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WO1998024549A1 - Dispositif de transfert et de separation de micrograins - Google Patents

Dispositif de transfert et de separation de micrograins Download PDF

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Publication number
WO1998024549A1
WO1998024549A1 PCT/EP1997/006948 EP9706948W WO9824549A1 WO 1998024549 A1 WO1998024549 A1 WO 1998024549A1 EP 9706948 W EP9706948 W EP 9706948W WO 9824549 A1 WO9824549 A1 WO 9824549A1
Authority
WO
WIPO (PCT)
Prior art keywords
bead
cavity
beads
conduit
communication
Prior art date
Application number
PCT/EP1997/006948
Other languages
English (en)
Inventor
John Barry Marlow
Mark Jeffrey Pallett
Paul Stephen Lloyd
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to EP97952923A priority Critical patent/EP0942782A1/fr
Publication of WO1998024549A1 publication Critical patent/WO1998024549A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G47/00—Article or material-handling devices associated with conveyors; Methods employing such devices
    • B65G47/02—Devices for feeding articles or materials to conveyors
    • B65G47/04—Devices for feeding articles or materials to conveyors for feeding articles
    • B65G47/12—Devices for feeding articles or materials to conveyors for feeding articles from disorderly-arranged article piles or from loose assemblages of articles
    • B65G47/14—Devices for feeding articles or materials to conveyors for feeding articles from disorderly-arranged article piles or from loose assemblages of articles arranging or orientating the articles by mechanical or pneumatic means during feeding
    • B65G47/1407—Devices for feeding articles or materials to conveyors for feeding articles from disorderly-arranged article piles or from loose assemblages of articles arranging or orientating the articles by mechanical or pneumatic means during feeding the articles being fed from a container, e.g. a bowl
    • B65G47/1478—Devices for feeding articles or materials to conveyors for feeding articles from disorderly-arranged article piles or from loose assemblages of articles arranging or orientating the articles by mechanical or pneumatic means during feeding the articles being fed from a container, e.g. a bowl by means of pick-up devices, the container remaining immobile
    • B65G47/1485—Devices for feeding articles or materials to conveyors for feeding articles from disorderly-arranged article piles or from loose assemblages of articles arranging or orientating the articles by mechanical or pneumatic means during feeding the articles being fed from a container, e.g. a bowl by means of pick-up devices, the container remaining immobile using suction or magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L99/00—Subject matter not provided for in other groups of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00564—Handling or washing solid phase elements, e.g. beads
    • G01N2035/00574—Means for distributing beads

Definitions

  • This invention relates to a novel device, being an device for transferring polystyrene resin beads from a source which contains a number of such beads to a receiver for such beads.
  • chemical reactions are frequently performed on the surface of small polystyrene resin beads, typically 250-300 microns in diameter.
  • a coating of an active substance may be chemically absorbed onto the surface of such a bead, the coated bead may then be exposed to further active substances, and the occurrence of an interaction between the substances can be detected by monitoring the surface of the bead.
  • This technique is particularly useful in biological sciences where only minute amounts of such active substances may be available, and in the investigation of combinatorial chemistry libraries.
  • a device for transferring beads from a source containing a plurality of beads to a receptacle for beads comprises : a body having a bead receiving cavity in its surface, the cavity having an opening at a surface of the body, the cavity being of dimensions such that it can only fully contain one bead, beads in excess of one projecting for at least one third of their diameter above the surface, a bead entry conduit in communication with, or capable of being brought into communication with, the source and capable of allowing beads to pass along the bead entry conduit towards the body, the bead entry conduit terminating in an orifice bounded by a lip, the opening and the orifice being relatively moveable into communication with each other to allow beads to pass from the bead entry conduit into the cavity, and being thereafter relatively moveable out of communication, the surface of the body and the lip being in moveable contact with each other such that when the opening and the orifice move out of communication with each other beads in the cavity in excess of one bead are removed from the cavity and the
  • the body is a circular section body, for example of substantially cylindrical or frustro-conoidal shape, enabling the bead entry conduit and bead exit conduit to be provided in a correspondingly circular-section casing within which the body closely fits, and within which the body can rotate, the body surface thereby sliding across the internal surface of the casing.
  • a construction may be of a circular section plug and surrounding sleeve arrangement.
  • the bead receiving cavity is preferably of dimensions such that at least half of the diameter of beads in excess of one in the cavity projects above the body surface.
  • the cavity may be a cylindrical cavity.
  • a cylindrical cavity has a diameter of no larger than ca.l .65x the diameter of the beads and a depth from the surface of the body of no more than ca.1.65x the diameter of the beads.
  • the above-mentioned beads of diameter 250- 300 microns such a cylindrical cavity may have a diameter of ca. 400 microns and a depth from the surface of ca. 400 microns.
  • the cavity preferably has its opening in a circumferential surface of the body.
  • the surface of the body and the lip are in slideably moveable contact with each other, and the lip and opening can thereby move relative to each other in a direction perpendicular to the depth of the cavity, and the lip thereby moves across the opening to sweep beads in excess of one from the cavity back into the bead entry conduit.
  • this conduit may be a passage through the casing, terminating in an orifice opening in the internal surface of the casing, the internal surfaces of the edge of the orifice forming the lip. Rotation of the body within the casing provides the above- described slideably moveable contact.
  • the source of beads may be a reservoir communicating with the bead entry conduit.
  • a reservoir may comprise a small container, or a reaction vessel, containing a slurry of the beads in a suitable liquid vehicle such as methanol as commonly used.
  • the bead entry conduit may be made connectable with a mouth opening or other opening of a vessel to facilitate communication, cleaning, replenishment with fresh beads etc.
  • the source may comprise a bead feeding line from, for example, a reaction vessel or bead storage vessel. Beads may be fed into the bead entry conduit by gravity, or additionally or alternatively beads may be fed into the bead entry conduit by means of fluid flow or fluid pressure etc. of a fluid they are suspended or slurried in.
  • the bead entry conduit can have dimensions convenient for its application, for example wide enough to allow beads to pass along its length without jamming together.
  • the cavity opening and the bead entry conduit may be brought into and out of communication by rotation of the body within the casing.
  • the lip formed by the edge of the orifice will sweep excess beads out of the cavity and back into the bead entry conduit. In this way only one bead remains within the cavity. Also if the beads have a tendency to stick together this sweeping action can separate them.
  • the bead exit conduit may also be a passage through the casing.
  • the bead exit conduit may for example be a tube, and the bead exit conduit and a receptacle for the beads may be moveable relative to each other to deposit a bead into a defined location.
  • the receptacle may be a vessel, and vessels may be sequentially brought into communication with the bead exit conduit so that each bead is deposited in an identifiable location or vessel.
  • the receptacle may be a well in a microtitre plate, and the conduit and the plate may be relatively moveable about X-Y axes to allow one or a desired number of beads to be deposited in a well of defined location.
  • the conduit and the opening may be brought into and out of communication by rotation of the body within the casing.
  • the means to direct one or more beads from the bead entry conduit into the cavity may comprise gravity, in that the conduit and its orifice may be positioned above the opening of the cavity when they are in communication. Additionally or alternatively the means may comprise some driving means to positively urge beads into the cavity.
  • a preferred driving means comprises the application of reduced pressure to the cavity to suck beads into the cavity. This may be achieved by the provision of a small conduit in a lower part of the cavity, of too small dimensions to allow a bead to enter it, and via which reduced pressure may be applied when the cavity and bead entry conduit are in communication. The reduced pressure may be discontinued when the conduit and cavity are out of communication. For example this may be achieved by means of the small conduit and a vacuum application line moving relative to each other into communication when the opening and the orifice are in communication, and moving relative to each other out of communication when the orifice and opening move out of communication.
  • the means to direct a bead from the cavity into the bead exit conduit preferably comprises a driving means.
  • a preferred driving means is a driving fluid directed into the cavity to drive a bead out of the cavity.
  • a preferred driving fluid is air as this can help to remove excess liquid vehicle from the bead e.g. by evaporation or dispersal.
  • the driving fluid may conveniently be applied by means of the above mentioned small conduit, which when the cavity and bead exit conduit are in communication can be used to direct pressurised driving fluid into the lower part of the cavity to drive a bead out through the opening of the cavity.
  • Such a driving fluid can additionally serve to direct the bead along the bead exit conduit towards and into the receptacle.
  • the application of driving fluid may be discontinued when the conduit and cavity are out of communication.
  • this may be achieved by means of the small conduit and a driving fluid application line moving relative to each other into communication when the opening and the bead exit conduit are in communication, and moving relative to each other out of communication when the opening and bead exit conduit move out of communication.
  • the body may be moved e.g. in the case of a circular sectioned body rotated into a first position, such that the orifice and opening are in communication, to allow beads to enter the cavity. If necessary the body may be stopped e.g. momentarily if necessary, in this position for long enough for one or more beads to enter the cavity e.g. under the action of the driving means. The body may then be further moved into a second position so that the opening and orifice are out of communication, and as this takes place beads in excess of one are removed from the cavity, for example by the action of the lip of the orifice moving across the opening as described above.
  • the body may then be moved into a third position such that the opening and the bead exit conduit are in communication with each other to allow a bead to exit the cavity and pass into the bead exit conduit.
  • the body may be stopped e.g. momentarily if necessary, in this position for long enough for a bead to pass from the cavity into the bead exit conduit, e.g. under the action of a driving fluid.
  • the body may then be moved into a fourth position so that the opening and bead exit conduit are out of communication, and the procedure repeated so as to return the body into the first position described above
  • the above described movements may be achieved by the said first, second, third and fourth positions being located sequentially circumferentially on a rotation cycle
  • the device of the invention may comprise one or more bead receiving cavities m its surface
  • each of two or more bead receiving cavities may be brought into communication sequentially with a bead entry conduit and then brought into commumcation with a bead exit conduit In this way the speed of operation and/or the capacity of the device in terms of the rate of bead handling may be increased
  • the device of the invention may be made of conventional materials, such as low friction plastics and/or metals
  • the device of the invention is capable of being automated, for example, a computer may control one or more motors which cause the relative movements of the above-mentioned elements of the invention, and such control may involve the incorporation of sensors at various points in the device to detect the presence or absence of beads at particular locations m the device, and/or the presence of more than one bead when only one should be present
  • An automated form of the device of this invention may be programmed, e g to deliver predetermined numbers of beads to particular receptacle(s) or m other ways Stepping motors, i e which rotate through a defined rotation angle upon each activation, are particularly suitable for operating a rotatable body of the type described above Automated forms of the device are encompassed within the scope of this invention
  • the device of this invention is also suitable for transferring other types of particulate matter, e g of chemical or biological materials
  • the invention provides a method of use of a device as described above in a process for the transfer of beads or other particulate matter from a source containing a plurality of beads or other particulate matter to a receptacle for the same
  • Fig 1 shows a cross section through a device of the invention in a first position
  • Fig 2 shows a cross section of a device of the invention in a third position
  • Fig 3 shows a longitudinal section through a device of the invention
  • Fig 4 shows an enlarged section through a cavity of a device of the invention.
  • Fig. 5 shows schematically a cross section through the body of a device of the invention having multiple bead receiving cavities.
  • a device comprises a body 1 in the form of a frustro-conoidal body of low friction plastics material.
  • a bead receiving cavity 2 In a circumferential surface of the body 1 is a bead receiving cavity 2, of cylindrical shape with its axis aligned radially of the body, ca. 400 microns deep and ca. 400 microns across.
  • the cavity 2 has an opening 3 in the surface of body 1. Note that in Figs. 1 , 2 and 3 the size of the cavity 2 is greatly exaggerated, the diameter of the body being ca. 1.5 cm.
  • the body 1 is situated within a casing 4, of internal shape and size closely corresponding to the outer shape and size of body 1 , and within which the body 1 can rotate, the respective inner and outer surfaces of the casing 4 and body 1 thereby sliding across each other in contact.
  • a bead entry conduit 5 which terminates in an orifice 6 bounded by a lip 7.
  • the bead entry conduit 5 is in communication with a reservoir 8 (shown schematically) of beads 9 slurried in a liquid vehicle 10.
  • Beads 9 are typically 250-300 micron diameter polystyrene beads and are slurried in a methanol vehicle.
  • the bead entry conduit 5 is capable of allowing beads 9 to pass along its length towards the body 1.
  • Fig. 1 the cavity 2 and the bead entry conduit 5 are shown in communication via orifice 6, and beads 9 have entered the cavity 2.
  • the dimensions of the cavity 2 are such that the cavity can only fully contain one bead 9A, and beads 9B in excess of one project for at least one third of their diameter.
  • Beads 9 are directed into the cavity 2 by means of gravity, the conduit 5 being above the cavity 2, and also by means of reduced pressure applied via reduced pressure application line 11 and channel 12 aligned axially to body 1 to a small conduit 13 in a lower part of the cavity 2.
  • the small conduit 13 is of too small diameter to allow a bead 9 to pass through it being ca 175 microns in diameter.
  • the small conduit 13 is provided in a small metal insert 14 forming the base of the cavity 2.
  • the use of such a small metal insert 14 facilitates the boring of the small conduit 13 and use of a plastics material body 1, although the entire body 1 and insert 14 could be replaced by an integral construction.
  • the cavity moves into a second position 2A shown representatively by dotted lines. In this position the bead entry conduit 5 is closed by the surface of the body 1 , and the cavity 2 is also closed by the internal surface of the casing 4.
  • beads 9B in excess of one bead are swept by the lip 7 out of the cavity 2 and are returned to the conduit 5. Also, if beads 9B are stuck to the bead 9A such beads 9B are detached from bead 9A and returned to the conduit 5. In this way only one bead 9 A is retained in cavity 2.
  • body 1 rotates further in casing 4 it moves into a third position as shown in Fig 2 in which cavity 2 is brought into communication with a bead exit conduit 15, also passing through casing 4.
  • channel 12 is brought into commumcation with a pressurised air line 16, down which air at ca 15-20 psi is applied, such an air pressure being found suitable to eject the bead 9A without excessive velocity.
  • This air pressure is directed into cavity 2 via the small conduit 13, and drives the bead 9 A out of the cavity 2 along conduit 15.
  • Body 1 is held in this third position for the short time necessary for the bead 9A to leave the cavity 2 and enter the conduit 15.
  • Conduit 15 is ca 500 microns in diameter to provide clearance for the beads 9 and is typically at least 6 mm long to direct the bead 9 into substantially linear travel so as to avoid loss of the bead.
  • a receptacle 17, shown in Fig 2 as a well of defined location in a microtitre plate 18.
  • the air applied in this way also serves to evaporate and/or disperse methanol vehicle 10.
  • the cavity 2 moves into a fourth position 2B in which the channel 12 is out of communication with the air line 16, and the cavity 2B is closed by the inner surface of the casing 4.
  • the body 1 continues to rotate, it is returned to the first position shown in
  • Fig 1 in which it is stopped for the time necessary for the above-described passage of the beads 9 into the cavity 2, and the process is repeated by continued rotation of the body 1. During this time the plate 18 may be moved in an X-Y direction so as to move an empty well 17 into position under the bead exit conduit 15.
  • the body 1 of the device is shown schematically in cross section.
  • the body 1 is in the form of a cylindrical body of low friction plastics material.
  • In a circumferential surface of the body 1 are four bead receiving cavities 2, of similar construction to that of Fig. 1.
  • the body 1 includes small conduits 13 communicating with cavities 2, and an axial channel 12.
  • the channel 12 branches into separate channels 19 which can be brought into communication with respective reduced pressure application lines 11 (not shown) and pressurised air lines 16 (not shown) in a casing 4 (not shown) in a similar manner to Figs. 1 to 4. Rotation of the body 1 in the direction of the arrow within a casing 4 (not shown) of similar construction to that shown in Figs.
  • each of the cavities 1 sequentially into communication with the bead entry conduit 5 (not shown) and bead exit conduit 15 (not shown) of the casing 4 (not shown) as described above.
  • the channels 19 are sequentially brought into communication with the reduced pressure application lines 11 (not shown) and pressurised air lines 16 (not shown) as described above.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Un dispositif pour transférer des grains d'une source contenant plusieurs grains à un récipient à grains comprend un corps ayant des cavités de logement de grains ne pouvant contenir qu'un grain à la fois. Les grains sont introduits dans lesdites cavités par un conduit d'entrée des grains et en sortent par un conduit de sortie des grains pour arriver dans un récipient à grains. Le dispositif facilite le transfert de micrograins provenant de réactions chimiques, par exemple, dans des récipients, d'une manière définie.
PCT/EP1997/006948 1996-12-04 1997-12-01 Dispositif de transfert et de separation de micrograins WO1998024549A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97952923A EP0942782A1 (fr) 1996-12-04 1997-12-01 Dispositif de transfert et de separation de micrograins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9625150.9A GB9625150D0 (en) 1996-12-04 1996-12-04 Novel device
GB9625150.9 1996-12-04

Publications (1)

Publication Number Publication Date
WO1998024549A1 true WO1998024549A1 (fr) 1998-06-11

Family

ID=10803888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006948 WO1998024549A1 (fr) 1996-12-04 1997-12-01 Dispositif de transfert et de separation de micrograins

Country Status (3)

Country Link
EP (1) EP0942782A1 (fr)
GB (1) GB9625150D0 (fr)
WO (1) WO1998024549A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042209A1 (fr) * 1998-02-23 1999-08-26 Takeda Chemical Industries, Ltd. Dispositif et procede de separation et d'apport de microspheres seules, a partir d'un groupe de microspheres, utiles dans des processus de synthese combinatoire
WO1999058476A3 (fr) * 1998-05-08 2000-03-02 Chiron Corp Procede et dispositif de deconvolution non synthetique
WO2005062018A3 (fr) * 2003-12-22 2005-11-03 Versamatrix As Appareil et procedes permettant d'analyser et de trier des particules telles que des billes de polymere
US7349158B2 (en) 2002-09-12 2008-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7375890B2 (en) 2002-09-12 2008-05-20 Cyvera Corporation Method of manufacturing of a diffraction grating-based optical identification element
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US9268983B2 (en) 2003-01-22 2016-02-23 Illumina, Inc. Optical system and method for reading encoded microbeads
EP4293305A1 (fr) * 2022-06-15 2023-12-20 Owens Design, Inc. Procédé et appareil pour séparer et distribuer des billes

Citations (4)

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Publication number Priority date Publication date Assignee Title
US4000927A (en) * 1975-06-26 1977-01-04 Hitachi, Ltd. Capsule hydraulic-transportation system
WO1991006496A1 (fr) * 1989-10-30 1991-05-16 Autotrol Corporation Distributeur de pellets
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