WO1998017373A1 - Method and apparatus for removing particles from suspension - Google Patents
Method and apparatus for removing particles from suspension Download PDFInfo
- Publication number
- WO1998017373A1 WO1998017373A1 PCT/GB1997/002895 GB9702895W WO9817373A1 WO 1998017373 A1 WO1998017373 A1 WO 1998017373A1 GB 9702895 W GB9702895 W GB 9702895W WO 9817373 A1 WO9817373 A1 WO 9817373A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- fluid
- standing wave
- carrier element
- carrier
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract description 67
- 239000000725 suspension Substances 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims description 13
- 238000002604 ultrasonography Methods 0.000 claims abstract description 20
- 239000012530 fluid Substances 0.000 claims abstract description 19
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000004720 dielectrophoresis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
- B01D21/283—Settling tanks provided with vibrators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D51/00—Auxiliary pretreatment of gases or vapours to be cleaned
- B01D51/02—Amassing the particles, e.g. by flocculation
- B01D51/06—Amassing the particles, e.g. by flocculation by varying the pressure of the gas or vapour
- B01D51/08—Amassing the particles, e.g. by flocculation by varying the pressure of the gas or vapour by sound or ultrasonics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
Definitions
- the present invention relates to an apparatus and method for removing or separating particles from suspension in a fluid, using a standing wave ultrasound field.
- an apparatus or method for removing or separating particles from suspension in a fluid in which in use an ultrasound transducer arrangement forms a standing wave ultrasound field in the fluid in which particles are suspended, and at least one carrier element is positioned at one or more pressure amplitude maxima or minima in the standing wave field, to which in use the particles displace.
- this force acts to displace the particles either to the pressure amplitude maxima or minima in the standing wave field.
- Bjerknes force which is the force of attraction between particles: it has generally been assumed that the secondary force causes attraction between particles in suspension, to create larger groups of particles, so enhancing the effects of the primary force.
- the presence of one or more solid carrier elements (or attractors) in the standing wave field gives rise to acoustic microstreaming, dragging the suspended particles close to the attractor(s) and thus acting to enhance the interaction between the suspended particles and the attractor (s) .
- the carrier element may be of plastics for example. It is important that the carrier element does not significantly affect the standing wave field: preferably therefore the carrier element is thin and may be formed as a mesh.
- the carrier element or elements are removable, either individually or as a group, so that the particles collected on them can be examined (typically under the microscope) or discarded.
- the apparatus and method of the present invention draw particles out of suspension in a manner which is independent of particle concentration.
- the apparatus and method may be used in medical diagnostics, or for filter action in the water or food industries .
- transducer or reflector of the ultrasound transducer arrangement may be used as a carrier (or attractor) element.
- Retention of the particles on the carrier element or elements may be enhanced by i munological techniques, or by dielectrophoresis (where microelectrodes are etched on the carrier elements) : the latter arrangement enhances the trapping of dielectric particles out of suspension and selectivity in the retention of particles from suspension.
- one or more acoustically transparent separators may be used to isolate a volume in which the particle manipulation and removal takes place. The separators are placed where the attractive forces are minimal and/or where the "primary" force acts to repel particles away from that position.
- FIGURE 1 is a diagrammatic section through one embodiment of apparatus in accordance with the present invention
- FIGURE 2 shows one form which each carrier element of the apparatus of Figure 1 may take;
- FIGURE 3 shows another form which each carrier element of the apparatus of Figure 1 may take
- FIGURE 4 shows a further form which each carrier element of the apparatus of Figure 1 may take;
- FIGURE 5 is a plan view of a second embodiment of apparatus in accordance with the present invention.
- FIGURE 6 is a diagrammatic section through a modified form of the apparatus shown in Figure 1;
- FIGURE 7 is a diagrammatic sectional view of a further embodiment of the invention.
- an apparatus for removing or separating particles from suspension comprising a vessel or container 10 for the liquid L in which the particles e.g. P are suspended.
- the apparatus further comprises an ultrasound transducer arrangement which comprises a planar transducer T and a planar reflector R forming, or positioned in, opposite side walls of the vessel or container 10.
- the transducer arrangement provides a standing wave ultrasound field, with successive pressure amplitude minima (nodes) at spaced intervals between the transducer T and reflector R.
- Carrier elements 12 are positioned at selected nodes, to act as attractors for the particles P, as explained above. Where the particles and the fluid in which they are suspended are such that the particles move to the pressure amplitude maxima, then the carrier elements 12 are positioned at selected antinodes.
- the carrier elements or attractors 12 are planar, and positioned parallel to the transducer T and reflector R.
- the carrier elements 12 are required to have no significant affect on the standing wave field and are therefore of a solid material (e.g. plastics) of a compressibility similar to, but different from, that of water.
- the carrier elements 12 may be in the form of a mesh 12a ( Figure 2) or a sheet 12b with an array of apertures ( Figure 3) or they may comprise a series or array of filaments 12c ( Figure 4) .
- acoustically transparent separators S may be positioned within the container 10 in order to isolate a volume of the liquid L from the transducer T and reflector R, so preventing the particles being attracted to these components.
- transducer T and reflector R have been shown, other configurations may be employed, for example an annular or cylindrical transducer T, which provides a radial standing wave field, with a series of concentric nodes at which cylindrical carrier elements or attractors 12' are positioned (Figure 5).
- the container of vessel 10 may receive a sample to be tested, after which the carrier elements 12 are removed for inspection and the vessel 10 emptied, filled with a fresh sample and fresh carrier elements and re-used.
- the carrier elements 12 are joined together, e.g. by a bridge 13 as shown in Figure 1, so that they may be removed as a group.
- the container 10 may be arranged for the through-flow of liquid, the carrier elements or attractors 12 being used for filtering particles from the liquid: the carrier elements are shown mounted together and to the interior of the container 10 by supporting bridges 23.
- the carrier elements or attractors may comprise particles P 1 freely suspended in water or other liquid L ' , and introduced into the container or vessel: these particles P' are then free, when the ultrasound field is switched on, to move to the pressure amplitude minima (or maxima, depending on the density and compressibility of the particles) to act as attractors.
- the sample or liquid, in which the particles to be removed are suspended is then introduced into the water or other liquid already in the container or vessel: these particles then move to the attractor particles, in the manner described above.
- the attractor particles P' may comprise discs, spheres or other elements of plastics material, or may comprise dead cells or non-cellular substances.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU47145/97A AU4714597A (en) | 1996-10-19 | 1997-10-20 | Method and apparatus for removing particles from suspension |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9621832.6 | 1996-10-19 | ||
GBGB9621832.6A GB9621832D0 (en) | 1996-10-19 | 1996-10-19 | Removing partiles from suspension |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998017373A1 true WO1998017373A1 (en) | 1998-04-30 |
Family
ID=10801699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1997/002895 WO1998017373A1 (en) | 1996-10-19 | 1997-10-20 | Method and apparatus for removing particles from suspension |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU4714597A (en) |
GB (1) | GB9621832D0 (en) |
WO (1) | WO1998017373A1 (en) |
Cited By (47)
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---|---|---|---|---|
GB2339703A (en) * | 1998-07-22 | 2000-02-09 | Univ Cardiff | Separation of particles from fluid using acoustic standing wave field |
DE102005050167A1 (en) * | 2005-10-19 | 2007-04-26 | Advalytix Ag | Concentration method, concentration apparatus and reaction method |
WO2009071733A1 (en) * | 2007-12-05 | 2009-06-11 | Consejo Superior De Investigaciones Cientificas | Micro-device and method for non-invasive and selective separation and extraction of particles in polydispersed suspensions, production method, and the applications thereof |
US7568251B2 (en) | 2006-12-28 | 2009-08-04 | Kimberly-Clark Worldwide, Inc. | Process for dyeing a textile web |
WO2011146991A1 (en) * | 2010-05-25 | 2011-12-01 | Crc Care Pty Ltd | Improved gravity sedimentation process and apparatus |
WO2013030691A2 (en) | 2011-08-30 | 2013-03-07 | Centre National De La Recherche Scientifique | Device for handling objects, using acoustic force fields |
US8858892B2 (en) | 2007-12-21 | 2014-10-14 | Kimberly-Clark Worldwide, Inc. | Liquid treatment system |
CN104409126A (en) * | 2014-11-25 | 2015-03-11 | 中国人民解放军第二炮兵工程大学 | Ultrasonic standing wave radioactive wastewater treatment device |
US9239036B2 (en) | 2006-09-08 | 2016-01-19 | Kimberly-Clark Worldwide, Inc. | Ultrasonic liquid treatment and delivery system and process |
US9283188B2 (en) | 2006-09-08 | 2016-03-15 | Kimberly-Clark Worldwide, Inc. | Delivery systems for delivering functional compounds to substrates and processes of using the same |
WO2016054192A1 (en) * | 2014-09-30 | 2016-04-07 | Flodesign Sonics, Inc. | Acoustophoretic clarification of particle-laden non-flowing fluids |
US9421504B2 (en) | 2007-12-28 | 2016-08-23 | Kimberly-Clark Worldwide, Inc. | Ultrasonic treatment chamber for preparing emulsions |
US9701955B2 (en) | 2012-03-15 | 2017-07-11 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US9738867B2 (en) | 2012-03-15 | 2017-08-22 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
US9783775B2 (en) | 2012-03-15 | 2017-10-10 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9796956B2 (en) | 2013-11-06 | 2017-10-24 | Flodesign Sonics, Inc. | Multi-stage acoustophoresis device |
US9987625B2 (en) | 2006-10-02 | 2018-06-05 | M-I Drilling Fluids Uk Limited | Desulfurization agent |
US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
US10350514B2 (en) | 2012-03-15 | 2019-07-16 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US10370635B2 (en) | 2012-03-15 | 2019-08-06 | Flodesign Sonics, Inc. | Acoustic separation of T cells |
US10427956B2 (en) | 2009-11-16 | 2019-10-01 | Flodesign Sonics, Inc. | Ultrasound and acoustophoresis for water purification |
US10640760B2 (en) | 2016-05-03 | 2020-05-05 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US10662402B2 (en) | 2012-03-15 | 2020-05-26 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10710006B2 (en) | 2016-04-25 | 2020-07-14 | Flodesign Sonics, Inc. | Piezoelectric transducer for generation of an acoustic standing wave |
US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
US10785574B2 (en) | 2017-12-14 | 2020-09-22 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
US10975368B2 (en) | 2014-01-08 | 2021-04-13 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
US11007457B2 (en) | 2012-03-15 | 2021-05-18 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US11179747B2 (en) | 2015-07-09 | 2021-11-23 | Flodesign Sonics, Inc. | Non-planar and non-symmetrical piezoelectric crystals and reflectors |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11420136B2 (en) | 2016-10-19 | 2022-08-23 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
WO2024017663A1 (en) * | 2022-07-21 | 2024-01-25 | Centre National De La Recherche Scientifique | Assembling and growing cellular objects on a contact structure by means of axial and transverse acoustic radiation forces |
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-
1997
- 1997-10-20 AU AU47145/97A patent/AU4714597A/en not_active Abandoned
- 1997-10-20 WO PCT/GB1997/002895 patent/WO1998017373A1/en active Application Filing
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Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2339703A (en) * | 1998-07-22 | 2000-02-09 | Univ Cardiff | Separation of particles from fluid using acoustic standing wave field |
GB2339703B (en) * | 1998-07-22 | 2002-05-01 | Univ Cardiff | Particle manipulation device |
DE102005050167A1 (en) * | 2005-10-19 | 2007-04-26 | Advalytix Ag | Concentration method, concentration apparatus and reaction method |
DE102005050167B4 (en) * | 2005-10-19 | 2009-02-19 | Advalytix Ag | Concentration method, concentration apparatus and reaction method |
US9023658B2 (en) | 2005-10-19 | 2015-05-05 | Beckman Coulter, Inc | Acoustic concentration method and device and a reaction method |
US9283188B2 (en) | 2006-09-08 | 2016-03-15 | Kimberly-Clark Worldwide, Inc. | Delivery systems for delivering functional compounds to substrates and processes of using the same |
US9239036B2 (en) | 2006-09-08 | 2016-01-19 | Kimberly-Clark Worldwide, Inc. | Ultrasonic liquid treatment and delivery system and process |
US9987625B2 (en) | 2006-10-02 | 2018-06-05 | M-I Drilling Fluids Uk Limited | Desulfurization agent |
US7568251B2 (en) | 2006-12-28 | 2009-08-04 | Kimberly-Clark Worldwide, Inc. | Process for dyeing a textile web |
CN102026699A (en) * | 2007-12-05 | 2011-04-20 | 康斯乔最高科学研究公司 | Micro-device and method for non-invasive and selective separation and extraction of particles in polydispersed suspensions, production method, and the applications thereof |
ES2326109B1 (en) * | 2007-12-05 | 2010-06-25 | Consejo Superior De Investigaciones Cientificas | SELECTIVE AND NON INVASIVE SEPARATION AND EXTRACTION MICRODISPOSITIVE OF PARTICLES IN POLIDISPERSE SUSPENSIONS, MANUFACTURING PROCEDURE AND ITS APPLICATIONS. |
ES2326109A1 (en) * | 2007-12-05 | 2009-09-30 | Consejo Superior De Investigaciones Cientificas | SELECTIVE AND NON INVASIVE SEPARATION AND EXTRACTION MICRODISPOSITIVE OF PARTICLES IN POLIDISPERSE SUSPENSIONS, MANUFACTURING PROCEDURE AND ITS APPLICATIONS. |
WO2009071733A1 (en) * | 2007-12-05 | 2009-06-11 | Consejo Superior De Investigaciones Cientificas | Micro-device and method for non-invasive and selective separation and extraction of particles in polydispersed suspensions, production method, and the applications thereof |
US8858892B2 (en) | 2007-12-21 | 2014-10-14 | Kimberly-Clark Worldwide, Inc. | Liquid treatment system |
US9421504B2 (en) | 2007-12-28 | 2016-08-23 | Kimberly-Clark Worldwide, Inc. | Ultrasonic treatment chamber for preparing emulsions |
US10427956B2 (en) | 2009-11-16 | 2019-10-01 | Flodesign Sonics, Inc. | Ultrasound and acoustophoresis for water purification |
AU2011257902B2 (en) * | 2010-05-25 | 2014-04-17 | Crc Care Pty Ltd | Improved gravity sedimentation process and apparatus |
WO2011146991A1 (en) * | 2010-05-25 | 2011-12-01 | Crc Care Pty Ltd | Improved gravity sedimentation process and apparatus |
WO2013030691A2 (en) | 2011-08-30 | 2013-03-07 | Centre National De La Recherche Scientifique | Device for handling objects, using acoustic force fields |
US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
US10350514B2 (en) | 2012-03-15 | 2019-07-16 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US9738867B2 (en) | 2012-03-15 | 2017-08-22 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US10947493B2 (en) | 2012-03-15 | 2021-03-16 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10724029B2 (en) | 2012-03-15 | 2020-07-28 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
US9783775B2 (en) | 2012-03-15 | 2017-10-10 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US11007457B2 (en) | 2012-03-15 | 2021-05-18 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US10662404B2 (en) | 2012-03-15 | 2020-05-26 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
US10370635B2 (en) | 2012-03-15 | 2019-08-06 | Flodesign Sonics, Inc. | Acoustic separation of T cells |
US10662402B2 (en) | 2012-03-15 | 2020-05-26 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9701955B2 (en) | 2012-03-15 | 2017-07-11 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
US10308928B2 (en) | 2013-09-13 | 2019-06-04 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
US9796956B2 (en) | 2013-11-06 | 2017-10-24 | Flodesign Sonics, Inc. | Multi-stage acoustophoresis device |
US10975368B2 (en) | 2014-01-08 | 2021-04-13 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
US10814253B2 (en) | 2014-07-02 | 2020-10-27 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
WO2016054192A1 (en) * | 2014-09-30 | 2016-04-07 | Flodesign Sonics, Inc. | Acoustophoretic clarification of particle-laden non-flowing fluids |
US9675906B2 (en) | 2014-09-30 | 2017-06-13 | Flodesign Sonics, Inc. | Acoustophoretic clarification of particle-laden non-flowing fluids |
CN104409126A (en) * | 2014-11-25 | 2015-03-11 | 中国人民解放军第二炮兵工程大学 | Ultrasonic standing wave radioactive wastewater treatment device |
US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
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Also Published As
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GB9621832D0 (en) | 1996-12-11 |
AU4714597A (en) | 1998-05-15 |
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