WO1998003152A1

WO1998003152A1 - Compositions for treating sunburn and oral hygiene problems

Info

Publication number: WO1998003152A1
Application number: PCT/FR1996/001198
Authority: WO
Inventors: Daniel Greff
Original assignee: Sederma S.A.
Priority date: 1996-07-19
Filing date: 1996-07-19
Publication date: 1998-01-29
Also published as: AU6704396A

Abstract

The cosmetic use of topical glyceryl poly(meth)acrylate gels for treating various symptoms and preventing certain skin and mucosal disorders is disclosed. The discovery is useful for treating and preventing sunburn (solar erythema) and/or solar oedema, as well as treating and preventing oral hygiene problems such as dryness, mouth ulcers, dental plaque, periodontosis, irritation, and swelling. The gels consist of glyceryl poly(meth)acrylate, i.e. glycerine, water and polyacrylate, and may contain other polyols to reinforce the beneficial effect. Said gels may be used in sunscreen-type cosmetics and oral and dental hygiene products.

Description

COMPOSITIONS FOR THE TREATMENT OF SOLAR ERYTHEMS AND ORAL CONDITIONS

This patent relates to the gels obtained by the mixture of the water, glycerin and other polyol components, and of polyacrylate or polymethacrylate and of their use in the pharmaceutical field. Certain activities, essentially cosmetic, of these gels have been described before. Patent FR 2682296 proposes a method of non-chemical preservation of cosmetic or dermopharmaceutical products which is based on the use of gels of the glyceryl poly (meth) acrylate type, the property of which has a strong osmotic effect on its environment, which inactivates the microorganisms introduced into a cosmetic preparation by depriving them of water. Patent application 95-09512 of August 4, 1995 proposed improving the efficiency of the method by combining polyols and a fluidizing agent with poly (meth) acrylic gel! The discovery object of this patent is that these gels have antimicrobial properties, moisturizing, healing, anti-inflammatory such as their cosmetic, dermopharmaceutical or ^oral hygiene is particularly interesting, especially since these gels are non-toxic, non-irritant, colorless and odorless, soluble and miscible in water, pleasant to the touch and economical.

Some examples will illustrate the type of gel covered by the patent as well as the possible applications:

The glyceryl poly (meth) acrylate gel is obtained by mixing water, glycerin, in a polyacrylic or polymethacrylic acid polymer in selected proportions (about 30-50% water, 30-60% glycerin and 0.1 to 5% of polymer) according to a particular manufacturing process which gives the gel physical activity (osmotic power and water absorption capacity). This physical activity is the important key of the compositions for carrying out the invention. This chlatrate gel is characterized by its strong water retention power. It does not dry, even exposed for months to ambient air or subjected to a vacuum for 48 hours. This property is essential, conventional hydrogels, alginate, polysaccharide, cellulose or its derivatives or silicate gels do not meet this criterion.

This gel is particularly effective in inactivating the microorganisms with which it comes into contact, depriving germs by its osmotic effect of the water they need to survive. The gel is also characterized by its viscosity (50,000-2,000,000 centipoises; nevertheless with a non-Newtonian rheological behavior). The polymer is preferably chosen from sodium, potassium, triethylamine, triethanolamine, ammoniacal salts of acrylic acid and / or methacrylic acid, but also from the esters or amides of these acid polymers, or the crosslinked derivatives of carbomer type (crosslinking with allyl ethers of pentaerythritol, sucrose or propylene, for example).

The polyol contained in the base gel is preferably glycerin, to which other polyols can be mixed in variable proportions: alkane-diols and their monoethers, polyalkylglycols, various sugars. These gels can then be used either in pure form or in diluted form, or incorporated into other gels or other dosage forms.

Example 1:

Pure gel:% (W / W)

Glycerin 65

Water 34 sodium polyacrylate 1.

This represents the type of basic poly (meth) acrylate gel. It can be reformulated for specific applications, for example as follows: Example 2:

Improved gel:

Glycerin 55

1, 2-Octanediol 3

Ethoxydiglycol 20

Polyacrylate 1

Water qs. 100

With these basic gels one can formulate;

Example 3:

Formulated gel:

Carbopol ^R 934 (Goodrich) 0.2

Glyceryl polyacrylate 5

Glyceryl polymethacrylate 5

Butylene glycol 5

Ethoxyethanolacetate 4

Ethylhexylglycol 1

Water qs 100

Triethanolamine qs pH 5.

Example 4

Carboxy methyl cellulose 0.5

Glyceryl polymethacrylate 20

Polyethylene glycol PEG 400 5

1, 2 Pentanediol 1.5

Sorbitol 10

Water qs 100

Example 5

Carbopol 940 (Goodrich) 0.2

Glyceryl polyacrylate 15

Ethoxydiglycol 4

Octane 1, 2 diol 1

Water qs 100

Soda (30%) qs pH 5.5 These examples are not limitative. The base vehicle can be prepared from the substances usually used to make hydrogels acceptable in the food industry or for topical application (carrageenans, xanthan gums and other polysaccharides, polyacrylates or polymethacrylates and their crosslinked derivatives such as carbomers, aluminum soda silicates etc.). Examples of cosmetic applications of these gels: Example n ° 6: The gel of example n ° 5 was tested for its anti-solar erythema activity. Protocol:

10 volunteers, 6 men and 4 women, aged between 25 and 47 years, participated in ^the study. They undergo UV irradiation simulating part of the solar spectrum (40W UVB lamp) which causes a detectable erythema (2 to 3 DEM). Two sites chosen on the back of the panelists are thus irradiated. Then a site is treated by I ^application of the gel with light massage, I the ^other is left untreated. Clinical examination (assessment of redness, dryness) and a chromametric examination (numerical measure of redness) are performed at different times after ^irradiation. This gives maximum rating values and an estimate of the time required for the disappearance of ^the rash. Results:

5 hours after ^the irradiation, the notation of ^the erythema and chromametric value are at their maximum. The sites treated with the gel are noted on average 45% less red, less dried out than the untreated sites. The disappearance of all visible rash is two times faster on treated sites in Gel ^Example No. 5 as the untreated sites. Example 7:

Oral treatment 30 people diagnosed with either gum hypersensitivity, a dry mouth or mouth ulcers or dental plates or loosening problems (mild periodontitis) participated in ^the study. They are divided into 2 groups of 15 people. After clinical examination by the stomatologist, the two groups receive a toothpaste specially formulated for the test; ^one containing 15% of the gel of ^Example No. 2, the other - without gel - being placebo. The panelists use the toothpaste twice a day, morning and evening, after the meal, for 4 weeks.

After this period, a new clinical examination is carried out, the states of the affections are noted on analog scales.

While in the group receiving the placebo toothpaste, there are only slight improvements (partially due to more regular oral hygiene), people who have used the toothpaste containing the gel show a very clear improvement in symptoms: disappearance of dryness, reduction bleeding when brushing, rapid healing of canker sores. ^The beneficial action of frost (due to its moisturizing and antimicrobial potency) was very much appreciated and confirmed by this clinical study. These examples are not limitative. Those skilled in the art can formulate products according to the needs of the application by incorporating the glyceryl poly (meth) acrylate type gel in any suitable dosage form. Possible applications of these gels include: cosmetic and dermopharmaceutical products called "sun" and "after sun", toothpaste pastes and gels, mouthwashes without this list being exhaustive.

The glyceryl poly (meth) acrylate gels which are the subject of this patent can be used in any dosage form used in cosmetics or dermopharmacy or dental hygiene for local application on the skin, mucous membranes, mouth: aqueous solutions, O / W and E emulsions / H, milks, lotions, gels, ointments, soaps, sticks, sprays, poultices, dressings, without this list being exhaustive.

The concentration of use of these glycerylpoly (meth) acrylate type gels which are the subject of this patent can vary between 1 and 100% (w / w) depending on the application. A particularly interesting embodiment of the invention is the gel which is composed of glycerin (40-70% w / w), water (10-50% w / w), 1, 2-octanediol (0.1 to 10% w / w), polyethylene glycol (0.1 to 30% w / w) and neutralized polyacrylate or polymethacrylate (0.1 to 5%). The glyceryl poly (meth) acrylate type gels which are the subject of this patent can be combined in cosmetic or dermopharmaceutical compositions with any other ingredient usually used in this field: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, water- or fat-soluble active ingredients, vitamins, plant extracts, tissue extracts, marine extracts, alcohols and polyols, softeners, anti-microbial agents, etc.

These compositions containing the glyceryl poly (meth) acrylate type gels which are the subject of this patent can therefore be intended for the treatment and prevention of "sunburn" burns, erythemas and / or solar edemas, as well as ^for the prevention and the treatment of oral diseases (dryness, canker sores, dental plaques, mild periodontoses, irritations, swelling, loosening).

Claims

1. Compositions for cosmetic or dermopharmaceutical use for local application, characterized in that they contain at least one gel of the hydrating and non-drying glyceryl poly (meth) acrylate type, composed of glycerin, water and poly (meth) acrylate and manufactured in such a way as to give the gel physical activity (osmotic power and water absorption capacity).

2. Compositions for cosmetic or dermopharmaceutical use for local application according to claim 1, characterized in that they additionally contain at least one other polyol chosen from alkane diols, monoethers of alkane diols, polyalkylglycols.

3. Compositions for cosmetic or dermopharmaceutical use for local application according to claims 1 or 2, characterized in that they contain the gel at a concentration which varies between 1 and 100%.

4. Compositions for cosmetic or dermopharmaceutical use for local application according to any one of claims 1 to 3, characterized in that the gel is composed of glycerin (40-70% w / w), water (10- 50% w / w), 1, 2-octanediol (0.1 to 10% w / w), polyethylene glycol (0.1 to 30% w / w) and neutralized polyacrylate or polymethacrylate (0.1 to 5%).

5. Compositions for cosmetic or dermopharmaceutical use for local application according to any one of claims 1 to 4, characterized in that the gel is used in any galenical form used in cosmetics, dermopharmacy or oral hygiene for local application on the skin , mucous membranes, mouth: aqueous solutions, O / W and W / O emulsions, milks, lotions, gels, ointments, soaps, sticks, sprays, poultices, dressings.

6. Compositions for cosmetic or dermopharmaceutical use for local application according to any one of claims 1 to 5, characterized in that they also contain any other ingredient usually used in this field: extraction lipids and / or synthesis, gelling and viscosifying polymers, surfactants and emulsifiers, water- or fat-soluble active ingredients, vitamins, plant extracts, tissue extracts, marine extracts, alcohols and polyols, softeners, anti-microbial agents.

7. Use of the cosmetic, dermopharmaceutical or oral hygiene compositions prepared according to any one of claims 1 to 6 for the prevention and treatment of "sunburn" burns, erythemas and / or solar edemas, as well as prevention and treatment of oral diseases (dryness, canker sores, dental plaques, mild periodontoses, irritations, swelling, loosening).