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WO1997031614A1 - Composition de stabilisateur de prothese dentaire - Google Patents

Composition de stabilisateur de prothese dentaire Download PDF

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Publication number
WO1997031614A1
WO1997031614A1 PCT/JP1997/000542 JP9700542W WO9731614A1 WO 1997031614 A1 WO1997031614 A1 WO 1997031614A1 JP 9700542 W JP9700542 W JP 9700542W WO 9731614 A1 WO9731614 A1 WO 9731614A1
Authority
WO
WIPO (PCT)
Prior art keywords
stabilizer composition
denture
denture stabilizer
adhesive
polyvinyl alcohol
Prior art date
Application number
PCT/JP1997/000542
Other languages
English (en)
Japanese (ja)
Inventor
Toshiko Sato
Kazushi Ebisudani
Chikako Yonezato
Original Assignee
Sunstar Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunstar Kabushiki Kaisha filed Critical Sunstar Kabushiki Kaisha
Publication of WO1997031614A1 publication Critical patent/WO1997031614A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • A61K6/35—Preparations for stabilising dentures in the mouth

Definitions

  • the present invention relates to a denture stabilizer composition which has excellent adhesiveness and adhesive stability in the oral cavity and can stably stabilize a denture.
  • Conventional technology Changes in the oral environment due to factors such as aging and inflammation, which lowers the compatibility of dentures with the ridge, so that many denture wearers cannot eat hard food or have difficulty talking. I am concerned about the stability of dentures. In such cases, denture wearers have temporarily used denture stabilizer compositions to improve the stability of the denture.
  • denture stabilizer compositions disperse a water-soluble polymer such as sodium carboxymethylcellulose or polyethylene glycol in an oil-based base such as liquid paraffin / vaseline, and use the adhesive force of the water-soluble polymer due to moisture in the oral cavity to form a denture.
  • a water-soluble polymer such as sodium carboxymethylcellulose or polyethylene glycol
  • an oil-based base such as liquid paraffin / vaseline
  • denture stabilizer compositions disperse a water-soluble polymer such as sodium carboxymethylcellulose or polyethylene glycol in an oil-based base such as liquid paraffin / vaseline
  • an oil-based base such as liquid paraffin / vaseline
  • a cushion type that improves the stability of dentures by plasticizing polyvinyl acetate with a solvent such as ethanol and filling the gap between the denture and the mucous membrane of the ridge.
  • powder type, sheet type and the like can be mentioned.
  • the water-soluble polymer in the denture stabilizer composition flows out into the oral cavity due to moisture from saliva and food during wearing, Not only does not provide a sufficient stabilizing effect, but also gives discomfort.
  • the cushion-type denture stabilizer composition irritates the oral mucosa with a solvent such as ethanol as a plasticizer and elutes the plasticizer, thereby hardening the denture stabilizer composition and fixing it to the denture material to remove it.
  • a solvent such as ethanol as a plasticizer
  • the adjusted occlusal height of the denture changes and uneven stress is applied to the ridge, so that bone resorption may occur.
  • an important technical problem in the descendant type denture stabilizer composition is to improve the adhesive stability to the mucous membrane and the denture material to a satisfactory level for the denture wearer.
  • Japanese Unexamined Patent Publication No. 56-164107 discloses a technique which has been studied to improve the adhesive stability of the stabilizer composition.
  • Japanese Patent Application Laid-Open No. 56-164107 discloses sodium carboxymethylcellulose and poly (ethylene oxide) homo.
  • Denture stabilizer compositions comprising polymers have been proposed.
  • JP-A-5-32 ⁇ 15 a denture stabilizer composition comprising a spinnable polyacrylic acid salt and sodium carboxymethylcellulose is disclosed.
  • a denture stabilizer composition comprising a specific mixture salt of an alkyl vinyl ether-maleic acid copolymer has been proposed.
  • U.S. Pat. No. 5,302,628 discloses a denture stabilizer composition using polyvinyl alcohol.
  • polyacrylate is the main component of the adhesive.
  • Polyvinyl alcohol is one of the auxiliary adhesive components.
  • a suitable polyvinyl alcohol (Nippon Synthetic Chemical Co., Ltd.) KP-08) of KOGYO CO., LTD. Cannot be a sufficient tackifier because of its low adhesive strength, and it is clear that polyvinyl alcohol is not blended as the main tackifier in the denture stabilizer composition. It is.
  • Japanese Patent Application Laid-Open No. 63-169395 discloses a sheet-shaped denture stabilizer using a compound selected from sticky compounds including polyvinyl alcohol, wherein the outer layer and the inner layer have different properties.
  • a composition is disclosed.
  • polyvinyl alcohol is not disclosed as a component that contributes to the main adhesive force of a denture stabilizer composition having adhesiveness and retention, and therefore, the adhesive physicality that polyvinyl alcohol should have is not disclosed. .
  • Japanese Patent Application Laid-Open No. Hei 4-310558 discloses that polyorganosiloxane is used as a main component of a tackifier to improve tackiness, and polyvinyl alcohol is used as an auxiliary agent.
  • the technique of using polyvinyl alcohol for denture stabilizer compositions has been used as a conventional technique, but the purpose of blending polyvinyl alcohol is to aid in adhesion, and to impart initial adhesive strength.
  • An object of the present invention is to have excellent adhesiveness to materials such as oral mucosa and allyl resin, and in particular, its adhesiveness is remarkably improved as compared with the preparation according to the prior art.
  • An object of the present invention is to provide a denture stabilizing composition which maintains a denture firmly against sway such as mastication.
  • the present inventors have studied polyvinyl alcohol as an adhesive main component in order to improve the adhesive strength of a denture stabilizer composition.
  • polyvinyl alcohol having specific adhesive physical properties By using polyvinyl alcohol having specific adhesive physical properties, One or more of a specific water-soluble polymer compound such as sodium alginate and an alkaline earth metal salt can be used as an adhesive strength-enhancing component in combination with the polyvinyl alcohol to improve the adhesive stability of the stabilizer composition. It has been found that a compound having a high adhesive strength can be obtained by adding the compound of formula (1) to the denture stabilizer, and the present invention has been completed.
  • the present invention relates to a denture stabilizer composition containing one or more adhesive components, wherein the adhesive strength of a 50% water mixture is 2 ⁇ 0 g / cm 2 or more and / or a 25% water mixture.
  • the present invention relates to a denture stabilizer composition comprising polyvinyl alcohol having an adhesive strength of not less than 200 g Z cm 2 as an adhesive main component.
  • the denture stability which can solve the above-mentioned problem and is excellent in the adhesiveness in an oral cavity and an adhesive stability, and can stabilize a denture suitably.
  • Agent composition can be provided.
  • DETAILED DISCLOSURE OF THE INVENTION The cohesive strength of a denture stabilizer composition is related to its ability to absorb liquids such as saliva while it remains in the oral cavity and still have cohesive strength. Therefore, when considering the adhesive stability, the adhesive strength at the stage of high water content, that is, at the water content of 50% and 75% is important.
  • the polyvinyl alcohol used as an adhesive main component in the present invention has an adhesive strength of 250 g / cm 2 or more in a 50% water mixture (water content 50%) or an adhesive strength in a 25% water mixture (water content 75%). May be in the form of a chain or a cross-link, as long as it satisfies one or both of the conditions of 200 g Z cm 2 or more.
  • the polyvinyl alcohol satisfying the former condition include commercially available Gohsenol KH-20 (manufactured by Nippon Synthetic Chemical Co., Ltd.) and Poval PA-05 (manufactured by Shin-Etsu Chemical Co., Ltd.).
  • Gohsenol KH-17 manufactured by Nippon Kasei Kagaku Co., Ltd.
  • Gohsenol KH-17 can be exemplified.
  • the adhesive strength means that the measurement sample is compressed between two acrylic plates, the acrylic plate is attached to an autograph, and one acrylic plate is vertically moved downward at a constant speed. This is the value obtained by dividing the maximum stress value (total adhesive force) when the material was moved to by the area of the acrylic plate.
  • the main component of the adhesive refers to a component having the largest value when comparing the total adhesive strength of each adhesive component measured in an amount proportional to the amount of the component.
  • a 50% water mixture of the adhesive components was used, and the maximum amount of 1 g of the adhesive components in the preparation was used as the sample amount.
  • the total adhesive strength is measured and determined in the same manner as the adhesive strength using the amount of pull (g).
  • polybutyl alcohol has the largest total adhesive force among one or more kinds of adhesive components to be blended.
  • the above polyvinyl alcohol may be used alone, or may be used in combination with a specific adhesion-enhancing component.
  • Alcohol and its salts sodium carboquine methylcellulose, polyethylene glycol with a molecular weight of 200,000 or more, polyvinylpyrrolidone, polyvinyl ether-maleic acid copolymer, Examples include compounds selected from the group consisting of lithium earth metal compound salts, and these may be used alone or in combination of two or more.
  • the alginic acid and its salts are selected from alginic acid, sodium alginate, potassium alginate, calcium alginate, and magnesium alginate. Particularly, the viscosity of a 1% aqueous solution at 20 ° C. is 40 cps to 100 cps. It is preferred to distribute the sodium in combination with the polyvinyl alcohol to the denture stabilizer.
  • the alkaline earth metal compound salt is selected from magnesium chloride, calcium chloride, calcium lactate, calcium nitrate, calcium formate, strontium chloride, barium chloride, etc., and in particular, magnesium chloride or chloride chloride Is preferred.
  • those commonly used in denture stabilizer compositions can be used.
  • low molecular weight polyhydric alcohols such as glycerin-propylene glycol, polyethylene glycol 400, sodium carboxymethyl cellulose, Drokinethyl cellulose, hydroquinopropylmethyl
  • Water-soluble polymers such as cellulose-based polymer compounds such as cellulose, natural polysaccharides, and polymer compounds composed of amino acids such as gelatin can be exemplified.
  • the denture stabilizer composition of the present invention can be produced by a conventional method and can be provided in the form of a solid powder, an oily or aqueous paste, a gum, a film, a sheet, and the like. Powder, paste and gum forms are preferred.
  • the formulation of the adhesion-enhancing component such as polyvinyl alcohol or alginic acid in the formulation can be any of dissolution, emulsification, suspension, and simple dispersion as solid particles.
  • the particles are preferably fine powder, and the particle size is 60 mesh or less, more preferably 100 mesh or less. Is desirable.
  • the blending amount of polyvinyl alcohol is 5% to 60% by weight, preferably 25% to 50% by weight of the total weight of the denture stabilizer composition, and has the strongest adhesive strength. By adding 2.5% to 40% by weight, preferably 2.5% to 20% by weight of the total weight, the adhesive strength is enhanced.
  • the denture stabilizer composition of the present invention may contain other components, such as an oily base, an aqueous base, a powder base, a gum base, an excipient, an emulsifier, a wetting agent, Adjusters, viscosity adjusters, preservatives, pigments, sweeteners, fragrances, water, etc. can be added as appropriate.
  • each polyvinyl alcohol was stirred to a 50% concentration in liquid paraffin Z-Serine base, and filled in a tube container. Test denture stabilizer compositions were produced and their adhesive strength was evaluated.
  • the above composition was allocated to 5 subjects recruited for this test, one item per day, and each subject used and evaluated all 15 items.
  • Subjects wear the assigned denture stabilizer composition early in the morning, and after three meals in the morning, noon, and evening, evaluate the adhesive stability at the beginning of wearing, after breakfast, after lunch, and after dinner. It was evaluated by sensory evaluation.
  • the denture stabilizer composition of the present invention was found to have improved adhesive stability due to its excellent adhesive strength, and was a superior denture stabilizer composition as compared with Comparative Examples.
  • Polyvinyl alcohol (adhesive strength of 50% water mixture: 390 g_cm2) was added at 35% to the total weight, and a predetermined amount of the adhesion-enhancing component was added to the total weight.
  • the formulation base was added and mixed.
  • the ratio of the adhesive force of each test preparation was determined, with the adhesive force of Example 9 without the addition of the adhesion-enhancing component as 100.
  • the evaluation of the effect of the adhesion-enhancing component those having an index of more than 100 were evaluated as having an effect, and those having an index of more than 20 were evaluated as having a particular effect.
  • sodium alginate, polyethylene glycol with a molecular weight of 200,000 or more, sodium carboquine methylcellulose, methyl vinyl ether; maleic acid copolymer, polyvinylpyrrolidone, magnesium chloride, and calcium chloride have the effect of enhancing adhesion.
  • the denture stabilizer compositions of Examples 26 to 30, and Examples 31 and 32 produced by a conventional method also have excellent denture stability due to good adhesive strength.
  • Example 26 Paste denture stabilizer composition
  • Component Amount Polyvinyl alcohol 35.0 Sodium alginate 5.0 Sodium carboxymethylcellulose 5.0 Preservative Trace amount Vaseline appropriate amount
  • Example 31 Film denture stabilizer composition
  • polyvinyl alcohol (adhesive strength of 50% water mixture: 288 ⁇ 111 2 ; adhesive strength of 25% mixture: 315 g / cm 2 ), sodium carboxymethyl cellulose, polyethylene glycol (average molecular weight: 4,000,000) and polybutene Then, it is extruded and molded by an extruder to obtain a film-shaped denture stabilizer composition.
  • the mixing ratio at the time of mixing is 40% of polyvinyl alcohol, 10% of sodium carboxymethylcellulose, 40% of polyethylene glycol, and 10% of polybutene, based on the total amount of the mixture.
  • the denture gradually flows out as in the case of the conventional denture stabilizer composition.
  • An excellent denture stabilizer composition can be provided that can stably wear a denture for a long time without losing stability.

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Preparations (AREA)

Abstract

Une composition de stabilisateur pour prothèse dentaire comprend, en tant qu'ingrédient collant principal, un alcool polyvinylique présentant une résistance adhésive spécifique et contient facultativement un agent collant spécifique tel que l'acide alginique. La composition présente un pouvoir collant et une stabilité adhésive excellents, elle reste en place à l'intérieur de la bouche et peut être utilisée de façon avantageuse.
PCT/JP1997/000542 1996-03-01 1997-02-26 Composition de stabilisateur de prothese dentaire WO1997031614A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/45036 1996-03-01
JP4503696 1996-03-01

Publications (1)

Publication Number Publication Date
WO1997031614A1 true WO1997031614A1 (fr) 1997-09-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/000542 WO1997031614A1 (fr) 1996-03-01 1997-02-26 Composition de stabilisateur de prothese dentaire

Country Status (1)

Country Link
WO (1) WO1997031614A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002544214A (ja) * 1999-05-18 2002-12-24 スリーエム イノベイティブ プロパティズ カンパニー 歯科材料
WO2004010961A1 (fr) * 2002-07-29 2004-02-05 Sakamoto Yakuhin Kogyo Co., Ltd. Humidifiants oraux
JP2006280672A (ja) * 2005-03-31 2006-10-19 Kobayashi Pharmaceut Co Ltd 義歯安定用シートおよびその粉末組成物
JP2009514648A (ja) * 2005-11-09 2009-04-09 ザ プロクター アンド ギャンブル カンパニー 義歯接着剤組成物
US8735465B2 (en) 2010-03-10 2014-05-27 The Procter & Gamble Company Denture adhesive compositions
JP2020105164A (ja) * 2018-12-26 2020-07-09 ライオン株式会社 義歯装着用組成物及び義歯装着方法
CN111870539A (zh) * 2020-07-30 2020-11-03 深圳市第二人民医院(深圳市转化医学研究院) 一种医用粘合剂及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62129210A (ja) * 1985-12-02 1987-06-11 Kobayashi Seiyaku Kk 義歯安定剤
US4880702A (en) * 1986-12-26 1989-11-14 Shionogi & Co., Ltd. Three layer composition for stablizing a denture
JPH04305508A (ja) * 1991-04-01 1992-10-28 Nippon Kayaku Co Ltd 義歯安定剤
EP0555019A1 (fr) * 1992-02-03 1993-08-11 Block Drug Company Inc. Composition adhésive pour dentiers
JPH06211618A (ja) * 1993-01-20 1994-08-02 Sunstar Inc 義歯安定剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62129210A (ja) * 1985-12-02 1987-06-11 Kobayashi Seiyaku Kk 義歯安定剤
US4880702A (en) * 1986-12-26 1989-11-14 Shionogi & Co., Ltd. Three layer composition for stablizing a denture
JPH04305508A (ja) * 1991-04-01 1992-10-28 Nippon Kayaku Co Ltd 義歯安定剤
EP0555019A1 (fr) * 1992-02-03 1993-08-11 Block Drug Company Inc. Composition adhésive pour dentiers
JPH06211618A (ja) * 1993-01-20 1994-08-02 Sunstar Inc 義歯安定剤

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002544214A (ja) * 1999-05-18 2002-12-24 スリーエム イノベイティブ プロパティズ カンパニー 歯科材料
JP4723096B2 (ja) * 1999-05-18 2011-07-13 スリーエム イノベイティブ プロパティズ カンパニー 歯科材料
WO2004010961A1 (fr) * 2002-07-29 2004-02-05 Sakamoto Yakuhin Kogyo Co., Ltd. Humidifiants oraux
JP2006280672A (ja) * 2005-03-31 2006-10-19 Kobayashi Pharmaceut Co Ltd 義歯安定用シートおよびその粉末組成物
WO2006112123A1 (fr) * 2005-03-31 2006-10-26 Kobayashi Pharmaceutical Co., Ltd. Feuille de stabilisation de prothese dentaire et composition de poudre pour celle-ci
JP2009514648A (ja) * 2005-11-09 2009-04-09 ザ プロクター アンド ギャンブル カンパニー 義歯接着剤組成物
JP4920694B2 (ja) * 2005-11-09 2012-04-18 ザ プロクター アンド ギャンブル カンパニー 義歯接着剤組成物
US8735465B2 (en) 2010-03-10 2014-05-27 The Procter & Gamble Company Denture adhesive compositions
US9463145B2 (en) 2010-03-10 2016-10-11 The Procter & Gamble Company Denture adhesive compositions
JP2020105164A (ja) * 2018-12-26 2020-07-09 ライオン株式会社 義歯装着用組成物及び義歯装着方法
CN111870539A (zh) * 2020-07-30 2020-11-03 深圳市第二人民医院(深圳市转化医学研究院) 一种医用粘合剂及其制备方法和应用
CN111870539B (zh) * 2020-07-30 2023-02-03 深圳市第二人民医院(深圳市转化医学研究院) 一种医用粘合剂及其制备方法和应用

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