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WO1998014577B1 - Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation - Google Patents

Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation

Info

Publication number
WO1998014577B1
WO1998014577B1 PCT/US1997/018026 US9718026W WO9814577B1 WO 1998014577 B1 WO1998014577 B1 WO 1998014577B1 US 9718026 W US9718026 W US 9718026W WO 9814577 B1 WO9814577 B1 WO 9814577B1
Authority
WO
WIPO (PCT)
Prior art keywords
mammastatin
kda
composition
dna sequence
nucleic acid
Prior art date
Application number
PCT/US1997/018026
Other languages
English (en)
Other versions
WO1998014577A9 (fr
WO1998014577A2 (fr
WO1998014577A3 (fr
Filing date
Publication date
Application filed filed Critical
Priority to EP97945531A priority Critical patent/EP0929675A2/fr
Priority to CA2267095A priority patent/CA2267095C/fr
Priority to BR9713248-9A priority patent/BR9713248A/pt
Priority to IL12924197A priority patent/IL129241A0/xx
Priority to JP51695598A priority patent/JP4452331B2/ja
Priority to AU46709/97A priority patent/AU733380B2/en
Priority to EA199900256A priority patent/EA199900256A1/ru
Publication of WO1998014577A2 publication Critical patent/WO1998014577A2/fr
Publication of WO1998014577A3 publication Critical patent/WO1998014577A3/fr
Publication of WO1998014577B1 publication Critical patent/WO1998014577B1/fr
Publication of WO1998014577A9 publication Critical patent/WO1998014577A9/fr

Links

Abstract

L'invention concerne une séquence nucléotidique codant pour la mammastatine, un inhibiteur de croissance spécifique de cellule mammaire. La mammastatine est codée par une seule séquence nucléotidique, et possède un poids moléculaire approximatif de 44 kDa dans sa forme inactive, non phosphorylée. Les cellules mammaires normales expriment des formes phosphorylées fonctionnelles possédant des poids moléculaires approximatifs de 53 kDa et 49 kDa. Des cellules mammaires métastatiques, ou n'expriment pas du tout la mammastatine, ou n'expriment pas les formes phosphorylées à 53 kDa ou 49 kDa. L'administration de mammastatine phosphorylée permet d'inhiber la croissance de cellules mammaires cancéreuses.
PCT/US1997/018026 1996-10-03 1997-10-03 Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation WO1998014577A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP97945531A EP0929675A2 (fr) 1996-10-03 1997-10-03 Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation
CA2267095A CA2267095C (fr) 1996-10-03 1997-10-03 Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation
BR9713248-9A BR9713248A (pt) 1996-10-03 1997-10-03 Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso
IL12924197A IL129241A0 (en) 1996-10-03 1997-10-03 Nucleotide and protein sequence of mammastatin and methods of use
JP51695598A JP4452331B2 (ja) 1996-10-03 1997-10-03 ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法
AU46709/97A AU733380B2 (en) 1996-10-03 1997-10-03 Nucleotide and protein sequence of mammastatin and methods of use
EA199900256A EA199900256A1 (ru) 1996-10-03 1997-10-03 Нуклеотидная и белковая последовательность маммастатина и способы применения

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2731596P 1996-10-03 1996-10-03
US60/027,315 1996-10-03

Publications (4)

Publication Number Publication Date
WO1998014577A2 WO1998014577A2 (fr) 1998-04-09
WO1998014577A3 WO1998014577A3 (fr) 1998-04-09
WO1998014577B1 true WO1998014577B1 (fr) 1998-07-30
WO1998014577A9 WO1998014577A9 (fr) 1998-08-27

Family

ID=21836977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018026 WO1998014577A2 (fr) 1996-10-03 1997-10-03 Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation

Country Status (8)

Country Link
US (6) US6451765B1 (fr)
EP (2) EP0929675A2 (fr)
JP (2) JP4452331B2 (fr)
AU (1) AU733380B2 (fr)
BR (1) BR9713248A (fr)
CA (1) CA2267095C (fr)
EA (1) EA199900256A1 (fr)
WO (1) WO1998014577A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500937B1 (en) 1996-10-03 2002-12-31 University Of Michigan Nucleotide sequence encoding a mammary cell growth inhibitor
CA2267095C (fr) * 1996-10-03 2010-08-10 Biotherapies, Inc. Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation
AU783373B2 (en) * 1999-06-18 2005-10-20 Biotherapies, Inc. Epithelial cell growth inhibitors
US6939714B2 (en) 1999-06-18 2005-09-06 Biotherapies, Inc. Epithelial cell growth inhibitors
WO2001000832A1 (fr) 1999-06-28 2001-01-04 Genentech, Inc. Methodes de fabrication de ligands apo-2 a l'aide d'ions metalliques divalents
US20030212263A1 (en) * 2000-06-19 2003-11-13 The University Of Michigan Mammastatin sequence variant C
WO2001098496A1 (fr) * 2000-06-19 2001-12-27 The University Of Michigan Allele c de sequence de mammastatine
CA3112837A1 (fr) * 2018-10-19 2020-04-23 Translate Bio, Inc. Encapsulation sans pompe d'arn messager

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379839A (en) 1977-05-23 1983-04-12 The Trustees Of Columbia University In The City Of New York Method for detecting cancer
US4753894A (en) 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
EP0414807A4 (en) * 1988-05-20 1991-07-03 The Regents Of The University Of Michigan Human mammary cell growth inhibitor and methods of production and use
JPH05506351A (ja) * 1988-05-20 1993-09-22 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン ヒト乳房細胞成長インヒビターに対する抗体ならびにその製造方法および使用
US6500937B1 (en) * 1996-10-03 2002-12-31 University Of Michigan Nucleotide sequence encoding a mammary cell growth inhibitor
CA2267095C (fr) * 1996-10-03 2010-08-10 Biotherapies, Inc. Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation

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