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WO1997036627A1 - Methode et dispositif pour diminuer les risques du traitement par inhalation de monoxyde d'azote - Google Patents

Methode et dispositif pour diminuer les risques du traitement par inhalation de monoxyde d'azote Download PDF

Info

Publication number
WO1997036627A1
WO1997036627A1 PCT/EP1997/001565 EP9701565W WO9736627A1 WO 1997036627 A1 WO1997036627 A1 WO 1997036627A1 EP 9701565 W EP9701565 W EP 9701565W WO 9736627 A1 WO9736627 A1 WO 9736627A1
Authority
WO
WIPO (PCT)
Prior art keywords
filter
gas
sulfur
gas mixture
patient
Prior art date
Application number
PCT/EP1997/001565
Other languages
German (de)
English (en)
Inventor
Manfred Eschwey
Klaus Hege
Christian Krebs
Original Assignee
Messer Griesheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Messer Griesheim Gmbh filed Critical Messer Griesheim Gmbh
Publication of WO1997036627A1 publication Critical patent/WO1997036627A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
    • B01D53/04—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/107—Filters in a path in the inspiratory path
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/20—Organic adsorbents
    • B01D2253/202—Polymeric adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/40—Nitrogen compounds
    • B01D2257/404—Nitrogen oxides other than dinitrogen oxide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/45—Gas separation or purification devices adapted for specific applications
    • B01D2259/4533—Gas separation or purification devices adapted for specific applications for medical purposes

Definitions

  • the invention relates to a method for reducing risks in inhalative NO therapy according to the preamble of claim 1 and to a device suitable for carrying out the method.
  • NO nitrogen monoxide
  • NO 2 nitrogen dioxide
  • N0 2 nitrite
  • NO 3 nitrate
  • a gas mixture containing NO can either be added directly in the respirator or in the inspiratory leg of the hose system.
  • the patient thus receives the breathing gas together with the NO-containing gas mixture.
  • the inevitable presence of oxygen and water (moisture) leads to the formation of NO 2 and N0 2 " .
  • NO can be administered to the patient using simple breaths such as breathing masks or nasal cannulae in oxygen or oxygen mixtures with air and / or noble gases such as helium. Both here and in respiratory weaning therapies, NO showed a significant improvement in health.
  • NO-N 2 or NO-He or also NO-noble gas mixtures are added to the spontaneous breather either in batches (in the rhythm of breathing) or continuously to the "auxiliary breathing volume flow".
  • longer oxidation times lead to higher oxidation rates, ie to an increased production of toxic NO 2 .
  • HNO 2 nitrous acid
  • HN0 3 nitric acid
  • the invention has for its object to provide a method for inhalative NO therapy, which ensures a homogeneous mixing of the gas streams used and preferably at the same time allows removal of the gaseous impurities NO2, N 2 O 3 and N 2 O 4 .
  • a filter is preferably used which is filled with a filter or absorber mass which is capable of selectively absorbing NO 2 from gas mixtures containing NO.
  • a filter or absorber mass which is capable of selectively absorbing NO 2 from gas mixtures containing NO.
  • This can be a sulfur-containing polymer, as described in DE 44 19 860 A1.
  • a particular advantage of such a filter is that it simultaneously prevents the formation of N0 2 ' (nitrite) and N0 3 " (nitrate) in the condensate and any anions that may have formed can be removed.
  • the NO-conducting line part can also be used as a support also contain a sulfur-containing polymer
  • the filter material can consist, for example, of a granulate or fleece.
  • Figure 1 possible filter arrangements in connection with a
  • Respirator Figure 2: possible filter arrangements for spontaneous breathing.
  • the device shown in FIG. 1 contains a respirator 1 with a connection piece 2 for the supply of oxygen, a connection piece 3 for the supply of air and an exhaust air connection 4.
  • a patient 7 is connected to the respirator 1 via a line 5 with a humidifier 6 .
  • a line 8 for the exhaled gas leads from a point near the patient 7 from line 5 back into the respirator.
  • Another component of the device is an NO metering device 9, which is connected via a line 10 to a bottle 11 with a gas mixture containing NO. NO is metered into line 5 through line 12, and the analysis is withdrawn via line 13.
  • a filter with a sulfur-containing polymer as an effective component is arranged in the NO-conducting line part.
  • Possible filter arrangements are labeled A, B1, B2, C1, C2 and C3.
  • the lines 14, 15 and 16 shown in dashed lines show further possibilities for the NO supply, which may also be provided with filters effective according to the invention.
  • Figure 2 shows a device with possible filter arrangements for spontaneous breathing.
  • the NO-containing gas mixture is in the store 17, in the store 18 there is noble gas, in the store 19 air and in the store 20 oxygen.
  • a breathing gas is formed from noble gas, air and oxygen, to which the NO-containing gas mixture is admixed.
  • the entire mixture passes through line 21 to the humidifier 97/36627 PC17EP97 / 01565
  • Filterpositione ⁇ effective according to the invention are denoted by D1, D2 and.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

Dans le traitement par inhalation de NO, on prépare au moyen d'un filtre un mélange parfaitement homogène constitué d'un mélange gazeux contenant du NO et d'un gaz respiratoire. On utilise de préférence un filtre qui comporte un polymère contenant du soufre comme constituant actif. Ceci permet d'éliminer du mélange gazeux le NO2, le N¿2?O3 et le N2O4 ainsi que, en présence d'un humidificateur (6.22), le NO2?-¿ et le NO¿3?-.
PCT/EP1997/001565 1996-03-28 1997-03-27 Methode et dispositif pour diminuer les risques du traitement par inhalation de monoxyde d'azote WO1997036627A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19612289A DE19612289A1 (de) 1996-03-28 1996-03-28 Verfahren und Vorrichtung zur Minderung von Risiken bei der inhalativen NO-Therapie
DE19612289.9 1996-03-28

Publications (1)

Publication Number Publication Date
WO1997036627A1 true WO1997036627A1 (fr) 1997-10-09

Family

ID=7789692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/001565 WO1997036627A1 (fr) 1996-03-28 1997-03-27 Methode et dispositif pour diminuer les risques du traitement par inhalation de monoxyde d'azote

Country Status (3)

Country Link
DE (1) DE19612289A1 (fr)
WO (1) WO1997036627A1 (fr)
ZA (1) ZA972728B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011094684A1 (fr) * 2010-02-01 2011-08-04 Geno Llc Système d'administration d'oxyde nitrique

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005277397B2 (en) 2004-08-18 2011-08-25 VERO Biotech LLC. Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
EP2247381B1 (fr) 2008-01-28 2016-11-30 Geno LLC Conversion de dioxyde d'azote (no<sb>2</sb>) en monoxyde d'azote (no)
US8701657B2 (en) * 2008-08-21 2014-04-22 Geno Llc Systems for generating nitric oxide
US8607785B2 (en) * 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
WO2010151505A1 (fr) 2009-06-22 2010-12-29 Geno Llc Thérapies par oxyde nitrique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360018A (en) * 1979-12-20 1982-11-23 American Hospital Supply Corporation Anesthesia system and method of filtering respiratory gas
DE4327730C1 (de) * 1993-08-18 1995-03-02 Messer Griesheim Gmbh Einrichtung zum Verarbreichen von NO an spontanatmende Patienten mit pulmonalen Krankheitsbildern
EP0659445A1 (fr) * 1993-11-22 1995-06-28 Ohmeda Inc. Système d'alimentation en oxyde nitrique
DE4419860A1 (de) * 1994-06-07 1995-12-14 Hoechst Ag Verfahren und Filter zur Herstellung von NO¶2¶-freiem Stickstoffmonoxid mit schwefelhaltigen Polymeren

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360018A (en) * 1979-12-20 1982-11-23 American Hospital Supply Corporation Anesthesia system and method of filtering respiratory gas
DE4327730C1 (de) * 1993-08-18 1995-03-02 Messer Griesheim Gmbh Einrichtung zum Verarbreichen von NO an spontanatmende Patienten mit pulmonalen Krankheitsbildern
EP0659445A1 (fr) * 1993-11-22 1995-06-28 Ohmeda Inc. Système d'alimentation en oxyde nitrique
DE4419860A1 (de) * 1994-06-07 1995-12-14 Hoechst Ag Verfahren und Filter zur Herstellung von NO¶2¶-freiem Stickstoffmonoxid mit schwefelhaltigen Polymeren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011094684A1 (fr) * 2010-02-01 2011-08-04 Geno Llc Système d'administration d'oxyde nitrique

Also Published As

Publication number Publication date
ZA972728B (en) 1997-10-23
DE19612289A1 (de) 1997-10-02

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