WO1998006749B1 - Proteines de fusion de classe ii du cmh, solubles, monovalentes ou polyvalentes, et utilisations associees - Google Patents
Proteines de fusion de classe ii du cmh, solubles, monovalentes ou polyvalentes, et utilisations associeesInfo
- Publication number
- WO1998006749B1 WO1998006749B1 PCT/US1997/014503 US9714503W WO9806749B1 WO 1998006749 B1 WO1998006749 B1 WO 1998006749B1 US 9714503 W US9714503 W US 9714503W WO 9806749 B1 WO9806749 B1 WO 9806749B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- class
- mhc class
- major histocompatibility
- fusion protein
- histocompatibility complex
- Prior art date
Links
Abstract
La présente invention concerne le domaine de l'immunologie. Elle se rapporte notamment à la conception, à la production et à l'utilisation de protéines de fusion recombinées dérivées, en partie, des protéines du complexe majeur d'histocompatibilité (CMH) humain.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10510100A JP2000516470A (ja) | 1996-08-16 | 1997-08-15 | 可溶性一価および多価mhcクラスii融合タンパク質およびそれらの使用 |
AT97938386T ATE272070T1 (de) | 1996-08-16 | 1997-08-15 | Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen |
NZ333915A NZ333915A (en) | 1996-08-16 | 1997-08-15 | Soluble monovalent and multivalent MHC class II fusion proteins |
EP97938386A EP0935607B1 (fr) | 1996-08-16 | 1997-08-15 | Proteines de fusion de classe ii du cmh, solubles, monovalentes ou polyvalentes, et utilisations associees |
AU40723/97A AU730457B2 (en) | 1996-08-16 | 1997-08-15 | Soluble monovalent and multivalent MHC class II fusion proteins, and uses therefor |
DE69730038T DE69730038T2 (de) | 1996-08-16 | 1997-08-15 | Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen |
CA002263195A CA2263195A1 (fr) | 1996-08-16 | 1997-08-15 | Proteines de fusion de classe ii du cmh, solubles, monovalentes ou polyvalentes, et utilisations associees |
US10/895,543 US20050003431A1 (en) | 1996-08-16 | 2004-07-21 | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2407796P | 1996-08-16 | 1996-08-16 | |
US60/024,077 | 1996-08-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/895,543 Continuation-In-Part US20050003431A1 (en) | 1996-08-16 | 2004-07-21 | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1998006749A2 WO1998006749A2 (fr) | 1998-02-19 |
WO1998006749A3 WO1998006749A3 (fr) | 1998-06-11 |
WO1998006749B1 true WO1998006749B1 (fr) | 1998-07-16 |
Family
ID=21818743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/014503 WO1998006749A2 (fr) | 1996-08-16 | 1997-08-15 | Proteines de fusion de classe ii du cmh, solubles, monovalentes ou polyvalentes, et utilisations associees |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0935607B1 (fr) |
JP (1) | JP2000516470A (fr) |
AT (1) | ATE272070T1 (fr) |
AU (1) | AU730457B2 (fr) |
CA (1) | CA2263195A1 (fr) |
DE (1) | DE69730038T2 (fr) |
DK (1) | DK0935607T3 (fr) |
ES (1) | ES2221065T3 (fr) |
NZ (1) | NZ333915A (fr) |
PT (1) | PT935607E (fr) |
WO (1) | WO1998006749A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9404916B2 (en) | 2008-09-20 | 2016-08-02 | University College Cardiff Consultants Limited | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11507843A (ja) | 1996-03-28 | 1999-07-13 | ザ・ジョンズ・ホプキンス・ユニバーシティー | タンパク質の可溶性二価および多価ヘテロ二量体類縁体 |
US6458354B1 (en) | 1996-03-28 | 2002-10-01 | The Johns Hopkins University | Molecular complexes which modify immune responses |
US6268411B1 (en) | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
AU765378B2 (en) * | 1998-02-19 | 2003-09-18 | President And Fellows Of Harvard College | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
FR2778669B1 (fr) * | 1998-05-14 | 2002-06-14 | Centre Nat Rech Scient | Procede d'expression d'un complexe forme d'au moins un produit du complexe majeur d'histocompatibilite et d'un peptide chez un phage, phages et complexes ainsi obtenus et leurs applications |
EP1066380B1 (fr) * | 1998-05-19 | 2001-11-14 | Avidex Ltd | Recepteur de lymphocyte t soluble |
FR2796953B1 (fr) * | 1999-07-29 | 2003-10-10 | Centre Nat Rech Scient | Proteines recombinantes, et complexes moleculaires derives de ces proteines, analogues a des molecules impliquees dans les reponses immunitaires |
US7541429B2 (en) | 2000-10-10 | 2009-06-02 | The Board Of Regents Of The University Of Oklahoma | Comparative ligand mapping from MHC positive cells |
WO2002062846A2 (fr) * | 1999-12-17 | 2002-08-15 | The Board Of Regents Of The University Of Oklahoma | Procede et dispositif de production d'antigenes et utilisation de ceux-ci |
US7521202B2 (en) | 1999-12-17 | 2009-04-21 | The Board Of Regents Of The University Of Oklahoma | Method and apparatus for the production of soluble MHC antigens and uses thereof |
US20070026433A1 (en) | 2001-03-09 | 2007-02-01 | Hildebrand William H | Epitope testing using soluble HLA |
CA2440474A1 (fr) | 2001-04-05 | 2002-10-17 | Virginia Mason Research Center | Procedes de cartographie d'epitopes de la classe i du complexe majeur d'histocompatibilite, cmh, detection de lymphocytes t autoimmuns et d'antigenes, et traitement autoimmun. |
GB2392158B (en) * | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
EP1400534B1 (fr) * | 2002-09-10 | 2015-10-28 | Affimed GmbH | Anticorps humain spécifique pour CD3 avec des propriétés immunosupressives |
AU2004256354B2 (en) | 2003-07-15 | 2011-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
JP4762717B2 (ja) | 2003-10-09 | 2011-08-31 | 中外製薬株式会社 | IgM高濃度安定化溶液 |
GB2409456B (en) * | 2003-10-30 | 2006-01-04 | Proimmune Ltd | Oligomeric receptor ligand pair member complexes |
EP2361930A3 (fr) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimeres du complexes peptide-cmh et leur utilisation dans des maladies infectieuses de borrelia |
WO2009003493A2 (fr) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Procédés compilés pour analyser et trier des échantillons |
US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
WO2010009735A2 (fr) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Analyse et réparation combinatoires |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
GB201002730D0 (en) * | 2010-02-18 | 2010-04-07 | Uni I Oslo | Product |
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
RU2014132426A (ru) * | 2012-01-06 | 2016-02-27 | Орегон Хэлт Энд Сайенс Юниверсити | Частичные конструкты мнс и способы их применения |
RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
EP3052526A4 (fr) | 2013-10-03 | 2017-04-19 | Oregon Health & Science University | Polypeptides recombinés comprenant des domaines 1 du cmh de classe ii |
PT3065771T (pt) | 2013-11-04 | 2019-06-24 | Uti Lp | Metodos e composicoes para imunoterapia prolongada |
US10857219B2 (en) | 2014-03-28 | 2020-12-08 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof |
CN113549153A (zh) | 2014-05-29 | 2021-10-26 | 宏观基因有限公司 | 三特异性结合分子和其使用方法 |
US11585806B2 (en) | 2014-06-13 | 2023-02-21 | Immudex Aps | General detection and isolation of specific cells by binding of labeled molecules |
BR112017023853A2 (pt) | 2015-05-06 | 2018-07-17 | Uti Limited Partnership | composições de nanopartícula para terapia sustentada. |
GEP20217317B (en) | 2015-10-08 | 2021-11-10 | Macrogenics Inc | Combination therapy for the treatment of cancer |
CN116875635A (zh) | 2015-10-22 | 2023-10-13 | 朱诺治疗学有限公司 | 用于转导的方法、反应剂盒、反应剂和设备 |
MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
WO2018087597A1 (fr) * | 2016-11-09 | 2018-05-17 | Uti Limited Partnership | Molécules de classe ii de pmhc de recombinaison |
CA3060526A1 (fr) | 2017-04-27 | 2018-11-01 | Juno Therapeutics Gmbh | Reactifs particulaires oligomeres et leurs methodes d'utilisation |
US20220275043A1 (en) * | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
US12258373B2 (en) | 2018-12-17 | 2025-03-25 | Immudex Aps | Panel comprising Borrelia MHC multimers |
GB201909509D0 (en) * | 2019-07-02 | 2019-08-14 | Immunocore Ltd | Peptide-MHC complexes |
CN112816595A (zh) * | 2021-01-06 | 2021-05-18 | 海默斯(重庆)医学生物技术有限公司 | 一种重组角蛋白液体制剂及其纯度检测方法 |
US20240190941A1 (en) * | 2021-04-07 | 2024-06-13 | Repertoire Immune Medicines, Inc. | Peptide-mhc-immunoglobulin multimers and methods of use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993010220A1 (fr) * | 1991-11-19 | 1993-05-27 | Anergen, Inc. | Molecules solubles du complexe majeur d'histocompatibilite et leurs utilisations |
ES2152424T5 (es) * | 1994-07-29 | 2010-07-05 | Sunol Molecular Corporation | Complejos del mhc y usos de los mismos. |
-
1997
- 1997-08-15 AU AU40723/97A patent/AU730457B2/en not_active Ceased
- 1997-08-15 WO PCT/US1997/014503 patent/WO1998006749A2/fr active IP Right Grant
- 1997-08-15 DE DE69730038T patent/DE69730038T2/de not_active Expired - Fee Related
- 1997-08-15 ES ES97938386T patent/ES2221065T3/es not_active Expired - Lifetime
- 1997-08-15 EP EP97938386A patent/EP0935607B1/fr not_active Expired - Lifetime
- 1997-08-15 JP JP10510100A patent/JP2000516470A/ja active Pending
- 1997-08-15 PT PT97938386T patent/PT935607E/pt unknown
- 1997-08-15 AT AT97938386T patent/ATE272070T1/de not_active IP Right Cessation
- 1997-08-15 NZ NZ333915A patent/NZ333915A/xx unknown
- 1997-08-15 CA CA002263195A patent/CA2263195A1/fr not_active Abandoned
- 1997-08-15 DK DK97938386T patent/DK0935607T3/da active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9404916B2 (en) | 2008-09-20 | 2016-08-02 | University College Cardiff Consultants Limited | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
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