WO1997034637A3 - Photodynamic therapy using nuclear hormone receptors to target photosensitizers - Google Patents
Photodynamic therapy using nuclear hormone receptors to target photosensitizers Download PDFInfo
- Publication number
- WO1997034637A3 WO1997034637A3 PCT/US1997/004542 US9704542W WO9734637A3 WO 1997034637 A3 WO1997034637 A3 WO 1997034637A3 US 9704542 W US9704542 W US 9704542W WO 9734637 A3 WO9734637 A3 WO 9734637A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hormone
- receptors
- photodynamic therapy
- nuclear hormone
- hormone receptors
- Prior art date
Links
- 239000003504 photosensitizing agent Substances 0.000 title abstract 3
- 102000007399 Nuclear hormone receptor Human genes 0.000 title abstract 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 title abstract 2
- 238000002428 photodynamic therapy Methods 0.000 title abstract 2
- 229940088597 hormone Drugs 0.000 abstract 4
- 239000005556 hormone Substances 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 3
- 102000005962 receptors Human genes 0.000 abstract 3
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 108091008039 hormone receptors Proteins 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 231100000518 lethal Toxicity 0.000 abstract 1
- 230000001665 lethal effect Effects 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 229940034208 thyroxine Drugs 0.000 abstract 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention exploits a novel mechanism for photosensitizer localization, namely interaction with the high-affinity receptors which mediate the hormonal signals transmitted by steroids (and some other hormones such as thyroxine, retinoids, and members of vitamin D family). These receptors are expressed only in specific cell types - and by their expression they confer hormone sensitivity on those cells. This invention provides hormone/chromophore conjugates which have reasonable binding affinity towards the hormone receptor protein and methods of administering them to patients as specific photosensitizing agents which can direct lethal damage towards receptor-positive cell lines upon irradiation with visible light. These hormone/chromophore conjugates bound to nuclear hormone receptors can be used as selective molecular delivery systems for photodynamic therapy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU25387/97A AU2538797A (en) | 1996-03-22 | 1997-03-21 | Photodynamic therapy using nuclear hormone receptors to target photosensitizers |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1387196P | 1996-03-22 | 1996-03-22 | |
| US60/013,871 | 1996-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997034637A2 WO1997034637A2 (en) | 1997-09-25 |
| WO1997034637A3 true WO1997034637A3 (en) | 1998-01-29 |
Family
ID=21762233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/004542 WO1997034637A2 (en) | 1996-03-22 | 1997-03-21 | Photodynamic therapy using nuclear hormone receptors to target photosensitizers |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2538797A (en) |
| WO (1) | WO1997034637A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1187609A4 (en) * | 1999-06-03 | 2003-07-02 | Gen Hospital Corp | Treatment and analysis of proliferative disorders |
| WO2005120588A2 (en) * | 2004-05-26 | 2005-12-22 | The Curators Of The University Of Missouri | Peptides delivered to cell nuclei |
| CN104302177B (en) | 2012-05-17 | 2019-05-28 | 延伸生物科学股份有限公司 | Carrier for improved drug delivery |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| JP6946182B2 (en) | 2014-10-22 | 2021-10-06 | エクステンド バイオサイエンシズ インコーポレーテッドＥｘｔｅｎｄ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ | Therapeutic Vitamin D Conjugate |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| WO2024072637A2 (en) | 2022-09-30 | 2024-04-04 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014493A1 (en) * | 1991-02-20 | 1992-09-03 | Christopher Capelli | Non-protein intracellular receptor binding conjugates and a method of use thereof |
| WO1995010307A1 (en) * | 1993-10-12 | 1995-04-20 | Board Of Regents, The University Of Texas System | Radiation sensitization using texaphyrins |
| US5591422A (en) * | 1995-06-02 | 1997-01-07 | Pharmacyclics, Inc. | Texaphyrin complexes having improved functionalization |
-
1997
- 1997-03-21 WO PCT/US1997/004542 patent/WO1997034637A2/en active Application Filing
- 1997-03-21 AU AU25387/97A patent/AU2538797A/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014493A1 (en) * | 1991-02-20 | 1992-09-03 | Christopher Capelli | Non-protein intracellular receptor binding conjugates and a method of use thereof |
| WO1995010307A1 (en) * | 1993-10-12 | 1995-04-20 | Board Of Regents, The University Of Texas System | Radiation sensitization using texaphyrins |
| US5591422A (en) * | 1995-06-02 | 1997-01-07 | Pharmacyclics, Inc. | Texaphyrin complexes having improved functionalization |
Non-Patent Citations (3)
| Title |
|---|
| BATS, JAN W. ET AL: "Synthesis of oxochlorins from the red blood pigment heme and their transformation into potentially biologically active chlorin derivatives", LIEBIGS ANN. (1995), (9), 1617-31 CODEN: LANAEM;ISSN: 0947-3440, 1995, XP002047327 * |
| MONTFORTS, FRANZ PETER ET AL: "Tailored chlorins for photodynamic tumor therapy and as model systems for photosynthesis", ANGEW. CHEM. (1992), 104(12), 1650-2 (SEE ALSO ANGEW. CHEM., INT. ED. ENGL., 1992, 31(12), 1592-4) CODEN: ANCEAD;ISSN: 0044-8249, 1992, XP002047328 * |
| T.V. AKHLYNINA ET AL.: "Insulin-mediated intracellular targeting enhances the photodynamic activity of Chlorin e6.", CANCER RESEARCH, vol. 55, 1 March 1995 (1995-03-01), MD US, pages 1014 - 1019, XP002047329 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997034637A2 (en) | 1997-09-25 |
| AU2538797A (en) | 1997-10-10 |
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