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WO1998033929A3 - Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus - Google Patents

Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus Download PDF

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Publication number
WO1998033929A3
WO1998033929A3 PCT/FR1998/000184 FR9800184W WO9833929A3 WO 1998033929 A3 WO1998033929 A3 WO 1998033929A3 FR 9800184 W FR9800184 W FR 9800184W WO 9833929 A3 WO9833929 A3 WO 9833929A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
cell receptor
polypeptide
receptor
adenoviruses
Prior art date
Application number
PCT/FR1998/000184
Other languages
English (en)
Other versions
WO1998033929A2 (fr
Inventor
Pierre Boulanger
Saw See Hong
Lucie Karayan
Original Assignee
Centre Nat Rech Scient
Pierre Boulanger
Saw See Hong
Lucie Karayan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9701005A external-priority patent/FR2758821B1/fr
Application filed by Centre Nat Rech Scient, Pierre Boulanger, Saw See Hong, Lucie Karayan filed Critical Centre Nat Rech Scient
Priority to JP10532596A priority Critical patent/JP2000510708A/ja
Priority to EP98905474A priority patent/EP0900280A2/fr
Priority to AU61046/98A priority patent/AU731911B2/en
Priority to US09/155,613 priority patent/US6420120B1/en
Publication of WO1998033929A2 publication Critical patent/WO1998033929A2/fr
Publication of WO1998033929A3 publication Critical patent/WO1998033929A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a pour objet l'utilisation d'un polypeptide comprenant au moins 6 acides aminés continus de la séquence telle que montrée dans les identificateurs de séquence 1 à 5 à titre de récepteur et/ou co-récepteur cellulaire des adénovirus. Elle concerne également l'utilisation d'une cellule capable d'exprimer un tel polypeptide ainsi que celle d'un ligand capable d'influencer l'attachement d'un adénovirus à une cellule hôte et/ou son entrée au sein de ladite cellule hôte. Enfin, elle a également trait à une méthode pour sélectionner ou identifier un récepteur cellulaire d'un virus ou la partie d'une protéine virale déterminant l'attachement du virus à son récepteur cellulaire ainsi qu'à l'utilisation d'un ligand bifonctionnel pour cibler un adénovirus vers une cellule hôte portant à sa surface une protéine de surface autre que le récepteur cellulaire naturel dudit adénovirus.
PCT/FR1998/000184 1997-01-30 1998-01-30 Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus WO1998033929A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP10532596A JP2000510708A (ja) 1997-01-30 1998-01-30 アデノウイルスの細胞レセプターとしてのポリペプチドの使用
EP98905474A EP0900280A2 (fr) 1997-01-30 1998-01-30 Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus
AU61046/98A AU731911B2 (en) 1997-01-30 1998-01-30 Use of a polypeptide as cellular receptor for adenoviruses
US09/155,613 US6420120B1 (en) 1997-01-30 1998-01-30 Use of a polypeptide as cell receptor for adenoviruses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR97/01005 1997-01-30
FR9701005A FR2758821B1 (fr) 1997-01-30 1997-01-30 Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus
FR97/11166 1997-09-09
FR9711166A FR2758822B1 (fr) 1997-01-30 1997-09-09 Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/155,613 A-371-Of-International US6420120B1 (en) 1997-01-30 1998-01-30 Use of a polypeptide as cell receptor for adenoviruses
US10/156,820 Division US20020150558A1 (en) 1997-01-30 2002-05-30 Use of a polypeptide as cellular receptor for adenoviruses

Publications (2)

Publication Number Publication Date
WO1998033929A2 WO1998033929A2 (fr) 1998-08-06
WO1998033929A3 true WO1998033929A3 (fr) 1998-11-19

Family

ID=26233288

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1998/000184 WO1998033929A2 (fr) 1997-01-30 1998-01-30 Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus

Country Status (7)

Country Link
US (2) US6420120B1 (fr)
EP (1) EP0900280A2 (fr)
JP (1) JP2000510708A (fr)
AU (1) AU731911B2 (fr)
CA (1) CA2251036A1 (fr)
FR (1) FR2758822B1 (fr)
WO (1) WO1998033929A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4070499A (en) 1998-04-30 1999-11-16 Cornell Research Foundation Inc. Adenoviral vectors with tandem fiber proteins
JP2002525065A (ja) 1998-09-11 2002-08-13 ジェンベク、インコーポレイティッド 選択的にターゲッティングされるアデノウイルス
IL133032A (en) * 1998-11-20 2007-06-03 Introgene Bv Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells
EP1020529B1 (fr) * 1998-11-20 2005-06-01 Crucell Holland B.V. Vecteurs d'apport de gènes munis d'un tropisme pour les cellules des muscles lisses et/ou les cellules endothéliales
JP2004510433A (ja) 2000-10-06 2004-04-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク Ｄｎａおよびｒｎａを解読するための大量並行方法
US7026164B2 (en) * 2003-07-03 2006-04-11 Cell Genesys, Inc. Adenovirus packaging cell lines
US20060052947A1 (en) * 2004-05-17 2006-03-09 Evelyn Hu Biofabrication of transistors including field effect transistors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005303A1 (fr) * 1992-08-31 1994-03-17 Board Of Regents Of The University Of Oklahoma Diagnostique et therapie peptidiques pour spondyloarthropathies
US5385888A (en) * 1987-03-20 1995-01-31 The Regents Of The University Of California Class I MHC modulation or surface receptor activity
WO1995005189A1 (fr) * 1993-08-12 1995-02-23 The Regents Of The University Of California Modulation des antigenes de classe i du complexe majeur d'histocompatibilite (cmh) de l'activite d'un recepteur de surface

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
GB9514368D0 (en) * 1995-07-13 1995-09-13 Medical Res Council Improvements in or relating to binding assays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385888A (en) * 1987-03-20 1995-01-31 The Regents Of The University Of California Class I MHC modulation or surface receptor activity
WO1994005303A1 (fr) * 1992-08-31 1994-03-17 Board Of Regents Of The University Of Oklahoma Diagnostique et therapie peptidiques pour spondyloarthropathies
WO1995005189A1 (fr) * 1993-08-12 1995-02-23 The Regents Of The University Of California Modulation des antigenes de classe i du complexe majeur d'histocompatibilite (cmh) de l'activite d'un recepteur de surface

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHROBOCZEK, J. ET AL.: "Adenovirus fiber", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 199, 1995, pages 163 - 200, XP002051923 *
HENRY, L.J. ET AL.: "Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli", JOURNAL OF VIROLOGY., vol. 68, no. 8, August 1994 (1994-08-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 5239 - 5246, XP002051921 *
HONG, J.S. & ENGLER, J. A.: "Domains required for assembly of adenovirus type 2 fiber trimers", JOURNAL OF VIROLOGY., vol. 70, no. 10, October 1996 (1996-10-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 7071 - 7078, XP002052153 *
HONG, S.S. & BOULANGER, P.: "Protein ligands of the human adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of wild-type and mutant penton capsomers", EMBO JOURNAL., vol. 14, no. 19, 1995, EYNSHAM, OXFORD GB, pages 4714 - 4727, XP002051922 *
HONG, S.S. ET AL.: "Adenovirus type 5 fiber knob binds to MHC class I alpha 2 domain at the surface of the human epithelial and B lymphoblastoid cells", EMBO JOURNAL., vol. 16, no. 9, 1 May 1997 (1997-05-01), EYNSHAM, OXFORD GB, pages 2294 - 2306, XP002051924 *

Also Published As

Publication number Publication date
US6420120B1 (en) 2002-07-16
FR2758822B1 (fr) 1999-07-02
AU6104698A (en) 1998-08-25
WO1998033929A2 (fr) 1998-08-06
EP0900280A2 (fr) 1999-03-10
AU731911B2 (en) 2001-04-05
JP2000510708A (ja) 2000-08-22
CA2251036A1 (fr) 1998-08-06
US20020150558A1 (en) 2002-10-17
FR2758822A1 (fr) 1998-07-31

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