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WO1998050325A3 - Building blocks derived from 1,2-aminoalcohols - Google Patents

Building blocks derived from 1,2-aminoalcohols Download PDF

Info

Publication number
WO1998050325A3
WO1998050325A3 PCT/US1998/009383 US9809383W WO9850325A3 WO 1998050325 A3 WO1998050325 A3 WO 1998050325A3 US 9809383 W US9809383 W US 9809383W WO 9850325 A3 WO9850325 A3 WO 9850325A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
independently
protecting group
aminoalcohols
building blocks
Prior art date
Application number
PCT/US1998/009383
Other languages
French (fr)
Other versions
WO1998050325A2 (en
Inventor
Richard L Gabriel
Jurjus Jurayj
Original Assignee
Pharm Eco Lab Inc
Richard L Gabriel
Jurjus Jurayj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharm Eco Lab Inc, Richard L Gabriel, Jurjus Jurayj filed Critical Pharm Eco Lab Inc
Priority to CA002289120A priority Critical patent/CA2289120A1/en
Priority to EP98920336A priority patent/EP0984926A2/en
Priority to AU72937/98A priority patent/AU744060B2/en
Priority to IL13281298A priority patent/IL132812A0/en
Priority to JP54851198A priority patent/JP2001525810A/en
Publication of WO1998050325A2 publication Critical patent/WO1998050325A2/en
Publication of WO1998050325A3 publication Critical patent/WO1998050325A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/10—Isocyanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/13—Amines containing three or more amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Disclosed are novel compounds represented by structural Formula (XX), (XXI) or (XXII); R1, R21 and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 and R12 are independently -NR4R5 or -N?+ C-. R¿3 is -H or an alcohol protecting group. R4 and R5 are independently -H or an amine protecting group. R11 is a side chain of a naturally occurring amino acid or a protected side chain of a naturally occurring amino acid. R1 and R2, and R11 and R12, taken together with the methine group to which they are bonded, can form a moiety represented by structural Formula (XXIII). R6 is -H or an amine protecting group. R7 is -H, -OH or -OR8. R8 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.
PCT/US1998/009383 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols WO1998050325A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002289120A CA2289120A1 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols
EP98920336A EP0984926A2 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols
AU72937/98A AU744060B2 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols
IL13281298A IL132812A0 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols
JP54851198A JP2001525810A (en) 1997-05-09 1998-05-08 Partial structure derived from 1,2-amino alcohol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4612997P 1997-05-09 1997-05-09
US60/046,129 1997-05-09

Publications (2)

Publication Number Publication Date
WO1998050325A2 WO1998050325A2 (en) 1998-11-12
WO1998050325A3 true WO1998050325A3 (en) 1999-02-11

Family

ID=21941779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/009383 WO1998050325A2 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols

Country Status (6)

Country Link
EP (1) EP0984926A2 (en)
JP (1) JP2001525810A (en)
AU (1) AU744060B2 (en)
CA (1) CA2289120A1 (en)
IL (1) IL132812A0 (en)
WO (1) WO1998050325A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864051A (en) * 1988-09-02 1989-09-05 E. R. Squibb & Sons, Inc. Process for preparing 2-methoxyisobutylisonitrile
WO1997009051A1 (en) * 1995-09-05 1997-03-13 Cambridge Neuroscience, Inc. Analogs for specific oligosaccharide-neuregulin interactions and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864051A (en) * 1988-09-02 1989-09-05 E. R. Squibb & Sons, Inc. Process for preparing 2-methoxyisobutylisonitrile
WO1997009051A1 (en) * 1995-09-05 1997-03-13 Cambridge Neuroscience, Inc. Analogs for specific oligosaccharide-neuregulin interactions and uses thereof

Also Published As

Publication number Publication date
JP2001525810A (en) 2001-12-11
WO1998050325A2 (en) 1998-11-12
CA2289120A1 (en) 1998-11-12
AU744060B2 (en) 2002-02-14
EP0984926A2 (en) 2000-03-15
IL132812A0 (en) 2001-03-19
AU7293798A (en) 1998-11-27

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