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WO1998004289A3 - Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist - Google Patents

Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist Download PDF

Info

Publication number
WO1998004289A3
WO1998004289A3 PCT/EP1997/004159 EP9704159W WO9804289A3 WO 1998004289 A3 WO1998004289 A3 WO 1998004289A3 EP 9704159 W EP9704159 W EP 9704159W WO 9804289 A3 WO9804289 A3 WO 9804289A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonist
5ht2c
pharmaceutical composition
composition containing
compounds
Prior art date
Application number
PCT/EP1997/004159
Other languages
French (fr)
Other versions
WO1998004289A2 (en
Inventor
Thomas Paul Blackburn
Original Assignee
Smithkline Beecham Plc
Thomas Paul Blackburn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002261813A priority Critical patent/CA2261813A1/en
Priority to PL97331426A priority patent/PL331426A1/en
Priority to JP10508522A priority patent/JP2000516924A/en
Priority to IL12821997A priority patent/IL128219A0/en
Priority to NZ333813A priority patent/NZ333813A/en
Priority to EP97918947A priority patent/EP0936924A2/en
Application filed by Smithkline Beecham Plc, Thomas Paul Blackburn filed Critical Smithkline Beecham Plc
Priority to HU9903619A priority patent/HUP9903619A3/en
Priority to BR9710568A priority patent/BR9710568A/en
Priority to AU42972/97A priority patent/AU725817B2/en
Publication of WO1998004289A2 publication Critical patent/WO1998004289A2/en
Publication of WO1998004289A3 publication Critical patent/WO1998004289A3/en
Priority to NO990322A priority patent/NO990322L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to combinations of compounds having 5HT2C and D2 antagonist activity, compounds having activity at the two receptors, pharmaceutical compositions containing them, and their use in treating schizophrenia.
PCT/EP1997/004159 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist WO1998004289A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
PL97331426A PL331426A1 (en) 1996-07-26 1997-07-22 Pharmaceutic composition containing the 5ht2c antagonist and the d2 antagonist
JP10508522A JP2000516924A (en) 1996-07-26 1997-07-22 Pharmaceutical composition comprising 5HT 2C antagonist and D 2 antagonist
IL12821997A IL128219A0 (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist
NZ333813A NZ333813A (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5HT2C antagonist and a D2 antagonist
EP97918947A EP0936924A2 (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5ht 2c? antagonist and a d 2? antagonist
CA002261813A CA2261813A1 (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist
HU9903619A HUP9903619A3 (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist
BR9710568A BR9710568A (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5Hht2c antagonist and a d2 antagonist
AU42972/97A AU725817B2 (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5HT2c antagonist and a D2 antagonist
NO990322A NO990322L (en) 1996-07-26 1999-01-25 Pharmaceutical mixture containing a 5HT2c antagonist and a D2 antagonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9615767.2 1996-07-26
GBGB9615767.2A GB9615767D0 (en) 1996-07-26 1996-07-26 Novel treatment

Publications (2)

Publication Number Publication Date
WO1998004289A2 WO1998004289A2 (en) 1998-02-05
WO1998004289A3 true WO1998004289A3 (en) 1998-03-19

Family

ID=10797573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/004159 WO1998004289A2 (en) 1996-07-26 1997-07-22 Pharmaceutical composition containing a 5ht2c antagonist and a d2 antagonist

Country Status (19)

Country Link
EP (1) EP0936924A2 (en)
JP (1) JP2000516924A (en)
KR (1) KR20000029564A (en)
CN (1) CN1230894A (en)
AR (1) AR008083A1 (en)
AU (1) AU725817B2 (en)
BR (1) BR9710568A (en)
CA (1) CA2261813A1 (en)
CO (1) CO5031292A1 (en)
CZ (1) CZ23799A3 (en)
GB (1) GB9615767D0 (en)
HU (1) HUP9903619A3 (en)
IL (1) IL128219A0 (en)
NO (1) NO990322L (en)
NZ (1) NZ333813A (en)
PL (1) PL331426A1 (en)
TR (1) TR199900140T2 (en)
WO (1) WO1998004289A2 (en)
ZA (1) ZA976593B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9612883D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
JP2002530340A (en) * 1998-11-23 2002-09-17 セプラコール， インク． Pharmaceutical composition containing olanzapine-N-oxide
DE69923081T2 (en) 1998-11-23 2005-12-08 Sepracor Inc., Marlborough DESMETHYLOLANZAPINE CONTAINING COMPOSITIONS AND METHOD
JP2002530339A (en) 1998-11-23 2002-09-17 セプラコール， インク． 2-Hydroxymethylolanzapine compositions and methods
JP2003525865A (en) * 1999-03-18 2003-09-02 チルドレンズ・ホスピタル・リサーチ・ファウンデイション Treatment of bulimia nervosa and related eating disorders by administration of atypical antipsychotics
WO2000071106A2 (en) * 1999-05-19 2000-11-30 Astrazeneca Ab Method of treating weight gain
WO2005013969A1 (en) * 2003-07-15 2005-02-17 Janssen Pharmaceutica N.V. Antipsychotic agent with socializing properties

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029316A1 (en) * 1995-03-19 1996-09-26 Wikstroem Haakan NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029316A1 (en) * 1995-03-19 1996-09-26 Wikstroem Haakan NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A.M.J.MONTGOMERY ET AL.: "Potentiation of the effects of raclopride on sucrose consumption by the 5-HT2 antagonist ritanserin", PSYCHOPHARMACOLOGY, vol. 123, no. 1, 1996, pages 98 - 102, XP002051726 *
ARIEL Y. DEUTCH: "Mechanism of action of atypical antipsychotic drugs", SCHIZOPHREN. RES., vol. 4, no. 2, 1991, pages 121 - 156, XP002051731 *
D.S.BALDWIN ET AL.: "First clinical experience with olanzapine (LY 170053): results of an open-label safety and dose-ranging study in patients with schizophrenia", INT.CLIN.PSYCHOPHARMACOL., vol. 10, no. 4, 1995, pages 239 - 244, XP002051729 *
E.MEIER ET AL.: "The atypical neuroleptic, sertindole, is a 5-HT2C receptor antagonist", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 20, no. 1-2, 1994, pages 1543, XP002051725 *
FRANK P. BYMASTER ET AL.: "Radioreceptor binding profile of the atypical antipsychotic olanzapine", NEUROPSYCHOPHARMACOLOGY, vol. 14, no. 2, February 1996 (1996-02-01), pages 87 - 96, XP002051728 *
HERBERT Y. MELTZER: "An overview of the mechanism of action of clozapine", J.CLIN.PSYCHIATRY, vol. 55, no. 9 suppl. B, 1994, pages 47 - 52, XP002051727 *
T.F.SEEGER ET AL.: "Ziprasidone (CP-88,059): A new antipsychotic with combined dopamine and serotonin receptor antagonist activity", J.PHARMACOL.EXP.THER., vol. 275, no. 1, 1995, pages 101 - 113, XP002051730 *

Also Published As

Publication number Publication date
AU4297297A (en) 1998-02-20
AU725817B2 (en) 2000-10-19
ZA976593B (en) 1999-01-25
PL331426A1 (en) 1999-07-19
CZ23799A3 (en) 1999-06-16
BR9710568A (en) 1999-08-17
CN1230894A (en) 1999-10-06
CO5031292A1 (en) 2001-04-27
NO990322D0 (en) 1999-01-25
KR20000029564A (en) 2000-05-25
NZ333813A (en) 2000-07-28
AR008083A1 (en) 1999-12-09
CA2261813A1 (en) 1998-02-05
HUP9903619A3 (en) 2001-03-28
HUP9903619A2 (en) 2000-10-28
EP0936924A2 (en) 1999-08-25
GB9615767D0 (en) 1996-09-04
IL128219A0 (en) 1999-11-30
TR199900140T2 (en) 1999-03-22
JP2000516924A (en) 2000-12-19
WO1998004289A2 (en) 1998-02-05
NO990322L (en) 1999-03-24

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