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WO1998001176A1 - Appareil pour la preparation d'un gaz respiratoire - Google Patents

Appareil pour la preparation d'un gaz respiratoire Download PDF

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Publication number
WO1998001176A1
WO1998001176A1 PCT/EP1997/003544 EP9703544W WO9801176A1 WO 1998001176 A1 WO1998001176 A1 WO 1998001176A1 EP 9703544 W EP9703544 W EP 9703544W WO 9801176 A1 WO9801176 A1 WO 9801176A1
Authority
WO
WIPO (PCT)
Prior art keywords
gas
oxygen
breathing
breathing gas
pressure
Prior art date
Application number
PCT/EP1997/003544
Other languages
German (de)
English (en)
Inventor
Burkhard Lachmann
N. Govinda Rajan
Original Assignee
Epazon B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epazon B.V. filed Critical Epazon B.V.
Priority to EP97934447A priority Critical patent/EP0925085A1/fr
Publication of WO1998001176A1 publication Critical patent/WO1998001176A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/201—Controlled valves
    • A61M16/202—Controlled valves electrically actuated
    • A61M16/203—Proportional
    • A61M16/204—Proportional used for inhalation control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0066—Blowers or centrifugal pumps
    • A61M16/0069—Blowers or centrifugal pumps the speed thereof being controlled by respiratory parameters, e.g. by inhalation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A61M16/024—Control means therefor including calculation means, e.g. using a processor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0036—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the breathing tube and used in both inspiratory and expiratory phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/435—Composition of exhalation partial O2 pressure (P-O2)

Definitions

  • the invention relates to a device for providing a breathing gas with at least one breathing gas source, a controller for the breathing gas flow and a gas delivery device for the controlled breathing gas flow, the gas delivery device being connectable to at least one oxygen que 1 le.
  • a central compressed air or oxygen supply with corresponding connection points in the treatment rooms and hospital rooms usually serves as the respiratory gas source.
  • the devices themselves are usually movable on rollers and have corresponding connection lines with which the devices can be connected to the central breathing gas source.
  • Common compressed gas cylinders for compressed air and / or oxygen serve as the breathing gas source.
  • the gas contained in the compressed gas cylinders is usually filled under an overpressure of approximately 200 bar.
  • At least one breathing gas supply available for transport to a hospital, at least one such gas cylinder with a filling volume of 10 l is required. Due to the bulky dimensions and in particular the high weight of such a filled pressurized gas bottle, such a device for outpatient emergency use is only for use in vehicles or e.g. a helicopter practically possible.
  • CONFIRMATION COPY bottles required as a breathing gas source namely a compressed air bottle and an oxygen bottle, which leads to a further increase in weight.
  • a breathing gas source namely a compressed air bottle and an oxygen bottle
  • the known devices also have a mechanical or electronic control, by means of which the respiratory gas flow can be controlled in accordance with the required ventilation frequency.
  • a device of the type mentioned at the outset is known, for example, from W087 / 06142.
  • the device disclosed therein includes a monitor for monitoring the breathability of a patient. At the beginning of each inhalation, a volume pulse of oxygen is delivered to the patient. If the patient breathes irregularly or cannot breathe spontaneously at all, the device provides a continuous flow of oxygen.
  • EP-A-324 275 which comprises a ventilator and a breath synchronization.
  • the device is intended for use when the breath is stopped, wherein a breathing gas can be released from the ventilator to the patient at selected times after the start of inhalation or exhalation.
  • the synchronization device is connected to a monitor for monitoring breathing. The monitor records the body condition, electromyograms, chest movements and the like.
  • a device of the type mentioned at the outset which is characterized in that the respiratory gas source comprises a motor-driven blower. Due to the design of the device according to the invention, it is no longer necessary to carry large compressed gas cylinders. For the medically necessary oxygen demand in a device according to the invention, a 1-liter bottle is sufficient to supply a patient with about 3 hours. Due to the small, handy 1-liter bottle, it is possible to operate such a device, especially in outpatient use, and in particular, fixed installation in vehicles is no longer necessary. This also enables the use of such a device in other hi-fi vehicles as an ambulance. When using an electric motor, a device according to the invention can be operated practically anywhere where there is a possibility of a power supply. With appropriate equipment with accumulators, it is even possible to design a device according to the invention in such a way that the device manages completely without external power supply for a while. This can e.g. be useful when rescuing injured people from rough terrain.
  • a drive other than an electric motor can also be provided, for example a compressed air drive.
  • a compressed air drive This is useful if the device is to be used in places where a compressed air supply is guaranteed for other reasons, but the compressed air does not have the purity required for medical treatment, for example, it contains oil. This could be the case, for example, in large ambulance vehicles or when carrying such a device on overseas flights in commercial aircraft.
  • the device, in operation has a dynamic pressure of more than 400 Pa, in particular of about 600 Pa, in relation to the ambient pressure at one end of the gas delivery device , can deliver.
  • Another device according to the invention of the type mentioned at the outset can be used for ventilation with positive end-expiratory pressure (PEEP) while still being compact and easy to handle, if the device further comprises a backflow device and a valve device which is used to control the respiratory gas flow is connected, the valve device essentially releasing the cross section of the gas delivery device in the direction of its consumer end in a first operating position and largely closing and / or connecting the cross section of the gas delivery device to the environment in a second operating position, and wherein the valve device in the the first operating position essentially closes the cross section of the backflow device and essentially releases it in the second operating position.
  • PEEP positive end-expiratory pressure
  • the return flow device is connected to the gas delivery device in the vicinity of the consumer end of the gas delivery device.
  • the device delivers a dynamic pressure above the ambient pressure at the consumer end of the gas delivery device when the valve device is in the second operating position, especially when the Dynamic pressure above the ambient pressure is set by a pressure regulator 1 in the return flow device, the dynamic pressure expediently being approximately 50-200 Pa.
  • the device further comprises a metering device for metering an amount of oxygen to be conveyed to the breathing gas and the control influences the metering device.
  • the device is characterized by at least one measuring device for determining at least one parameter of the pumped gas, the at least one measuring device influencing the control.
  • a device of the type mentioned at the outset which is characterized by at least one measuring device for determining at least one parameter of the conveyed gas, the at least one measuring device influencing the control, in particular via the control the metering device for metering the oxygen to be conveyed to the breathing gas is affected.
  • the inventive design of the device of the type mentioned at the outset now makes it possible to adjust the supply of breathing gas depending on the condition of the patient and his needs, in particular also the addition of oxygen to the breathing gas.
  • the at least one measuring device expediently comprises a gas flow measuring device and / or a gas pressure measuring device and / or a device for determining a gas concentration, in particular an oxygen concentration, in the conveyed gas.
  • the object is further achieved by a method for providing a breathing gas for living beings, which is characterized by detecting at least one parameter of the gas conveyed and for measuring a certain amount of oxygen as a function of the at least one detected parameter.
  • a specific amount of oxygen is preferably metered in after a predetermined value for the at least one parameter has been recorded, in particular at a specific point in time after such a value has been recorded, in particular at a specific point in time after the start of an inhalation phase.
  • this is characterized in that the metering of a certain amount of oxygen is proportional to a peak value of a respiratory gas flow and / or a respiratory gas pressure in a breathing cycle, in particular that the peak value of the respiratory gas flow and / or the respiratory gas pressure is determined as the peak value of the breathing gas flow and / or breathing gas pressure in a previous breathing cycle, in particular as an average of the peak values of a certain number of previous breathing cycles.
  • a particularly low oxygen consumption can be achieved if a certain amount of oxygen is added to the breathing gas as a function of a detected value of the oxygen concentration in the exhaled gas, in particular if the duration of the oxygen release of the oxygen source is determined as a function of a detected value the oxygen concentration in the exhaled gas.
  • the method is advantageously characterized by the use of a device according to the invention.
  • the breathing gas supply to the patient can be detected on the basis of the parameter of the conveyed gas flow detected by the measuring device.
  • oxygen is delivered to the patient in an impulse-like manner.
  • the supply of oxygen can take place shortly after the start of inhalation or with a suitable delay, for example if the lungs are strongly atelectatic or collapsed.
  • the expression "positive gas pressure” is used here for a pressure above a a predetermined basic pressure (atmospheric pressure or positive pressure during ventilation with positive end-expiratory pressure / PEEP) after spontaneous or forced inhalation. In contrast, the start of spontaneous inhalation is recognized by a decrease in gas pressure.
  • oxygen replaces nitrogen and accumulates in the alveoli within 1 or 2 minutes of ventilation.
  • This embodiment of the invention can be used with practically all ventilation and breathing support systems, either by installation in the system or as an external accessory.
  • the use of a certain time delay for the addition of oxygen from the oxygen source may be advantageous.
  • the time delay can be fixed by a doctor on the device, but is preferably done according to the condition of the lungs.
  • the delay time can e.g. can be determined as the average time to reach a certain percentage of a peak value over a preselected number of breathing cycles or depending on the condition, compliance and the functional residual capacity of the lungs.
  • Figure 1 is a schematic representation of an inventive
  • FIG. 2 is a block diagram of another invention
  • Figure 3 is a diagram illustrating the operation of the device in a first mode of operation
  • Figure 4 is a diagram illustrating the operation of the device in a second mode.
  • FIG. 1 shows a device 1 according to the invention for providing a breathing gas which can be connected to a patient 2. Cleaned air is drawn in and conveyed from the environment by a motor-driven blower 4 via a suitable filter 3, the blower 4 serving as a breathing gas source. A conventional compressed gas source can also be used as the breathing gas source.
  • valve device 5 Via a valve device 5, the volume flow delivered by the blower 4 into a supply line 6 as a gas delivery device or the pressure built up in the gas delivery device 6 can be adjusted.
  • the valve device 5 can assume at least two operating positions. In a first operating position of the valve device 5, this essentially releases the cross section of the gas conveying device 6 in the direction of a consumer end 7. In a second operating position, the valve device 5 completely or partially closes the cross section of the gas delivery device 6 and / or connects the gas delivery device 6 to the surroundings, i.e. the gas delivery device 6 is vented.
  • the consumer end 7 of the gas delivery device 6 serves to connect the device 1 to the patient 2 and can e.g. be designed as a tube device.
  • a flow meter 8 is expediently integrated into the consumer end 7 as a gas flow measuring device.
  • a line 9 is expediently connected as a backflow device to the consumer-side end 7 of the gas delivery device 6.
  • a gas pressure measuring device 10 is also expedient to integrate into the consumer-side end 7 of the gas delivery device 6.
  • a pressure relief valve 11 can be integrated, via which the line 9 is vented i d when a critical pressure is exceeded.
  • a pressure relief valve 11 serves as a safety valve in the event of failure of the valve device 5, in particular in its first operating position.
  • the signals from measuring devices are fed to a controller 12, which at least applies a control signal to the valve device 5.
  • An actuator 13 which e.g. can be formed by a stepper motor or an electromagnet. Furthermore, feedback from the actuator 13 about the position of the valve device 5 to the controller 12 can take place. Furthermore, the controller 12 can also influence the fan 4, e.g. to minimize the power consumption of device 1.
  • the valve device 5 includes both influencing the gas flow in the gas delivery device 6 and in the return flow device 9. Downstream of the valve device 5, a pressure control valve 1 14 is arranged at the end of the return flow device 9, which sets the desired overpressure in the return flow device 9 against that patient 2 should exhale.
  • the pressure which is set via the pressure control valve 14 can expediently be changed directly or via the controller 12 and a corresponding actuator in the pressure control valve 14 in accordance with the medically desired specifications.
  • valve 15 in the gas delivery device 6 and the backflow device 9 a direction of the gas flow are forced.
  • the check valves 15 can be formed, for example, by conventional flap valves.
  • an optional oxygen source 16 is indicated in FIG. 1, by means of which the breathing gas can be enriched with oxygen. Details of such an arrangement with an oxygen source 16 are described below.
  • FIG. 2 shows a device 1 for providing a breathing gas according to a further embodiment of the device according to the invention.
  • a patient 2 connected to the device 1 is also shown to illustrate the mode of operation.
  • the device 1 shown comprises a respiratory gas source, which can either comprise a blower 4, as described above, or can be formed by a conventional breathing apparatus or respirator.
  • the breathing device can e.g. be a stationary hospital device with all known special features, e.g. Volume and pressure control as well as patient monitor.
  • the breathing gas can accordingly be provided in a conventional manner via a central compressed gas supply or pressure cylinders.
  • the device 1 shown further comprises a flow meter 8, a pressure measuring device 10, a controller 12 and an oxygen source 16.
  • the controller 12 is connected to a control valve 17 as a metering device for measuring an amount of oxygen to be conveyed.
  • the control valve 17 is integrated in a gas line 18 which connects the oxygen source 16 with a gas delivery device 6 designed as a tube system.
  • a measuring device 19 for the oxygen concentration is arranged in the consumer end 7 of the tube system 6.
  • the breathing aid 4 is connected to the patient 2 via a tube device 6.
  • the tube device 6 comprises a tube for inhalation and can also be connected to another tube 9 for exhalation.
  • the use of an additional tube 9 for exhaling depends essentially on the Type of respiratory device 4 used. In portable devices for accident medicine and domestic use, only one tube is usually used for inhalation.
  • the patient exhales directly into the environment through a valve.
  • the flow meter 8 and the pressure measuring device 10 are arranged in the tube system 6 in order to determine the gas volume flow to the patient 2 and the airway pressure in the patient 2.
  • the measured values are transmitted to the controller 12, which controls the breathing apparatus 4 in accordance with the measured values.
  • the controller 12 also controls the control valve 7 for adding oxygen from the oxygen source 16 to the patient 2 via a gas line 18 and the tube system 6.
  • FIG. 3 shows a diagram in which the volume flow and the pressure are shown over two breathing cycles. The diagram shows how the device works volume-controlled.
  • a first inhalation volume flow 20A is supplied to the patient.
  • the volume flow 20A is constant.
  • a first exhalation 20B takes place, which in turn is followed by a second inhalation stream 20C and another exhalation 20D.
  • the pressure P in the airways 22A increases as the patient is supplied with breathing gas.
  • pressure begins to drop and continues to decrease during exhalation 22B.
  • the pressure drops to atmospheric pressure or an elevated pressure level if ventilation with positive end-expiratory pressure (PEEP) takes place.
  • PEEP positive end-expiratory pressure
  • NEEP negative end-expiratory pressure
  • ARDS acute respiratory failure
  • closed breathing cycles do not have uniform time constants, ie different characteristics of flow resistance and compliance. If oxygen applied immediately after inhalation, vital parts of the lungs may not yet be effectively ventilated.
  • the addition of oxygen is delayed until the lungs are opened sufficiently, as indicated by the pressure curve in 22A in Figure 3. When a certain pressure P is reached in relation to the maximum pressure, oxygen is added, as shown by the black bars 24 and 26.
  • Figure 4 shows essentially the same for a pressure controlled mode.
  • a first inhalation 32A and a second inhalation 32C take place at a predetermined pressure level.
  • a first and second exhalation 32B and 32C occurs at a positive end expiratory pressure (PEEP).
  • the pressure pulse 32A causes an inhalation flow 30A to the patient.
  • the inhalation stream 30A is large at the beginning of the inhalation and then decreases until the exhalation 30B begins.
  • a second inhalation 30C and exhalation 30D follow accordingly.
  • oxygen is only added when the gas flow reaches a predetermined percentage ⁇ of the maximum gas flow, which is indicated by the black bars 34 and 36 in FIG. 4.
  • the measured maximum values in one breathing cycle or the calculated mean values of several previous breathing cycles can be used as a reference axima.
  • oxygen is added.
  • a combination of volume flow and pressure can also be used.
  • a certain time delay can also be entered by the doctor or calculated by the controller 12.
  • the oxygen is added after a certain time delay.
  • the size of this time delay is determined by the state of the Lung and corresponds to a time behavior that ensures the best efficiency when adding oxygen.
  • a doctor can set a certain time delay after the start of inhalation for the addition of oxygen.
  • the controller 12 can be programmed to calculate the time delay based on the measurements of the volume flow and the pressure. For example, the controller can calculate an average value for the time delay over a number of breathing cycles, as shown in FIGS. 3 and 4, and then use the calculated time delay.
  • the time delay can also be set to a fixed value without adapting to the individual lung constitution, for example for devices used in accident medicine.
  • the same mode of operation can be used for other modes of operation of a breathing apparatus or a respirator, e.g. in breathing support.
  • manually operated ventilators can also be equipped accordingly by medical personnel.
  • Another possible control variable is the duration of the oxygen addition. This is controlled so that it is long enough to deliver oxygen to the corresponding parts of the lungs, i.e. Airways and alveoli, but not so long that oxygen is exhaled again unused. This can be done by measuring the oxygen concentration in the exhaled air, e.g. with the measuring device for the oxygen concentration 19 in Figure 1, or by the oxygen concentration of the blood (not shown).

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  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

L'invention a pour objet un appareil pour la préparation d'un gaz respiratoire, comprenant au moins une source de gaz respiratoire (4), des moyens de contrôle (12) du courant de gaz respiratoire, ainsi que des moyens de transfert pour le courant gazeux contrôlé (6), ces derniers moyens pouvant être connectés à au moins une source d'oxygène (16). Selon l'invention, la source de gaz respiratoire comprend un ventilateur (4) entraîné par un moteur; en outre, il est prévu au moins un dispositif de mesure (8, 10, 19) pour la détermination d'au moins un paramètre du courant gazeux transféré, ce dispositif de mesure (8, 10, 19) agissant sur les moyens de contrôle (12). L'invention concerne également un procédé pour la préparation d'un gaz respiratoire pour des êtres vivants (2).
PCT/EP1997/003544 1996-07-04 1997-07-04 Appareil pour la preparation d'un gaz respiratoire WO1998001176A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97934447A EP0925085A1 (fr) 1996-07-04 1997-07-04 Appareil pour la preparation d'un gaz respiratoire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19626924.5 1996-07-04
DE19626924A DE19626924C2 (de) 1996-07-04 1996-07-04 Gerät zur Bereitstellung eines Atemgases

Publications (1)

Publication Number Publication Date
WO1998001176A1 true WO1998001176A1 (fr) 1998-01-15

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ID=7798897

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Application Number Title Priority Date Filing Date
PCT/EP1997/003544 WO1998001176A1 (fr) 1996-07-04 1997-07-04 Appareil pour la preparation d'un gaz respiratoire

Country Status (3)

Country Link
EP (1) EP0925085A1 (fr)
DE (1) DE19626924C2 (fr)
WO (1) WO1998001176A1 (fr)

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AU750730B2 (en) * 1998-07-21 2002-07-25 Laboratorios Liconsa, S.A. Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
US7487778B2 (en) 2003-08-11 2009-02-10 Breathe Technologies, Inc. Tracheal catheter and prosthesis and method of respiratory support of a patient
US7533670B1 (en) 2005-09-20 2009-05-19 Breathe Technologies, Inc. Systems, methods and apparatus for respiratory support of a patient
US7588033B2 (en) 2003-06-18 2009-09-15 Breathe Technologies, Inc. Methods, systems and devices for improving ventilation in a lung area
US7631642B2 (en) 2006-05-18 2009-12-15 Breathe Technologies, Inc. Tracheostoma spacer, tracheotomy method, and device for inserting a tracheostoma spacer
DE102010035167A1 (de) 2010-08-23 2012-02-23 F. Stephan Gmbh Medizintechnik Respirator
CN104014063A (zh) * 2014-06-20 2014-09-03 昌克勤 无创一氧化氮自主呼吸供给系统
CN104014062A (zh) * 2014-06-20 2014-09-03 昌克勤 吸氧仪
US8925545B2 (en) 2004-02-04 2015-01-06 Breathe Technologies, Inc. Methods and devices for treating sleep apnea
US8939152B2 (en) 2010-09-30 2015-01-27 Breathe Technologies, Inc. Methods, systems and devices for humidifying a respiratory tract
US9132250B2 (en) 2009-09-03 2015-09-15 Breathe Technologies, Inc. Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with an entrainment port and/or pressure feature
US9180270B2 (en) 2009-04-02 2015-11-10 Breathe Technologies, Inc. Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles within an outer tube
US9962512B2 (en) 2009-04-02 2018-05-08 Breathe Technologies, Inc. Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with a free space nozzle feature
US10058668B2 (en) 2007-05-18 2018-08-28 Breathe Technologies, Inc. Methods and devices for sensing respiration and providing ventilation therapy
US10099028B2 (en) 2010-08-16 2018-10-16 Breathe Technologies, Inc. Methods, systems and devices using LOX to provide ventilatory support
US10252020B2 (en) 2008-10-01 2019-04-09 Breathe Technologies, Inc. Ventilator with biofeedback monitoring and control for improving patient activity and health
CN112169130A (zh) * 2010-03-25 2021-01-05 瑞思迈巴黎股份有限公司 用于呼吸治疗装置的可呼吸气体进气口控制设备
DE102022002797A1 (de) 2022-08-02 2024-02-08 Rajan Govinda Dosiereinrichtung zur Zugabe wenigstens einer pharmazeutisch wirksamen Substanz zu einem extrakorporal bereitgestellten Atemgas, Gerät zur Bereitstellung eines Atemgases mit einer solchen Dosiereinrichtung und Verfahren

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AUPR315401A0 (en) 2001-02-16 2001-03-15 Resmed Limited An apparatus for supplying clean breathable gas
AU2004266693B2 (en) 2003-08-18 2011-03-10 Breathe Technologies, Inc Method and device for non-invasive ventilation with nasal interface
JP2009545384A (ja) 2006-08-03 2009-12-24 ブリーズ テクノロジーズ， インコーポレイテッド 最小侵襲性呼吸補助のための方法および装置
EP1930043B8 (fr) * 2006-12-05 2018-06-27 Löwenstein Medical Technology S.A. Procédé pour déterminer la concentration d'oxygène dans un mélange gazeux pour la respiration
WO2009042974A1 (fr) 2007-09-26 2009-04-02 Breathe Technologies, Inc. Procédés et dispositifs permettant d'assister le flux d'inspiration et d'expiration dans une thérapie par ventilation
WO2009129506A1 (fr) 2008-04-18 2009-10-22 Breathe Technologies, Inc. Procédés et dispositifs pour détecter la respiration et commander des fonctions d’insufflateur
US8776793B2 (en) 2008-04-18 2014-07-15 Breathe Technologies, Inc. Methods and devices for sensing respiration and controlling ventilator functions
EP2326376B1 (fr) 2008-08-22 2019-07-24 Breathe Technologies, Inc. Dispositifs pour fournir une ventilation mécanique avec une interface de voies respiratoires ouvertes
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EP0925085A1 (fr) 1999-06-30
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