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WO1998008854A3 - Sugar derivatives as sialyl lewis x mimetics - Google Patents

Sugar derivatives as sialyl lewis x mimetics Download PDF

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Publication number
WO1998008854A3
WO1998008854A3 PCT/EP1997/004649 EP9704649W WO9808854A3 WO 1998008854 A3 WO1998008854 A3 WO 1998008854A3 EP 9704649 W EP9704649 W EP 9704649W WO 9808854 A3 WO9808854 A3 WO 9808854A3
Authority
WO
WIPO (PCT)
Prior art keywords
mimetics
sialyl lewis
sugar derivatives
sialyl
lewis
Prior art date
Application number
PCT/EP1997/004649
Other languages
French (fr)
Other versions
WO1998008854A2 (en
WO1998008854B1 (en
Inventor
Chi-Huey Wong
Chun-Cheng Lin
Thomas J Woltering
Thomas G Marron
Francisco Moris-Varas
Jill Jablonowski
Gabriele Weitz-Schmidt
Original Assignee
Ciba Geigy Ag
Scripps Research Inst
Wong Chi Huey
Lin Chun Cheng
Thomas J Woltering
Thomas G Marron
Moris Varas Francisco
Jill Jablonowski
Weitz Schmidt Gabriele
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/744,744 external-priority patent/US5830871A/en
Priority claimed from US08/764,315 external-priority patent/US5837862A/en
Application filed by Ciba Geigy Ag, Scripps Research Inst, Wong Chi Huey, Lin Chun Cheng, Thomas J Woltering, Thomas G Marron, Moris Varas Francisco, Jill Jablonowski, Weitz Schmidt Gabriele filed Critical Ciba Geigy Ag
Priority to AU47004/97A priority Critical patent/AU4700497A/en
Publication of WO1998008854A2 publication Critical patent/WO1998008854A2/en
Publication of WO1998008854A3 publication Critical patent/WO1998008854A3/en
Publication of WO1998008854B1 publication Critical patent/WO1998008854B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Sialyl Lewis X mimetics which mimic the inhibition of selectin-mediated cellular adhesion by sialyl X having a core of formula (I).
PCT/EP1997/004649 1996-08-26 1997-08-26 Sugar derivatives as sialyl lewis x mimetics WO1998008854A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47004/97A AU4700497A (en) 1996-08-26 1997-08-26 Organic compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2455696P 1996-08-26 1996-08-26
US60/024,556 1996-08-26
US08/744,744 US5830871A (en) 1996-10-28 1996-10-28 Inhibitors of E-, P- and L-selectin binding
US08/764,315 US5837862A (en) 1996-12-12 1996-12-12 Sialyl Lewis X mimetics incorporating mannopeptides

Publications (3)

Publication Number Publication Date
WO1998008854A2 WO1998008854A2 (en) 1998-03-05
WO1998008854A3 true WO1998008854A3 (en) 1998-08-20
WO1998008854B1 WO1998008854B1 (en) 1998-10-01

Family

ID=27362340

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/004649 WO1998008854A2 (en) 1996-08-26 1997-08-26 Sugar derivatives as sialyl lewis x mimetics

Country Status (2)

Country Link
AU (1) AU4700497A (en)
WO (1) WO1998008854A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
WO1999010359A2 (en) * 1997-08-26 1999-03-04 Novartis Ag Liposomic based sialyl lewis x mimetics
ATE361082T1 (en) 1999-02-01 2007-05-15 Dermal Res Lab Inc PHARMACEUTICAL COMPOSITION OF COMPLEX CARBOHYDRATES ITS APPLICATION
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
CA2501842C (en) * 2002-10-11 2012-07-17 Yamanouchi Europe B.V. Glucose-based compounds with affinity to p-selectin
CN115197185B (en) * 2021-04-12 2024-03-22 中国科学院大连化学物理研究所 A kind of preparation method of transition metal catalyzed pyranoside derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
UCHIYAMA, TAKETO ET AL: "Design and Synthesis of Sialyl Lewis X Mimetics", J. AM. CHEM. SOC. (1995), 117(19), 5395-6 CODEN: JACSAT;ISSN: 0002-7863, 1995, XP000570082 *
UCHIYAMA, TRAKETO ET AL: "Design and synthesis of C-linked fucosides as inhibitors of E-selectin", BIOORG. MED. CHEM. (1996), 4(7), 1149-1165 CODEN: BMECEP;ISSN: 0968-0896, 9 July 1996 (1996-07-09), XP002054353 *
WOLTERING, THOMAS J. ET AL: "C-Fucopeptides as selection antagonists: attachment of lipid moieties enhances the activity", TETRAHEDRON LETT. (1996), 37(50), 9033-9036 CODEN: TELEAY;ISSN: 0040-4039, 9 December 1996 (1996-12-09), XP002054357 *
WONG, CHI-HUEY ET AL: "Small Molecules as Structural and Functional Mimics of Sialyl Lewis X in Selectin Inhibition: A Remarkable Enhancement of Inhibition by Additional Negative Charge and/or Hydrophobic Group", J. AM. CHEM. SOC. (1997), 119(35), 8152-8158 CODEN: JACSAT;ISSN: 0002-7863, 1997, XP002054358 *

Also Published As

Publication number Publication date
WO1998008854A2 (en) 1998-03-05
AU4700497A (en) 1998-03-19

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