WO1998020842A2 - Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine - Google Patents
Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine Download PDFInfo
- Publication number
- WO1998020842A2 WO1998020842A2 PCT/US1997/019162 US9719162W WO9820842A2 WO 1998020842 A2 WO1998020842 A2 WO 1998020842A2 US 9719162 W US9719162 W US 9719162W WO 9820842 A2 WO9820842 A2 WO 9820842A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymyxin
- composition
- compositions
- present
- periodontal disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
Definitions
- an object of the present invention is to provide topical, stable oral compositions comprising polymyxin for the treatment of periodontal disease and/or breath malodor.
- compositions of the present invention are in the form of toothpaste.
- Components of such toothpaste generally include a dental abrasive (from about 10% > to about 50%>), a surfactant (from about 0.5% to about 10%o), a thickening agent (from about 0.1% to about 5%), a humectant (from about 10% to about 55%>), a flavoring agent (from about 0.04% to about 2%), a sweetening agent (from about 0.1% to about 3%), a coloring agent (from about 0.01% to about 0.5%>) and water (from about 2%> to about 45%).
- a dental abrasive from about 10% > to about 50%>
- a surfactant from about 0.5% to about 10%o
- a thickening agent from about 0.1% to about 5%
- a humectant from about 10% to about 55%>
- a flavoring agent from about 0.04% to about 2%
- a sweetening agent from about 0.1% to about 3%
- a coloring agent
- compositions of the present invention are dental solutions.
- Components of such dental solutions generally include water (from about 90% to about 99%), preservative (from about 0.01% to about 0.5%), thickening agent (from about 0%> to about 5%), flavoring agent (from about 0.04% to about 2%>), sweetening agent (from about 0.1% to about 3%), and surfactant (from 0% to about 5%).
- polymyxin The topical application of polymyxin to the oral cavity tissues avoids the adverse side effects associated with systemic concentrations of polymyxins.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
La présente invention porte sur des compositions destinées à être utilisées dans le traitement local de la parodontopathie et de la mauvaise haleine. Ces compositions comprennent: (a) une quantité inoffensive et efficace de polymyxine A, B, C, D, E et de sels ou de mélanges de celle-ci; et (b) un excipient oral, local, pharmaceutiquement acceptable. Cette invention porte également sur un procédé de traitement ou de prévention de la parodontopathie et/ou de la mauvaise haleine dans la cavité buccale d'un être humain ou d'un animal, ce procédé consistant à appliquer sur les tissus de la cavité buccale une quantité inoffensive et efficace de la composition précitée. Ces compositions sont des pâtes dentifrices, des gels dentifrices, des poudres dentifrices, des bains de bouche, des pulvérisations buccales, des pâtes à prophylaxie, des solutions de traitement dentaires, des pastilles, des chewing-gums et autres.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3057996P | 1996-11-12 | 1996-11-12 | |
US60/030,579 | 1996-11-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998020842A2 true WO1998020842A2 (fr) | 1998-05-22 |
WO1998020842A3 WO1998020842A3 (fr) | 1998-06-25 |
Family
ID=21854877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/019162 WO1998020842A2 (fr) | 1996-11-12 | 1997-10-29 | Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1998020842A2 (fr) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO69627A2 (fr) * | 1978-01-21 | 1981-06-22 | Intreprinderea De Medicamente,Ro | Comprimes pour le traitement d'alveolite post-extractionel |
JPS59222406A (ja) * | 1983-06-01 | 1984-12-14 | Teijin Ltd | 歯周疾患治療用製剤及びその製造法 |
US5082653A (en) * | 1990-10-31 | 1992-01-21 | Warner-Lambert Company | Anti-plaque compositions comprising a combination of morpholinoamino alcohol and antibiotic |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
US5711935A (en) * | 1994-05-10 | 1998-01-27 | Whitehill Oral Technologies, Inc. | Dental floss |
WO1996009829A1 (fr) * | 1994-09-27 | 1996-04-04 | Virotex Corporation | Ameliorations d'excipients pour application locale par voie muqueuse |
-
1997
- 1997-10-29 WO PCT/US1997/019162 patent/WO1998020842A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO1998020842A3 (fr) | 1998-06-25 |
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