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WO1997039128A3 - Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection - Google Patents

Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection Download PDF

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Publication number
WO1997039128A3
WO1997039128A3 PCT/GB1997/001054 GB9701054W WO9739128A3 WO 1997039128 A3 WO1997039128 A3 WO 1997039128A3 GB 9701054 W GB9701054 W GB 9701054W WO 9739128 A3 WO9739128 A3 WO 9739128A3
Authority
WO
WIPO (PCT)
Prior art keywords
rre
compositions
methods
hiv infection
responsive element
Prior art date
Application number
PCT/GB1997/001054
Other languages
French (fr)
Other versions
WO1997039128A2 (en
Inventor
Jonathan Karn
Rodney Warren Zemmel
Peter Jonathan Gasking Butler
Roger Kingdon Craig
Alistair Simpson Irvine
Original Assignee
Therexsys Ltd
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607819.1A external-priority patent/GB9607819D0/en
Application filed by Therexsys Ltd, Medical Res Council filed Critical Therexsys Ltd
Priority to JP53687397A priority Critical patent/JP2001517074A/en
Priority to AU25720/97A priority patent/AU2572097A/en
Priority to EP97917335A priority patent/EP0914443A2/en
Publication of WO1997039128A2 publication Critical patent/WO1997039128A2/en
Priority to GBGB9802172.8A priority patent/GB9802172D0/en
Publication of WO1997039128A3 publication Critical patent/WO1997039128A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to an isolated nucleic acid comprising two operatively linked binding sites for HIV Rev protein, the sites comprising a nucleation motif and an oligomerization motif, wherein the nucleic acid binds Rev protein monomers with a higher degree of co-operativity than wild-type RRE.
PCT/GB1997/001054 1996-04-15 1997-04-15 Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection WO1997039128A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP53687397A JP2001517074A (en) 1996-04-15 1997-04-15 Use of the modified REV responsive element (RRE) in methods and compositions for combating HIV infection
AU25720/97A AU2572097A (en) 1996-04-15 1997-04-15 Use of a modified REV-responsive element (RRE) in methods and compositions fo r combatting HIV infection
EP97917335A EP0914443A2 (en) 1996-04-15 1997-04-15 Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection
GBGB9802172.8A GB9802172D0 (en) 1997-04-15 1998-02-03 Labelling arrangement

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9607819.1A GB9607819D0 (en) 1996-04-15 1996-04-15 Anti-hiv agents
GB9607819.1 1996-04-15
US1726896P 1996-05-13 1996-05-13
US60/017,268 1996-05-13

Publications (2)

Publication Number Publication Date
WO1997039128A2 WO1997039128A2 (en) 1997-10-23
WO1997039128A3 true WO1997039128A3 (en) 1998-11-12

Family

ID=26309134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001054 WO1997039128A2 (en) 1996-04-15 1997-04-15 Use of a modified rev-responsive element (rre) in methods and compositions for combatting hiv infection

Country Status (5)

Country Link
EP (1) EP0914443A2 (en)
JP (1) JP2001517074A (en)
AU (1) AU2572097A (en)
CA (1) CA2252225A1 (en)
WO (1) WO1997039128A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2493300A (en) * 1999-01-06 2000-07-24 Regents Of The University Of California, The Modulation of hiv replication using sam68
GB0719367D0 (en) * 2007-10-03 2007-11-14 Procarta Biosystems Ltd Transcription factor decoys, compositions and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005195A1 (en) * 1990-09-20 1992-04-02 Medical Research Council Viral growth inhibition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005195A1 (en) * 1990-09-20 1992-04-02 Medical Research Council Viral growth inhibition

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GIVER, L. ET AL.: "Selective optimization of the REV-binding element of HIV-1", NUCLEIC ACIDS RESEARCH, vol. 21, no. 23, 1993, pages 5509 - 5516, XP002041543 *
IWAI, S. ET AL.: "Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein", NUCLEIC ACIDS RESEARCH, vol. 20, no. 24, 25 December 1992 (1992-12-25), pages 6465 - 6472, XP002041542 *
KIMURA, T. AND OHYAMA, A.: "Interaction with the rev response element along an extended stem I duplex structure is required to complete human immunodeficiency virus type 1 rev-mediated trans activation in vivo", THE JOURNAL OF BIOCHEMISTRY, vol. 115, 1994, pages 945 - 952, XP002041544 *
MANN, D. A. ET AL.: "A molecular rheostat. Co-operative REV binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression", JOURNAL OF MOLECULAR BIOLOGY, vol. 241, no. 2, 1994, pages 193 - 207, XP002041541 *
SUN, L.Q., ET AL.: "Resistance to human immunodificiency virus type 1 infection conferred by transduction of human peripheral blood lymphocytes with ribozyme, antisense, or polymeric trans-activation response element constructs", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 92, August 1995 (1995-08-01), pages 7272 - 7276, XP002041545 *
ZEMMEL, R.W. ET AL.: "Flexible regions of RNA structure faciliate co-operative rev assembly on the rev-response element", JOURNAL OF MOLECULAR BIOLOGY, vol. 258, no. 5, 24 May 1996 (1996-05-24), pages 763 - 777, XP002041546 *

Also Published As

Publication number Publication date
WO1997039128A2 (en) 1997-10-23
JP2001517074A (en) 2001-10-02
EP0914443A2 (en) 1999-05-12
AU2572097A (en) 1997-11-07
CA2252225A1 (en) 1997-10-23

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