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WO1998020842A2 - Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine - Google Patents

Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine Download PDF

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Publication number
WO1998020842A2
WO1998020842A2 PCT/US1997/019162 US9719162W WO9820842A2 WO 1998020842 A2 WO1998020842 A2 WO 1998020842A2 US 9719162 W US9719162 W US 9719162W WO 9820842 A2 WO9820842 A2 WO 9820842A2
Authority
WO
WIPO (PCT)
Prior art keywords
polymyxin
composition
compositions
present
periodontal disease
Prior art date
Application number
PCT/US1997/019162
Other languages
English (en)
Other versions
WO1998020842A3 (fr
Inventor
Duane Larry Charbonneau
William Buchanan
Rebecca Jo Donovan-Brand
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of WO1998020842A2 publication Critical patent/WO1998020842A2/fr
Publication of WO1998020842A3 publication Critical patent/WO1998020842A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof

Definitions

  • an object of the present invention is to provide topical, stable oral compositions comprising polymyxin for the treatment of periodontal disease and/or breath malodor.
  • compositions of the present invention are in the form of toothpaste.
  • Components of such toothpaste generally include a dental abrasive (from about 10% > to about 50%>), a surfactant (from about 0.5% to about 10%o), a thickening agent (from about 0.1% to about 5%), a humectant (from about 10% to about 55%>), a flavoring agent (from about 0.04% to about 2%), a sweetening agent (from about 0.1% to about 3%), a coloring agent (from about 0.01% to about 0.5%>) and water (from about 2%> to about 45%).
  • a dental abrasive from about 10% > to about 50%>
  • a surfactant from about 0.5% to about 10%o
  • a thickening agent from about 0.1% to about 5%
  • a humectant from about 10% to about 55%>
  • a flavoring agent from about 0.04% to about 2%
  • a sweetening agent from about 0.1% to about 3%
  • a coloring agent
  • compositions of the present invention are dental solutions.
  • Components of such dental solutions generally include water (from about 90% to about 99%), preservative (from about 0.01% to about 0.5%), thickening agent (from about 0%> to about 5%), flavoring agent (from about 0.04% to about 2%>), sweetening agent (from about 0.1% to about 3%), and surfactant (from 0% to about 5%).
  • polymyxin The topical application of polymyxin to the oral cavity tissues avoids the adverse side effects associated with systemic concentrations of polymyxins.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention porte sur des compositions destinées à être utilisées dans le traitement local de la parodontopathie et de la mauvaise haleine. Ces compositions comprennent: (a) une quantité inoffensive et efficace de polymyxine A, B, C, D, E et de sels ou de mélanges de celle-ci; et (b) un excipient oral, local, pharmaceutiquement acceptable. Cette invention porte également sur un procédé de traitement ou de prévention de la parodontopathie et/ou de la mauvaise haleine dans la cavité buccale d'un être humain ou d'un animal, ce procédé consistant à appliquer sur les tissus de la cavité buccale une quantité inoffensive et efficace de la composition précitée. Ces compositions sont des pâtes dentifrices, des gels dentifrices, des poudres dentifrices, des bains de bouche, des pulvérisations buccales, des pâtes à prophylaxie, des solutions de traitement dentaires, des pastilles, des chewing-gums et autres.
PCT/US1997/019162 1996-11-12 1997-10-29 Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine WO1998020842A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3057996P 1996-11-12 1996-11-12
US60/030,579 1996-11-12

Publications (2)

Publication Number Publication Date
WO1998020842A2 true WO1998020842A2 (fr) 1998-05-22
WO1998020842A3 WO1998020842A3 (fr) 1998-06-25

Family

ID=21854877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019162 WO1998020842A2 (fr) 1996-11-12 1997-10-29 Compositions de polymyxine et procedes de traitement de la parodontopathie et de la mauvaise haleine

Country Status (1)

Country Link
WO (1) WO1998020842A2 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO69627A2 (fr) * 1978-01-21 1981-06-22 Intreprinderea De Medicamente,Ro Comprimes pour le traitement d'alveolite post-extractionel
JPS59222406A (ja) * 1983-06-01 1984-12-14 Teijin Ltd 歯周疾患治療用製剤及びその製造法
US5082653A (en) * 1990-10-31 1992-01-21 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and antibiotic
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5711935A (en) * 1994-05-10 1998-01-27 Whitehill Oral Technologies, Inc. Dental floss
AU3726395A (en) * 1994-09-27 1996-04-19 Virotex Corporation Improved topical carriers for mucosal applications

Also Published As

Publication number Publication date
WO1998020842A3 (fr) 1998-06-25

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