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WO1998003643A3 - Animaux transgenic avec sequences app ou a4ct mutantes humaines - Google Patents

Animaux transgenic avec sequences app ou a4ct mutantes humaines Download PDF

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Publication number
WO1998003643A3
WO1998003643A3 PCT/EP1997/003960 EP9703960W WO9803643A3 WO 1998003643 A3 WO1998003643 A3 WO 1998003643A3 EP 9703960 W EP9703960 W EP 9703960W WO 9803643 A3 WO9803643 A3 WO 9803643A3
Authority
WO
WIPO (PCT)
Prior art keywords
a4ct
transgenic animals
sequences
human app
mutant human
Prior art date
Application number
PCT/EP1997/003960
Other languages
English (en)
Other versions
WO1998003643A2 (fr
Inventor
Stefan Lichtenthaler
Peter Prior
Colin Louis Masters
Konrad Beyreuther
Original Assignee
Smitkline Beecham Pharma Gmbh
Smithkline Beecham Australia P
Stefan Lichtenthaler
Peter Prior
Colin Louis Masters
Konrad Beyreuther
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9615351.5A external-priority patent/GB9615351D0/en
Priority claimed from GBGB9618804.0A external-priority patent/GB9618804D0/en
Priority claimed from GBGB9709239.9A external-priority patent/GB9709239D0/en
Application filed by Smitkline Beecham Pharma Gmbh, Smithkline Beecham Australia P, Stefan Lichtenthaler, Peter Prior, Colin Louis Masters, Konrad Beyreuther filed Critical Smitkline Beecham Pharma Gmbh
Publication of WO1998003643A2 publication Critical patent/WO1998003643A2/fr
Publication of WO1998003643A3 publication Critical patent/WO1998003643A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Produits de recombinaison qui comportent une séquence d'ADN APP ou A4CT codant des mutations qui entraînent un taux plus élevé de βA41-42/βA41-40 que le type sauvage et utilisation desdits produits dans la production d'animaux transgéniques développant des plaques amyloïdes, destinés à servir de modèles pour la maladie d'Alzheimer.
PCT/EP1997/003960 1996-07-22 1997-07-17 Animaux transgenic avec sequences app ou a4ct mutantes humaines WO1998003643A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9615351.5A GB9615351D0 (en) 1996-07-22 1996-07-22 Compounds
GB9615351.5 1996-07-22
GBGB9618804.0A GB9618804D0 (en) 1996-09-09 1996-09-09 Compounds
GB9618804.0 1996-09-09
GBGB9709239.9A GB9709239D0 (en) 1997-05-08 1997-05-08 APP transgenic model
GB9709239.9 1997-05-08

Publications (2)

Publication Number Publication Date
WO1998003643A2 WO1998003643A2 (fr) 1998-01-29
WO1998003643A3 true WO1998003643A3 (fr) 1998-04-30

Family

ID=27268398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/003960 WO1998003643A2 (fr) 1996-07-22 1997-07-17 Animaux transgenic avec sequences app ou a4ct mutantes humaines

Country Status (1)

Country Link
WO (1) WO1998003643A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9712849D0 (en) * 1997-06-18 1997-08-20 Smithkline Beecham Pharma Gmbh Compounds
US6815175B2 (en) 2001-03-16 2004-11-09 Cornell Research Foundation, Inc. Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
GB0120344D0 (en) * 2001-08-21 2001-10-17 Smithkline Beecham Plc Compounds
AU2003299025A1 (en) * 2002-09-17 2004-04-08 K.U. Leuven Research & Development Peptides inhibiting specific cleaving activities of presenilins
GB0511861D0 (en) * 2005-06-13 2005-07-20 Merck Sharp & Dohme Proteins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014200A1 (fr) * 1992-01-07 1993-07-22 Tsi Corporation Modeles d'animaux transgeniques utilises pour tester des traitements potentiels relatifs a la maladie d'alzheimer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014200A1 (fr) * 1992-01-07 1993-07-22 Tsi Corporation Modeles d'animaux transgeniques utilises pour tester des traitements potentiels relatifs a la maladie d'alzheimer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LICHTENTHALER, S. ET AL.: "Mutations near the C-terminus of beta-A4 influence the gamma cleavage of A4CT (C99) in COS7 cells", NEUROBIOLOGY OF AGING, vol. 17, no. 4 sup, 19 July 1996 (1996-07-19), pages s130 - s131, XP002056699 *
LICHTENTHALER, S.F. ET AL.: "Mutations in the transmembrane domain of APP altering gamma-secretase specifity", BIOCHEMISTRY., vol. 36, no. 49, 9 December 1997 (1997-12-09), EASTON, PA US, pages 15396 - 15403, XP002056700 *

Also Published As

Publication number Publication date
WO1998003643A2 (fr) 1998-01-29

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