+

WO1998007851A3 - Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans - Google Patents

Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans Download PDF

Info

Publication number
WO1998007851A3
WO1998007851A3 PCT/EP1997/004600 EP9704600W WO9807851A3 WO 1998007851 A3 WO1998007851 A3 WO 1998007851A3 EP 9704600 W EP9704600 W EP 9704600W WO 9807851 A3 WO9807851 A3 WO 9807851A3
Authority
WO
WIPO (PCT)
Prior art keywords
agents
genes
humans
breast cancer
prevention
Prior art date
Application number
PCT/EP1997/004600
Other languages
French (fr)
Other versions
WO1998007851A2 (en
Inventor
Johanna E Bergmann
Enrique R Preddie
Original Assignee
Johanna E Bergmann
Enrique R Preddie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johanna E Bergmann, Enrique R Preddie filed Critical Johanna E Bergmann
Priority to AU59398/98A priority Critical patent/AU5939898A/en
Priority to DE69737570T priority patent/DE69737570T2/en
Priority to EP97948755A priority patent/EP0991756B1/en
Publication of WO1998007851A2 publication Critical patent/WO1998007851A2/en
Publication of WO1998007851A3 publication Critical patent/WO1998007851A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Agents and methods for diagnosis of breast and ovarian cancer are disclosed. These agents are targets for immunological and anti-nucleic acid therapy to prevent and stop breast and ovarian cancer in humans. Such agents including ten genes (L-oncogenes) transcribed, in the opposite direction, from the locus of genes predisposing for breast cancer, the proteins encoded in these genes, the promoters that program transcription of the genes and endogenous antibodies produced in human blood, serum, saliva, urine, etc., against the proteins expressed by the ten L-oncogenes.
PCT/EP1997/004600 1996-08-22 1997-08-22 Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans WO1998007851A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU59398/98A AU5939898A (en) 1996-08-22 1997-08-22 Agent for the pre-symptomatic detection, prevention and treatment of breast cancer in humans
DE69737570T DE69737570T2 (en) 1996-08-22 1997-08-22 Agents for presymptomatic detection, prevention and treatment of breast cancer in humans
EP97948755A EP0991756B1 (en) 1996-08-22 1997-08-22 Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,183,900 1996-08-22
CA002183900A CA2183900A1 (en) 1996-08-22 1996-08-22 Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans

Publications (2)

Publication Number Publication Date
WO1998007851A2 WO1998007851A2 (en) 1998-02-26
WO1998007851A3 true WO1998007851A3 (en) 1998-08-13

Family

ID=4158776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/004600 WO1998007851A2 (en) 1996-08-22 1997-08-22 Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans

Country Status (5)

Country Link
EP (1) EP0991756B1 (en)
AU (1) AU5939898A (en)
CA (1) CA2183900A1 (en)
DE (1) DE69737570T2 (en)
WO (1) WO1998007851A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710174B2 (en) 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
SE9801695D0 (en) * 1998-05-14 1998-05-14 Karolinska Innovations Ab Inhibition of p53 function by a p53-derived peptide
US7306919B1 (en) * 2001-10-31 2007-12-11 Thornthwaite Jerry T Antigen-antibody cancer recognition system
US20040115656A1 (en) * 2002-12-16 2004-06-17 Tai-Jay Chang Treating breast cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021791A1 (en) * 1993-03-16 1994-09-29 Johanna Eugenie Bergmann Agents for the prevention and treatment of breast cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021791A1 (en) * 1993-03-16 1994-09-29 Johanna Eugenie Bergmann Agents for the prevention and treatment of breast cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARLOW E ET AL: "MOLECULAR CLONING AND IN VITRO EXPRESSION OF A CDNA CLONE FOR HUMANCELLULAR TUMOR ANTIGEN P53", MOLECULAR AND CELLULAR BIOLOGY, vol. 5, no. 7, July 1985 (1985-07-01), pages 1601 - 1610, XP000619201 *
MERINO, E. ET AL.: "Antisense overlapping open reading frames in genes from bacteria to humans", NUCLEIC ACIDS RESEARCH., vol. 22, 1994, OXFORD GB, pages 1903 - 1908, XP002066206 *
MIKI Y ET AL: "A STRONG CANDIDATE FOR THE BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE BRCA1", SCIENCE, vol. 266, no. 5182, 7 October 1994 (1994-10-07), pages 66 - 71, XP002024010 *

Also Published As

Publication number Publication date
AU5939898A (en) 1998-03-06
DE69737570D1 (en) 2007-05-16
DE69737570T2 (en) 2008-03-13
EP0991756A2 (en) 2000-04-12
CA2183900A1 (en) 1998-02-23
EP0991756B1 (en) 2007-04-04
WO1998007851A2 (en) 1998-02-26

Similar Documents

Publication Publication Date Title
WO2001000828A3 (en) Compositions and methods for the therapy and diagnosis of lung cancer
EP0288082A3 (en) A tumor specific assay for ca125 ovarian cancer antigen
WO2001040269A3 (en) Compositions and methods for therapy and diagnosis of breast cancer
WO2000004149A3 (en) Compositions and methods for therapy and diagnosis of prostate cancer
WO2001075171A3 (en) Methods, compositions and kits for the detection and monitoring of breast cancer
IL144559A0 (en) Antibodies for cancer therapy and diagnosis
WO2000060076A3 (en) Compositions for the treatment and diagnosis of breast cancer and methods for their use
WO2001096388A3 (en) Compositions and methods for the therapy and diagnosis of colon cancer
WO2000060077A3 (en) Compounds for therapy and diagnosis of lung cancer and methods for their use
WO2001034802A3 (en) Compositions and methods for the therapy and diagnosis of prostate cancer
WO2001096390A3 (en) Compositions and methods for the therapy and diagnosis of colon cancer
WO2001073027A3 (en) Compositions and methods for therapy and diagnosis of colon cancer
WO1997029199A3 (en) Prostate specific antigen peptides and uses thereof
WO2000035950A3 (en) Reagents and methods useful for detecting diseases of the breast
WO2002064839A3 (en) Methods for the diagnosis and treatment of tumors employing the hepsin gene
WO2001018046A3 (en) Ovarian tumor sequences and methods of use therefor
WO1998007851A3 (en) Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans
WO1999000671A3 (en) Method for identification of tumor antigens with autoantibodies in serum
WO2000078960A3 (en) Compositions and methods for the therapy and diagnosis of breast cancer
WO2001057207A3 (en) Compositions and methods for the therapy and diagnosis of ovarian cancer
WO2004071273A3 (en) Method of employing elevation of marinobufagenin in determining the presence of preeclampsia and related apparatus
WO2002004952A3 (en) Diagnostic and therapeutic methods based on the l1 adhesion molecule for ovarian and endometrial tumors
WO2001051513A3 (en) Ovarian tumor-associated sequences
WO2001070976A3 (en) Compositions and methods for the therapy and diagnosis of ovarian and endometrial cancer
CA2100464A1 (en) Prescreening of prostate cancer by serum prostatic specific antigen

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CH CN JP NO NZ RU US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CH CN JP NO NZ RU US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 1997948755

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998510438

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09242451

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1997948755

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1997948755

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载