WO1997032617B1 - Modification covalente de surfaces au moyen de polymeres pour un accroissement de la biocompatibilite - Google Patents
Modification covalente de surfaces au moyen de polymeres pour un accroissement de la biocompatibiliteInfo
- Publication number
- WO1997032617B1 WO1997032617B1 PCT/US1997/003591 US9703591W WO9732617B1 WO 1997032617 B1 WO1997032617 B1 WO 1997032617B1 US 9703591 W US9703591 W US 9703591W WO 9732617 B1 WO9732617 B1 WO 9732617B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- cellular
- biocompatible polymer
- alternative
- end group
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims abstract 6
- 230000004048 modification Effects 0.000 title claims abstract 4
- 238000012986 modification Methods 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 24
- 230000001413 cellular effect Effects 0.000 claims abstract 14
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 5
- 210000004204 blood vessel Anatomy 0.000 claims abstract 4
- 238000001727 in vivo Methods 0.000 claims abstract 4
- 230000002792 vascular Effects 0.000 claims abstract 4
- 150000001412 amines Chemical class 0.000 claims abstract 3
- 208000007536 Thrombosis Diseases 0.000 claims abstract 2
- 230000005847 immunogenicity Effects 0.000 claims abstract 2
- 208000037803 restenosis Diseases 0.000 claims abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 239000012948 isocyanate Substances 0.000 claims 5
- 150000002513 isocyanates Chemical class 0.000 claims 5
- 150000008064 anhydrides Chemical class 0.000 claims 3
- 150000002118 epoxides Chemical class 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 125000005442 diisocyanate group Chemical group 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 239000002953 phosphate buffered saline Substances 0.000 claims 2
- -1 tresylate Chemical class 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 abstract 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 238000002650 immunosuppressive therapy Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
Abstract
La présente invention décrit une technique de modification par covalence de surfaces tissulaires et cellulaires permettant d'inhiber l'adhésion cellulaire. Le procédé décrit dans le présent contexte s'effectue dans des conditions tolérables in vivo et emploie un polymère biocompatible ayant un groupe réactif attaché à au moins une extrémité et qui réagit avec des groupes présents dans ou sur des surfaces tissulaires et cellulaires dans des conditions aqueuses douces et, de ce fait, attache le polymère par covalence à la surface tissulaire ou cellulaire. De manière préférentielle, le groupe réactif attaché au polymère réagit avec des amines et des hydroxyles présents sur les surfaces tissulaires et cellulaires. Dans une réalisation préférée, les procédés décrits dans le présent contexte fournissent une modification covalente des surfaces tissulaires et cellulaires utilisant une solution PEG-diisocyanate. Les procédés décrits ici sont particulièrement utiles en cas de dépôt dommageable de plaquettes et de leucocytes dans les vaisseaux sanguins lors de thromboses et de resténoses récalcitrantes, complication courante lors des procédures vasculaires comprenant l'ACTP et la chirurgie vasculaire. En outre, en masquant les protéines de surface tissulaire des éléments sanguins, les procédés décrits dans le présent contexte sont utiles car ils diminuent la thrombogénicité de la greffe et réduisent les complications de chirurgie vasculaire. Enfin, les procédés décrits ici réduisent les capacités immunogènes des cellules et tissus transplantés et, de ce fait, réduisent le besoin d'une thérapie immunodépressive.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97914905A EP0885023A1 (fr) | 1996-03-07 | 1997-03-07 | Modification covalente de surfaces au moyen de polymeres pour un accroissement de la biocompatibilite |
| SK1229-98A SK122998A3 (en) | 1996-03-07 | 1997-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
| HU9903953A HUP9903953A3 (en) | 1996-03-07 | 1997-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
| PL97328720A PL328720A1 (en) | 1996-03-07 | 1997-03-07 | Covalent modification of surfaces by use of polymers in order to improve biological compatibility |
| IL12608597A IL126085A0 (en) | 1996-03-07 | 1997-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
| AU21988/97A AU711031B2 (en) | 1996-03-07 | 1997-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
| JP9531964A JP2000507849A (ja) | 1996-03-07 | 1997-03-07 | 生体適合性を向上させるためのポリマーによる表面の共有結合修飾 |
| NO984076A NO984076L (no) | 1996-03-07 | 1998-09-04 | Kovalent modifisering av overflater med polymerer for Õ °ke biokompatibiliteten |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/612,270 | 1996-03-07 | ||
| US08/612,270 US5977252A (en) | 1996-03-07 | 1996-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997032617A1 WO1997032617A1 (fr) | 1997-09-12 |
| WO1997032617B1 true WO1997032617B1 (fr) | 1997-11-20 |
| WO1997032617A9 WO1997032617A9 (fr) | 1998-04-16 |
Family
ID=24452457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/003591 WO1997032617A1 (fr) | 1996-03-07 | 1997-03-07 | Modification covalente de surfaces au moyen de polymeres pour un accroissement de la biocompatibilite |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5977252A (fr) |
| EP (1) | EP0885023A1 (fr) |
| JP (1) | JP2000507849A (fr) |
| CN (1) | CN1217664A (fr) |
| AU (1) | AU711031B2 (fr) |
| CA (1) | CA2248124A1 (fr) |
| CZ (1) | CZ278498A3 (fr) |
| HU (1) | HUP9903953A3 (fr) |
| IL (1) | IL126085A0 (fr) |
| NO (1) | NO984076L (fr) |
| PL (1) | PL328720A1 (fr) |
| SK (1) | SK122998A3 (fr) |
| WO (1) | WO1997032617A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002000685A1 (fr) * | 2000-06-28 | 2002-01-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Administration localisee sur une surface cible |
| DE10136722A1 (de) * | 2001-07-27 | 2003-02-13 | Evotec Ag | Verfahren zur Verhinderung der Adhäsion von Partikeln |
| US7198945B2 (en) | 2001-08-09 | 2007-04-03 | Teruyuki Nagamune | Cell having modified cell membrane |
| AU2002359340A1 (en) * | 2001-10-31 | 2003-05-12 | Ventrigraft Inc | Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo |
| DE10162435A1 (de) * | 2001-12-19 | 2003-07-17 | Joerg Lahann | Verfahren zur Erzeugung von Oberflächenbeschichtungen, die die Adsorption von Proteinen bzw. die Adhäsion von Bakterien und/oder Zellen vermindern |
| US7767220B2 (en) * | 2004-04-23 | 2010-08-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical articles having covalently modified, biocompatible surfaces |
| US20050281866A1 (en) * | 2004-05-24 | 2005-12-22 | Genzyme Corporation | Adherent polymeric compositions |
| US7919112B2 (en) * | 2004-08-26 | 2011-04-05 | Pathak Holdings, Llc | Implantable tissue compositions and method |
| WO2006037095A2 (fr) * | 2004-09-28 | 2006-04-06 | Baylor University | Procedes de modification de tissu frais definie spatialement utilisant la chimie covalente |
| JP6786120B2 (ja) * | 2016-08-17 | 2020-11-18 | 国立研究開発法人物質・材料研究機構 | 細胞の内包化方法および内包化細胞 |
| US10814036B2 (en) | 2016-11-07 | 2020-10-27 | Baylor University | Drug-eluting live tissue for transplantation |
| JP7286078B2 (ja) * | 2018-09-26 | 2023-06-05 | 国立研究開発法人物質・材料研究機構 | 細胞凝集抑制剤、細胞凝集抑制方法、細胞分散方法、及び、細胞分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1541435A (en) * | 1975-02-04 | 1979-02-28 | Searle & Co | Immunological materials |
| US4373009A (en) * | 1981-05-18 | 1983-02-08 | International Silicone Corporation | Method of forming a hydrophilic coating on a substrate |
| JPS60227763A (ja) * | 1984-04-27 | 1985-11-13 | 筏 義人 | 抗血栓性医用材料 |
| US5462990A (en) * | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
| US5580923A (en) * | 1995-03-14 | 1996-12-03 | Collagen Corporation | Anti-adhesion films and compositions for medical use |
-
1996
- 1996-03-07 US US08/612,270 patent/US5977252A/en not_active Expired - Lifetime
-
1997
- 1997-03-07 PL PL97328720A patent/PL328720A1/xx unknown
- 1997-03-07 IL IL12608597A patent/IL126085A0/xx unknown
- 1997-03-07 HU HU9903953A patent/HUP9903953A3/hu unknown
- 1997-03-07 CN CN97192849A patent/CN1217664A/zh not_active Withdrawn
- 1997-03-07 EP EP97914905A patent/EP0885023A1/fr not_active Withdrawn
- 1997-03-07 JP JP9531964A patent/JP2000507849A/ja active Pending
- 1997-03-07 SK SK1229-98A patent/SK122998A3/sk unknown
- 1997-03-07 CZ CZ982784A patent/CZ278498A3/cs unknown
- 1997-03-07 WO PCT/US1997/003591 patent/WO1997032617A1/fr not_active Application Discontinuation
- 1997-03-07 AU AU21988/97A patent/AU711031B2/en not_active Ceased
- 1997-03-07 CA CA002248124A patent/CA2248124A1/fr not_active Abandoned
-
1998
- 1998-09-04 NO NO984076A patent/NO984076L/no unknown
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