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WO1997026016A3 - Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores - Google Patents

Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores Download PDF

Info

Publication number
WO1997026016A3
WO1997026016A3 PCT/EP1997/000208 EP9700208W WO9726016A3 WO 1997026016 A3 WO1997026016 A3 WO 1997026016A3 EP 9700208 W EP9700208 W EP 9700208W WO 9726016 A3 WO9726016 A3 WO 9726016A3
Authority
WO
WIPO (PCT)
Prior art keywords
application
gas bubble
contrast medium
ultrasound contrast
bubble suspensions
Prior art date
Application number
PCT/EP1997/000208
Other languages
German (de)
English (en)
Other versions
WO1997026016A2 (fr
Inventor
Martina Bergmann
Dieter Heldmann
Werner Weitschies
Original Assignee
Schering Ag
Martina Bergmann
Dieter Heldmann
Werner Weitschies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Martina Bergmann, Dieter Heldmann, Werner Weitschies filed Critical Schering Ag
Priority to JP9525697A priority Critical patent/JP2000504317A/ja
Priority to AU15925/97A priority patent/AU1592597A/en
Priority to EP97902178A priority patent/EP0874644A2/fr
Publication of WO1997026016A2 publication Critical patent/WO1997026016A2/fr
Publication of WO1997026016A3 publication Critical patent/WO1997026016A3/fr
Priority to NO983332A priority patent/NO983332D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C08J9/147—Halogen containing compounds containing carbon and halogen atoms only
    • C08J9/148—Halogen containing compounds containing carbon and halogen atoms only perfluorinated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des matrices poreuses constituées de substances de faible poids moléculaire servant à générer des suspensions de bulles de gaz stables, leur utilisation sous forme d'agents de contraste ultrasonores et des procédés de production de ces matrices et agents de contraste.
PCT/EP1997/000208 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores WO1997026016A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP9525697A JP2000504317A (ja) 1996-01-18 1997-01-16 気泡懸濁物と超音波造影剤への応用
AU15925/97A AU1592597A (en) 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium
EP97902178A EP0874644A2 (fr) 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores
NO983332A NO983332D0 (no) 1996-01-18 1998-07-17 Gassboblesuspensjoner og deres anvendelse som ultralydkontrastmiddel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602930A DE19602930A1 (de) 1996-01-18 1996-01-18 Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
DE19602930.9 1996-01-18

Publications (2)

Publication Number Publication Date
WO1997026016A2 WO1997026016A2 (fr) 1997-07-24
WO1997026016A3 true WO1997026016A3 (fr) 1997-10-23

Family

ID=7783852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/000208 WO1997026016A2 (fr) 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores

Country Status (8)

Country Link
EP (1) EP0874644A2 (fr)
JP (1) JP2000504317A (fr)
AU (1) AU1592597A (fr)
CA (1) CA2243174A1 (fr)
DE (1) DE19602930A1 (fr)
NO (1) NO983332D0 (fr)
WO (1) WO1997026016A2 (fr)
ZA (1) ZA97414B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997032609A2 (fr) 1996-03-05 1997-09-12 Acusphere, Inc. Gaz fluores micro-encapsules utilises en qualite d'agents d'imagerie
US20070123478A1 (en) * 2005-11-28 2007-05-31 Rowe Vernon D Compositions useful for reducing nephrotoxicity and methods of use thereof
JP5196896B2 (ja) * 2007-07-13 2013-05-15 花王株式会社 微細気泡前駆体の製造方法
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
KR101927614B1 (ko) 2017-03-30 2018-12-10 숭실대학교산학협력단 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법
JP7211699B2 (ja) * 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤
US20240226418A1 (en) * 2021-01-26 2024-07-11 Agitated Solutions Inc. Syringe-Based Microbubble Generator

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (fr) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
EP0123235A2 (fr) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
EP0365467A2 (fr) * 1988-10-07 1990-04-25 Schering Aktiengesellschaft Agent de contraste ultrasonique à base de bulles de gaz et de microparticules contenant des acides gras
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5160725A (en) * 1987-03-24 1992-11-03 Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau Magnetic liquid compositions
WO1992021382A1 (fr) * 1991-06-03 1992-12-10 Holmes, Michael, John Ameliorations apportees a ou concernant des agents contrastants
WO1993000933A1 (fr) * 1991-07-05 1993-01-21 University Of Rochester Particules poreuses non agregees ultra-petites piegant des bulles gazeuses
WO1993013808A2 (fr) * 1992-01-09 1993-07-22 Holmes, Michael, John Perfectionnements apportes aux agents de contraste
WO1995003835A1 (fr) * 1993-07-30 1995-02-09 Alliance Pharmaceutical Corp. Compositions a mocrobulles stabilisees pour applications mettant en ×uvre des ultrasons
WO1995021631A1 (fr) * 1994-02-15 1995-08-17 Nycomed Imaging As Perfectionnements relatifs a des agents de contraste
WO1996026746A1 (fr) * 1995-02-28 1996-09-06 Alliance Pharmaceutical Corp. Emulsions gazeuses stabilisees contenant des phospholipides renforçant les contrastes dans les techniques d'imagerie par ultrasons

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
JPH06510758A (ja) * 1991-07-05 1994-12-01 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたは造影剤に関する改良
AU679428C (en) * 1991-09-17 2006-07-13 Ge Healthcare As Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
KR100295173B1 (ko) * 1993-12-15 2001-09-17 엔. 토모브 초음파콘트라스트매질로서유용한가스혼합물
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (fr) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
EP0123235A2 (fr) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
US5160725A (en) * 1987-03-24 1992-11-03 Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau Magnetic liquid compositions
EP0365467A2 (fr) * 1988-10-07 1990-04-25 Schering Aktiengesellschaft Agent de contraste ultrasonique à base de bulles de gaz et de microparticules contenant des acides gras
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
WO1992021382A1 (fr) * 1991-06-03 1992-12-10 Holmes, Michael, John Ameliorations apportees a ou concernant des agents contrastants
WO1993000933A1 (fr) * 1991-07-05 1993-01-21 University Of Rochester Particules poreuses non agregees ultra-petites piegant des bulles gazeuses
WO1993013808A2 (fr) * 1992-01-09 1993-07-22 Holmes, Michael, John Perfectionnements apportes aux agents de contraste
WO1995003835A1 (fr) * 1993-07-30 1995-02-09 Alliance Pharmaceutical Corp. Compositions a mocrobulles stabilisees pour applications mettant en ×uvre des ultrasons
US5605673A (en) * 1993-07-30 1997-02-25 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
WO1995021631A1 (fr) * 1994-02-15 1995-08-17 Nycomed Imaging As Perfectionnements relatifs a des agents de contraste
WO1996026746A1 (fr) * 1995-02-28 1996-09-06 Alliance Pharmaceutical Corp. Emulsions gazeuses stabilisees contenant des phospholipides renforçant les contrastes dans les techniques d'imagerie par ultrasons

Also Published As

Publication number Publication date
DE19602930A1 (de) 1997-07-24
CA2243174A1 (fr) 1997-07-24
ZA97414B (en) 1997-07-17
JP2000504317A (ja) 2000-04-11
WO1997026016A2 (fr) 1997-07-24
NO983332L (no) 1998-07-17
NO983332D0 (no) 1998-07-17
AU1592597A (en) 1997-08-11
EP0874644A2 (fr) 1998-11-04

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