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WO1998017284A3 - Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy - Google Patents

Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy Download PDF

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Publication number
WO1998017284A3
WO1998017284A3 PCT/CA1997/000794 CA9700794W WO9817284A3 WO 1998017284 A3 WO1998017284 A3 WO 1998017284A3 CA 9700794 W CA9700794 W CA 9700794W WO 9817284 A3 WO9817284 A3 WO 9817284A3
Authority
WO
WIPO (PCT)
Prior art keywords
heparin
hiv
mimetics
cap
gene therapy
Prior art date
Application number
PCT/CA1997/000794
Other languages
French (fr)
Other versions
WO1998017284A2 (en
Inventor
Daniel Favre
Original Assignee
Daniel Favre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daniel Favre filed Critical Daniel Favre
Priority to AU47691/97A priority Critical patent/AU4769197A/en
Publication of WO1998017284A2 publication Critical patent/WO1998017284A2/en
Publication of WO1998017284A3 publication Critical patent/WO1998017284A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a method of inhibiting cap-independent protein synthesis of eukaryotic cells, which comprises adding heparin or heparin mimetics thereof to said eukaryotic cells. There is also disclosed a method of inhibiting translation of HIV TAR-containing messenger ribonucleic acids (mRNA) of HIV infected eukaryotic cells, which comprises adding heparin or heparin mimetics thereof to said eukaryotic cells. There is also disclosed a composition for gene therapy using glycosaminoglycan N-acetylglycosaminyl N-deacetylase/N-sulfotransferase cDNA.
PCT/CA1997/000794 1996-10-22 1997-10-21 Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy WO1998017284A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47691/97A AU4769197A (en) 1996-10-22 1997-10-21 Inhibition of cap-independent protein synthesis by heparin or heparin mimetics thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2873696P 1996-10-22 1996-10-22
US60/028,736 1996-10-22
US3201896P 1996-11-22 1996-11-22
US60/032,018 1996-11-22

Publications (2)

Publication Number Publication Date
WO1998017284A2 WO1998017284A2 (en) 1998-04-30
WO1998017284A3 true WO1998017284A3 (en) 1998-08-20

Family

ID=26704031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000794 WO1998017284A2 (en) 1996-10-22 1997-10-21 Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy

Country Status (2)

Country Link
AU (1) AU4769197A (en)
WO (1) WO1998017284A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846917B2 (en) 2001-01-23 2005-01-25 Massachusetts Institute Of Technology Solid- and solution-phase synthesis of heparin and other glycosaminoglycans

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2907303A1 (en) * 1978-02-24 1979-09-06 Demetrios P Papahadjopoulos PROCESS FOR ENCAPSULATING BIOLOGICALLY ACTIVE SUBSTANCES
JPS59222410A (en) * 1983-06-01 1984-12-14 Terumo Corp Pharmaceutical preparation of liposome for keeping drug
WO1992013524A1 (en) * 1991-02-07 1992-08-20 A. Nattermann & Cie. Gmbh Pharmaceutical for treating viral diseases
JPH07145038A (en) * 1993-11-26 1995-06-06 Terumo Corp Constituent component for membrane of small closed cell
JPH0827030A (en) * 1994-07-08 1996-01-30 Terumo Corp Medicine carrier recognizing kidney

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2907303A1 (en) * 1978-02-24 1979-09-06 Demetrios P Papahadjopoulos PROCESS FOR ENCAPSULATING BIOLOGICALLY ACTIVE SUBSTANCES
JPS59222410A (en) * 1983-06-01 1984-12-14 Terumo Corp Pharmaceutical preparation of liposome for keeping drug
WO1992013524A1 (en) * 1991-02-07 1992-08-20 A. Nattermann & Cie. Gmbh Pharmaceutical for treating viral diseases
JPH07145038A (en) * 1993-11-26 1995-06-06 Terumo Corp Constituent component for membrane of small closed cell
JPH0827030A (en) * 1994-07-08 1996-01-30 Terumo Corp Medicine carrier recognizing kidney

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
CHANNAVAJJALA ET AL.: "CELL SURFACE HEPARIN PROTEOGLYCAN MEDIATE ATTACHMENT TO BASIC DOMAIN OF HIV-1 TAT PROTEIN", AIDS RES. HUMAN RETROV., vol. 10, no. suppl. 3, 1994, pages s77, XP002056009 *
DATABASE WPI Section Ch Week 8505, Derwent World Patents Index; Class B05, AN 85-027827, XP002056019 *
DATABASE WPI Section Ch Week 9531, Derwent World Patents Index; Class B04, AN 95-237131, XP002056018 *
DATABASE WPI Section Ch Week 9614, Derwent World Patents Index; Class A96, AN 96-136210, XP002056017 *
GREENBERG ET AL.: "Effect of Protein Synthesis Inhibitors on Growth Factor Activation of c-fos, c-myc, and Actin Gene Transcription", MOL. CELL. BIOL., vol. 6, no. 4, 1986, pages 1050 - 1057, XP002056016 *
HALPER ET AL.: "Modulation of Growth of Human Carcinoma SW-13 Cells by Heparin and Growth Factors", J. CELL. PHYS., vol. 141, no. 1, 1989, pages 16 - 23, XP002056011 *
HOWELL ET AL.: "LOW MOLECULAR WEIGHT HEPARIN INHIBITS INFECTIVITY AND PREVENTS REPLICATION OF HIV-1 IN T CELLS", BLOOD, vol. 84, no. 10 suppl. 1, 1994, pages 701a, XP002056015 *
MANALAYSAY ET AL.: "Inhibition of Mesothelial Cell Growth and Protein Synthesis by Heparin", ADV. PERITON. DIAL., vol. 11, 1995, pages 239 - 242, XP002056007 *
MEYLAN ET AL.: "Influence of Host Cell Type and V3 Loop of the Surface Glycoprotein on Susceptibility of Human Immunodeficiency Virus Type 1 to Polyanion Compounds", ANTIMICROBIAL AGENTS CHEMOTHER., vol. 38, no. 12, 1994, pages 2910 - 2916, XP002056014 *
REILLY ET AL.: "Rat Vascular Smooth Muscle Cells Immortalized with SV40 Large T antigen Possess Defined Smooth Muscle Inhibition by Heparin", J. CELL. PHYS., vol. 142, no. 2, 1990, pages 342 - 351, XP002056012 *
WACKER ET AL.: "Spezifische und unspezifische Hemmung der zellfreien Proteinsynthese mit Polyanionen", Z. NATURFORSCH. B, vol. 22, no. 4, 1967, pages 413 - 417, XP002056008 *
WALDMAN ET AL.: "Heparin as inhibitor of mammalian protein synthesis. II. Degree of sulfation. Related sulfated mucopolysaccharides", BIOCHIM. BIOPHYS. ACTA, vol. 343, no. 2, 1974, pages 324 - 329, XP002056010 *
WITVROUW ET AL.: "Sulfated polysaccharides Extracted from Sea Algae as Potential Antiviral Drugs", GEN. PHARMAC., vol. 29, no. 4, 1997, pages 497 - 511, XP002056013 *

Also Published As

Publication number Publication date
AU4769197A (en) 1998-05-15
WO1998017284A2 (en) 1998-04-30

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