+

WO1998001159A3 - Composition en vue d'une meilleure assimilation par les muqueuses de medicaments a molecules polaires - Google Patents

Composition en vue d'une meilleure assimilation par les muqueuses de medicaments a molecules polaires Download PDF

Info

Publication number
WO1998001159A3
WO1998001159A3 PCT/GB1997/001852 GB9701852W WO9801159A3 WO 1998001159 A3 WO1998001159 A3 WO 1998001159A3 GB 9701852 W GB9701852 W GB 9701852W WO 9801159 A3 WO9801159 A3 WO 9801159A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
mucosal surfaces
enhanced uptake
polar drugs
metabolisable
Prior art date
Application number
PCT/GB1997/001852
Other languages
English (en)
Other versions
WO1998001159A2 (fr
Inventor
Lisbeth Illum
Peter James Watts
Original Assignee
Danbiosyst Uk
Lisbeth Illum
Peter James Watts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danbiosyst Uk, Lisbeth Illum, Peter James Watts filed Critical Danbiosyst Uk
Priority to GB9900050A priority Critical patent/GB2330533B/en
Priority to AU34539/97A priority patent/AU722724B2/en
Priority to EP97930663A priority patent/EP0993305A2/fr
Priority to JP10504949A priority patent/JP2000515503A/ja
Publication of WO1998001159A2 publication Critical patent/WO1998001159A2/fr
Publication of WO1998001159A3 publication Critical patent/WO1998001159A3/fr
Priority to NO985956A priority patent/NO985956D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne une composition à administrer sur la muqueuse d'un mammifère, comprenant un analogue de sel biliaire non métabolisable et un agent thérapeutique. L'analogue de sel biliaire non métabolisable est de préférence un conjugué d'origine artificielle d'acide cholique et d'un acide aminé, en particulier de la cholysarcosine. L'agent thérapeutique est de préférence une molécule polaire.
PCT/GB1997/001852 1996-07-06 1997-07-07 Composition en vue d'une meilleure assimilation par les muqueuses de medicaments a molecules polaires WO1998001159A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB9900050A GB2330533B (en) 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces
AU34539/97A AU722724B2 (en) 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces
EP97930663A EP0993305A2 (fr) 1996-07-06 1997-07-07 Composition en vue d'une meilleure assimilation par les muqueuses de medicaments a molecules polaires
JP10504949A JP2000515503A (ja) 1996-07-06 1997-07-07 極性薬剤の粘膜表面からの摂取を増進するための組成物
NO985956A NO985956D0 (no) 1996-07-06 1998-12-18 Blanding for forbedret opptak av polare medikamenter fra mukosale overflater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614235.1A GB9614235D0 (en) 1996-07-06 1996-07-06 Composition for enhanced uptake of polar drugs from mucosal surfaces
GB9614235.1 1996-07-06

Publications (2)

Publication Number Publication Date
WO1998001159A2 WO1998001159A2 (fr) 1998-01-15
WO1998001159A3 true WO1998001159A3 (fr) 1998-03-26

Family

ID=10796483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001852 WO1998001159A2 (fr) 1996-07-06 1997-07-07 Composition en vue d'une meilleure assimilation par les muqueuses de medicaments a molecules polaires

Country Status (8)

Country Link
EP (1) EP0993305A2 (fr)
JP (1) JP2000515503A (fr)
KR (1) KR20000023583A (fr)
AU (1) AU722724B2 (fr)
CA (1) CA2257563A1 (fr)
GB (2) GB9614235D0 (fr)
NO (1) NO985956D0 (fr)
WO (1) WO1998001159A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572874B1 (en) * 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
EP1154761B1 (fr) * 1999-02-22 2008-02-20 Merrion Research I Limited Dose orale solide contenant un agent de potentialisation
GB2355009A (en) 1999-07-30 2001-04-11 Univ Glasgow Peptides conjugated to bile acids/salts
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1572244A1 (fr) * 2002-12-11 2005-09-14 Chong Kun Dang Pharmaceutical Corp. Formulations a administration par voie orale pour medicaments hydrophiles a faible capacite d'absorption
DE102004027924A1 (de) * 2004-06-09 2005-12-29 Röhm GmbH & Co. KG Arzneiform, enthaltend den Wirkstoff Cholylsarcosin
MX2008012678A (es) 2006-04-07 2008-12-17 Merrion Res Iii Ltd Forma de dosis oral solida que contiene un mejorador.
WO2009137080A1 (fr) 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions de composés apparentés à la gnrh et leurs procédés de préparation
PL2442821T3 (pl) 2009-06-18 2018-04-30 Serenity Pharmaceuticals Llc Bezpieczne podawanie desmopresyny
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
CN103476419A (zh) 2011-01-07 2013-12-25 梅里翁第三研究有限公司 口服投药的含铁药物组合物
EP3250191B1 (fr) 2015-01-29 2024-01-17 Novo Nordisk A/S Comprimés contenant un agoniste de glp-1 et revêtement gastro-résistant
CN108201531A (zh) * 2016-12-19 2018-06-26 湖南尔康湘药制药有限公司 高溶解性磺苄西林钠结肠靶向淀粉胶囊及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007923A1 (fr) * 1989-01-19 1990-07-26 California Biotechnology Inc. Compositions d'aministration de medicaments a travers des membranes
DE4222647A1 (de) * 1991-07-15 1993-01-21 Sandoz Ag Peptid-zubereitungen
WO1995001183A1 (fr) * 1993-06-29 1995-01-12 Ferring B.V. Compositions permettant l'administration par voie nasale de desmopressine
WO1997006813A1 (fr) * 1995-08-15 1997-02-27 Asahi Kasei Kogyo Kabushiki Kaisha Preparation pour muqueuses a base de peptides a activite physiologique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007923A1 (fr) * 1989-01-19 1990-07-26 California Biotechnology Inc. Compositions d'aministration de medicaments a travers des membranes
DE4222647A1 (de) * 1991-07-15 1993-01-21 Sandoz Ag Peptid-zubereitungen
WO1995001183A1 (fr) * 1993-06-29 1995-01-12 Ferring B.V. Compositions permettant l'administration par voie nasale de desmopressine
WO1997006813A1 (fr) * 1995-08-15 1997-02-27 Asahi Kasei Kogyo Kabushiki Kaisha Preparation pour muqueuses a base de peptides a activite physiologique

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
AUNGST, BRUCE J. ET AL: "Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter", J. PHARMACOL. EXP. THER. (1988), 244(1), 23-8 CODEN: JPETAB;ISSN: 0022-3565, 1988, XP002049338 *
BIOCHEM. PHARMACOL. (1983), 32(5), 773-6 CODEN: BCPCA6;ISSN: 0006-2952, 1983 *
CHEMICAL ABSTRACTS, vol. 112, no. 6, 5 February 1990, Columbus, Ohio, US; abstract no. 42406, NAGAI, T. ET AL: "Absorption of fibroblast interferon -.beta. in powder dosage form from nasal mucosa in rabbits" XP002049341 *
CHEMICAL ABSTRACTS, vol. 95, no. 13, 28 September 1981, Columbus, Ohio, US; abstract no. 109081, ZIV, EHUD ET AL: "Bile salts promote the absorption of insulin from the rat colon" XP002049343 *
CHEMICAL ABSTRACTS, vol. 98, no. 23, 6 June 1983, Columbus, Ohio, US; abstract no. 191258, ZIV, E. ET AL: "Bile salts facilitate the absorption of heparin from the intestine" XP002049342 *
CONGR. INT. TECHNOL. PHARM., 5TH (1989), VOLUME 1, 91-8 PUBLISHER: ASSOC. PHARM. GALENIQUE IND., CHATENAY MALABRY, FR. CODEN: 56SEA5, 1989 *
GORDON, G. S. ET AL: "Nasal absorption of insulin: enhancement by hydrophobic bile salts", PROC. NATL. ACAD. SCI. U. S. A. (1985), 82(21), 7419-23 CODEN: PNASA6;ISSN: 0027-8424, 1985, XP002049334 *
KRAMER W ET AL: "MODIFIED BILE ACIDS AS CARRIERS FOR PEPTIDES AND DRUGS", JOURNAL OF CONTROLLED RELEASE, vol. 46, no. 1/02, 5 May 1997 (1997-05-05), pages 17 - 30, XP000680749 *
LIFE SCI. (1981), 29(8), 803-9 CODEN: LIFSAK;ISSN: 0024-3205, 1981 *
LONGENECKER, JOHN P. ET AL: "Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep", J. PHARM. SCI. (1987), 76(5), 351-5 CODEN: JPMSAE;ISSN: 0022-3549, 1987, XP002049340 *
NAKADA, YUICHIRO ET AL: "The effect of additives on the oral mucosal absorption of human calcitonin in rats", J. PHARMACOBIO-DYN. (1988), 11(6), 395-401 CODEN: JOPHDQ;ISSN: 0386-846X, 1988, XP002049337 *
NAKADA, YUICHIRO ET AL: "The effect of bile salts on the oral mucosal absorption of human calcitonin in rats", J. PHARMACOBIO-DYN. (1989), 12(12), 736-43 CODEN: JOPHDQ;ISSN: 0386-846X, 1989, XP002049336 *
SCOTT-MONCRIEFF, J. CATHARINE ET AL: "Enhancement of Intestinal Insulin Absorption by Bile Salt Fatty Acid Mixed Micelles in Dogs", J. PHARM. SCI. (1994), 83(10), 1465-9 CODEN: JPMSAE;ISSN: 0022-3549, 1994, XP002049335 *
UCHIDA, NAOKI ET AL: "Influence of bile salts on the permeability of insulin through the nasal mucosa of rabbits in comparison with dextran derivatives", INT. J. PHARM. (1991), 74(2-3), 95-103 CODEN: IJPHDE;ISSN: 0378-5173, 1991, XP002049339 *

Also Published As

Publication number Publication date
NO985956L (no) 1998-12-18
GB9900050D0 (en) 1999-02-24
NO985956D0 (no) 1998-12-18
KR20000023583A (ko) 2000-04-25
GB2330533A (en) 1999-04-28
AU722724B2 (en) 2000-08-10
AU3453997A (en) 1998-02-02
GB9614235D0 (en) 1996-09-04
WO1998001159A2 (fr) 1998-01-15
JP2000515503A (ja) 2000-11-21
GB2330533B (en) 2000-10-25
EP0993305A2 (fr) 2000-04-19
CA2257563A1 (fr) 1998-01-15

Similar Documents

Publication Publication Date Title
WO1998001159A3 (fr) Composition en vue d'une meilleure assimilation par les muqueuses de medicaments a molecules polaires
WO1999015210A3 (fr) Compositions bioadhesives et methodes d'administration locale d'agents actifs
AU3070395A (en) Use of low molecular weight amino acids in ophthalmic compositions
WO2003079972A3 (fr) Systemes de distribution d'agents actifs et methodes de protection et d'administration d'agents actifs
WO1997044063A3 (fr) Conjugues d'acide cis-docosahexanoïque et d'agents pharmaceutiques
AU6675198A (en) Transdermal drug delivery system for the administration of tamsulosin, and related compositions and methods of use
WO1997049736A3 (fr) Particules comprenant des copolymeres amphiphiles, possedant un domaine de reticulation croisee et un domaine de noyau interne, utilisables en pharmacologie et autres applications
WO1996040086A3 (fr) Compositions et methodes pour l'administration locale d'agents pharmaceutiquement actifs
HUP0004439A3 (en) 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
WO2000038626A3 (fr) Composition de substrat et procede d'utilisation associe, aux fins de sequestration de substances irritantes pour la peau
WO2000033825A3 (fr) Compositions et methodes visant a attenuer un dysfonctionnement sexuel chez la femme
BR9812469A (pt) Composições farmacêuticas contendo proteina de plasma
EP0354992A3 (fr) Conjugués de VIP et de ses fragments actifs avec des portions hydrophobiques et des préparations pour l'utilisation dans le traitement de l'impuissance masculine
WO2003045332A3 (fr) Methodes et compositions permettant de traiter des lesions de l'epithelium respiratoire
CA2268455A1 (fr) Methodes et appareil de traitement de la maladie de parkinson
CA2140361A1 (fr) Composition et methodes pour diminuer l'affaissement musculaire
CA2278422A1 (fr) D-methadone, analgesique non opioide
WO2002009679A3 (fr) Utilisation de l'acide 13-cis-retinoique pour le traitement de l'emphyseme
WO2001054706A3 (fr) Methode de traitement d'affections renales
WO2000069445A8 (fr) Polytherapie pour traiter l'hypercholesterolemie
WO2002058589A3 (fr) Agents et methodes favorisant la croissance osseuse
AU3771697A (en) Amino acid compositions and use thereof in immunosuppression
CA2251132A1 (fr) Utilisation de derives phosphonamidoalkyles de cyclopentane/ene en tant qu'agents therapeutiques
CA2189145A1 (fr) Tri-, tetra-, penta- et polypeptides et leur usage therapeutique en tant qu'agent antidepresseur
AU2921999A (en) Indole-2,3-dione-3-oxime derivatives for therapeutic use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA GB JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA GB JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2257563

Country of ref document: CA

Ref country code: CA

Ref document number: 2257563

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: GB

Ref document number: 9900050

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1997930663

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1019997000028

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 09214527

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1997930663

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1019997000028

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1997930663

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1019997000028

Country of ref document: KR

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载