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WO1998004710A3 - Live recombinant bhv/brsv vaccine - Google Patents

Live recombinant bhv/brsv vaccine Download PDF

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Publication number
WO1998004710A3
WO1998004710A3 PCT/IB1997/001040 IB9701040W WO9804710A3 WO 1998004710 A3 WO1998004710 A3 WO 1998004710A3 IB 9701040 W IB9701040 W IB 9701040W WO 9804710 A3 WO9804710 A3 WO 9804710A3
Authority
WO
WIPO (PCT)
Prior art keywords
recombinants
relates
live
bovine
vaccines
Prior art date
Application number
PCT/IB1997/001040
Other languages
French (fr)
Other versions
WO1998004710A9 (en
WO1998004710A2 (en
Inventor
Gunther M Keil
Franciscus A M Rijsewijk
Original Assignee
Akzo Nobel Nv
Gunther M Keil
Franciscus A M Rijsewijk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Gunther M Keil, Franciscus A M Rijsewijk filed Critical Akzo Nobel Nv
Priority to AU37819/97A priority Critical patent/AU3781997A/en
Publication of WO1998004710A2 publication Critical patent/WO1998004710A2/en
Publication of WO1998004710A3 publication Critical patent/WO1998004710A3/en
Publication of WO1998004710A9 publication Critical patent/WO1998004710A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16741—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention refers to synthetic Bovine Respiratory Syncytium virus genes. Also the invention relates to live attenuated Bovine Herpesvirus recombinants carrying such synthetic genes. Furthermore, the invention relates to vaccines based on these live attenuated recombinants, for the protection of cattle against both Bovine herpesvirus infection and against Bovine Respiratory Syncytium virus infection. Also the invention relates to methods for the preparation of such live attenuated recombinants and to methods for the preparation of such vaccines. Furthermore, the invention relates to live Bovine herpesvirus recombinant particles carrying a class II membrane glycoprotein and to live Bovine herpesvirus recombinants carrying a heterologous gene fused to a class II membrane glycoprotein membrane anchor, to vaccines based thereon, and to methods for the preparation of such recombinants, such particles and such vaccines.
PCT/IB1997/001040 1996-07-26 1997-07-28 Live recombinant bhv/brsv vaccine WO1998004710A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37819/97A AU3781997A (en) 1996-07-26 1997-07-28 Live recombinant bhv/brsv vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68788196A 1996-07-26 1996-07-26
US08/687,881 1996-07-26

Publications (3)

Publication Number Publication Date
WO1998004710A2 WO1998004710A2 (en) 1998-02-05
WO1998004710A3 true WO1998004710A3 (en) 1998-04-09
WO1998004710A9 WO1998004710A9 (en) 1998-05-22

Family

ID=24762255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/001040 WO1998004710A2 (en) 1996-07-26 1997-07-28 Live recombinant bhv/brsv vaccine

Country Status (2)

Country Link
AU (1) AU3781997A (en)
WO (1) WO1998004710A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1026252A1 (en) * 1999-02-02 2000-08-09 Akzo Nobel N.V. Synthetic gene of bovine viral diarrhoea virus

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007940A2 (en) * 1990-11-05 1992-05-14 Siba Kumar Samal Bovine respiratory syncytial virus genes
WO1995003070A1 (en) * 1993-07-22 1995-02-02 Syntro Corporation Recombinant swinepox virus
EP0663403A1 (en) * 1993-11-23 1995-07-19 Akzo Nobel N.V. Vector vaccines of bovine herpesvirus I

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007940A2 (en) * 1990-11-05 1992-05-14 Siba Kumar Samal Bovine respiratory syncytial virus genes
WO1995003070A1 (en) * 1993-07-22 1995-02-02 Syntro Corporation Recombinant swinepox virus
EP0663403A1 (en) * 1993-11-23 1995-07-19 Akzo Nobel N.V. Vector vaccines of bovine herpesvirus I

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.T. VAN OIRSCHOT ET AL.: "Construction of a recombinant vector vaccine against bovine herpes virus (BHV) type I and bovine respiratory syncytial virus (BRSV) infections", 1990, DEKKERS ET AL. EDS., WAGENINGEN, NETHERLANDS: BIOTECHNOLOGY IN ANIMAL HEALTH AND IN FOOD APPLICATIONS, XP002053861 *
R.A. LERCH ET AL.: "Nucleotide sequence analysis of the bovine syncytial fusion protein mRNA and expression from a recombinant vaccinia virus", VIROLOGY, vol. 181, no. 1, March 1991 (1991-03-01), ORLANDO US, pages 118 - 131, XP002053484 *
R.S. SCHRIJVER ET AL.: "Immunization of cattle with a BHV1 vector vaccine or a DNA vaccine both coding for the G protein of BRSV", VACCINE, vol. 15, no. 17/18, December 1997 (1997-12-01), GUILDFORD GB, pages 1908 - 1916, XP002053485 *

Also Published As

Publication number Publication date
WO1998004710A2 (en) 1998-02-05
AU3781997A (en) 1998-02-20

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