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WO1998020162A3 - Electrodes linked via conductive oligomers to nucleic acids - Google Patents

Electrodes linked via conductive oligomers to nucleic acids Download PDF

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Publication number
WO1998020162A3
WO1998020162A3 PCT/US1997/020014 US9720014W WO9820162A3 WO 1998020162 A3 WO1998020162 A3 WO 1998020162A3 US 9720014 W US9720014 W US 9720014W WO 9820162 A3 WO9820162 A3 WO 9820162A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
via conductive
conductive oligomers
linked via
electrodes
Prior art date
Application number
PCT/US1997/020014
Other languages
French (fr)
Other versions
WO1998020162A2 (en
Inventor
Jon F Kayyem
Stephen D O'connor
Michael Gozin
Changjun Yu
Original Assignee
Clinical Micro Sensors Inc
Jon F Kayyem
Connor Stephen D O
Michael Gozin
Changjun Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/743,798 external-priority patent/US6096273A/en
Priority claimed from US08/873,597 external-priority patent/US7381525B1/en
Priority claimed from US08/873,978 external-priority patent/US7014992B1/en
Application filed by Clinical Micro Sensors Inc, Jon F Kayyem, Connor Stephen D O, Michael Gozin, Changjun Yu filed Critical Clinical Micro Sensors Inc
Priority to CA002270633A priority Critical patent/CA2270633A1/en
Priority to EP97946876A priority patent/EP0939762A2/en
Priority to AU51967/98A priority patent/AU739375B2/en
Priority to JP52166898A priority patent/JP4072206B2/en
Publication of WO1998020162A2 publication Critical patent/WO1998020162A2/en
Publication of WO1998020162A3 publication Critical patent/WO1998020162A3/en
Priority to US09/452,277 priority patent/US7160678B1/en
Priority to US11/208,384 priority patent/US7393645B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
PCT/US1997/020014 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids WO1998020162A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002270633A CA2270633A1 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids
EP97946876A EP0939762A2 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids
AU51967/98A AU739375B2 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids
JP52166898A JP4072206B2 (en) 1996-11-05 1997-11-05 Electrode linked to nucleic acid via conductive oligomer
US09/452,277 US7160678B1 (en) 1996-11-05 1999-11-30 Compositions for the electronic detection of analytes utilizing monolayers
US11/208,384 US7393645B2 (en) 1996-11-05 2005-08-19 Compositions for the electronic detection of analytes utilizing monolayers

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US08/743,798 1996-11-05
US08/743,798 US6096273A (en) 1996-11-05 1996-11-05 Electrodes linked via conductive oligomers to nucleic acids
US4015597P 1997-03-07 1997-03-07
US60/040,155 1997-03-07
US08/873,597 US7381525B1 (en) 1997-03-07 1997-06-12 AC/DC voltage apparatus for detection of nucleic acids
US08/873,597 1997-06-12
US08/873,978 US7014992B1 (en) 1996-11-05 1997-06-12 Conductive oligomers attached to electrodes and nucleoside analogs
US08/873,978 1997-06-12
US08/899,510 1997-07-24
US08/899,510 US6221583B1 (en) 1996-11-05 1997-07-24 Methods of detecting nucleic acids using electrodes
US08/911,085 1997-08-14
US08/911,085 US6090933A (en) 1996-11-05 1997-08-14 Methods of attaching conductive oligomers to electrodes
US08/911,589 1997-08-14
US08/911,589 US6232062B1 (en) 1997-03-07 1997-08-14 AC methods for the detection of nucleic acids

Publications (2)

Publication Number Publication Date
WO1998020162A2 WO1998020162A2 (en) 1998-05-14
WO1998020162A3 true WO1998020162A3 (en) 1998-11-12

Family

ID=27567906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020014 WO1998020162A2 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids

Country Status (5)

Country Link
EP (1) EP0939762A2 (en)
JP (1) JP4072206B2 (en)
AU (1) AU739375B2 (en)
CA (1) CA2270633A1 (en)
WO (1) WO1998020162A2 (en)

Cited By (9)

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US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US9340567B2 (en) 2011-11-04 2016-05-17 Ohmx Corporation Chemistry used in biosensors

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US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6387625B1 (en) 1995-06-27 2002-05-14 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6600026B1 (en) 1998-05-06 2003-07-29 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
JP2002513592A (en) * 1998-05-06 2002-05-14 クリニカル・マイクロ・センサーズ・インコーポレイテッド Electronic detection of nucleic acids using a monolayer
US6653462B2 (en) 1998-05-29 2003-11-25 Applera Corporation Nucleotide compounds including a rigid linker
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381533B2 (en) 1996-11-05 2008-06-03 Clinical Micro Sensors, Inc. Electrodes linked via oligomers to nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7534331B2 (en) 1999-04-21 2009-05-19 Osmetech Technology Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US8486247B2 (en) 1999-04-21 2013-07-16 Osmetch Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9557295B2 (en) 1999-04-21 2017-01-31 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US9340567B2 (en) 2011-11-04 2016-05-17 Ohmx Corporation Chemistry used in biosensors

Also Published As

Publication number Publication date
JP4072206B2 (en) 2008-04-09
JP2001507930A (en) 2001-06-19
WO1998020162A2 (en) 1998-05-14
AU5196798A (en) 1998-05-29
AU739375B2 (en) 2001-10-11
EP0939762A2 (en) 1999-09-08
CA2270633A1 (en) 1998-05-14

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