WO1998002139A1

WO1998002139A1 - Liquid antiseptic soap for skin care

Info

Publication number: WO1998002139A1
Application number: PCT/BR1997/000028
Authority: WO
Inventors: Simoni Chitarra Souza; Luiz Gustavo Martins Matheus
Original assignee: Indústria e Comércio de Cosméticos Natura Ltda.
Priority date: 1996-07-12
Filing date: 1997-07-10
Publication date: 1998-01-22
Also published as: AR007869A1; BR9603085A; UY24615A1; CO6040037A1

Abstract

The present invention provides an antiseptic, liquid, mild action composition, with the specific function of skin impurities removal and excessive oiliness fight in order to avoid, specially, the sebaceous follicle inflammation and infection. This is obtained through active components association, constituted of mild surfactant agents, for skin cleansing, together with a specific keratolytic agent, being this d-tartaric acid, and two antiseptic agents, being them predominantly triclosan, and thymol, as cooperative. This set of active components is dissolved and/or dispersed in an aqueous vehicle, which also contains adjuvant components, chosen between preserving agents, thickeners, solutizers, humectant and refreshing agents and perfumes usual in liquid, aqueous cosmetics, all of them cooperating for the physicochemical stability, germicide and/or bacteriostatic action, as well as a pleasant sensorial when the composition, formulated in the described way, is applied to the skin.

Description

"LIQUID ANTISEPTIC SOAP FOR SKIN CARE".

Invention General Description

The present invention provides a liquid soap composition, antiseptic, of mild action, intended for skin impurities removal, protecting the skin against exogenous germs, avoiding their propagation.

With this objective, was investigated the cooperative action between the specific additives, exhibiting keratolytic and antiseptic action, and the basis components, which are already usual cleansing agents used in the formulation of toilet soaps and other cosmetic preparations.

In this new soap composition, the referred components physical or aggregation state is also important. The composition shall present the form of a viscous liquid of easy skin application, with no free flowing, exhibiting adequate organoleptic properties referring to pleasant aroma and color, and be lightly colorless to light yellow and transparent to lightly translucent.

The here described cosmetic composition was developed as the result of several researches, exhibiting physicochemical and microbiological stabilities and also a pleasant sensorial when applied to the skin.

The cosmetic composition basis is an aqueous phase, which can contain sodium salts and, eventually, potassium and/or ammonium salts, of fatty acids C12-C18, of saponaceous nature, which constitutes the present invention vehicle, corresponding to 40,00% to 70,00%, by weight, in relation to the global composition.

This vehicle actuates as dissolving or dispersing medium for the specific additives. The composition active principles are: (i) surfactant agents,

(ii) a keratolytic agent, (iii) antiseptic agents, and the usual additives that are chosen among the group comprising: preservatives, thickeners, solutizers, humectants, refreshing agents and fragrance or perfumes. Detailed description

The active principles, associated in the present liquid soap, comprise mild action surfactant compounds as cleansing surfactant agents. These compounds promote skin cleansing and excessive oiliness removal, with no skin aggressing action. These surfactants are already usual by themselves, and it is possible to name, among others, ethylene and/or propylene oxide adducts as fatty alcohols or fatty acids, their derivatives, as esters including amino derivatives, as, for example, ethanolamines, and amides, that belong to the non-ionic surfactants class; eventually, it is possible to add cationic surfactants, specially quaternary ammonium compounds, mainly as additive to non-ionic surfactants.

In the present compositions, these active components are used in a ratio varying between 10,00% to 30,00%, by weight, in relation to the global composition. The keratolytic agent chosen is tartaric acid, which can be considered a natural product, since it is obtained as a byproduct of the wine-growing industry. It is a dioxide-diacid or an alpha-hydroxy acid exhibiting the following formula:

CHOH-COOH

I

CHOH-COOH being used, preferably, dextrogyrate among the several optical isomers of this acid, added in a 0,05 to 2,00% ratio, by weight.

The specific action of this active component is to help in the sebaceous follicle clearance, allowing free sebum, or fat, secretion (formed in these follicles). Consequently, the component contributes for a good sebaceous glands functioning, whose disturbance is one of the causes responsible for their inflammation, with consequent skin affection. The tartaric acid also reduces the corneal layer cells cohesion, causing a microexfoliation, mainly of cells exhibiting low or none vitality, removing them. An other tartaric acid function is to contribute to the product pH adjustment in a range closer to the physiologically adequate value, so that it does not promote undesirable skin alterations, usually near pH = 7,0 or lower.

In the present soap, two antiseptic agents were added, one exhibiting bacteriostatic action, namely, specially the triclosan product, acting on the skin superficial area. The second antiseptic agent is thymol, a natural product, being extracted of the Thymus vulgaris and Monarda punctata plants.

This two antiseptics exhibit synergistic cooperation in the fight against microbial proliferation, to which the air exposed skin (hands, arms, face and neck) is more subjected. They are added in a rather low ratio, between 0,05 to 0,50%, by weight, for triclosan, and between 0,001 to 0,100%, by weight, for thymol. These values refer to the global composition.

The usual additives, which complete the present composition, are all widely known and of common usage in skin cleansing cosmetics and were already generally mentioned above.

In detail, these additives comprise: a) A preservative agent, to protect the composition against the degrading action of actinic light, oxygen contained in air and accidental components, as acid vapors and gases, oxidants and other degrading agents, which can also be biological, for example bacteria.

The preservative agent(s) is(are) chosen within the group comprising parabens, thiazolidines, imidazolidinyl urea, diazolidinyl urea, formaldehyde, or formaldehyde in situ forming compounds, as paraformaldehyde, benzoic acid and their alkyl and benzyl esters, quaternium 15, phenoxyethanol, 2-bromo-2-nitropropane-1 ,3-diol. These preserving agents are added in a 0,10 to 1 ,00% ratio, by weight, in relation to the composition. b) A thickener is incorporated to improve compojϊitFon's consistency

an undesirable product flowing when it is applied onto the skin. These are widely available in the market, and can be organic, as hydrophilic and carboxyvinyl polymers, as poly(vinyl acetate), which can be associated to poly(vinyl alcohol), acrylic, as the acids themselves or their acrylic and metaacrylic acid esters, natural gums, starch or modified starch, for example, hydrolyzed, cellulose derivative, for example ethers and esters and/or salts, fatty alcohols, polyethylene glycol stearates, or inorganic, as modified aluminium or magnesium silicates, esmectitas and hydrated aluminium silicates. It is also possible to use a mixture containing two or more above mentioned thickeners, which are added at a 0,10 to 5,00% ratio, by weight, in relation to the soap. c) The solutizing agents function is to facilitate the solid components or little hydrophilic oils dissolution or fine dispersion; these are chosen between ethanol, its lower ethers and esters, ethoxylated fatty alcohols derivatives, in other words, containing more than 5 ethylene oxide units for each alcohol molecule, and/or hydrogenated fatty alcohols, their sulphonic derivatives and respective alkaline and alkaline-earth salts, as for example sodium and calcium dodecylbenzenesulphonate. These adjuvants are usually added in a 1 ,00 to 5,00% ratio, by weight, also relating to the global composition. d) If the superficial tension's modifying action exerted by the main, cleansing, surfactant agent is not enough to obtain the desired soap mass humectation and softness, it is possible to complete this property through the addition of an usual typically humectant agent in a 2,00 to 20,00% ratio.

This can be chosen between glycerol and its lower esters and ethers, glycols and their derivatives, for example, propylene glycol, sorbitol, hydrosoluble or hydrophilic silicones. e) Refreshing agents, as camphor and menthol, are simple compositions refining complements, in order to associate a skin freshness sensation, being usually used in a rather low ratio of 0,01 to 0,20%, by weight. Fragrance and perfume are also optional additives, usually added in a 0,05 to 0,50% ratio, by weight, being chosen between those usually used in toilet soaps, as for example lavender, floral, cologne and others. However, these additives can be omitted in some cases, specially in the manufacturing of neutral and odorless soaps, meant for sensitive skins.

As variation, the vehicle itself can also dispense the presence of usual soaps, so that the cleansing action is performed by the surfactants.

The liquid soap preparation process, although employing customary operations for components dissolution and dispersion in the aqueous vehicle, requires some special precautions. Thus, the antiseptic agents and the fragrance, usually being an oily essence, should be previously solubilized in the solutizing agent (c) or in a specific and adequate solvent. The resulting solution is added after concluding total dispersion or mixture of the other components in the aqueous phase. This can contain fatty acids Ci2-C₁₈ alkaline salt, or, for some specific applications, as soaps meant for sensitive skins, these salts are not added.

The aqueous phase constitutes global composition's 40% to 70%, by weight. With the aid of mechanical stirring equipment, the chosen ratios of surfactants, humectant, tartaric acid, preserving and, eventually, refreshing agents, thickener and, at last, the previously prepared solution containing antiseptic agents and essence or fragrance are dissolved or dispersed in the aqueous phase, through vigorous stirring until complete homogenization. The components quantity is adjusted to result in 100%, by weight total, being also by weight the component ratios described bellow. Following some examples, with simple illustration character, of the present invention compositions:

Example 1

An initial water quantity, corresponding to final mixture's 50%, is used to dissolve or disperse, through stirring, 10%, by weight, of a neutral sodium soap. After that, the following components are dispersed or dissolved, successively, in this solution:

20,00% surfactant agents, chosen between polyoxiethylene adducts, with 5 to

40 ethylene oxide units for each molecule, linoleic or oleic or palmitic acid and/or ceryl alcohol and/or castor-oil;

0,50% keratolytic agent, d-tartaric acid;

2,50% thickener, chosen between hydrolyzed starch, solubilized gum tragacanth, carboxymethylcellulose and their mixtures;

4,00% solutizer, which can be pure ethanol, preferably an ethoxylated cetyl or myristyl alcohol derivative, or the mixture of them;

12,00% humectant, as glycol oleate;

0,15% menthol, as refreshing agent;

0,15% floral fragrance; and

0,20% antiseptic agent, triclosan based, with adjunction of 0,01% thymol.

Example 2

The example 1 was repeated, having 60,00% water as vehicle and the adjunction of the other above mentioned components.

Example 3

The example 1 was repeated, using diethylene glycol stearate and/or glycerol monostearate as thickener together with poly(vinyl alcohol) and/or poly(vinyl acetate). Conducted Tests

Several above described antiseptic soaps types, for skin care, were submitted to usual dermatological tests, including primary and accumulated irritability, sensitization, phototoxicity and photoallergy evaluations. The conducted tests demonstrated the present composition innocuousness, conferring them the status of dermatologist tested and accepted.

The comedogenicity test was also conducted, conferring this invention product the status of "not comedogenic" and, thus, accepted in this particular subject.

To demonstrate the invented antiseptic liquid soap performance, referring to its specific cleansing and skin care function, a clinical test was conducted with volunteers, adolescents and young individuals, mostly subjected to skin irritation and sebaceous glands affections, which can cause acne development in grades I and II.

The results demonstrated the present liquid soap efficiency, being antiseptic in skin cleansing and hygienic in at least 65,0% of the cases.

It was also verified that, through the association of the present composition with an other product of the same here claimant, presented as co-pending request, namely, an "oiliness balancing gel", occurred a synergistic effect, resulting in skin oiliness reduction in 92,5% test volunteers, with lesion number reduction (due to acne) in 65,0% of the observed cases.

Claims

1. Liquid antiseptic soap for skin care, of mild action, with the specific function of skin impurities removal, characterized by the fact of comprising 10,101% to 32,600%, by weight, of a set of active components, constituted of:

10,00 to 30,000%, by weight, of surfactant agents, for skin cleansing;

0,050 to 2,000%, by weight, of keratolytic agent, d-tartaric acid;

0,050 to 0,500%, by weight, of antiseptic agent, triclosan;

0,001 to 0,100%, by weight, of cooperative antiseptic agent, thymol, being the remaining to complete composition's 100,000%, by weight, constituted of a liquid, aqueous vehicle, containing one or more adjuvants, chosen between preserving agents, thickeners, solutizers, humectants, refreshing agents and fragrance or perfumes.

2. Liquid antiseptic soap, according to vindication 1 , characterized by the fact of comprising, as cleansing surfactant agents, mild action surfactant compounds, which remove skin excessive oiliness, chosen between the ethylene oxide adducts and/or propylene oxide with fatty alcohols, fatty acids, their respective esters, alcohols derivatives, as alkanolamines, specially ethanolamines, and amines, as fatty amides, and dependent non-ionic surfactants and, if convenient, specially as additional surfactants, cationic surfactant agents, specially quaternary ammonium compounds.

3. Liquid antiseptic soap, according to vindication 1 , characterized by the fact of comprising, as vehicle, an aqueous medium, water based, containing usual quantities of sodium salts and, eventually, potassium and/or ammonium salts of fatty acids C₁₂-Ci₈.

4. Liquid antiseptic soap, according to vindication 1 , characterized by the fact of comprising, as vehicle, an aqueous medium, water based, containing in itself dissolved or dispersed, one or more of the following additives: 0,10 to 1 ,00%, by weight, of preserving agent, chosen between parabens, thiazolidines, imidazolidinyl urea, diazolidinyl urea, formaldehyde, benzoic acid and their derivatives, quatemium 15, phenoxyethanol, 2-bromo- 2-nitropropane-1 ,3-diol.

5. Liquid antiseptic soap, according to vindications 1 or 4, characterized by the fact of comprising also 1 ,00 to 5,00%, by weight, of a solutizing agent, chosen between ethanol compounds, ethoxylated and/or hydrogenated fatty alcohols derivatives and sulphonic derivatives and respective alkaline and alkaline-earth salts and their mixtures.

6. Liquid antiseptic soap, according to vindications 1 or 5, characterized by the fact of comprising also 0,10 to 5,00%, by weight, of a thickener agent chosen between hydrophilic polymers, specially vinyl, as poly(vinyl acetate), poly(vinyl alcohol), acrylic, as acrylic and metaacrylic acid derivatives and the (met)acrylic acids themselves, natural gums, starch and modified starches, cellulose derivatives, fatty alcohols, polyethylene glycol stearates and hydrated aluminium silicates.

7. Liquid antiseptic soap, according to vindications 1 or 6, characterized by the fact of comprising also 2,00 to 20,00%, by weight, of an humectant agent, chosen between glycerol and its lower esters and ethers, glycols and their derivatives, sorbitol and hydrophilic silicones.

8. Liquid antiseptic soap, according to vindications 1 or 7, characterized by the fact of comprising also 0,01 to 0,20%, by weight, of a refreshing agent, specially camphor or menthol, as well as 0,05 to 0,50%, by weight, of a fragrance or perfume.