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WO1998053069A3 - Gdnf receptors - Google Patents

Gdnf receptors Download PDF

Info

Publication number
WO1998053069A3
WO1998053069A3 PCT/US1998/010328 US9810328W WO9853069A3 WO 1998053069 A3 WO1998053069 A3 WO 1998053069A3 US 9810328 W US9810328 W US 9810328W WO 9853069 A3 WO9853069 A3 WO 9853069A3
Authority
WO
WIPO (PCT)
Prior art keywords
gdnfr
cell line
factor receptor
neurotrophic factor
derived neurotrophic
Prior art date
Application number
PCT/US1998/010328
Other languages
French (fr)
Other versions
WO1998053069A2 (en
Inventor
Jian Ni
Tsu-An Hsu
Paul Young
Reiner L Gentz
Steven M Ruben
Original Assignee
Human Genome Sciences Inc
Jian Ni
Hsu Tsu An
Paul Young
Reiner L Gentz
Steven M Ruben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Jian Ni, Hsu Tsu An, Paul Young, Reiner L Gentz, Steven M Ruben filed Critical Human Genome Sciences Inc
Priority to AU75838/98A priority Critical patent/AU7583898A/en
Publication of WO1998053069A2 publication Critical patent/WO1998053069A2/en
Publication of WO1998053069A3 publication Critical patent/WO1998053069A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a novel glial cell line-derived neurotrophic factor receptor beta (GDNFR-β) and novel glial cell line-derived neurotrophic factor receptor gamma 1 and 2 (GDNFR-ηl and GDNFR-η2). The receptors of the present invention share high homology with glial cell line-derived neurotrophic factor receptor alpha and have been named GDNFR-β, GDNFR-η1 and GDNFR-η2. More specifically, isolated nucleic acid molecules are provided encoding human GDNFR-β, GDNFR-η1 and GDNFR-η2 receptors. GDNFR-β, GDNFR-η1 and GDNFR-η2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of GDNFR-β, GDNFR-η1 and GDNFR-η2 activity. Also provided are diagnostic and therapeutic methods for disorders and diseases including Parkinson's disease, thyroid tumor, kidney failure and gut dysfunction.
PCT/US1998/010328 1997-05-20 1998-05-20 Gdnf receptors WO1998053069A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU75838/98A AU7583898A (en) 1997-05-20 1998-05-20 Gdnf receptors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4709297P 1997-05-20 1997-05-20
US60/047,092 1997-05-20
US88463897A 1997-06-27 1997-06-27
US08/884,638 1997-06-27

Publications (2)

Publication Number Publication Date
WO1998053069A2 WO1998053069A2 (en) 1998-11-26
WO1998053069A3 true WO1998053069A3 (en) 1999-02-25

Family

ID=26724625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/010328 WO1998053069A2 (en) 1997-05-20 1998-05-20 Gdnf receptors

Country Status (2)

Country Link
AU (1) AU7583898A (en)
WO (1) WO1998053069A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696259B1 (en) 1995-11-13 2004-02-24 Licentia Ltd. Assays using glial cell line-derived neurotrophic factor receptors
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
NZ501199A (en) * 1997-05-22 2001-12-21 Carlos F Glial cell line-derived neurotrophic factor receptors (BDNFR-beta)
JP4469935B2 (en) * 1998-03-23 2010-06-02 ジェネンテック， インコーポレイテッド GFRα3 and uses thereof
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
DE19816186A1 (en) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-encoding DNA, parts thereof and GDNF variants
CA2728351A1 (en) * 2008-06-16 2010-01-14 Chiralix B.V. Peptidylarginine deiminase (pad) inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044356A2 (en) * 1996-05-08 1997-11-27 Biogen, Inc. RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044356A2 (en) * 1996-05-08 1997-11-27 Biogen, Inc. RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADAMS M D ET AL: "3,400 NEW EXPRESSED SEQUENCE TAGS IDENTIFY DIVERSITY OF TRANSCRIPTSIN HUMAN BRAIN", NATURE GENETICS, vol. 4, no. 3, July 1993 (1993-07-01), pages 256 - 267, XP000611495 *
ADAMS M D ET AL: "INITIAL ASSESSMENT OF HUMAN GENE DIVERSITY AND EXPRESSION PATTERNS BASED UPON 83 MILLION NUCLEOTIDES OF CDNA SEQUENCE", NATURE, vol. 377, 28 September 1995 (1995-09-28), pages 3 - 17, XP002042918 *
BALOH, R.H. ET AL.: "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.", NEURON, vol. 18, May 1997 (1997-05-01), pages 793 - 802, XP002072635 *
DATABASE EMBL - EMEST11 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST56965 Infant brain Homo sapiens cDNA 5' end.", XP002072636 *
DATABASE EMBL - EMEST11 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST90281 Synovial sarcoma Homo sapiens cDNA 5' end.", XP002072637 *
JING S ET AL: "GDNF-INDUCED ACTIVATION OF THE RET PROTEIN TYROSINE KINASE IS MEDIATED BY GDNFR-ALPHA, A NOVEL RECEPTOR FOR GDNF", CELL, vol. 85, 28 June 1996 (1996-06-28), pages 1113 - 1124, XP002036435 *

Also Published As

Publication number Publication date
AU7583898A (en) 1998-12-11
WO1998053069A2 (en) 1998-11-26

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