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WO1998000130A3 - Anticonvulsant sulfamate derivatives useful in treating obesity - Google Patents

Anticonvulsant sulfamate derivatives useful in treating obesity Download PDF

Info

Publication number
WO1998000130A3
WO1998000130A3 PCT/US1997/010953 US9710953W WO9800130A3 WO 1998000130 A3 WO1998000130 A3 WO 1998000130A3 US 9710953 W US9710953 W US 9710953W WO 9800130 A3 WO9800130 A3 WO 9800130A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating obesity
derivatives useful
sulfamate derivatives
anticonvulsant sulfamate
anticonvulsant
Prior art date
Application number
PCT/US1997/010953
Other languages
French (fr)
Other versions
WO1998000130A2 (en
Inventor
Richard P Shank
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21807338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998000130(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE69715631T priority Critical patent/DE69715631T2/en
Priority to AU39578/97A priority patent/AU732923B2/en
Priority to DK97936939T priority patent/DK0915697T3/en
Priority to HU0001192A priority patent/HU226775B1/en
Priority to CA002258893A priority patent/CA2258893C/en
Priority to EP97936939A priority patent/EP0915697B1/en
Priority to CZ19984278A priority patent/CZ293876B6/en
Priority to BR9710994-0A priority patent/BR9710994A/en
Priority to AT97936939T priority patent/ATE224189T1/en
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Priority to JP10504244A priority patent/JP2000514425A/en
Priority to SI9730421T priority patent/SI0915697T1/en
Priority to SK1805-98A priority patent/SK284305B6/en
Priority to NZ333586A priority patent/NZ333586A/en
Priority to APAP/P/1998/001429A priority patent/AP1285A/en
Priority to IL12771597A priority patent/IL127715A/en
Priority to UA98126944A priority patent/UA53655C2/en
Publication of WO1998000130A2 publication Critical patent/WO1998000130A2/en
Publication of WO1998000130A3 publication Critical patent/WO1998000130A3/en
Priority to NO19986052A priority patent/NO317754B1/en
Priority to HK99103712A priority patent/HK1018743A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Anticonvulsant derivatives useful in treating obesity are disclosed.
PCT/US1997/010953 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity WO1998000130A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
UA98126944A UA53655C2 (en) 1996-06-28 1997-06-23 Method for treating obesity
JP10504244A JP2000514425A (en) 1996-06-28 1997-06-23 Sulfamate derivatives of anticonvulsants useful for the treatment of obesity
DK97936939T DK0915697T3 (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in the treatment of obesity
HU0001192A HU226775B1 (en) 1996-06-28 1997-06-23 The use of topiramate and its derivatives for preparation of pharmaceutical compositions useful for treating obesity or for weight loss
CA002258893A CA2258893C (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity
EP97936939A EP0915697B1 (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity
CZ19984278A CZ293876B6 (en) 1996-06-28 1997-06-23 Medicament useful in treating obesity
BR9710994-0A BR9710994A (en) 1996-06-28 1997-06-23 Anticonvulsant derivatives useful in the treatment of obesity.
AT97936939T ATE224189T1 (en) 1996-06-28 1997-06-23 ANTICONVULSIVE SULFAMATE DERIVATIVES FOR THE TREATMENT OF OBESITY
DE69715631T DE69715631T2 (en) 1996-06-28 1997-06-23 ANTI-CONVULSIVE SULFAMATE DERIVATIVES FOR THE TREATMENT OF OBESITY
SK1805-98A SK284305B6 (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity
AU39578/97A AU732923B2 (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity
SI9730421T SI0915697T1 (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity
NZ333586A NZ333586A (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives, preferably topiramate, useful in treating obesity
APAP/P/1998/001429A AP1285A (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity.
IL12771597A IL127715A (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity
NO19986052A NO317754B1 (en) 1996-06-28 1998-12-22 Anticonvulsant sulphamate derivatives for use in the treatment of obesity
HK99103712A HK1018743A1 (en) 1996-06-28 1999-08-27 Anticonvulsant sulfamate derivatives useful in treating obesity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2200496P 1996-06-28 1996-06-28
US60/022,004 1996-06-28

Publications (2)

Publication Number Publication Date
WO1998000130A2 WO1998000130A2 (en) 1998-01-08
WO1998000130A3 true WO1998000130A3 (en) 1998-02-12

Family

ID=21807338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010953 WO1998000130A2 (en) 1996-06-28 1997-06-23 Anticonvulsant sulfamate derivatives useful in treating obesity

Country Status (24)

Country Link
US (1) US6071537A (en)
EP (1) EP0915697B1 (en)
JP (1) JP2000514425A (en)
CN (1) CN1106193C (en)
AP (1) AP1285A (en)
AT (1) ATE224189T1 (en)
AU (1) AU732923B2 (en)
BR (1) BR9710994A (en)
CA (1) CA2258893C (en)
CZ (1) CZ293876B6 (en)
DE (1) DE69715631T2 (en)
DK (1) DK0915697T3 (en)
ES (1) ES2184127T3 (en)
HK (1) HK1018743A1 (en)
HU (1) HU226775B1 (en)
IL (1) IL127715A (en)
NO (1) NO317754B1 (en)
NZ (1) NZ333586A (en)
PT (1) PT915697E (en)
RU (1) RU2214241C2 (en)
SK (1) SK284305B6 (en)
UA (1) UA53655C2 (en)
WO (1) WO1998000130A2 (en)
ZA (1) ZA975772B (en)

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US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
US9125868B2 (en) 2006-11-09 2015-09-08 Orexigen Therapeutics, Inc. Methods for administering weight loss medications
US9248123B2 (en) 2010-01-11 2016-02-02 Orexigen Therapeutics, Inc. Methods of providing weight loss therapy in patients with major depression
US9457005B2 (en) 2005-11-22 2016-10-04 Orexigen Therapeutics, Inc. Compositions and methods for increasing insulin sensitivity

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US6890951B2 (en) 1998-08-05 2005-05-10 Brookhaven Science Associates Llc Treatment of addiction and addiction-related behavior
CZ20013061A3 (en) * 1999-02-24 2002-06-12 University Of Cincinnati Use of sulfamate derivatives for treating disorders of pulse control
WO2000061140A1 (en) * 1999-04-08 2000-10-19 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in maintaining weight loss
WO2000061137A1 (en) * 1999-04-08 2000-10-19 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in lowering lipids
JP4709392B2 (en) * 1999-04-08 2011-06-22 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Anticonvulsant derivatives useful for lowering blood glucose levels
WO2000061136A1 (en) * 1999-04-08 2000-10-19 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in lowering blood pressure
NZ514811A (en) 1999-04-08 2005-01-28 Ortho Mcneil Pharm Inc Anticonvulsant derivatives useful in reducing blood glucose levels
US20080255093A1 (en) * 1999-06-14 2008-10-16 Tam Peter Y Compositions and methods for treating obesity and related disorders
US7553818B2 (en) * 1999-06-14 2009-06-30 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7674776B2 (en) 1999-06-14 2010-03-09 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7659256B2 (en) * 1999-06-14 2010-02-09 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7056890B2 (en) * 1999-06-14 2006-06-06 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US20080103179A1 (en) * 2006-10-27 2008-05-01 Tam Peter Y Combination Therapy
CA2415093A1 (en) 2000-07-07 2002-01-17 Carlos Plata-Salaman Anticonvulsant derivatives useful for preventing the development of type ii diabetes mellitus and syndrome x
DE10035227A1 (en) * 2000-07-20 2002-01-31 Solvay Pharm Gmbh Selection and use of lipogenesis inhibitors for the treatment and prevention of obesity
US6946243B2 (en) 2000-07-20 2005-09-20 Solvay Pharmaceuticals Gmbh Method of identifying compounds suitable for treatment and/or prophylaxis of obesity
ATE334718T1 (en) * 2000-10-30 2006-08-15 Ortho Mcneil Pharm Inc COMBINATION THERAPY WITH ANTIDIABETIC AND ANTICONVULSIVE AGENTS
WO2002043731A2 (en) * 2000-11-30 2002-06-06 University Of Florida Treatments for neurogenetic disorders, impulse control disorders, and wound healing
US6462084B1 (en) 2001-05-14 2002-10-08 Brookhaven Science Associates, Llc Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US6559293B1 (en) 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
US20040029941A1 (en) * 2002-05-06 2004-02-12 Jennings Julianne E. Zonisamide use in obesity and eating disorders
WO2003097046A1 (en) 2002-05-17 2003-11-27 Duke University Method for treating obesity
US20050215552A1 (en) * 2002-05-17 2005-09-29 Gadde Kishore M Method for treating obesity
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
MXPA05000232A (en) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution.
US7208477B2 (en) * 2002-12-02 2007-04-24 University Of Florida Research Foundation, Inc. Treatments for benign tumors, cancers, neoplasias, and/or other inflammatory disorders or diseases
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
MXPA05011557A (en) * 2003-04-29 2006-03-09 Orexigen Therapeutics Inc Compositions for affecting weight loss.
US6949518B1 (en) 2003-06-25 2005-09-27 Pao-Hsien Chu Methods for treating macular degeneration with topiramate
AU2005206139B2 (en) 2004-01-13 2009-02-26 Duke University Compositions of an anticonvulsant and an antipsychotic drug for affecting weight loss
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
US20060160750A1 (en) * 2004-01-13 2006-07-20 Krishnan K R R Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss
US20060100205A1 (en) * 2004-04-21 2006-05-11 Eckard Weber Compositions for affecting weight loss
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US8691867B2 (en) * 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US20070155827A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US20070155823A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191453A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
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US20070191449A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
US20070191459A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
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US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
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US8580298B2 (en) 2008-06-09 2013-11-12 Vivus, Inc. Low dose topiramate/phentermine composition and methods of use thereof
US20090304789A1 (en) 2008-06-09 2009-12-10 Thomas Najarian Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9457005B2 (en) 2005-11-22 2016-10-04 Orexigen Therapeutics, Inc. Compositions and methods for increasing insulin sensitivity
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
US9107837B2 (en) 2006-06-05 2015-08-18 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
US9125868B2 (en) 2006-11-09 2015-09-08 Orexigen Therapeutics, Inc. Methods for administering weight loss medications
US9248123B2 (en) 2010-01-11 2016-02-02 Orexigen Therapeutics, Inc. Methods of providing weight loss therapy in patients with major depression

Also Published As

Publication number Publication date
HUP0001192A3 (en) 2002-09-30
RU2214241C2 (en) 2003-10-20
EP0915697B1 (en) 2002-09-18
ES2184127T3 (en) 2003-04-01
ATE224189T1 (en) 2002-10-15
IL127715A0 (en) 1999-10-28
EP0915697A2 (en) 1999-05-19
NZ333586A (en) 2000-05-26
HK1018743A1 (en) 2000-01-07
NO317754B1 (en) 2004-12-13
CA2258893A1 (en) 1998-01-08
AP1285A (en) 2004-06-24
CZ293876B6 (en) 2004-08-18
AU3957897A (en) 1998-01-21
CA2258893C (en) 2005-06-14
AU732923B2 (en) 2001-05-03
BR9710994A (en) 2000-10-24
HU226775B1 (en) 2009-09-28
SK284305B6 (en) 2005-01-03
NO986052D0 (en) 1998-12-22
DK0915697T3 (en) 2003-01-27
HUP0001192A2 (en) 2000-11-28
IL127715A (en) 2004-07-25
NO986052L (en) 1999-02-23
US6071537A (en) 2000-06-06
WO1998000130A2 (en) 1998-01-08
CZ427898A3 (en) 1999-08-11
DE69715631D1 (en) 2002-10-24
PT915697E (en) 2003-02-28
DE69715631T2 (en) 2003-05-08
AP9801429A0 (en) 1998-12-31
UA53655C2 (en) 2003-02-17
ZA975772B (en) 1998-12-28
CN1224352A (en) 1999-07-28
JP2000514425A (en) 2000-10-31
SK180598A3 (en) 2000-07-11
CN1106193C (en) 2003-04-23

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