+

WO1998011437B1 - Bibliotheques de marquage d'affinite avec groupes partants marques - Google Patents

Bibliotheques de marquage d'affinite avec groupes partants marques

Info

Publication number
WO1998011437B1
WO1998011437B1 PCT/US1997/016435 US9716435W WO9811437B1 WO 1998011437 B1 WO1998011437 B1 WO 1998011437B1 US 9716435 W US9716435 W US 9716435W WO 9811437 B1 WO9811437 B1 WO 9811437B1
Authority
WO
WIPO (PCT)
Prior art keywords
affinity
group
amino acid
composition
amino acids
Prior art date
Application number
PCT/US1997/016435
Other languages
English (en)
Other versions
WO1998011437A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to AU43518/97A priority Critical patent/AU4351897A/en
Publication of WO1998011437A1 publication Critical patent/WO1998011437A1/fr
Publication of WO1998011437B1 publication Critical patent/WO1998011437B1/fr

Links

Abstract

L'invention concerne des procédés et des compositions permettant d'identifier des composés présentant une affinité vis à vis d'un site cible. Selon ledit procédé, le groupe à affinité est un groupe partant provenant d'une fonctionnalité réactive pouvant former une liaison covalente avec le site cible. Il est possible de combiner le composé comprenant le site cible avec la bibliothèque et de procéder à un dosage concernant la composition obtenue des groupes partants. Les groupes partants présentant la concentration la plus élevée peuvent être identifiés comme les groupes ayant la plus haute affinité de liaison vis à vis du site cible. Les composés sélectionnés peuvent ensuite être utilisés pour marquer la molécule cible, en particulier lorsque la molécule cible est trouvée naturellement dans un mélange complexe, tel qu'un liquide physiologique, par exemple le sang. Grâce à un marquage d'affinité in vivo, la durée de vie d'entités physiologiquement actives peut être grandement prolongée par le fait qu'elles se lient à des composants du sang à longue vie. L'entité liée par covalence peut également servir d'antagoniste ou d'agoniste de protéines de liaison particulières ou bien d'inhibiteur enzymatique.
PCT/US1997/016435 1996-09-16 1997-09-16 Bibliotheques de marquage d'affinite avec groupes partants marques WO1998011437A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43518/97A AU4351897A (en) 1996-09-16 1997-09-16 Affinity labeling libraries with tagged leaving groups

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71475496A 1996-09-16 1996-09-16
US08/714,754 1996-09-16

Publications (2)

Publication Number Publication Date
WO1998011437A1 WO1998011437A1 (fr) 1998-03-19
WO1998011437B1 true WO1998011437B1 (fr) 1998-06-11

Family

ID=24871322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/016435 WO1998011437A1 (fr) 1996-09-16 1997-09-16 Bibliotheques de marquage d'affinite avec groupes partants marques

Country Status (3)

Country Link
US (1) US6403324B1 (fr)
AU (1) AU4351897A (fr)
WO (1) WO1998011437A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1199566B1 (fr) * 1997-11-07 2008-08-27 ConjuChem Biotechnologies Inc. Méthodes de criblage de bibliothèques de marqueurs à affinité
CA2305597C (fr) 1997-11-07 2008-07-29 Conjuchem Inc. Marqueurs d'affinite pour la serum-albumine humaine
CA2330611A1 (fr) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Molecules bifonctionnelles et therapies basees sur celles-ci
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US6887470B1 (en) * 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
CA2501421A1 (fr) 1999-05-17 2000-11-23 Conjuchem Inc. Exendin-4 a longue duree d'action
US20040266673A1 (en) * 2002-07-31 2004-12-30 Peter Bakis Long lasting natriuretic peptide derivatives
US20090175821A1 (en) * 1999-05-17 2009-07-09 Bridon Dominique P Modified therapeutic peptides with extended half-lives in vivo
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6514500B1 (en) * 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
EP1229924A4 (fr) 1999-11-19 2004-12-15 Univ Leland Stanford Junior Molecules bifonctionnelles ciblees et therapies basees sur celles-ci
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
US20010051348A1 (en) 2000-01-28 2001-12-13 Lee Chee Wee Novel ligands and methods for preparing same
US20020045194A1 (en) * 2000-04-10 2002-04-18 Cravatt Benjamin F. Proteomic analysis
PT1360202E (pt) 2001-02-16 2008-09-01 Conjuchem Biotechnologies Inc Peptídeo do tipo glucagon 2 (glp-2) de longa duração para o tratamento de doenças e distúrbios gastrointestinais
US7927579B2 (en) * 2003-01-17 2011-04-19 Advanced Proteome Therapeutics, Inc Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites
PT2100904E (pt) * 2004-04-23 2010-09-24 Conjuchem Biotechnologies Inc Fase sólida para utilização num método para a purificação de conjugados de albumina
US8039432B2 (en) * 2005-11-09 2011-10-18 Conjuchem, Llc Method of treatment of diabetes and/or obesity with reduced nausea side effect
CA2634495A1 (fr) * 2005-12-22 2007-06-28 Conjuchem Biotechnologies Inc. Procede de production de conjugues d'albumine preformes et agent therapeutique
US20090099074A1 (en) * 2007-01-10 2009-04-16 Conjuchem Biotechnologies Inc. Modulating food intake
US20090186819A1 (en) * 2007-12-11 2009-07-23 Marieve Carrier Formulation of insulinotropic peptide conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
AU7516694A (en) * 1993-07-30 1995-02-28 Affymax Technologies N.V. Biotinylation of proteins
EP0639585A1 (fr) 1993-08-20 1995-02-22 Banyu Pharmaceutical Co., Ltd. Inhibiteur d'élastase
US5571681A (en) 1994-03-10 1996-11-05 The Scripps Research Institute Chemical event selection by suicide substrate conjugates
US5738996A (en) 1994-06-15 1998-04-14 Pence, Inc. Combinational library composition and method
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins

Similar Documents

Publication Publication Date Title
WO1998011437B1 (fr) Bibliotheques de marquage d'affinite avec groupes partants marques
DeLange et al. Calf and pea histone IV: II. The complete amino acid sequence of calf thymus histone IV; presence of ε-N-acetyllysine
Akiyama et al. Synthetic peptides competitively inhibit both direct binding to fibroblasts and functional biological assays for the purified cell-binding domain of fibronectin.
Waite Mussel glue from Mytilus californianus Conrad: a comparative study
Gregory et al. The primary structure of human urogastrone
Krieg et al. Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.
Aitken et al. Identification of the NH2-terminal blocking group of calcineurin B as myristic acid
Rawal et al. Structural specificity of substrate for S-adenosylmethionine protein arginine N-methyltransferases
Ozawa et al. The reactive site of trypsin inhibitors
Jones et al. Extension of the amino acid sequence of a lysine-rich histone
Gorman et al. Structural features of glutamine substrates for transglutaminases. Role of extended interactions in the specificity of human plasma factor XIIIa and of the guinea pig liver enzyme.
EP1456662B1 (fr) Procede pour detecter des auto-anticorps chez des patients souffrant de polyarthrite rhumatoïde
Shapira et al. Encephalitogenic fragment of myelin basic protein: amino acid sequence of bovine, rabbit, guinea pig, monkey, and human fragments
AU4829999A (en) Methods for rapidly identifying small organic ligands
CA2277832A1 (fr) Peptides cycliques se fixant a un recepteur de l'activateur de plasminogene de type urokinase
TAKAHARA et al. Purification and characterization of peptidylarginine deiminase from rabbit skeletal muscle
DE3244030A1 (de) Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
McFadden et al. Chemical conversion of aspartyl peptides to isoaspartyl peptides. A method for generating new methyl-accepting substrates for the erythrocyte D-aspartyl/L-isoaspartyl protein methyltransferase.
WO1995003327A3 (fr) Peptides de neutralisation de la toxicite du lipide a
Frøyshov et al. On the biosynthesis of bacitracin by a soluble enzyme complex from Bacillus licheniformis
Perham et al. The Determination of the Order of Lysine‐containing: Tryptic Peptides of Proteins by Diagonal Paper Electrophoresis A Carboxyl‐terminal Sequence for Pepsin
Morino et al. Primary structure of pyridoxal phosphate binding site in the mitochondrial and extramitochondrial aspartate aminotransferases from pig heart muscle. Chymotryptic peptides
König et al. The amino acid sequence of the peptide moiety of the pseudomurein from Methanobacterium thermoautotrophicum
Ramshaw et al. The amino acid sequence of plastocyanin from Solanum tuberosum L.(potato)
JP2009544638A (ja) タンパク質結合メトトレキサート誘導体、及びそれを含有する薬剤
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载