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WO1998013052A1 - Produit anti-allergique et anti-inflammatoire, procede de production de ce produit, produit cosmetique et produit hygienique - Google Patents

Produit anti-allergique et anti-inflammatoire, procede de production de ce produit, produit cosmetique et produit hygienique Download PDF

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Publication number
WO1998013052A1
WO1998013052A1 PCT/RU1997/000225 RU9700225W WO9813052A1 WO 1998013052 A1 WO1998013052 A1 WO 1998013052A1 RU 9700225 W RU9700225 W RU 9700225W WO 9813052 A1 WO9813052 A1 WO 9813052A1
Authority
WO
WIPO (PCT)
Prior art keywords
product
fact
amount
microorganism
miκροορganizma
Prior art date
Application number
PCT/RU1997/000225
Other languages
English (en)
Russian (ru)
Inventor
Alexandr Grigorievich Chuchalin
Nina Alexeevna Kolganova
Elena Borisovna Galkina
Polina Lvovna Zaslavskaya
Original Assignee
Chuchalin Alexandr Grigorievic
Nina Alexeevna Kolganova
Elena Borisovna Galkina
Polina Lvovna Zaslavskaya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chuchalin Alexandr Grigorievic, Nina Alexeevna Kolganova, Elena Borisovna Galkina, Polina Lvovna Zaslavskaya filed Critical Chuchalin Alexandr Grigorievic
Priority to AU37108/97A priority Critical patent/AU3710897A/en
Publication of WO1998013052A1 publication Critical patent/WO1998013052A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/44—Staphylococcus
    • C12R2001/445—Staphylococcus aureus

Definitions

  • the area of technology. 5 The invention relates to the field of medicine, in particular, to the manufacture of medical devices that are commercially available and have a commercially available product.
  • the preparation “Kazakhstan” takes advantage of an allergic action and contains 18.0-30.0 mg of white nitrogen in 100 ml of the preparation “Gazprom”, which is 1000 mg or 100 mg 1.1-1.87 mg / ml protein. However, it has a weak, potent inflammatory effect and a low biological value.
  • the method of receiving the product is compiled, t. ⁇ . Provides for the cultivation and processing of eight different microorganisms. By ⁇ 98/13052 ⁇ / ⁇ 7 / 00225
  • the closest analogue is the declared medicinal product used in the form of an ointment, which is a component of the product, which is sold as a rule for the sale of liquefied petroleum product (5.0) and a significant proportion of the average Community, Pharmaceuticals with Pharmaceuticals, Publishing House of Medicine, L, 1974), as well as medical treatment, as well as medical equipment
  • 15 contains oil like (2.0) and anesthetics (0.2) and is used in the form of suppositories for pain, pain, tendency, and hemostasis.
  • the purpose of the invention is to obtain a high-negative, commercially viable and non-profitable device.
  • the use of the Strain ⁇ arhusssis aigi ⁇ is known only in the treatment of the disease (Firms - Ge ⁇ maniya) wherein ⁇ n is ⁇ lzue ⁇ sya in s ⁇ s ⁇ ave 8 ⁇ azlichny ⁇ mi ⁇ ganizm ⁇ v ( ⁇ a ⁇ u ⁇ s ⁇ ssi ⁇ aureus, ⁇ a ⁇ u ⁇ s ⁇ ssiz a ⁇ iz, ⁇ ge ⁇ s ⁇ ssiz ⁇ s ⁇ a ⁇ , ⁇ ge ⁇ s ⁇ ssiz aet ⁇ u ⁇ siz, ⁇ s ⁇ ssiz ⁇ eit ⁇ ae, ⁇ e.zze ⁇ a sa ⁇ agayz, ⁇ aet ⁇ Piz ⁇ Pie ⁇ ae, Sa ⁇ sShs ⁇ a a ⁇ Ysa ⁇ ).
  • Bi ⁇ l ⁇ giches ⁇ uyu a ⁇ ivn ⁇ s ⁇ zayavlyaem ⁇ g ⁇ s ⁇ eds ⁇ va ⁇ edelyali ⁇ b ⁇ az ⁇ m follows: ⁇ ya ⁇ i bes ⁇ dnym white mice (19-21 g) ⁇ dn ⁇ a ⁇ n ⁇ vnu ⁇ ivenn ⁇ vv ⁇ dya ⁇ 0.5 ml zayavlyaem ⁇ g ⁇ s ⁇ eds ⁇ va, ⁇ azvedonn ⁇ g ⁇ 100 ⁇ az 0.9% ⁇ as ⁇ v ⁇ m ⁇ l ⁇ ida na ⁇ iya for ine ⁇ tsy, ⁇ ya ⁇ i ⁇ n ⁇ lnym mice vv ⁇ dya ⁇ 0.5 ml 0.9% disinfectant for injection.
  • each living subplant is injected with 0.02 ml of an external cannula ⁇ containing 5 mg / ml. Direct infusion of 0.02 ml of 0.9% disinfectant for injection. After 90 minutes, the animals are clogged up with excipients, they are separated by the knee joint and weighed for analytical weights. For each animal, I calculate the index of the reaction on the formula:
  • the received preparation is steadily poured into amp
  • D ⁇ ugimi therapeutic ⁇ mami D ⁇ ugimi therapeutic ⁇ mami, s ⁇ de ⁇ zhaschimi in ⁇ aches ⁇ ve a ⁇ ivn ⁇ g ⁇ vesches ⁇ va s ⁇ eds ⁇ v ⁇ ⁇ iv ⁇ alle ⁇ giches ⁇ g ⁇ and ⁇ iv ⁇ v ⁇ s ⁇ ali ⁇ eln ⁇ g ⁇ deys ⁇ viya, ⁇ luchenn ⁇ g ⁇ ⁇ u ⁇ om ⁇ b ⁇ ab ⁇ i ⁇ shedsheg ⁇ ⁇ e ⁇ m ⁇ ilnuyu s ⁇ adiyu ⁇ azvi ⁇ iya ⁇ .aigeiz sh ⁇ amm C2 ⁇ 222 and s ⁇ de ⁇ zhascheg ⁇ bel ⁇ in ⁇ liches ⁇ ve 0.0063 - 0.063 mg / ml (bel ⁇ vy az ⁇ in ⁇ liches ⁇ ve 100 - 1000 ⁇ ), are therapeutic ointments and suppositories.
  • Medicinal candles contain active substances in the amount of 5-10%, and in the amount of additives, anesthetics in the amount of 5-10%, as the oil in the amount of 80-90%.
  • a therapeutic medicinal product - a lysine contains active substances in the amount of 1-5%, and in the case of a supplementary food - 95% of a free food mixture.
  • the method of acquiring a direct and allergic and indirect product is as follows. ⁇ ez ⁇ ilnuyu s ⁇ u ⁇ u ⁇ u z ⁇ l ⁇ is ⁇ g ⁇ s ⁇ a ⁇ il ⁇ a ⁇ 1.aigeiz sh ⁇ amm C2 ⁇ 222 (De ⁇ ni ⁇ van in the museum and ⁇ II s ⁇ anda ⁇ izatsii ⁇ n ⁇ lya meditsins ⁇ i ⁇ and bi ⁇ l ⁇ giches ⁇ i ⁇ ⁇ e ⁇ a ⁇ a ⁇ v name ⁇ . ⁇ . ⁇ a ⁇ asevicha) ⁇ dg ⁇ vlennuyu mn ⁇ g ⁇ a ⁇ nymi ⁇ e ⁇ esevami ⁇ i ⁇ em ⁇ a ⁇ u ⁇ e ⁇ ul ⁇ ivi ⁇ vaniya d ⁇ 60-70 ° C, at zasevayu ⁇ s ⁇ e ⁇ ilnuyu ⁇ m ⁇ le ⁇ snuyu ⁇ i ⁇ a ⁇ elnuyu s ⁇ e
  • the treated substance is also used for the creation of medical, cosmetic and hygiene products.
  • Medicinal candles are produced by adding active substances in the amount of 5-10% to the original home-based base, which contains anesthetizing oil of 80 %- 5% ⁇ ⁇ 98 13052 ⁇ / ⁇ 97 / 00225
  • the human protein obtained by filtration 0.1 mg / ml.
  • the biological activity of the drug, which is distributed by the indus- try of the elimination of the total reaction, is 30%.
  • the facility is also equipped with a system for automatically regulating the temperature.
  • the volume of the medium in the group is 5 10 l, the aeration is maintained at a level of 4 l / min (0.4 rpm / min), and the stirring is 220 rpm, at a lower temperature.
  • the resulting mixture is homogenized and packaged in specially prepared tubes of 50 ml.
  • Medicinal candles are produced by adding active substances in the amount of 8% to the original self-relieving base, which saves 85%, which saves up to 50%. The resulting mixture is homogenized and poured into specially prepared forms.
  • 10 is 0.00125-0.0125 mg, and by analogy 0.225-0.375 mg, i.e. 30-180 times higher than the claimed method.
  • Medicinal suppositories with the addition of an active substance for the declared method were used for patients, in patients who have an allergic process, gastric mucosa is involved. Improvement was observed in 84% of the treated patients. ⁇ a ⁇ im ⁇ b ⁇ az ⁇ m, zayavlyaem ⁇ e s ⁇ eds ⁇ v ⁇ imee ⁇ neg ⁇ m ⁇ nalyyue ⁇ is ⁇ zhdenie, ⁇ bladae ⁇ vys ⁇ im ⁇ iv ⁇ alle ⁇ giches ⁇ im and ⁇ iv ⁇ v ⁇ s ⁇ ali ⁇ elnym deys ⁇ viem, ⁇ bladae ⁇ bel ⁇ v ⁇ y nag ⁇ uz ⁇ y on ⁇ atsien ⁇ a v30-180 ⁇ az less than ⁇ e ⁇ a ⁇ a ⁇ ⁇ ⁇ i ⁇ u, yavlyae ⁇ sya ⁇ du ⁇ m zhiznedeya ⁇ eln ⁇ s ⁇ i ⁇ l ⁇
  • Tables 4 and 5 additionally illustrate the effectiveness of the “UZAM” product, the different cases and the different operating modes.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Birds (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention se rapporte au domaine de la médecine et concerne un produit anti-allergique et anti-inflammatoire. Ce produit comprend un micro-organisme 'Staphylococcus aureus' qui a été préalablement soumis à une phase de développement thermophile. Cette invention concerne également la souche C2 N222, un procédé de production de cette dernière, ainsi qu'un produit cosmétique y faisant appel.
PCT/RU1997/000225 1996-09-26 1997-07-18 Produit anti-allergique et anti-inflammatoire, procede de production de ce produit, produit cosmetique et produit hygienique WO1998013052A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37108/97A AU3710897A (en) 1996-09-26 1997-07-18 Anti-allergic and anti-inflammatory product, method for producing the same, cosmetic product and hygienic product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU96118771 1996-09-26
RU9696118771A RU2098109C1 (ru) 1996-09-26 1996-09-26 Противоаллергическое, противовоспалительное средство, способ его получения, лечебное и косметическое средства с его использованием

Publications (1)

Publication Number Publication Date
WO1998013052A1 true WO1998013052A1 (fr) 1998-04-02

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Application Number Title Priority Date Filing Date
PCT/RU1997/000225 WO1998013052A1 (fr) 1996-09-26 1997-07-18 Produit anti-allergique et anti-inflammatoire, procede de production de ce produit, produit cosmetique et produit hygienique

Country Status (3)

Country Link
AU (1) AU3710897A (fr)
RU (1) RU2098109C1 (fr)
WO (1) WO1998013052A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7245920B2 (en) 2000-11-03 2007-07-17 Lucent Technologies Inc. Apparatus and method for use in allocating a channel resource in wireless multiple access communications systems
US7935787B2 (en) 2006-04-26 2011-05-03 Wyeth Llc Formulations which stabilize and inhibit precipitation of immunogenic compositions
US9095567B2 (en) 2010-06-04 2015-08-04 Wyeth Llc Vaccine formulations

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2161974C1 (ru) * 2000-01-20 2001-01-20 Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии" Лечебно-профилактическое средство для ухода за кожей (варианты)
RU2185183C1 (ru) * 2001-07-10 2002-07-20 Государственное учреждение Тверская государственная медицинская академия Способ лечения язвенно-эрозивных поражений гастродуоденальной зоны
RU2191024C1 (ru) * 2001-08-14 2002-10-20 Колганова Нина Алексеевна Ингаляционный препарат, купирующий удушье при бронхиальной астме и бронхоспазме
RU2192874C1 (ru) * 2001-08-14 2002-11-20 Колганова Нина Алексеевна Концентрат для получения противоаллергического, противовоспалительного средства
KR100615389B1 (ko) * 2002-08-23 2006-08-25 (주)헬릭서 다래 추출물을 함유하는 알러지성 질환 및 비알러지성염증 질환의 예방 및 개선용 건강 기능 식품

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2077101A (en) * 1980-05-12 1981-12-16 Kyokuto Fatty Acid Corp Antiallergic composition containing streptococci
WO1988003029A1 (fr) * 1986-10-28 1988-05-05 Pharmacia Ab Composition contenant une exotoxine bacterienne immunostimulante pour stimuler la cicatrisation, et son emploi
WO1989009607A1 (fr) * 1988-04-15 1989-10-19 Orenburgsky Gosudarstvenny Meditsinsky Institut Preparation bacterienne pour prophylaxie et traitement de processus inflammatoires et d'affections allergiques
WO1991004742A1 (fr) * 1989-10-06 1991-04-18 Szabo Janos Composition pharmaceutique destinee au traitement des maladies de la peau, notamment la dermatite pyogenique ou atopique, et procede de preparation
GB2240922A (en) * 1990-02-16 1991-08-21 Om Lab Sa Bacterial lysate for the treatment of dermatitis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2077101A (en) * 1980-05-12 1981-12-16 Kyokuto Fatty Acid Corp Antiallergic composition containing streptococci
WO1988003029A1 (fr) * 1986-10-28 1988-05-05 Pharmacia Ab Composition contenant une exotoxine bacterienne immunostimulante pour stimuler la cicatrisation, et son emploi
WO1989009607A1 (fr) * 1988-04-15 1989-10-19 Orenburgsky Gosudarstvenny Meditsinsky Institut Preparation bacterienne pour prophylaxie et traitement de processus inflammatoires et d'affections allergiques
WO1991004742A1 (fr) * 1989-10-06 1991-04-18 Szabo Janos Composition pharmaceutique destinee au traitement des maladies de la peau, notamment la dermatite pyogenique ou atopique, et procede de preparation
GB2240922A (en) * 1990-02-16 1991-08-21 Om Lab Sa Bacterial lysate for the treatment of dermatitis

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7245920B2 (en) 2000-11-03 2007-07-17 Lucent Technologies Inc. Apparatus and method for use in allocating a channel resource in wireless multiple access communications systems
US7935787B2 (en) 2006-04-26 2011-05-03 Wyeth Llc Formulations which stabilize and inhibit precipitation of immunogenic compositions
US8562999B2 (en) 2006-04-26 2013-10-22 Wyeth Llc Formulations which stabilize and inhibit precipitation of immunogenic compositions
US9095567B2 (en) 2010-06-04 2015-08-04 Wyeth Llc Vaccine formulations

Also Published As

Publication number Publication date
AU3710897A (en) 1998-04-17
RU2098109C1 (ru) 1997-12-10

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