WO1998002534A3 - Animal transgenique dont l'expression des recepteurs aux opiaces est modifiee - Google Patents
Animal transgenique dont l'expression des recepteurs aux opiaces est modifiee Download PDFInfo
- Publication number
- WO1998002534A3 WO1998002534A3 PCT/FR1997/001282 FR9701282W WO9802534A3 WO 1998002534 A3 WO1998002534 A3 WO 1998002534A3 FR 9701282 W FR9701282 W FR 9701282W WO 9802534 A3 WO9802534 A3 WO 9802534A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- modified
- whose expression
- opiate receptors
- transgenic animal
- animal whose
- Prior art date
Links
- 102000003840 Opioid Receptors Human genes 0.000 title abstract 3
- 108090000137 Opioid Receptors Proteins 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 210000000944 nerve tissue Anatomy 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/214,904 US6632977B2 (en) | 1996-07-15 | 1997-07-11 | Transgenic animal whose expression of the opiate receptors is modified |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9608810A FR2750825B1 (fr) | 1996-07-15 | 1996-07-15 | Animal transgenique non humain dans lequel l'expression de l'un au moins des genes codant pour les recepteurs aux opiaces est modifiee |
FR96/08810 | 1996-07-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998002534A2 WO1998002534A2 (fr) | 1998-01-22 |
WO1998002534A3 true WO1998002534A3 (fr) | 1998-02-26 |
Family
ID=9494043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1997/001282 WO1998002534A2 (fr) | 1996-07-15 | 1997-07-11 | Animal transgenique dont l'expression des recepteurs aux opiaces est modifiee |
Country Status (3)
Country | Link |
---|---|
US (1) | US6632977B2 (fr) |
FR (1) | FR2750825B1 (fr) |
WO (1) | WO1998002534A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115399B2 (en) * | 2001-07-31 | 2006-10-03 | Allergan, Inc. | Pinna reflex assay |
US7214534B2 (en) | 2002-06-18 | 2007-05-08 | Regents Of The University Of Minnesota | Isolated nucleic acid molecules encoding mutant μ opioid receptors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993021309A1 (fr) * | 1992-04-10 | 1993-10-28 | Duz Partnership | Sequences d'oligonucleotides et animaux transgeniques transfectes avec celles-ci et presentant une sensibilite reduite aux analgesiques narcotiques |
WO1995007983A1 (fr) * | 1993-09-13 | 1995-03-23 | Indiana University Foundation | Recepteur mu humain d'opioides |
WO1996001898A1 (fr) * | 1994-07-11 | 1996-01-25 | Universite Louis Pasteur | Recepteur opioide kappa humain, acides nucleiques et utilisations |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
-
1996
- 1996-07-15 FR FR9608810A patent/FR2750825B1/fr not_active Expired - Fee Related
-
1997
- 1997-07-11 US US09/214,904 patent/US6632977B2/en not_active Expired - Fee Related
- 1997-07-11 WO PCT/FR1997/001282 patent/WO1998002534A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993021309A1 (fr) * | 1992-04-10 | 1993-10-28 | Duz Partnership | Sequences d'oligonucleotides et animaux transgeniques transfectes avec celles-ci et presentant une sensibilite reduite aux analgesiques narcotiques |
WO1995007983A1 (fr) * | 1993-09-13 | 1995-03-23 | Indiana University Foundation | Recepteur mu humain d'opioides |
WO1996001898A1 (fr) * | 1994-07-11 | 1996-01-25 | Universite Louis Pasteur | Recepteur opioide kappa humain, acides nucleiques et utilisations |
Non-Patent Citations (1)
Title |
---|
MATTHES, H. ET AL.: "Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene", NATURE, vol. 383, no. 6603, 31 October 1996 (1996-10-31), LONDON GB, pages 819 - 823, XP000613442 * |
Also Published As
Publication number | Publication date |
---|---|
FR2750825A1 (fr) | 1998-01-16 |
US20010047519A1 (en) | 2001-11-29 |
WO1998002534A2 (fr) | 1998-01-22 |
FR2750825B1 (fr) | 2002-08-23 |
US6632977B2 (en) | 2003-10-14 |
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