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WO1998023962A8 - Diagnostic de maladies a prions - Google Patents

Diagnostic de maladies a prions

Info

Publication number
WO1998023962A8
WO1998023962A8 PCT/GB1997/003135 GB9703135W WO9823962A8 WO 1998023962 A8 WO1998023962 A8 WO 1998023962A8 GB 9703135 W GB9703135 W GB 9703135W WO 9823962 A8 WO9823962 A8 WO 9823962A8
Authority
WO
WIPO (PCT)
Prior art keywords
abnormal
prion diseases
diagnosis
detected
republic
Prior art date
Application number
PCT/GB1997/003135
Other languages
English (en)
Other versions
WO1998023962A1 (fr
Inventor
Denis Francois Hochstrasser
Christopher Donovan Jam Pearce
Original Assignee
Proteome Sciences Plc
Denis Francois Hochstrasser
Christopher Donovan Jam Pearce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteome Sciences Plc, Denis Francois Hochstrasser, Christopher Donovan Jam Pearce filed Critical Proteome Sciences Plc
Priority to JP52633398A priority Critical patent/JP2001508866A/ja
Priority to CA002271318A priority patent/CA2271318A1/fr
Priority to EP97913294A priority patent/EP0937260A1/fr
Priority to AU50597/98A priority patent/AU737326B2/en
Publication of WO1998023962A1 publication Critical patent/WO1998023962A1/fr
Publication of WO1998023962A8 publication Critical patent/WO1998023962A8/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Pour déceler ou diagnostiquer des maladies à prions dans lesquelles des prions anormaux sont impliqués, un échantillon sanguin est prélévé chez un animal ou un humain et des cellules mononucléaires sont isolées dudit échantillon. Les prions anormaux sont décelés dans le lysat des cellules ou après isolation d'une protéine du prion dudit lysat par une quelconque technique connue, en particulier par des techniques immunologiques dans lesquelles on utilise des anticorps dirigés contre la protéine du prion anormal et un dosage chimiluminescent ou immuno-PCR amélioré.
PCT/GB1997/003135 1996-11-23 1997-11-24 Diagnostic de maladies a prions WO1998023962A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP52633398A JP2001508866A (ja) 1996-11-23 1997-11-24 プリオン疾病の診断法
CA002271318A CA2271318A1 (fr) 1996-11-23 1997-11-24 Diagnostic de maladies a prions
EP97913294A EP0937260A1 (fr) 1996-11-23 1997-11-24 Diagnostic de maladies a prions
AU50597/98A AU737326B2 (en) 1996-11-23 1997-11-24 Diagnosis of prion diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9624411A GB2319607A (en) 1996-11-23 1996-11-23 Detection of prion proteins in mononuclear cells
GB9624411.6 1996-11-23

Publications (2)

Publication Number Publication Date
WO1998023962A1 WO1998023962A1 (fr) 1998-06-04
WO1998023962A8 true WO1998023962A8 (fr) 2000-02-17

Family

ID=10803399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/003135 WO1998023962A1 (fr) 1996-11-23 1997-11-24 Diagnostic de maladies a prions

Country Status (6)

Country Link
EP (1) EP0937260A1 (fr)
JP (1) JP2001508866A (fr)
AU (1) AU737326B2 (fr)
CA (1) CA2271318A1 (fr)
GB (1) GB2319607A (fr)
WO (1) WO1998023962A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI982480A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nisäkkäiden tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
FI982481A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nautaeläinten tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
US6605445B1 (en) 1999-02-22 2003-08-12 Bayer Corporation Rapid method of determining clearance of prion protein
US6166187A (en) 1999-03-05 2000-12-26 The Regents Of The University Of California Method of concentrating prion proteins in blood samples
DE60028233T2 (de) * 1999-10-27 2007-03-08 Universite De Liege Immuno-real-time-pcr unter verwendung einer chimären dna als amplifikationsmarker
GB2360089A (en) * 2000-03-10 2001-09-12 Univ Geneve Diagnostic assay for transmisible spongiform encephalopathies
AU5828201A (en) 2000-03-10 2001-09-17 Univ Geneve Diagnostic assay for transmissible spongiform encephalopathies
EP1249500A1 (fr) * 2001-04-12 2002-10-16 chimera biotec GmbH Procédé pour la détermination de la concentration d'un analyte
GB0110172D0 (en) * 2001-04-25 2001-06-20 Pa Consulting Services Improved analytical test approach for blood
EP1556702A2 (fr) 2002-10-30 2005-07-27 Proteome Sciences Plc Methodes destinees a diagnostiquer une encephalopathie spongiforme transmissible
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
WO2005070968A1 (fr) * 2004-01-21 2005-08-04 Wako Pure Chemical Industries, Ltd. Procede pour immobiliser et quantifier une proteine
EP1596199A1 (fr) * 2004-05-14 2005-11-16 Prionics AG Méthode de détection des formes pathogènes des protéines prions.
US20130109581A1 (en) 2009-11-04 2013-05-02 David Peretz Positively charged species as binding reagents in the separation of protein aggregates from monomers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011155A1 (fr) * 1991-12-03 1993-06-10 Proteus Molecular Design Limited Fragments de proteines de prion
WO1993023432A1 (fr) * 1992-05-15 1993-11-25 New York University Polypeptides de pion solubles et procedes de detection et de purification
EP0795133A1 (fr) * 1994-11-29 1997-09-17 The Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain Procedes de detection de l'encephalopathie spongiforme
WO1997010505A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California ANTICORPS SPECIFIQUE DU PrPSc NATIF
DE69720433T3 (de) * 1996-04-03 2009-07-30 Stichting Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Verfahren zum nachweis von prionkrankheit
US5998149A (en) * 1996-04-05 1999-12-07 The United States Of America As Represented By The Department Of Health And Human Services Method of detecting transmissible spongiform encephalopathies

Also Published As

Publication number Publication date
WO1998023962A1 (fr) 1998-06-04
JP2001508866A (ja) 2001-07-03
GB9624411D0 (en) 1997-01-08
AU5059798A (en) 1998-06-22
EP0937260A1 (fr) 1999-08-25
CA2271318A1 (fr) 1998-06-04
GB2319607A (en) 1998-05-27
AU737326B2 (en) 2001-08-16

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