WO1998059069A3 - Identification d'agents cancerogenes grace a un mammifere avec inhibition de la poly(adp-ribose)-polymerase - Google Patents
Identification d'agents cancerogenes grace a un mammifere avec inhibition de la poly(adp-ribose)-polymerase Download PDFInfo
- Publication number
- WO1998059069A3 WO1998059069A3 PCT/DE1998/001797 DE9801797W WO9859069A3 WO 1998059069 A3 WO1998059069 A3 WO 1998059069A3 DE 9801797 W DE9801797 W DE 9801797W WO 9859069 A3 WO9859069 A3 WO 9859069A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- agents
- cancerigenic
- adp
- ribose
- polymerase
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title abstract 2
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 title abstract 2
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 title abstract 2
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title abstract 2
- 230000000711 cancerogenic effect Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000033616 DNA repair Effects 0.000 abstract 1
- 239000003183 carcinogenic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50359699A JP2002507885A (ja) | 1997-06-24 | 1998-06-24 | ポリ(adpリボース)ポリメラーゼの阻害での哺乳類を使用する発癌性因子の同定方法 |
EP98941257A EP1015573A2 (fr) | 1997-06-24 | 1998-06-24 | Procede pour identifier des agents cancerogenes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19726824.2 | 1997-06-24 | ||
DE1997126824 DE19726824C1 (de) | 1997-06-24 | 1997-06-24 | Verfahren zur Identifizierung kanzerogener Agenzien |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998059069A2 WO1998059069A2 (fr) | 1998-12-30 |
WO1998059069A3 true WO1998059069A3 (fr) | 1999-04-29 |
Family
ID=7833520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1998/001797 WO1998059069A2 (fr) | 1997-06-24 | 1998-06-24 | Identification d'agents cancerogenes grace a un mammifere avec inhibition de la poly(adp-ribose)-polymerase |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1015573A2 (fr) |
JP (1) | JP2002507885A (fr) |
DE (1) | DE19726824C1 (fr) |
WO (1) | WO1998059069A2 (fr) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995024379A1 (fr) * | 1994-03-09 | 1995-09-14 | Newcastle University Ventures Limited | Analogues de benzamides utiles en tant qu'inhibiteurs de l'enzyme parp (adp-ribosyltransferase, adprt) de reparation de l'adn |
DE4433130A1 (de) * | 1994-09-16 | 1996-03-21 | Deutsches Krebsforsch | Identifizierung von DNA-schädigenden Substanzen durch Poly(ADP-Ribose)-Polymerase überexprimierende Zellinien |
WO1996018737A2 (fr) * | 1994-12-16 | 1996-06-20 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Vecteurs et virus utilises pour la therapie genique |
EP0757102A1 (fr) * | 1995-08-04 | 1997-02-05 | Plant Genetic Systems N.V. | Transformation génétique utilisant un inhibiteur de PARP |
-
1997
- 1997-06-24 DE DE1997126824 patent/DE19726824C1/de not_active Expired - Fee Related
-
1998
- 1998-06-24 EP EP98941257A patent/EP1015573A2/fr not_active Withdrawn
- 1998-06-24 JP JP50359699A patent/JP2002507885A/ja active Pending
- 1998-06-24 WO PCT/DE1998/001797 patent/WO1998059069A2/fr not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995024379A1 (fr) * | 1994-03-09 | 1995-09-14 | Newcastle University Ventures Limited | Analogues de benzamides utiles en tant qu'inhibiteurs de l'enzyme parp (adp-ribosyltransferase, adprt) de reparation de l'adn |
DE4433130A1 (de) * | 1994-09-16 | 1996-03-21 | Deutsches Krebsforsch | Identifizierung von DNA-schädigenden Substanzen durch Poly(ADP-Ribose)-Polymerase überexprimierende Zellinien |
WO1996018737A2 (fr) * | 1994-12-16 | 1996-06-20 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Vecteurs et virus utilises pour la therapie genique |
EP0757102A1 (fr) * | 1995-08-04 | 1997-02-05 | Plant Genetic Systems N.V. | Transformation génétique utilisant un inhibiteur de PARP |
Non-Patent Citations (3)
Title |
---|
KÜPPER, J.H. ET AL.: "Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen-induced gene amplification in SV40-transformed Chinese Hamter cells", CANCER RESEARCH, vol. 56, no. 12, 15 June 1996 (1996-06-15), MD US, pages 2715 - 2717, XP002090238 * |
KÜPPER, J.H. ET AL.: "Trans-dominant inhibition of poly(ADP-Ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-Nitro-N-nitroguanidine but does not limit DNA replication of a polyomavirus replicon", MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 6, WASHINGTON US, pages 3154 - 3163, XP002090237 * |
MOLINETE, M. ET AL.: "Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells", EMBO JOURNAL, vol. 12, no. 5, 1993, EYNSHAM, OXFORD GB, pages 2109 - 2117, XP002090239 * |
Also Published As
Publication number | Publication date |
---|---|
WO1998059069A2 (fr) | 1998-12-30 |
JP2002507885A (ja) | 2002-03-12 |
EP1015573A2 (fr) | 2000-07-05 |
DE19726824C1 (de) | 1999-03-04 |
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