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WO1998018805A3 - Composes organiques - Google Patents

Composes organiques Download PDF

Info

Publication number
WO1998018805A3
WO1998018805A3 PCT/EP1997/005909 EP9705909W WO9818805A3 WO 1998018805 A3 WO1998018805 A3 WO 1998018805A3 EP 9705909 W EP9705909 W EP 9705909W WO 9818805 A3 WO9818805 A3 WO 9818805A3
Authority
WO
WIPO (PCT)
Prior art keywords
mimetics
sialyl lewis
sugar derivatives
sialyl
lewis
Prior art date
Application number
PCT/EP1997/005909
Other languages
English (en)
Other versions
WO1998018805A2 (fr
Inventor
Chi-Huey Wong
Francisco Moris-Varas
Chun-Cheng Lin
Thomas G Marron
Thomas Woltering
Gabriele Weitz-Schmidt
Jill Jablonowski
Original Assignee
Novartis Ag
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/744,744 external-priority patent/US5830871A/en
Priority claimed from US08/764,315 external-priority patent/US5837862A/en
Application filed by Novartis Ag, Scripps Research Inst filed Critical Novartis Ag
Priority to AU53137/98A priority Critical patent/AU5313798A/en
Publication of WO1998018805A2 publication Critical patent/WO1998018805A2/fr
Publication of WO1998018805A3 publication Critical patent/WO1998018805A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Composés mimétiques de sialyle Lewis X qui imitent l'inhibition de l'adhésion cellulaire à médiation de sélectine par le sialyl Lewis X, et qui présentent une partie centrale représentée par la formule (I).
PCT/EP1997/005909 1996-10-28 1997-10-27 Composes organiques WO1998018805A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53137/98A AU5313798A (en) 1996-10-28 1997-10-27 Organic compounds

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/744,744 US5830871A (en) 1996-10-28 1996-10-28 Inhibitors of E-, P- and L-selectin binding
US08/744,744 1996-10-28
US08/764,315 1996-12-12
US08/764,315 US5837862A (en) 1996-12-12 1996-12-12 Sialyl Lewis X mimetics incorporating mannopeptides
US89645297A 1997-07-18 1997-07-18
US08/896,452 1997-07-18

Publications (2)

Publication Number Publication Date
WO1998018805A2 WO1998018805A2 (fr) 1998-05-07
WO1998018805A3 true WO1998018805A3 (fr) 2003-04-17

Family

ID=27419313

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/005909 WO1998018805A2 (fr) 1996-10-28 1997-10-27 Composes organiques

Country Status (2)

Country Link
AU (1) AU5313798A (fr)
WO (1) WO1998018805A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010359A2 (fr) * 1997-08-26 1999-03-04 Novartis Ag Composes organiques
EP3513794A3 (fr) * 2010-08-05 2019-10-16 Seattle Genetics, Inc. Analogues du fucose pour inhibition de la fucosylation de protéines in vivo

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LUENGO, JUAN I. ET AL: "Synthesis of C-fucopyranosyl analogs of GDP-L-fucose as inhibitors of fucosyltransferases", TETRAHEDRON LETT. (1992), 33(46), 6911-14 CODEN: TELEAY;ISSN: 0040-4039, 1992, XP002054598 *
UCHIYAMA, TAKETO ET AL: "Design and Synthesis of Sialyl Lewis X Mimetics", J. AM. CHEM. SOC. (1995), 117(19), 5395-6 CODEN: JACSAT;ISSN: 0002-7863, 1995, XP000570082 *
UCHIYAMA, TRAKETO ET AL: "Design and synthesis of C-linked fucosides as inhibitors of E-selectin", BIOORG. MED. CHEM. (1996), 4(7), 1149-1165 CODEN: BMECEP;ISSN: 0968-0896, 9 July 1996 (1996-07-09), XP002054353 *
WONG, CHI-HUEY ET AL: "Small Molecules as Structural and Functional Mimics of Sialyl Lewis X in Selectin Inhibition: A Remarkable Enhancement of Inhibition by Additional Negative Charge and/or Hydrophobic Group", J. AM. CHEM. SOC. (1997), 119(35), 8152-8158 CODEN: JACSAT;ISSN: 0002-7863, 1997, XP002054599 *

Also Published As

Publication number Publication date
AU5313798A (en) 1998-05-22
WO1998018805A2 (fr) 1998-05-07

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