WO1998030223B1 - Traitements lies a la cytokine destines a des affections - Google Patents
Traitements lies a la cytokine destines a des affectionsInfo
- Publication number
- WO1998030223B1 WO1998030223B1 PCT/US1998/000634 US9800634W WO9830223B1 WO 1998030223 B1 WO1998030223 B1 WO 1998030223B1 US 9800634 W US9800634 W US 9800634W WO 9830223 B1 WO9830223 B1 WO 9830223B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- disease
- compound
- drug
- patient
- disease comprises
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title claims abstract 44
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 44
- 102000004127 Cytokines Human genes 0.000 title claims abstract 4
- 108090000695 Cytokines Proteins 0.000 title claims abstract 4
- 238000011282 treatment Methods 0.000 title claims abstract 3
- 239000002777 nucleoside Substances 0.000 claims abstract 21
- 150000001875 compounds Chemical class 0.000 claims abstract 20
- 239000003814 drug Substances 0.000 claims abstract 19
- 150000003833 nucleoside derivatives Chemical class 0.000 claims abstract 18
- 229940079593 drug Drugs 0.000 claims abstract 17
- 230000000694 effects Effects 0.000 claims abstract 10
- 230000004044 response Effects 0.000 claims abstract 10
- 230000005856 abnormality Effects 0.000 claims abstract 7
- 238000013270 controlled release Methods 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 68
- 239000003405 delayed action preparation Substances 0.000 claims 6
- 102000014150 Interferons Human genes 0.000 claims 4
- 108010050904 Interferons Proteins 0.000 claims 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 4
- 229940079322 interferon Drugs 0.000 claims 4
- 229960000329 ribavirin Drugs 0.000 claims 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 4
- 208000017667 Chronic Disease Diseases 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 208000009388 Job Syndrome Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000010362 Protozoan Infections Diseases 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 230000007815 allergy Effects 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 208000024908 graft versus host disease Diseases 0.000 claims 3
- 206010051040 hyper-IgE syndrome Diseases 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000002648 combination therapy Methods 0.000 claims 2
- 238000011294 monotherapeutic Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003241 dermatological agent Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
Abstract
L'invention concerne des nucléosides et d'autres composés permettant de moduler sélectivement des réponses Th1 et Th2 l'une par rapport à l'autre dans le traitement d'affections. Dans un aspect de l'invention, l'administration d'un nucléoside ou d'un autre composé permet de réduire la dose administrée d'un médicament principal. Dans un autre aspect de l'invention, on traite une anomalie révélée par une augmentation de la réponse dans un groupe de cytokines, par administration d'un nucléoside ou d'un autre composé qui augmente la réponse dans un autre groupe de cytokines. Dans un autre aspect de l'invention encore, un patient reçoit un traitement prophylactique consistant en l'administration d'un nucléoside ou d'un autre composé qui réduit sélectivement l'activité Th1, sans réduire de manière significative l'activité Th2. Dans un autre aspect de l'invention enfin, un nucléoside ou un autre composé est administré à un patient à une dose qui diminue le pool d'acide guanosine triphosphorique du patient à un degré réduisant sélectivement l'une des réponses Th1 ou Th2 sans réduction significative de l'autre réponse. Pour obtenir ce résultat, des formes de dosage par libération régulée sont particulièrement intéressantes.
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019997006393A KR20000070167A (ko) | 1997-01-14 | 1998-01-13 | 질병의 시토킨 관련 치료 방법 |
| SK940-99A SK94099A3 (en) | 1997-01-17 | 1998-01-13 | Cytokine related treatments of disease |
| EP98903474A EP0998293A4 (fr) | 1997-01-17 | 1998-01-13 | Traitements lies a la cytokine destines a des affections |
| BR9807473A BR9807473A (pt) | 1997-01-17 | 1998-01-13 | Tratamentos de doença relacionados à citocina |
| AU60238/98A AU736075B2 (en) | 1997-01-17 | 1998-01-13 | Cytokine related treatments of disease |
| JP53124598A JP2002515892A (ja) | 1997-01-17 | 1998-01-13 | サイトカインが関係する疾患治療法 |
| HU0001526A HUP0001526A3 (en) | 1997-01-17 | 1998-01-13 | Use of nucleozides for producing pharmaceutical compositions for cytokine related treatments of disease and the pharmaceutical compositions |
| SI9820003A SI9820003A (sl) | 1997-01-17 | 1998-01-13 | Zdravljenje bolezni povezano s citokini |
| CA002278158A CA2278158A1 (fr) | 1997-01-14 | 1998-01-13 | Traitements lies a la cytokine destines a des affections |
| IL13049798A IL130497A0 (en) | 1997-01-17 | 1998-01-13 | Controlled release preparations to selectively modulate Th1 and Th2 responses |
| NO993439A NO993439L (no) | 1997-01-17 | 1999-07-13 | Cytokinrelaterte behandlinger av sykdom |
| US09/467,443 US6423695B1 (en) | 1998-01-13 | 1999-12-20 | Cytokine related treatments of disease |
| NO20004329A NO20004329D0 (no) | 1997-01-17 | 2000-08-31 | Cytokinrelaterte behandlinger av sykdom |
| NO20004327A NO20004327D0 (no) | 1997-01-17 | 2000-08-31 | Cytokinrelaterte behandlinger av sykdom |
| US10/428,806 US20030207826A1 (en) | 1998-01-13 | 2003-04-30 | Cytokine related treatments of disease |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3609497P | 1997-01-17 | 1997-01-17 | |
| US60/036,094 | 1997-01-17 | ||
| US2858697P | 1997-04-23 | 1997-04-23 | |
| US4397497P | 1997-04-23 | 1997-04-23 | |
| US5548797P | 1997-08-12 | 1997-08-12 | |
| US60/043,974 | 1997-08-12 | ||
| US60/055,487 | 1997-08-12 | ||
| US60/028,586 | 1997-08-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/018387 Continuation-In-Part WO1998016184A2 (fr) | 1996-10-16 | 1997-10-15 | Analogues de nucleosides l purine et leurs utilisations |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/467,443 Continuation US6423695B1 (en) | 1998-01-13 | 1999-12-20 | Cytokine related treatments of disease |
| US09/467,443 A-371-Of-International US6423695B1 (en) | 1998-01-13 | 1999-12-20 | Cytokine related treatments of disease |
| US09/594,647 Division US6455690B1 (en) | 1996-10-16 | 2000-06-15 | L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine |
| US10/136,745 Division US20020132784A1 (en) | 1999-12-20 | 2002-04-29 | Cytokine related treatments of disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998030223A1 WO1998030223A1 (fr) | 1998-07-16 |
| WO1998030223B1 true WO1998030223B1 (fr) | 1998-10-01 |
Family
ID=27487693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1998/000634 WO1998030223A1 (fr) | 1997-01-14 | 1998-01-13 | Traitements lies a la cytokine destines a des affections |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0998293A4 (fr) |
| JP (3) | JP2002515892A (fr) |
| KR (1) | KR20000070167A (fr) |
| CN (3) | CN1253504A (fr) |
| AU (1) | AU736075B2 (fr) |
| BR (1) | BR9807473A (fr) |
| CA (1) | CA2278158A1 (fr) |
| HU (1) | HUP0001526A3 (fr) |
| IL (1) | IL130497A0 (fr) |
| NO (3) | NO993439L (fr) |
| PL (1) | PL336579A1 (fr) |
| SI (1) | SI9820003A (fr) |
| SK (1) | SK94099A3 (fr) |
| WO (1) | WO1998030223A1 (fr) |
| YU (1) | YU61598A (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223743B2 (en) | 2000-08-17 | 2007-05-29 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7226912B2 (en) | 2000-08-17 | 2007-06-05 | Tripep Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
| US7261883B2 (en) | 2000-08-29 | 2007-08-28 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455690B1 (en) * | 1996-10-16 | 2002-09-24 | Robert Tam | L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| JP5230052B2 (ja) | 2000-05-26 | 2013-07-10 | イデニクス（ケイマン）リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
| EP1311289B1 (fr) | 2000-08-17 | 2007-10-17 | Tripep Ab | Vaccins contenant de la ribavirine |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| ATE423990T1 (de) * | 2004-05-06 | 2009-03-15 | Us Gov Health & Human Serv | Verfahren und zusammensetzungen zur behandlung von uveitis |
| SE534514C2 (sv) * | 2006-03-14 | 2011-09-20 | Wholesome Biopharm Pty Ltd | Komposition för behandling av allergiska sjukdomar |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| WO2016049415A1 (fr) * | 2014-09-26 | 2016-03-31 | Riboscience Llc | Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4950652A (en) * | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
| NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
| CA2109528A1 (fr) * | 1991-05-01 | 1992-11-02 | Gregory A. Prince | Methode de traitement des maladies respiratoires infectieuses |
-
1998
- 1998-01-13 BR BR9807473A patent/BR9807473A/pt unknown
- 1998-01-13 KR KR1019997006393A patent/KR20000070167A/ko not_active Ceased
- 1998-01-13 CN CN98801801A patent/CN1253504A/zh active Pending
- 1998-01-13 AU AU60238/98A patent/AU736075B2/en not_active Ceased
- 1998-01-13 YU YU61598A patent/YU61598A/sh unknown
- 1998-01-13 PL PL98336579A patent/PL336579A1/xx unknown
- 1998-01-13 HU HU0001526A patent/HUP0001526A3/hu unknown
- 1998-01-13 IL IL13049798A patent/IL130497A0/xx unknown
- 1998-01-13 SI SI9820003A patent/SI9820003A/sl not_active IP Right Cessation
- 1998-01-13 EP EP98903474A patent/EP0998293A4/fr not_active Withdrawn
- 1998-01-13 SK SK940-99A patent/SK94099A3/sk unknown
- 1998-01-13 JP JP53124598A patent/JP2002515892A/ja active Pending
- 1998-01-13 WO PCT/US1998/000634 patent/WO1998030223A1/fr not_active Application Discontinuation
- 1998-01-13 CA CA002278158A patent/CA2278158A1/fr not_active Abandoned
-
1999
- 1999-07-13 NO NO993439A patent/NO993439L/no not_active Application Discontinuation
-
2000
- 2000-07-22 CN CN00121912A patent/CN1312254A/zh active Pending
- 2000-08-29 CN CN00126807A patent/CN1289594A/zh active Pending
- 2000-08-31 NO NO20004327A patent/NO20004327D0/no unknown
- 2000-08-31 NO NO20004329A patent/NO20004329D0/no not_active Application Discontinuation
-
2001
- 2001-05-24 JP JP2001155321A patent/JP2002080490A/ja active Pending
-
2003
- 2003-04-21 JP JP2003115258A patent/JP2004035546A/ja not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223743B2 (en) | 2000-08-17 | 2007-05-29 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7226912B2 (en) | 2000-08-17 | 2007-06-05 | Tripep Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
| US7241440B2 (en) | 2000-08-17 | 2007-07-10 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7307066B2 (en) | 2000-08-17 | 2007-12-11 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7439347B2 (en) | 2000-08-17 | 2008-10-21 | Tripep Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
| US7638499B2 (en) | 2000-08-17 | 2009-12-29 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7261883B2 (en) | 2000-08-29 | 2007-08-28 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
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