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WO1998002146A3 - Systeme de distribution chimiomecanique a expansion - Google Patents

Systeme de distribution chimiomecanique a expansion Download PDF

Info

Publication number
WO1998002146A3
WO1998002146A3 PCT/US1997/012704 US9712704W WO9802146A3 WO 1998002146 A3 WO1998002146 A3 WO 1998002146A3 US 9712704 W US9712704 W US 9712704W WO 9802146 A3 WO9802146 A3 WO 9802146A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
biological environment
container
chemo
delivery system
Prior art date
Application number
PCT/US1997/012704
Other languages
English (en)
Other versions
WO1998002146A2 (fr
Inventor
Eyal S Ron
Original Assignee
Gel Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gel Sciences Inc filed Critical Gel Sciences Inc
Priority to EP97938003A priority Critical patent/EP0853474A2/fr
Priority to JP10506332A priority patent/JPH11513041A/ja
Publication of WO1998002146A2 publication Critical patent/WO1998002146A2/fr
Publication of WO1998002146A3 publication Critical patent/WO1998002146A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Système de distribution d'une substance biologiquement active dans un milieu. On décrit un contenant à un seul élément ou à deux éléments jumeaux définissant un premier et un deuxième compartiment. Le contenant a des pores au moins sur une partie qui définit le premier compartiment, lequel contient un réseau en gel de polymère qui subit une expansion de volume suite à une modification d'état dans le milieu biologique. Le deuxième compartiment renferme une quantité efficace de composés biologiquement actifs et peut comporter au moins une communication avec le milieu biologique. La distribution du ou des médicaments est amorcée et se poursuit uniquement lorsque l'état ou le seuil approprié du milieu est rencontré, moyennant quoi l'expansion du volume du réseau en gel de polymère induit l'introduction du composé biologiquement actif dans le milieu biologique.
PCT/US1997/012704 1996-07-16 1997-07-16 Systeme de distribution chimiomecanique a expansion WO1998002146A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97938003A EP0853474A2 (fr) 1996-07-16 1997-07-16 Systeme de distribution chimiomecanique a expansion
JP10506332A JPH11513041A (ja) 1996-07-16 1997-07-16 化学−機械的膨張供給装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2209296P 1996-07-16 1996-07-16
US60/022,092 1996-07-16

Publications (2)

Publication Number Publication Date
WO1998002146A2 WO1998002146A2 (fr) 1998-01-22
WO1998002146A3 true WO1998002146A3 (fr) 1998-03-12

Family

ID=21807776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012704 WO1998002146A2 (fr) 1996-07-16 1997-07-16 Systeme de distribution chimiomecanique a expansion

Country Status (4)

Country Link
EP (1) EP0853474A2 (fr)
JP (1) JPH11513041A (fr)
CA (1) CA2230656A1 (fr)
WO (1) WO1998002146A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052982B2 (en) 1998-07-20 2011-11-08 Peptech Animal Health Pty Limited Bioimplant formulation comprising lecithin and stearin
EP1786485A4 (fr) 2004-02-06 2012-05-30 Georgia Tech Res Inst Implantation cellulaire a adhesion de surface
WO2005077304A1 (fr) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Dispositif biocompatible porteur
NZ543314A (en) * 2005-10-28 2007-08-31 Interag A delivery system where the driving substance contains the active component
CA3048443C (fr) 2011-05-26 2021-01-05 Cartiva, Inc. Implant d'articulation conique et outils associes
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
US10758374B2 (en) 2015-03-31 2020-09-01 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
CA2981074C (fr) 2015-04-14 2023-03-28 Cartiva, Inc. Outillage pour creation d'une ouverture conique dans le tissu et procedes associes
US11141486B2 (en) 2015-10-23 2021-10-12 National University Corporation Tokyo Medical And Dental University Drug delivery device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4180073A (en) * 1977-08-29 1979-12-25 Alza Corporation Device for delivering drug to biological environment
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
WO1992005775A1 (fr) * 1990-09-28 1992-04-16 Pfizer Inc. Dispositif de distribution contenant un milieu hydrophobe
WO1996002276A2 (fr) * 1994-07-18 1996-02-01 Gel Sciences, Inc. Nouveaux reseaux de gel polymere et procedes d'utilisation
WO1996040082A2 (fr) * 1995-06-07 1996-12-19 Gel Sciences, Inc. Appareil et procede d'administration d'un compose biologiquement actif dans un milieu biologique

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4180073A (en) * 1977-08-29 1979-12-25 Alza Corporation Device for delivering drug to biological environment
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
WO1992005775A1 (fr) * 1990-09-28 1992-04-16 Pfizer Inc. Dispositif de distribution contenant un milieu hydrophobe
WO1996002276A2 (fr) * 1994-07-18 1996-02-01 Gel Sciences, Inc. Nouveaux reseaux de gel polymere et procedes d'utilisation
WO1996040082A2 (fr) * 1995-06-07 1996-12-19 Gel Sciences, Inc. Appareil et procede d'administration d'un compose biologiquement actif dans un milieu biologique

Also Published As

Publication number Publication date
CA2230656A1 (fr) 1998-01-22
WO1998002146A2 (fr) 1998-01-22
EP0853474A2 (fr) 1998-07-22
JPH11513041A (ja) 1999-11-09

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