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WO1998000538A3 - Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization - Google Patents

Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization Download PDF

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Publication number
WO1998000538A3
WO1998000538A3 PCT/IB1997/000814 IB9700814W WO9800538A3 WO 1998000538 A3 WO1998000538 A3 WO 1998000538A3 IB 9700814 W IB9700814 W IB 9700814W WO 9800538 A3 WO9800538 A3 WO 9800538A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
peptides
coupled receptors
peptidomimetic compounds
activity
Prior art date
Application number
PCT/IB1997/000814
Other languages
French (fr)
Other versions
WO1998000538A2 (en
Inventor
Michel Bouvier
Michael Dennis
Terence E Hebert
Original Assignee
Biosignal Inc
Univ Montreal L
Michel Bouvier
Michael Dennis
Terence E Hebert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosignal Inc, Univ Montreal L, Michel Bouvier, Michael Dennis, Terence E Hebert filed Critical Biosignal Inc
Priority to EP97933814A priority Critical patent/EP0910640A2/en
Priority to AU37050/97A priority patent/AU3705097A/en
Publication of WO1998000538A2 publication Critical patent/WO1998000538A2/en
Publication of WO1998000538A3 publication Critical patent/WO1998000538A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to peptides and peptidomimetic compounds that modulate the function of G-protein-coupled receptors by affecting the ratio of receptor monomer to homo-oligomeric forms. Novel short peptides of a preferred length of up to about 15-20 amino acid residues are modeled on transmembrane domains of G-protein-coupled receptors, whose activities are affected by the formation of oligomers. These novel peptides and peptidomimetic compounds can be used to selectively affect the activity of G-protein-coupling receptors, thereby functioning as potential therapeutic drugs, etc.. A preferred peptide is GIIMGTFTLCWLPFFIVNIV.
PCT/IB1997/000814 1996-07-01 1997-07-01 Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization WO1998000538A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97933814A EP0910640A2 (en) 1996-07-01 1997-07-01 Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization
AU37050/97A AU3705097A (en) 1996-07-01 1997-07-01 Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2103196P 1996-07-01 1996-07-01
US60/021,031 1996-07-01

Publications (2)

Publication Number Publication Date
WO1998000538A2 WO1998000538A2 (en) 1998-01-08
WO1998000538A3 true WO1998000538A3 (en) 1998-05-07

Family

ID=21801930

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/000814 WO1998000538A2 (en) 1996-07-01 1997-07-01 Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization

Country Status (4)

Country Link
EP (1) EP0910640A2 (en)
AU (1) AU3705097A (en)
CA (2) CA2259132A1 (en)
WO (1) WO1998000538A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2209511A1 (en) * 1996-07-01 1998-01-01 Michael Dennis Method of assaying compounds which affect the activity of g-protein-coupled receptors based on measurement of receptor oligomerization
US6555522B1 (en) 1998-02-05 2003-04-29 Mount Sinai School Of Medicine Of The City Of New York Peptides and other small molecules derived from regions of interacting proteins and uses thereof
AU760208B2 (en) * 1998-02-27 2003-05-08 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The G protein-coupled receptor antagonists
US7105488B1 (en) 1998-02-27 2006-09-12 The United States Of America As Represented By The Department Of Health And Human Services G protein-coupled receptor antagonists
US7304127B2 (en) 1999-08-27 2007-12-04 United States Of America As Represented By The Secretary, Department Of Health And Human Services Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
WO2001016182A2 (en) * 1999-08-27 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services POLYPEPTIDES THAT BIND HIV gp120 AND RELATED NUCLEIC ACIDS, ANTIBODIES, COMPOSITIONS, AND METHODS OF USE
US20010053848A1 (en) * 2000-03-10 2001-12-20 Patel Yogesh C. Hetero-oligomeric G protein-coupled receptors as novel drug targets
US7696168B2 (en) 2000-04-21 2010-04-13 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
CA2406839C (en) 2000-04-21 2013-06-11 Athan Kuliopulos G-protein coupled receptor (gpcr) agonists and antagonists and methods of activating and inhibiting gpcr using the same
US8440627B2 (en) 2004-11-04 2013-05-14 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of use
TWI818938B (en) 2017-12-19 2023-10-21 南韓商Ｇｐｃｒ醫療公司 Gpcr heteromer inhibitors and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008160A1 (en) * 1989-01-20 1990-07-26 Imperial Cancer Research Technology Ltd. Growth factor receptor-like peptides without tyrosine-kinase activity
WO1994005695A1 (en) * 1992-09-10 1994-03-17 New York University Polypeptides of g-coupled receptor proteins, and compositions and methods thereof
WO1994024162A1 (en) * 1993-04-21 1994-10-27 Vetigen NUCLEOTIDE SEQUENCES CODING FOR THE BOVINE β3-ADRENERGIC RECEPTOR, AND APPLICATIONS THEREOF
WO1997035881A2 (en) * 1996-03-27 1997-10-02 Ng Gordon Y K Receptor and transporter antagonists
WO1997040148A2 (en) * 1996-04-22 1997-10-30 L'universite De Montreal Peptide antagonists derived from the transmembrane domains of g protein-coupled receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008160A1 (en) * 1989-01-20 1990-07-26 Imperial Cancer Research Technology Ltd. Growth factor receptor-like peptides without tyrosine-kinase activity
WO1994005695A1 (en) * 1992-09-10 1994-03-17 New York University Polypeptides of g-coupled receptor proteins, and compositions and methods thereof
WO1994024162A1 (en) * 1993-04-21 1994-10-27 Vetigen NUCLEOTIDE SEQUENCES CODING FOR THE BOVINE β3-ADRENERGIC RECEPTOR, AND APPLICATIONS THEREOF
WO1997035881A2 (en) * 1996-03-27 1997-10-02 Ng Gordon Y K Receptor and transporter antagonists
WO1997040148A2 (en) * 1996-04-22 1997-10-30 L'universite De Montreal Peptide antagonists derived from the transmembrane domains of g protein-coupled receptors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GREGORY, H. ET AL.: "Luteinizing hormone release from dissociated pituitary cells by dimerization of occupied LHRH receptors.", NATURE, vol. 300, 18 November 1982 (1982-11-18), pages 269 - 271, XP002057464 *
HEBERT T E ET AL: "A PEPTIDE DERIVED FROM A BETA2-ADRENERGIC RECEPTOR TRANSMEMBRANE DOMAIN INHIBITS BOTH RECEPTOR DIMERIZATION AND ACTIVATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 27, 5 July 1996 (1996-07-05), pages 16384 - 16392, XP002045155 *
WAGNER T ET AL: "DIFFERENTIAL REGULATION OF G-PROTEIN ALPHA-SUBUNIT GTPASE ACTIVITY BY PEPTIDES DERIVED FROM THE THIRD CYTOPLASMIC LOOP OF THE ALPHA2-ADRENERGIC RECEPTOR", FEBS LETTERS, vol. 365, no. 1, 1995, pages 13 - 17, XP002045148 *

Also Published As

Publication number Publication date
AU3705097A (en) 1998-01-21
WO1998000538A2 (en) 1998-01-08
CA2205543A1 (en) 1998-01-01
EP0910640A2 (en) 1999-04-28
CA2259132A1 (en) 1998-01-08

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