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WO1998046589B1 - Composes d'amide d'indazole utilises comme agents serotoninergiques - Google Patents

Composes d'amide d'indazole utilises comme agents serotoninergiques

Info

Publication number
WO1998046589B1
WO1998046589B1 PCT/EP1998/002129 EP9802129W WO9846589B1 WO 1998046589 B1 WO1998046589 B1 WO 1998046589B1 EP 9802129 W EP9802129 W EP 9802129W WO 9846589 B1 WO9846589 B1 WO 9846589B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
hydrogen
pharmaceutically acceptable
isopropyl
Prior art date
Application number
PCT/EP1998/002129
Other languages
English (en)
Other versions
WO1998046589A2 (fr
WO1998046589A3 (fr
Filing date
Publication date
Priority claimed from IT97MI000867A external-priority patent/IT1291569B1/it
Priority to UA99116211A priority Critical patent/UA58550C2/uk
Priority to AU72159/98A priority patent/AU740360B2/en
Priority to SI9830218T priority patent/SI0975623T1/xx
Priority to HU0002057A priority patent/HU227973B1/hu
Priority to DK98919257T priority patent/DK0975623T3/da
Priority to EP98919257A priority patent/EP0975623B1/fr
Priority to JP54347598A priority patent/JP4578581B2/ja
Priority to IL13212798A priority patent/IL132127A/xx
Priority to AT98919257T priority patent/ATE219490T1/de
Application filed filed Critical
Priority to KR1019997009198A priority patent/KR100563867B1/ko
Priority to CA002286870A priority patent/CA2286870C/fr
Priority to DE69806141T priority patent/DE69806141T2/de
Priority to US09/403,007 priority patent/US6197769B1/en
Priority to EA199900935A priority patent/EA002352B1/ru
Priority to SK1423-99A priority patent/SK284731B6/sk
Publication of WO1998046589A2 publication Critical patent/WO1998046589A2/fr
Publication of WO1998046589A3 publication Critical patent/WO1998046589A3/fr
Publication of WO1998046589B1 publication Critical patent/WO1998046589B1/fr
Priority to BG103863A priority patent/BG64006B1/bg
Priority to HK00107144A priority patent/HK1027811A1/xx

Links

Abstract

L'invention a pour objet un composé présentant la formule générale (I) dans laquelle R1, R2, R3, R'3, R4, R5 et R6 ont la signification stipulée dans le descriptif. L'invention traite également de sels d'addition acides de ce composé avec des acides organiques et inorganiques pharmaceutiquement acceptables, et des sels quaternaires pharmaceutiquement acceptables de ce composé.
PCT/EP1998/002129 1997-04-15 1998-04-02 Composes d'amide d'indazole utilises comme agents serotoninergiques WO1998046589A2 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
UA99116211A UA58550C2 (uk) 1997-04-15 1998-02-04 Індазоламідні сполуки, спосіб одержання, індазоламідна проміжна сполука та фармацевтична композиція
SK1423-99A SK284731B6 (sk) 1997-04-15 1998-04-02 Indazolamidová zlúčenina, spôsob jej prípravy, medziprodukt na jej prípravu a farmaceutický prostriedok s jej obsahom
KR1019997009198A KR100563867B1 (ko) 1997-04-15 1998-04-02 혈관 수축제로써의 인다졸 아마이드 화합물
HU0002057A HU227973B1 (hu) 1997-04-15 1998-04-02 Indazolamidok és az ezeket tartalmazó gyógyszerek
DK98919257T DK0975623T3 (da) 1997-04-15 1998-04-02 Indazolamidforbindelser som sertoninerge midler
EP98919257A EP0975623B1 (fr) 1997-04-15 1998-04-02 Composes d'amide d'indazole utilises comme agents serotoninergiques
JP54347598A JP4578581B2 (ja) 1997-04-15 1998-04-02 セロトニン様作用薬としてのインダゾールアミド化合物
IL13212798A IL132127A (en) 1997-04-15 1998-04-02 Indazole amide compounds, a process for their preparation, intermediates thereof and pharmaceutical compositions comprising them
AT98919257T ATE219490T1 (de) 1997-04-15 1998-04-02 Indazoleamid-verbindungen als serotoninergene mittel
AU72159/98A AU740360B2 (en) 1997-04-15 1998-04-02 Indazole amide compounds as serotoninergic agents
SI9830218T SI0975623T1 (en) 1997-04-15 1998-04-02 Indazole amide compounds as serotoninergic agents
CA002286870A CA2286870C (fr) 1997-04-15 1998-04-02 Composes d'amide d'indazole utilises comme agents serotoninergiques
DE69806141T DE69806141T2 (de) 1997-04-15 1998-04-02 Indazoleamid-verbindungen als serotoninergene mittel
US09/403,007 US6197769B1 (en) 1997-04-15 1998-04-02 Indazole amide compounds as serotoninergic agents
EA199900935A EA002352B1 (ru) 1997-04-15 1998-04-02 Производные индазоламида в качестве серотонинергических агентов
BG103863A BG64006B1 (bg) 1997-04-15 1999-11-05 Индазоламидни съединения като серотонинергични средства
HK00107144A HK1027811A1 (en) 1997-04-15 2000-11-09 Indazole amide compounds as serotoninergic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (it) 1997-04-15 1997-04-15 Indazolammidi come agenti serotoninergici
ITMI97A000867 1997-04-15

Publications (3)

Publication Number Publication Date
WO1998046589A2 WO1998046589A2 (fr) 1998-10-22
WO1998046589A3 WO1998046589A3 (fr) 1999-01-28
WO1998046589B1 true WO1998046589B1 (fr) 1999-03-04

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/002129 WO1998046589A2 (fr) 1997-04-15 1998-04-02 Composes d'amide d'indazole utilises comme agents serotoninergiques

Country Status (27)

Country Link
US (1) US6197769B1 (fr)
EP (1) EP0975623B1 (fr)
JP (2) JP4578581B2 (fr)
KR (1) KR100563867B1 (fr)
CN (1) CN1318416C (fr)
AR (1) AR012426A1 (fr)
AT (1) ATE219490T1 (fr)
AU (1) AU740360B2 (fr)
BG (1) BG64006B1 (fr)
CA (1) CA2286870C (fr)
CZ (1) CZ295190B6 (fr)
DE (1) DE69806141T2 (fr)
DK (1) DK0975623T3 (fr)
EA (1) EA002352B1 (fr)
ES (1) ES2178205T3 (fr)
GE (1) GEP20022654B (fr)
HK (1) HK1027811A1 (fr)
HU (1) HU227973B1 (fr)
IL (1) IL132127A (fr)
IT (1) IT1291569B1 (fr)
PL (1) PL193308B1 (fr)
PT (1) PT975623E (fr)
SK (1) SK284731B6 (fr)
TR (1) TR199902546T2 (fr)
UA (1) UA58550C2 (fr)
WO (1) WO1998046589A2 (fr)
ZA (1) ZA982926B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US7217716B2 (en) 2001-02-23 2007-05-15 Merck & Co., Inc. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
EP1390034A4 (fr) * 2001-04-03 2005-07-13 Merck & Co Inc Antagonistes de nmda/nr2b nonaryl-heterocyclo amidyle n-substitues
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
ES2332808T3 (es) * 2004-11-05 2010-02-12 Theravance, Inc. Compuestos agonistas del receptor 5-ht4.
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
US7419989B2 (en) * 2004-12-22 2008-09-02 Theravance, Inc. Indazole-carboxamide compounds
EP1848716A1 (fr) * 2005-02-17 2007-10-31 Theravance, Inc. Forme cristalline d'un compose d'indazole/carboxamide
ES2523851T3 (es) * 2005-03-02 2014-12-02 Theravance Biopharma R&D Ip, Llc Compuestos de quinolinona como agonistas de los receptores 5-HT4
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
MX2013014427A (es) * 2011-06-07 2014-01-23 Dainippon Sumitomo Pharma Co Derivado de indazol y pirrolopiridina y uso farmaceutico del mismo.
WO2013124158A1 (fr) * 2012-02-21 2013-08-29 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Composés 1h-indazole-3-carboxamide en tant qu'inhibiteurs de la glycogène synthase kinase 3 bêta
DK2817301T3 (en) * 2012-02-21 2016-03-14 Acraf Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase-3 beta inhibitors
EP2961403A4 (fr) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd Inhibiteurs hétérocycliques du canal sodique
CN114340670A (zh) 2019-07-11 2022-04-12 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
NZ243993A (en) * 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
DE69627323T2 (de) * 1995-05-31 2004-01-15 Nisshin Seifun Group Inc Indazolderivate mit einer cyclischen aminogruppe
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici

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