WO1998040493A1 - Vaccin anti-vif - Google Patents
Vaccin anti-vif Download PDFInfo
- Publication number
- WO1998040493A1 WO1998040493A1 PCT/GB1998/000715 GB9800715W WO9840493A1 WO 1998040493 A1 WO1998040493 A1 WO 1998040493A1 GB 9800715 W GB9800715 W GB 9800715W WO 9840493 A1 WO9840493 A1 WO 9840493A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fipv
- fiv
- polynucleotide
- deletion
- pol gene
- Prior art date
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- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000002353 niosome Substances 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 108010089520 pol Gene Products Proteins 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002342 ribonucleoside Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000007390 skin biopsy Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940031626 subunit vaccine Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000017960 syncytium formation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Definitions
- This PCR product was cloned into the Hinc II site of plasmid vector pIC19R (Marsh et al. (1984) Gene 32 pp 481-485) to yield pPBSGAG.
- FIV sequence from pPBSGAG was then released as a Sal I fragment and cloned into the Sal I site of pIC20H (Marsh et al. supra) to give pPBSSal.
- the CMV IE promoter was cloned infront of these FIV sequences as a Bgl II-Kpn I fragment from expression vector pcDNA3 (Invitrogen) , yielding pCMVPBS.
- Sst I fragment from this clone including the IE promoter and FIV sequences from the primer binding site to the proviral Sst I site, was then cloned into the Sst I site in ⁇ RT-Sal/Sst.
- the resulting DNA sequence from within the CMV IE promoter to a point downstream of the FIV proviral Sst I site was confirmed by direct sequencing.
- A485 4 A495 6 mean 2.6 1 4.8
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des formulations de vaccins contre les maladies liées au VIF (virus de l'immunodéficience féline), comportant un polynucléotide PVIF (provirus de l'immunodéficience féline) renfermant un gène pol dysfonctionnel, des fragments du polynucléotide PVIF et leurs utilisations dans la prophylaxie et/ou le traitement de maladies liées au VIF.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53935198A JP2002501369A (ja) | 1997-03-11 | 1998-03-10 | Ｆｉｖワクチン |
| EP98912585A EP1007687A1 (fr) | 1997-03-11 | 1998-03-10 | Vaccin anti-vif |
| CA002283490A CA2283490A1 (fr) | 1997-03-11 | 1998-03-10 | Vaccin anti-vif |
| AU67369/98A AU6736998A (en) | 1997-03-11 | 1998-03-10 | Fiv vaccine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9704977.9A GB9704977D0 (en) | 1997-03-11 | 1997-03-11 | FIV vaccine |
| GB9704977.9 | 1997-03-11 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09380990 A-371-Of-International | 1999-11-08 | ||
| US10/205,534 Continuation US20030118601A1 (en) | 1997-03-11 | 2002-07-25 | FIV vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998040493A1 true WO1998040493A1 (fr) | 1998-09-17 |
Family
ID=10809020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1998/000715 WO1998040493A1 (fr) | 1997-03-11 | 1998-03-10 | Vaccin anti-vif |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1007687A1 (fr) |
| JP (1) | JP2002501369A (fr) |
| AU (1) | AU6736998A (fr) |
| CA (1) | CA2283490A1 (fr) |
| GB (1) | GB9704977D0 (fr) |
| WO (1) | WO1998040493A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0997529A2 (fr) * | 1998-08-24 | 2000-05-03 | Pfizer Products Inc. | Souche FIV-141 du virus de l'immunodéficience féline et ses utilisations |
| EP1037669A1 (fr) * | 1997-12-12 | 2000-09-27 | Luigi Naldini | Emploi therapeutique de vecteurs lentiviraux |
| US6667295B1 (en) | 1999-06-14 | 2003-12-23 | Pfizer, Inc. | DNA vaccine against feline immunodeficiency virus |
| US6713286B2 (en) | 1998-08-24 | 2004-03-30 | Pfizer Inc. | Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus |
| US20130254112A1 (en) * | 2010-04-09 | 2013-09-26 | Ayman Hammad | System and Method Including Chip-Based Device Processing For Transaction |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003435A2 (fr) * | 1994-07-21 | 1996-02-08 | Q-One Biotech Limited | Gamma-interferon d'origine feline |
| WO1997032983A1 (fr) * | 1996-03-05 | 1997-09-12 | The Regents Of The University Of California | Virus de l'immunodeficience feline vivants recombines et vaccins d'adn proviraux |
-
1997
- 1997-03-11 GB GBGB9704977.9A patent/GB9704977D0/en active Pending
-
1998
- 1998-03-10 JP JP53935198A patent/JP2002501369A/ja active Pending
- 1998-03-10 CA CA002283490A patent/CA2283490A1/fr not_active Abandoned
- 1998-03-10 EP EP98912585A patent/EP1007687A1/fr not_active Withdrawn
- 1998-03-10 AU AU67369/98A patent/AU6736998A/en not_active Abandoned
- 1998-03-10 WO PCT/GB1998/000715 patent/WO1998040493A1/fr not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003435A2 (fr) * | 1994-07-21 | 1996-02-08 | Q-One Biotech Limited | Gamma-interferon d'origine feline |
| WO1997032983A1 (fr) * | 1996-03-05 | 1997-09-12 | The Regents Of The University Of California | Virus de l'immunodeficience feline vivants recombines et vaccins d'adn proviraux |
Non-Patent Citations (2)
| Title |
|---|
| LU S ET AL.: "Simian Immunodeficiency Virus DNA vaccine trial in macaques", JOURNAL OF VIROLOGY, vol. 70, no. 6, June 1996 (1996-06-01), AMERICAN SOCIETY FOR MICROBIOLOGY US, pages 3978 - 3991, XP002071527 * |
| LUTZ H ET AL.: "Vaccination of cats with recombinant envelope glycoprotein of Feline Immunodeficiency Virus: Decreased virus load after challenge infection", AIDS RESEARCH AND HUMAN RETROVIRUSES., vol. 12, no. 5, 20 March 1996 (1996-03-20), LIEBERT US, pages 431 - 433, XP002071528 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1037669A1 (fr) * | 1997-12-12 | 2000-09-27 | Luigi Naldini | Emploi therapeutique de vecteurs lentiviraux |
| EP1037669A4 (fr) * | 1997-12-12 | 2003-04-02 | Cell Genesys Inc | Emploi therapeutique de vecteurs lentiviraux |
| EP0997529A2 (fr) * | 1998-08-24 | 2000-05-03 | Pfizer Products Inc. | Souche FIV-141 du virus de l'immunodéficience féline et ses utilisations |
| EP0997529A3 (fr) * | 1998-08-24 | 2002-05-22 | Pfizer Products Inc. | Souche FIV-141 du virus de l'immunodéficience féline et ses utilisations |
| US6713286B2 (en) | 1998-08-24 | 2004-03-30 | Pfizer Inc. | Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus |
| US6764676B1 (en) | 1998-08-24 | 2004-07-20 | Pfizer Inc. | Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus |
| US6667295B1 (en) | 1999-06-14 | 2003-12-23 | Pfizer, Inc. | DNA vaccine against feline immunodeficiency virus |
| US20130254112A1 (en) * | 2010-04-09 | 2013-09-26 | Ayman Hammad | System and Method Including Chip-Based Device Processing For Transaction |
| US8977570B2 (en) * | 2010-04-09 | 2015-03-10 | Visa International Service Association | System and method including chip-based device processing for transaction |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002501369A (ja) | 2002-01-15 |
| AU6736998A (en) | 1998-09-29 |
| CA2283490A1 (fr) | 1998-09-17 |
| EP1007687A1 (fr) | 2000-06-14 |
| GB9704977D0 (en) | 1997-04-30 |
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