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WO1998003537A3 - Hirustasin and a hirustasin/kallikrein complex in crystalline form - Google Patents

Hirustasin and a hirustasin/kallikrein complex in crystalline form Download PDF

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Publication number
WO1998003537A3
WO1998003537A3 PCT/EP1997/003990 EP9703990W WO9803537A3 WO 1998003537 A3 WO1998003537 A3 WO 1998003537A3 EP 9703990 W EP9703990 W EP 9703990W WO 9803537 A3 WO9803537 A3 WO 9803537A3
Authority
WO
WIPO (PCT)
Prior art keywords
hirustasin
kallikrein
complex
crystalline form
crystals
Prior art date
Application number
PCT/EP1997/003990
Other languages
French (fr)
Other versions
WO1998003537A2 (en
Inventor
Peer Mittl
Marco Stefania Di
Markus Gruetter
Original Assignee
Ciba Geigy Ag
Peer Mittl
Marco Stefania Di
Markus Gruetter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag, Peer Mittl, Marco Stefania Di, Markus Gruetter filed Critical Ciba Geigy Ag
Priority to AU42968/97A priority Critical patent/AU4296897A/en
Publication of WO1998003537A2 publication Critical patent/WO1998003537A2/en
Publication of WO1998003537A3 publication Critical patent/WO1998003537A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to crystals of the hirustasin/kallikrein-complex, methods for their production and the use of said crystals or the structure in drug design.
PCT/EP1997/003990 1996-07-24 1997-07-23 Hirustasin and a hirustasin/kallikrein complex in crystalline form WO1998003537A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42968/97A AU4296897A (en) 1996-07-24 1997-07-23 Complex crystal form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96810487 1996-07-24
EP96810487.7 1996-07-24

Publications (2)

Publication Number Publication Date
WO1998003537A2 WO1998003537A2 (en) 1998-01-29
WO1998003537A3 true WO1998003537A3 (en) 1998-05-07

Family

ID=8225658

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/003990 WO1998003537A2 (en) 1996-07-24 1997-07-23 Hirustasin and a hirustasin/kallikrein complex in crystalline form

Country Status (2)

Country Link
AU (1) AU4296897A (en)
WO (1) WO1998003537A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068366A1 (en) * 1999-05-07 2000-11-16 E.I. Du Pont De Nemours And Company D1-c-terminal processing protease: methods for three dimensional structural determination and rational inhibitor design
CA2691849A1 (en) * 2007-06-28 2008-12-31 Novartis Ag Kallikrein 7 modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558773A (en) * 1966-02-23 1971-01-26 Bayer Ag Crystalline kallikrein-inactivator and process for preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558773A (en) * 1966-02-23 1971-01-26 Bayer Ag Crystalline kallikrein-inactivator and process for preparing the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ASCENZI, P. ET AL.: "Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: ...", MOLEC. ASPECTS MED., vol. 16, 1995, pages 215 - 312, XP002049279 *
BODE, W. & CHEN, Z.: "The X-ray structure of porcine pancreatic Kallicrein and of its compex with bovine pancreatic trypsin inhibitor", ADV. EXP. MED. BIOL., vol. 156a, 1983, pages 289 - 308, XP000612228 *
BODE, W. ET AL.: "Refined 2 A X-ray crystal structure of porcine pancreatic Kallikrein A ...", J. MOL. BIOL., vol. 164, 1983, pages 237 - 282, XP000612227 *
SÖLLNER, C. ET AL.: "Isolation and characterization of hirustasin ...", EUR. J. BIOCHEM., vol. 219, 1994, pages 937 - 943, XP000612209 *

Also Published As

Publication number Publication date
AU4296897A (en) 1998-02-10
WO1998003537A2 (en) 1998-01-29

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