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WO1998053737A1 - Procede et systeme pour determiner de maniere non invasive les parametres cardiorespiratoires principaux du corps humain - Google Patents

Procede et systeme pour determiner de maniere non invasive les parametres cardiorespiratoires principaux du corps humain Download PDF

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Publication number
WO1998053737A1
WO1998053737A1 PCT/IL1997/000174 IL9700174W WO9853737A1 WO 1998053737 A1 WO1998053737 A1 WO 1998053737A1 IL 9700174 W IL9700174 W IL 9700174W WO 9853737 A1 WO9853737 A1 WO 9853737A1
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WO
WIPO (PCT)
Prior art keywords
individual
arm
leg
electrodes
measured
Prior art date
Application number
PCT/IL1997/000174
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English (en)
Inventor
Alexander Tsoglin
Efim Frinerman
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N.I. Medical Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N.I. Medical Ltd. filed Critical N.I. Medical Ltd.
Priority to AU29133/97A priority Critical patent/AU2913397A/en
Priority to PCT/IL1997/000174 priority patent/WO1998053737A1/fr
Publication of WO1998053737A1 publication Critical patent/WO1998053737A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0535—Impedance plethysmography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/085—Measuring impedance of respiratory organs or lung elasticity
    • A61B5/086—Measuring impedance of respiratory organs or lung elasticity by impedance pneumography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography

Definitions

  • the present invention relates to non-invasive cardiac and respiratory monitors, more particularly, to such systems for determining cardiac and respiratory performance using electrical bioimpedance measure- ments.
  • U.S. Patent No. 5,469,859 discloses a non-invasive method and device for determination of the main cardiovascular parameters of a patient's body.
  • two or four electrodes are applied to the patient's body in a manner enabling the measurement of total body (integral) bioimpedance.
  • High stability amplitude alternating current is passed through the body by the electrodes to allow the obtaining of an integral impedance curve and derivation therefrom of an active (resistive) component.
  • the cardiorespirato- ry parameters of the body are calculated from the active component, using an empiric formulae, with the calculation being based on the average data obtained during a respiration cycle.
  • EBM electric bioimpedance measurement
  • the invention provides by a first of its aspects, a non-invasive method for determining the main cardiorespiratory parameters of an individual.
  • electrodes are applied to at least two of the individual's arms and legs, a high stability amplitude alternating current is injected through the electrode into the body, and an impedance curve is thus obtained.
  • An active (i.e. resistive) component is then separated from the impedance and by employing an empiric formula applicable to integral bioimpedance measurements, cardiorespiratory parameters of the individual are calculated from said active component.
  • a method for non-invasively determining at least one main cardiorespiratory parameter of an individual comprising the steps of: attaching at least two electrodes to the individual's body in a manner ensuring a low impedance contact between the electrodes and the individual's skin, and positioning the electrodes so that current which passes between the at least two electrodes flows between at least one arm or at least one leg to at least another arm or at least another leg of the individual; passing an alternating current with a stable and constant amplitude through said at least two electrodes and at the same time, measuring the potential change as the result of the current flow, whereby an electrical bioimpedance measurement of the individual's body from the measured potential between the said at least two electrodes is obtained; simultaneously separating an active component from said bioimpedance; calculating the at least one cardiorespiratory parameter of said individual from the active component of said bioimpedance, using an empiric formula applicable to integral bioimpedance measurements, in such a manner
  • the basic hemodynamic parameter Stroke Volume may be calculated according to the following semi-empiric formula applicable to integral bioimpedance measurements:
  • Hct Hematocrit obtained from the blood analysis of the individual
  • K(shape*sex*age) a coefficient of the individual's body, being: men younger than 20 years old women younger than 18 years old
  • ⁇ r the amplitude value of the change of the individual's body basic resistance R on the anacrotic (systolic) portion of a cardiocycle.
  • Hcorr ( # «* ) if 0- 62 ⁇ 1Cngth ⁇ 0.58 ree body length
  • Kel coefficient of electrolytic ions in the individual's blood calculated based on the blood analysis and being given by: a) for an individual exposed to a hemodialysis
  • IB Index Balance reflecting ratio between the measured volume of extracellular fluids and the individual's proper volume of extracellular fluids. This is calculated on the basis of a formula for the "ideal content of body water", adapted from Kushner, R.T. et al, (Amer. J. Clin. Nutr. , 44:417-424, 1986):
  • R measured the individual's active (resistive) component of the bioimpedance measured either by tetrapolar mode, or by bipolar mode with correction to the individual's skin resistance.
  • R individual's proper is calculated according to the two following formulae:
  • the electrodes may, in principle, be attached to any portion of the individual's extremities, and preferably to distal parts thereof.
  • the method in accordance with the invention can be carried out either in a bipolar or a tetrapolar mode.
  • a bipolar mode of carrying out the invention at least two electrodes are utilized, wherein any electrode attached to an arm or a leg is used both for current injection and voltage measurement.
  • a tetrapolar mode of carrying out the invention at least four electrodes are utilized; different electrodes are used for current injection than those which are used for voltage measurement.
  • the arm or leg under examination is typically fitted with two electrodes, the current injection being between a first pair of electrodes located each on a different arm or leg, and the voltage is measured by a second pair of electrodes, located on same, respective, arm or leg.
  • two electrodes are usually utilized. Where two electrodes are being used they are typically attached, one to an arm and the other to a contralateral leg. However, it is possible to determine the main cardiorespiratory parameters by attaching the two electrodes to the two arms of the individual, to the two legs, or to one arm and one semi-lateral leg. Although the attachment of one electrode to an arm and the other to a contralateral leg is preferred, the other mode of attachments may at times be used where an arm or a leg are diseased in a manner which avoids attachment and/or obtaining accurate or reliable readings.
  • two electrodes connected to one another are attached to each of the individual's arms, and another two electrodes, again connected to one another, are attached to each of the individual's legs.
  • the current in injected in parallel between the two arms and the two legs and the voltage is simultaneously measured also between the two arms and the two legs.
  • an auxiliary pair of current injecting electrodes is used in addition to the standard pair of current injecting electrodes applied in accordance with the bipolar mode described above, and constituting also the voltage measuring electrodes.
  • the auxiliary current injecting electrodes are attached so that each one of the pair of such electrodes is placed at a certain distance, e.g.
  • the auxiliary current injecting electrodes will be placed on the same arms and legs, a certain distance from the standard electrode pair.
  • the auxiliary electrodes will be placed to be more distal than the standard electrodes.
  • current will first be passed through the standard electrodes and voltage will be measured by the same standard electrodes.
  • Current will then be passed through the auxiliary electrodes and voltage will be measured again between the standard electrodes, the difference in measured voltage being accountable for the skin resistance.
  • the standard measurement is made by utilizing the bipolar mode, but for the auxiliary measurement the tetrapolar mode is used, in which the electrodes utilizing the bipolar mode serve then for voltage measurement only.
  • the electrodes utilizing the bipolar mode serve then for voltage measurement only.
  • R j - is the skin resistance, i.e. resistance between the current injection electrode and the skin in the bipolar mode
  • R j - is the individual's resistance measured between two electrodes according to the bipolar mode
  • R 2 - is the resistance measured in the same individual when applying the tetrapolar mode.
  • the measured active component of the individual's bioimpedance which forms a basis for the calculation of main cardiorespiratory parameters, constitutes R j . Since the value of skin resistance R s may vary during the measurements, the value of the measured resistive component should be adjusted, so as to reduce the error of measurement.
  • the skin resistance may have also a separate diagnostic significance.
  • the general approach in the art for example that of Lukaski, et al, (The American Journal of Clinical Nutrition, 41:810-817, 1985) states that various configurations of electrode's placement (i.e., arm-leg, leg-leg, arm-arm) do not substantially affect results of whole body EBM measurements, more particularly, measurements of the resistive component R of the bioimpedance.
  • results obtained at different electrodes' configurations may be somewhat different from one another, and therefore by comparison of such different results, it is possible to obtain information having a diagnostic significance.
  • the readings obtained are influenced primarily by the pulmonary circulatory system and functions of the individual's right ventricle.
  • the results will characterize a systemic circulation (represented mainly by the aorta) and thus will reflect functions of the individual's left ventricle.
  • Step 1 Examination of the peripheral blood circulation
  • parameter P represented by the following equation (8) (see below) and forming part of the equation (1) can be chosen:
  • portions of the equation (8) may be used as parameters P 1 ⁇ P 2 or P 3 represented by the following formulae (9-11):
  • the peripheral circulation i.e. the circulation in the arms and legs is checked using the basic "leg-leg", "arm -arm ", and "arm -leg "connectivity configurations together with an addition connectivity configurations, which include measurement between pairs of electrodes, one situated at a distal part of an arm or leg and the other on the shoulder or hip.
  • the readings of P and P 1 -P 3 which are obtained using the "leg- leg” configuration are characteristic primarily of the individual's peripheral blood circulation (i.e., without the aorta and the pulmonary arteries).
  • a pair of additional electrodes may be attached to the individual's hips, to provide EBM measurements between the distal parts of the leg and the hip for each leg. Values of P and ? x to P 3 which are obtained for both legs, may then be compared to one another and with the value of the proper P and proper Pj to P 2 , for the individual (i.e. values for these parameters which are obtained with R proper - see equation (6).
  • a pathologic arm may be diagnosed in an analogous manner applying additional electrodes to the shoulders of the individual, obtaining readings of P and Pi-P 3 , and processing thereof, in a similar manner as in the leg.
  • Step 2 Examination of left ventricle and right ventricle functions
  • the parameters such as the Stroke Volume (SV) and the Index Balance (IB)
  • SV Stroke Volume
  • IB Index Balance
  • LVHF left ventricle heart failure
  • impaired blood may accumulate in the lungs even when the output of the left ventricle is normal or increased, but it is lagging behind that of the right ventricle, i.e.
  • the left ventricle is unable to sufficiently increase its output to clear the lungs. Such a case may occur when a patient suffers from fever, anemia, beriberi, thyrotoxicosis, etc., where normal function of the left ventricle is impared by the desease. It is understood that if the SV value measured by the "arm-leg" electrode's placement (and predominantly characterizing functions of the left ventricle) is substantially less than the normal known SV value for the left ventricle, it indicates the left vetricle heart failure (LVHF).
  • LVHF left vetricle heart failure
  • the SV value measured by the "arm-leg" electrode's placement (and predominantly characterizing functions of the left ventricle) is substantially lower than the SV value measured by the "arm -arm "electrodes placement, this may be an indication of at least one of the following:
  • the discrepancy may be indicative of the existence of disturbances in the lung blood circulation.
  • a non-invasive medical device for accurately determining at least one cardiorespiratory parameter of the human body, said device comprising: at least two electrodes, electrical body integral bioimpedance measuring unit coupled to the electrodes and including a high stability amplitude alternative current source and an electronic circuit for automatic derivation of an active component of said integral bioimpedance; and a computer coupled to the electrical integral bioimpedance measuring unit and to a display means for calculating and displaying said at least one cardiorespiratory parameter from the active component of the integral bioimpedance.
  • Fig. 1 is a representation of a number of cardiac cycles during a respiratory cycle and the corresponding electrocardiography (ECG) measurement for illustrating the averaging method according to the invention
  • Fig. 2A is a block diagram showing functionally a measuring system according to the invention using two electrodes applied to an individual's one arm and one leg, respectively;
  • Fig. 2B is a schematic circuit diagram representing the system shown in Fig. 2A;
  • Figs. 2C, 2D and 2E depict bipolar and tetrapolar modifications of the system shown in Fig. 2A;
  • Fig. 2F illustrates a measuring system using two (or four) electrodes applied to two arms of the individual
  • Fig. 2G illustrates a measuring system using two (or four) electrodes applied to the individual's legs
  • Fig. 2H illustrates the best mode of electrodes' placement suitable both for obtaining the main cardiorespiratory parameters according to the invention, and for diagnosing disturbances in the heart right and left ventricle functions and in the peripheral blood circulation;
  • Fig. 3 is a block diagram showing one embodiment of an electrical bioimpedance measuring system according to the invention.
  • Figs. 4A and 4B are a flow chart showing the principal steps in a method for using the measuring system according to the invention. DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
  • Fig. 1 illustrates two curves.
  • the lower curve 2 is a superposition of two curves, a curve 4 reflecting resistive changes of the bioimpedance caused by the respiration process, and another curve (not shown alone) representing resistive changes of the bioimpdance resulting from the cariac cycles.
  • the upper curve 6 is an ECG curve.
  • the ECG curve may serve for the synchronization of the bioimpedance measurement, namely it defines time boundaries of cardiac cycles.
  • a number of readings of the parameter must be obtained for a number of cardiac cycles during a single respiratory cycle (for example, three readings in the specific illustrative example of curve 2), and then an average of the measured readings is to be defined.
  • the readings may be obtained during more than one respiratory cycle.
  • Figs. 2A and 2B show respectively a block-diagram of a non- invasive two-electrode system for automatic express determination of the main cardiorespiratory parameters of a patient 10 and an equivalent electrical circuit diagram of the patient 10.
  • Two electrodes 11 are applied to the distal parts of one arm and one leg of the individual.
  • a first electrode 11a is connected to the distal part of the left arm, and a second electrode lib to the distal part of the patient's right leg.
  • An electrical integral bioimpedance measuring unit 12 delivers a high stability amplitude alternating current through a single channel 13, via the electrodes 11 to the individual 10.
  • the integral impedance curve of the individual 10 is obtained from the same electrodes 11 and is transferred through the same single channel 13 to the measuring unit 12, which converts the integral impedance curve.
  • the converted working signal is then transferred through a second single channel 14 to a computer 15, where cardiorespiratory parameters of the whole body and parameters concerning extracellular fluids of the whole body are calculated using empiric formulae.
  • Personal data characteristic of the individual 10 which is entered into the computer 15 via a keyboard (not shown) can also be taken into account when calculating the cardiorespiratory parameters.
  • the personal data includes height, weight, age, sex, results of a blood test, identification index, etc.
  • An output signal 14 from the electrical integral bioimpedance measuring unit 12 is fed to the computer 15 and stored in an internal table.
  • Preliminary processing of the raw data is performed so as to derive a plethysmographic and rheographic curve, on the basis of which the respiratory cycle and heart beat complex indices (marks) are determined (the beginning of the anacrotic slope, the length of heart complexes' cycle, their maximum amplitude, e.g. by locating extremes of the curves, etc.) ( see Fig.l).
  • the area section under the initial impedance curve reflecting the phases of the fast and slow ejection of the blood during a cardiocycle is used for computing the main parameters. Based on this data and the individual's personal data, the parameters are determined using empiric formulae, such as those described in the present specification.
  • the computer 15 may be programmed to calculate a plurality of parameters based on the above definition of the Stroke Volume equation (1).
  • Figs. 2C to 2G Some other possible variants of the electrodes configurations are shown in Figs. 2C to 2G. In each case, either two or four electrodes may be connected to the patient. In case of the former, the arrangement reduces to the bipolar system described above with reference to Figs. 2A and 2B of the drawings. If the electrodes which are shown by dotted lines are also connected, then the arrangement yields a tetrapolar scheme in which two of the electrodes are active in injecting the current, whilst two of the electrodes are passive and measure the resultant signal.
  • Calculation of the cardiovascular parameters in this configuration needs specific corrections in comparison with hitherto-proposed calculations for the four-electrode system. These corrections may require means of adjusting of the empiric coefficients as defined above.
  • Fig. 2H illustrating the best mode of electrodes' placement suitable both for obtaining the main cardiorespiratory parameters according to the invention, and for diagnosing of disturbances in the heart right and left ventricle functions and in the periphery blood circulation.
  • Electrodes To the distal parts of all the individual's two arms and two legs, four electrodes are attached which are marked “a " in the figure, for measurement by the bipolar mode. Another pair of current injecting electrodes, marked “b", are attached to one arm and one leg of the individual, typically the right arm and the right leg. These electrodes which are preferably placed, as shown in the figure, in a more peripheral position than the "a " electrodes, are used to measure the skin resistance, R s , by the combined bipolar/tetrapolar mode described above.
  • Four additional and optional electrodes, marked “c” are attached to the shoulders and to the hips of the individual, which are used for the purpose of obtaining information on t ⁇ e peripheral circulation, the blood circulation in the arms and legs.
  • This electrode configuration thus allows derivation of a complete set of cardiorespiratory parameters, as described above, and also functional circulatory parameters, distribution of the extracellular fluid throughout the body, and diagnosis of disturbances in the blood circulation and in the heart right and left ventricle functions.
  • FIG. 2A there is introduced a multiplexer 16 enabling to perform a so-called multi-channel measurement.
  • a multi-channel mode allows, for example, to select a preferred electrode attachment for further bioimpedance measurements on the body of the individual.
  • Fig. 3 is a block-diagram of an electrical bioimpedance measuring system 60 according to the invention.
  • the Bioimpedance Measuring Unit is unit 61 in the drawing. It should be noted, that though two electrodes 62 and 63 are shown applied to the patient's arm and leg, according to the invention they may be applied to any two patient's extremities, and the block diagram may comprise a multiplexer, as shown in Fig. 2H.
  • a micro-controller 65 (such as model 80196KC manufactured by Intel * ) combining the functions of the A/D converter and a microprocessor, is provided for processing in real time a curve obtained from the ECG circuit 64, together with the curve obtained from the Bioimpedance Measuring Unit 61 and being a composition of a direct "R" and an alternating “or” components of an active bioimpedance component. Additionally, the micro-controller 65 receives the initial complete bioimpedance curve from the Bioimpedance Measuring Unit 61.
  • the micro-controller 65 and a computer 66 (such as a note-book computer) continuously calculate a capacitance of the electric circuit of the human body. It should be clarified that, from the electric point of view, the human body behaves as an RC (resistance-capacitance) impedance.
  • the value of the capacitance of the human body can be calculated bv the formula:
  • An excess of the capacitance over a predetermined threshold, or oscillation of the capacitance indicates degradation of the contacts between the electrodes and the patient's skin.
  • an appropriate alarm is activated under control of the computer 66.
  • the outputs of the microcontroller 65 are connected to the computer 66 via isolation circuits 67 (such as opto-isolators MOC 8080, Motorola * ) providing electrical protection of the patient from a random voltage, via a correction circuit 68 (such as the driver RS232C) and an appropriate RS232C cable 69.
  • the correction circuit 68 and the micro-controller 65 are supplied with electrical voltage of +5V from the computer 66.
  • the voltage ⁇ 5V from the power supply 70 is converted to +5V by a DC/DC converter 71.
  • the DC/DC converter 71 also performs a function of an isolation circuit.
  • the power supply unit 70 provides the blocks of the instrument 60 with electrical power of ⁇ 5V.
  • Figs. 4A and 4B shows a flow chart diagram of an algorithm of measuring of the main cardiorespiratory parameters in accordance with which the system functions.
  • step 98 the system is switched on, and, if the measurements are provided via a multiplexer, one channel (i.e. a specific electrode attachment) is selected for the bioimpedance measurements on the individual's body.
  • a channel is chosen after performing a number of preliminary measurements via different electrode attachments, and each os such measurements actually are made according to the flow chart which is described later on.
  • Step 98 allows to chose a pair of healthy extremities for the main session of the measurements and provides information which may be useful for diagnostic purposes.
  • the duration of the monitoring session is chosen.
  • the duration of the monitoring session can be defined as a duration of an initial bioimpedance curve section intended for an averaged calculation of the necessary parameters, and can be chosen in the range of about 10 to 30 sec.
  • a check is performed in order to determine whether the information from the Bioimpedance Measurement Unit 61 is obtained on the display. If not, the reason should be detected and indicated by at least one of the following test blocks:
  • Block 104 The impedance between electrodes and the skin is not stable; Block 106 There is no contact in the cable RS232C;
  • Block 108 The ECG electrodes contact is poor; Block 110 A poor contact of the bioimpedance measuring electrodes.
  • step 102 After overcoming the reason for the malfunction, the cycle should be started again (returning to step 102). If no exit command were keyed by an operator (block 112), the digital test readings of R (active impedance), C (capacitance), and Z (complete impedance) will be displayed in real time on the display (step 114). When these parameters are stabilized (step 116), the next procedure is started wherein the QRS pulse is derived from the ECG curve (step 118) for marking the bioimpedance curve.
  • Step 120 represents the processes of marking of the bioimpedance curve by the marks obtained at step 118, further processing of the rheographic information and computing the main cardiorespiratory parameters being based on the average data obtained during a respiration cycle.
  • the parameters in the system can be computed either in a regime of a single measurement (step 124), or in a continuous regime (step 126).
  • the computed parameters may be stored in the computer in one of the following two ways: the values of the parameters can be either entered into a data base of the patient in the computer (step 132), or the parameters can be written down as a temporary protocol in the computer (step 134). At step 130 it is decided whether or not the data base should be used for the record of the computed parameters.
  • step 136 When the single monitoring session is finished, a plurality of the computed parameters are indicated on the display (step 136). At step 138 there is defined whether or not to repeat the measurements.
  • the order to repeat the measurements can be entered either manually by the operator, or automatically, if the continuous regime were chosen. If such an order is received, another monitoring session will be started, and additional readings of the parameters will be recorded. If the measurements are not to be repeated, the process will be stopped at step 140.
  • the method according to the invention comprises applying the electrodes according to either a bipolar or tetrapolar system.
  • a preliminary connection of four electrodes may be effected to the respective distal parts of the human extremities, whereafter the integral impedance is preliminarily measured between each pair of electrodes placed on each arm and leg. Determination of the main cardiorespiratory parameters of the human body is made in accordance with which pair of electrodes is characterized by the lowest integral impedance.
  • the method according to the invention further includes a computerized calculation of parameters concerning extracellular fluids of the patient's body, the calculations being based on measurements accomplished at two different current frequencies.
  • the method according to one aspect of the invention may be employed for diagnosing some cardiorespiratory and blood cifculation diseases, for example for revealing the pathological extremities, where arterial blood circulation defects occur or another pathological defect takes place.
  • a plurality of such parameters are calculated by said method, including hemodynamic parameters such as Stroke Volume, Systolic Index, Pulse Rate, Cardiac Output, Heart Index, Reserve Index, Total Resistance Index, Index of Tone Stabilization; and respiratory parameters such as Rate of Respiration, Index of Respiration changes, Index of Respiration Intensiveness, Index of Hemodynamic Security; and additional parameters, such as Index of Respiratory Duration and Index of Tidal Respiratory Volume.
  • hemodynamic parameters such as Stroke Volume, Systolic Index, Pulse Rate, Cardiac Output, Heart Index, Reserve Index, Total Resistance Index, Index of Tone Stabilization
  • respiratory parameters such as Rate of Respiration, Index of Respiration changes, Index of Respiration Intensiveness, Index of Hemodynamic Security
  • additional parameters such as Index of Respiratory Duration and Index of Tidal Respiratory Volume.
  • a plurality of parameters characterizing extracellular fluids of the human body are calculated, such as Volume of Extracellular Fluids of the whole patient's body and Index of Fluid Balance of the whole body.

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Abstract

L'invention concerne un procédé et un système qui permettent de déterminer de manière non invasive au moins un paramètre cardiorespiratoire principal (tel que le volume d'éjection systolique) et au moins un paramètre caractérisant l'équilibre du liquide extracellulaire dans le corps (bilan hydrique, par exemple), et de diagnostiquer des problèmes circulatoires et/ou des défaillances des fonctions cardiaques. Pour déterminer le paramètre cardiorespiratoire principal, on fixe au moins deux électrodes sur le corps d'un individu de manière à pouvoir effectuer des mesures d'impédance bioélectrique sur l'ensemble du corps de l'individu, puis on fait circuler du courant alternatif à une amplitude stable et constante à travers les électrodes; on mesure ensuite l'impédance bioélectrique intégrale en fonction du flux de courant, puis on sépare simultanément une composante active de l'impédance bioélectrique intégrale; on calcule enfin le paramètre cardiorespiratoire de l'individu à partir de la composante active obtenue, au moyen d'une formule empirique applicable aux mesures d'impédance bioélectrique. Le calcul consiste à obtenir un certain nombre de valeurs du paramètre pour un certain nombre de cycles cardiaques pendant un cycle respiratoire, puis à calculer une moyenne du paramètre cardiorespiratoire pendant un seul cycle respiratoire.
PCT/IL1997/000174 1997-05-30 1997-05-30 Procede et systeme pour determiner de maniere non invasive les parametres cardiorespiratoires principaux du corps humain WO1998053737A1 (fr)

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AU29133/97A AU2913397A (en) 1997-05-30 1997-05-30 Method and system for non-invasive determination of the main cardiorespiratory parameters of the human body
PCT/IL1997/000174 WO1998053737A1 (fr) 1997-05-30 1997-05-30 Procede et systeme pour determiner de maniere non invasive les parametres cardiorespiratoires principaux du corps humain

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Cited By (6)

* Cited by examiner, † Cited by third party
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WO2003003920A3 (fr) * 2001-07-05 2003-04-17 Gennady Gedevanishvili Procede et dispositif de recherche non invasive de distribution sanguine et de ses caracteristiques circulatoire chez des organismes a sang chaud
EP1275342A3 (fr) * 2001-07-10 2004-04-14 CardioDynamics International Corporation Dispositif et méthode pour la détermination du débit cardiaque d'un sujet vivant
US7251524B1 (en) 2000-07-10 2007-07-31 Cardiodynamics International Corporation Apparatus and method for determining cardiac output in a living subject
WO2010091693A1 (fr) 2009-02-12 2010-08-19 JR Medical OÜ Cardiographe multicanaux à impédance et procédé de cardiographie multicanaux à impédance
CN111803042A (zh) * 2020-07-13 2020-10-23 深圳市泽辉医疗技术有限公司 血流动力学参数检测装置及方法
CN113727644A (zh) * 2019-04-18 2021-11-30 麦层移动健康管理有限公司 一种测量心肌组织运动特征的非侵入性方法及系统

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US5469859A (en) * 1992-06-24 1995-11-28 N.I. Medical Ltd. Non-invasive method and device for collecting measurements representing body activity and determining cardiorespiratory parameters of the human body based upon the measurements collected

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7251524B1 (en) 2000-07-10 2007-07-31 Cardiodynamics International Corporation Apparatus and method for determining cardiac output in a living subject
WO2003003920A3 (fr) * 2001-07-05 2003-04-17 Gennady Gedevanishvili Procede et dispositif de recherche non invasive de distribution sanguine et de ses caracteristiques circulatoire chez des organismes a sang chaud
EP1275342A3 (fr) * 2001-07-10 2004-04-14 CardioDynamics International Corporation Dispositif et méthode pour la détermination du débit cardiaque d'un sujet vivant
WO2010091693A1 (fr) 2009-02-12 2010-08-19 JR Medical OÜ Cardiographe multicanaux à impédance et procédé de cardiographie multicanaux à impédance
CN113727644A (zh) * 2019-04-18 2021-11-30 麦层移动健康管理有限公司 一种测量心肌组织运动特征的非侵入性方法及系统
EP3957239A4 (fr) * 2019-04-18 2022-05-04 Msheaf Health Management Technologies Limited Procédé et système non invasifs pour mesurer une caractéristique de mouvement d'un tissu myocardique
JP2022528823A (ja) * 2019-04-18 2022-06-16 麦層移動健康管理有限公司 心筋組織の運動特徴を測定するための非侵襲的方法及びシステム
CN111803042A (zh) * 2020-07-13 2020-10-23 深圳市泽辉医疗技术有限公司 血流动力学参数检测装置及方法

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