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WO1998046270A3 - Molecules presentant une pluralite de groupes fonctionnels actifs - Google Patents

Molecules presentant une pluralite de groupes fonctionnels actifs Download PDF

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Publication number
WO1998046270A3
WO1998046270A3 PCT/US1998/007171 US9807171W WO9846270A3 WO 1998046270 A3 WO1998046270 A3 WO 1998046270A3 US 9807171 W US9807171 W US 9807171W WO 9846270 A3 WO9846270 A3 WO 9846270A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyvalent
methods
presenters
presenter
polyvalently
Prior art date
Application number
PCT/US1998/007171
Other languages
English (en)
Other versions
WO1998046270A2 (fr
Inventor
George Whitesides
James B Tananbaum
John Griffin
Mathai Mammen
Original Assignee
Advanced Medicine Inc
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc, Harvard College filed Critical Advanced Medicine Inc
Priority to BR9808521-2A priority Critical patent/BR9808521A/pt
Priority to JP54407498A priority patent/JP2002503223A/ja
Priority to KR1019997009364A priority patent/KR20010006280A/ko
Priority to EP98918079A priority patent/EP0973551A2/fr
Priority to AU71069/98A priority patent/AU743028B2/en
Priority to CA002286692A priority patent/CA2286692A1/fr
Publication of WO1998046270A2 publication Critical patent/WO1998046270A2/fr
Publication of WO1998046270A3 publication Critical patent/WO1998046270A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00756—Compositions, e.g. coatings, crystals, formulations

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des compositions polyvalentes permettant de présenter de façon polyvalente un agent thérapeutique. Ces compositions pharmaceutiques contiennent un agent de présentation polyvalent. Selon une réalisation, l'agent de présentation est formulé comme (Y)-(X-A)n, Y étant un squelette, X une liaison directe ou un lien, A un groupe fonctionnel à fonction de présentation, et n un entier supérieur à 10 choisi de façon que les groupes à fonction de présentation puissent entrer en interaction avec une pluralité de sites cibles de liaison. La composition peut également comporter un vecteur pharmaceutiquement acceptable. Selon une autre réalisation, l'agent de présentation peut constituer lui-même son propre vecteur pharmaceutiquement acceptable. L'invention concerne également le traitement d'affections ou d'états. Ce traitement consiste en l'administration à un sujet d'une pluralité de groupes A de façon que le traitement se produise. Le traitement se produit du fait de l'interaction d'un agent de présentation polyvalent avec une pluralité de sites cibles de liaison B. Sous d'autres aspects, l'invention concerne, d'une part des agents de présentation polyvalents emballés avec un mode d'emploi destiné aux traitements considérés, et d'autre part des procédés de conception, d'agents de présentation polyvalent convenant particulièrement dans le cadre des procédés et traitements de l'invention. Les agents de présentation polyvalents de l'invention assurent une liaison spécifique, ce qui est relativement avantageux. En outre, ces agents de présentation polyvalents permettent des interactions positives et négatives.
PCT/US1998/007171 1997-04-11 1998-04-09 Molecules presentant une pluralite de groupes fonctionnels actifs WO1998046270A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR9808521-2A BR9808521A (pt) 1997-04-11 1998-04-09 Moléculas que apresentam um grande número de partes ativas.
JP54407498A JP2002503223A (ja) 1997-04-11 1998-04-09 複数の活性分子を供与する分子
KR1019997009364A KR20010006280A (ko) 1997-04-11 1998-04-09 다수개의 활성 잔기를 제공하는 분자
EP98918079A EP0973551A2 (fr) 1997-04-11 1998-04-09 Molecules presentant une pluralite de groupes fonctionnels actifs
AU71069/98A AU743028B2 (en) 1997-04-11 1998-04-09 Molecules presenting a multitude of active moieties
CA002286692A CA2286692A1 (fr) 1997-04-11 1998-04-09 Molecules presentant une pluralite de groupes fonctionnels actifs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4378197P 1997-04-11 1997-04-11
US60/043,781 1997-04-11
US4382697P 1997-04-14 1997-04-14
US60/043,826 1997-04-14

Publications (2)

Publication Number Publication Date
WO1998046270A2 WO1998046270A2 (fr) 1998-10-22
WO1998046270A3 true WO1998046270A3 (fr) 1999-01-07

Family

ID=26720814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/007171 WO1998046270A2 (fr) 1997-04-11 1998-04-09 Molecules presentant une pluralite de groupes fonctionnels actifs

Country Status (8)

Country Link
EP (1) EP0973551A2 (fr)
JP (1) JP2002503223A (fr)
KR (1) KR20010006280A (fr)
CN (1) CN1269013A (fr)
AU (1) AU743028B2 (fr)
BR (1) BR9808521A (fr)
CA (1) CA2286692A1 (fr)
WO (1) WO1998046270A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067148B2 (en) 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2330611A1 (fr) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Molecules bifonctionnelles et therapies basees sur celles-ci
JP3468149B2 (ja) * 1999-02-19 2003-11-17 松下電器産業株式会社 微細物体の操作装置および操作方法
ATE261754T1 (de) * 1999-05-10 2004-04-15 Glaxo Group Ltd Kristallform-screening-gerät für hohen durchsatz und dessen gebrauch
EP1229924A4 (fr) 1999-11-19 2004-12-15 Univ Leland Stanford Junior Molecules bifonctionnelles ciblees et therapies basees sur celles-ci
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
EG24716A (en) 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
KR100543171B1 (ko) * 2002-05-31 2006-01-20 한국과학기술원 분자수준에서 배향성을 조절하면서 항체 단분자막을 제조하는 방법
EP1802349A1 (fr) * 2004-10-13 2007-07-04 Ilypsa, Inc. Preparations pharmaceutiques comprenant un oligosaccharide complexant les toxines et une particule polymere
JP5345849B2 (ja) 2005-10-08 2013-11-20 ポテンシア ファーマシューティカルズ， インコーポレイテッド 眼の障害のためのコンプスタチンおよびそのアナログ
HUE026001T2 (en) 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system
EP2139524A1 (fr) * 2007-03-23 2010-01-06 The Governors of the University of Alberta Polymères hétérobifonctionnels multivalents et leurs procédés d'utilisation
US20090081249A1 (en) * 2007-08-27 2009-03-26 Massachusetts Institute Of Technology Bi-Functional Polymer-Attached Inhibitors of Influenza Virus
CN103687867B (zh) 2011-05-11 2017-02-08 阿佩利斯制药公司 细胞反应性的、长效的或靶向的坎普他汀类似物及其用途
EP3524258A1 (fr) 2011-06-22 2019-08-14 Apellis Pharmaceuticals, Inc. Méthodes de traitement de troubles chroniques au moyen d'inhibiteurs de complément
HUE055564T2 (hu) 2012-11-15 2021-11-29 Apellis Pharmaceuticals Inc Hosszan ható compstatin-analógok és kapcsolódó készítmények, valamint módszerek
EP2961482A4 (fr) * 2013-02-28 2016-10-05 Univ Southern Mississippi Liaison covalente de bactériophages à des surfaces polymères
CN117503905A (zh) 2015-10-07 2024-02-06 阿佩利斯制药有限公司 给药方案
US11564995B2 (en) 2018-10-29 2023-01-31 Wisconsin Alumni Research Foundation Peptide-nanoparticle conjugates
CN113613680A (zh) 2018-10-29 2021-11-05 威斯康星校友研究基金会 用于增强癌症免疫疗法的与免疫检查点抑制剂复合的树枝状聚合物
CN115087465A (zh) 2019-10-29 2022-09-20 威斯康星校友研究基金会 肽-纳米颗粒缀合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010023A1 (fr) * 1989-03-01 1990-09-07 Biocarb Ab Copolymeres a base d'acrylglucides et de methacrylglucides ainsi que leur fabrication
WO1998014215A2 (fr) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Für Med. Biochemie M.B.H. Glyconconjugues comme inhibiteurs d'adherence cellulaire virale

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010023A1 (fr) * 1989-03-01 1990-09-07 Biocarb Ab Copolymeres a base d'acrylglucides et de methacrylglucides ainsi que leur fabrication
WO1998014215A2 (fr) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Für Med. Biochemie M.B.H. Glyconconjugues comme inhibiteurs d'adherence cellulaire virale

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067148B2 (en) 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions

Also Published As

Publication number Publication date
AU743028B2 (en) 2002-01-17
EP0973551A2 (fr) 2000-01-26
AU7106998A (en) 1998-11-11
KR20010006280A (ko) 2001-01-26
JP2002503223A (ja) 2002-01-29
CA2286692A1 (fr) 1998-10-22
WO1998046270A2 (fr) 1998-10-22
CN1269013A (zh) 2000-10-04
BR9808521A (pt) 2000-05-23

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