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WO1997030085B1 - Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese - Google Patents

Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese

Info

Publication number
WO1997030085B1
WO1997030085B1 PCT/US1997/002439 US9702439W WO9730085B1 WO 1997030085 B1 WO1997030085 B1 WO 1997030085B1 US 9702439 W US9702439 W US 9702439W WO 9730085 B1 WO9730085 B1 WO 9730085B1
Authority
WO
WIPO (PCT)
Prior art keywords
fact
troponin subunit
peptide
subunit
human
Prior art date
Application number
PCT/US1997/002439
Other languages
English (en)
Other versions
WO1997030085A1 (fr
Filing date
Publication date
Priority claimed from US08/602,941 external-priority patent/US5837680A/en
Application filed filed Critical
Priority to AT97905992T priority Critical patent/ATE266675T1/de
Priority to EP97905992A priority patent/EP1007556B1/fr
Priority to DE69729125T priority patent/DE69729125T2/de
Priority to CA2247247A priority patent/CA2247247C/fr
Priority to JP52953997A priority patent/JP3990456B2/ja
Priority to AU22753/97A priority patent/AU707262B2/en
Publication of WO1997030085A1 publication Critical patent/WO1997030085A1/fr
Publication of WO1997030085B1 publication Critical patent/WO1997030085B1/fr

Links

Abstract

Des procédés permettent d'inhiber l'angiogénèse atopique à l'aide de sous-unités de troponine et de leurs fragments peptidiques. On décrit aussi des compositions pharmaceutiques comprenant une sous-unité de troponine ou un de ses fragments. Ces compositions et procédés permettent de traiter des tumeurs solides, particulièrement celles du système nerveux central et de l'oeil.
PCT/US1997/002439 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese WO1997030085A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT97905992T ATE266675T1 (de) 1996-02-16 1997-02-14 Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese
EP97905992A EP1007556B1 (fr) 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese
DE69729125T DE69729125T2 (de) 1996-02-16 1997-02-14 Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese
CA2247247A CA2247247C (fr) 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese
JP52953997A JP3990456B2 (ja) 1996-02-16 1997-02-14 血管形成の阻害剤として有用なトロポニンのサブユニットおよびフラグメント
AU22753/97A AU707262B2 (en) 1996-02-16 1997-02-14 Troponin subunits and fragments useful as angiogenesis inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/602,941 1996-02-16
US08/602,941 US5837680A (en) 1996-02-16 1996-02-16 Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis

Publications (2)

Publication Number Publication Date
WO1997030085A1 WO1997030085A1 (fr) 1997-08-21
WO1997030085B1 true WO1997030085B1 (fr) 1997-09-25

Family

ID=24413387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/002439 WO1997030085A1 (fr) 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese

Country Status (8)

Country Link
US (4) US5837680A (fr)
EP (1) EP1007556B1 (fr)
JP (1) JP3990456B2 (fr)
AT (1) ATE266675T1 (fr)
AU (1) AU707262B2 (fr)
CA (1) CA2247247C (fr)
DE (1) DE69729125T2 (fr)
WO (1) WO1997030085A1 (fr)

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US20030236188A1 (en) * 2001-05-03 2003-12-25 Spytek Kimberly A. Novel human proteins, polynucleotides encoding them and methods of using the same
US20050163807A1 (en) * 2002-02-04 2005-07-28 Xiaoyan Liu Anticancer agents using vero toxin variants
WO2003074005A2 (fr) 2002-03-01 2003-09-12 Dyax Corp. Peptides liant des recepteurs kdr et vegf/kdr et leurs utilisations en diagnostic et therapie
US7261876B2 (en) * 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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EP1490107A4 (fr) * 2002-03-21 2005-11-09 Univ Florida Modulation de l'angiogenese
US20060189519A1 (en) * 2002-09-26 2006-08-24 Karl Volz Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf)
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CN1294987C (zh) * 2003-04-15 2007-01-17 刘凤鸣 心肌肌钙蛋白i在制备抑制肿瘤药物中的应用
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US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis

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