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WO1998034583A3 - Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes - Google Patents

Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes Download PDF

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Publication number
WO1998034583A3
WO1998034583A3 PCT/US1998/002176 US9802176W WO9834583A3 WO 1998034583 A3 WO1998034583 A3 WO 1998034583A3 US 9802176 W US9802176 W US 9802176W WO 9834583 A3 WO9834583 A3 WO 9834583A3
Authority
WO
WIPO (PCT)
Prior art keywords
permanently charged
agonist
steroid hormones
angiogenic activity
enhanced anti
Prior art date
Application number
PCT/US1998/002176
Other languages
English (en)
Other versions
WO1998034583A2 (fr
Inventor
Anat Biegon
Marcus E Brewster
Original Assignee
Pharmos Corp
Anat Biegon
Marcus E Brewster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12018497A external-priority patent/IL120184A/xx
Priority claimed from US08/833,074 external-priority patent/US6083990A/en
Application filed by Pharmos Corp, Anat Biegon, Marcus E Brewster filed Critical Pharmos Corp
Priority to EP98903921A priority Critical patent/EP0981337A4/fr
Priority to JP53487698A priority patent/JP2001511182A/ja
Priority to AU60562/98A priority patent/AU746007B2/en
Priority to CA002280181A priority patent/CA2280181A1/fr
Publication of WO1998034583A2 publication Critical patent/WO1998034583A2/fr
Publication of WO1998034583A3 publication Critical patent/WO1998034583A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne l'utilisation d'agonistes ou d'antagonistes constamment chargés de stéroïdes comme compositions puissamment anti-angiogéniques, qui renferment comme principe actif un composé de formules générales I (médicament), II (anti-oestrogènes) ou III, dans lesquelles 'médicament' est un agoniste ou un antagoniste des stéroïdes, un mélange agoniste-antagoniste ou un agoniste partiel, et les substituants sont tels que définis dans la spécification.
PCT/US1998/002176 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes WO1998034583A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98903921A EP0981337A4 (fr) 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes
JP53487698A JP2001511182A (ja) 1997-02-09 1998-02-04 ステロイドホルモンの永久に荷電された誘導体の増進された抗血管形成誘導活性
AU60562/98A AU746007B2 (en) 1997-02-09 1998-02-04 Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
CA002280181A CA2280181A1 (fr) 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL120184 1997-02-09
IL12018497A IL120184A (en) 1997-02-09 1997-02-09 Pharmaceutical compositions comprising permanently charged derivatives of steroid agonists or antagonists for preventing angiogenesis
US08/833,074 1997-04-02
US08/833,074 US6083990A (en) 1997-04-02 1997-04-02 Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones

Publications (2)

Publication Number Publication Date
WO1998034583A2 WO1998034583A2 (fr) 1998-08-13
WO1998034583A3 true WO1998034583A3 (fr) 1998-11-05

Family

ID=26323367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/002176 WO1998034583A2 (fr) 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes

Country Status (5)

Country Link
EP (1) EP0981337A4 (fr)
JP (1) JP2001511182A (fr)
AU (1) AU746007B2 (fr)
CA (1) CA2280181A1 (fr)
WO (1) WO1998034583A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2017312499B2 (en) * 2016-08-19 2023-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026720A1 (fr) * 1994-04-04 1995-10-12 Pharmos Corporation Derives constamment ioniques d'hormones steroides et leurs antagonistes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2914561A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of triphenylethylene
US2971001A (en) * 1959-10-21 1961-02-07 Wm S Merrell Co Quaternary salts of triphenylethanols, -ethylenes, and -ethanes
BE637389A (fr) * 1962-09-13
EP0667768B1 (fr) * 1992-10-27 1999-03-03 Nippon Kayaku Kabushiki Kaisha Utilisation toremifene pour traiter sle

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026720A1 (fr) * 1994-04-04 1995-10-12 Pharmos Corporation Derives constamment ioniques d'hormones steroides et leurs antagonistes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0981337A4 *

Also Published As

Publication number Publication date
AU6056298A (en) 1998-08-26
AU746007B2 (en) 2002-04-11
EP0981337A4 (fr) 2003-03-12
WO1998034583A2 (fr) 1998-08-13
CA2280181A1 (fr) 1998-08-13
EP0981337A2 (fr) 2000-03-01
JP2001511182A (ja) 2001-08-07

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