIN RESEARCH, vol. 41, no. 1-2, 5 September 1996 (1996-09-05), AMSTERDAM NL, pages 192 - 199, XP002063941 *
RACKE M M ET AL: "Pharmacological evaluation of the human nerve growth factor promoters in mouse and human cells", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 23, no. 1-2, 25 October 1997 (1997-10-25), BETHESDA US, pages 2242, XP002063942 *

Also Published As

Publication number Publication date
WO1998035027A2 (fr) 1998-08-13
JP2001521375A (ja) 2001-11-06
EP0977778A2 (fr) 2000-02-09
AU5734298A (en) 1998-08-26
CA2280211A1 (fr) 1998-08-13

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