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WO1997022360A3 - Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques - Google Patents

Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques Download PDF

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Publication number
WO1997022360A3
WO1997022360A3 PCT/GB1996/003186 GB9603186W WO9722360A3 WO 1997022360 A3 WO1997022360 A3 WO 1997022360A3 GB 9603186 W GB9603186 W GB 9603186W WO 9722360 A3 WO9722360 A3 WO 9722360A3
Authority
WO
WIPO (PCT)
Prior art keywords
agents
control
protein synthesis
screening method
pkb
Prior art date
Application number
PCT/GB1996/003186
Other languages
English (en)
Other versions
WO1997022360A2 (fr
Inventor
Philip Cohen
Dario Alessi
Darren Cross
Original Assignee
Medical Res Council
Univ Dundee
Philip Cohen
Dario Alessi
Darren Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9526083.2A external-priority patent/GB9526083D0/en
Priority claimed from GBGB9610272.8A external-priority patent/GB9610272D0/en
Priority claimed from GBGB9615066.9A external-priority patent/GB9615066D0/en
Application filed by Medical Res Council, Univ Dundee, Philip Cohen, Dario Alessi, Darren Cross filed Critical Medical Res Council
Priority to EP96943208A priority Critical patent/EP0868195A2/fr
Priority to AU12004/97A priority patent/AU1200497A/en
Priority to JP09522599A priority patent/JP2000502097A/ja
Publication of WO1997022360A2 publication Critical patent/WO1997022360A2/fr
Publication of WO1997022360A3 publication Critical patent/WO1997022360A3/fr
Priority to US11/682,135 priority patent/US7897371B2/en
Priority to US13/021,048 priority patent/US20110275102A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procédé de criblage d'agents capables d'affecter l'activité des kinases GSK3 et PKB, qui consiste à évaluer la phosphorylation de PKB sur deux acides aminés sur la molécule de PKB en particulier.
PCT/GB1996/003186 1995-11-16 1996-12-20 Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques WO1997022360A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP96943208A EP0868195A2 (fr) 1995-12-20 1996-12-20 Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques
AU12004/97A AU1200497A (en) 1995-12-20 1996-12-20 Control of protein synthesis, and screening method for agents
JP09522599A JP2000502097A (ja) 1995-12-20 1996-12-20 タンパク質合成の制御、および作用薬のスクリーニング法
US11/682,135 US7897371B2 (en) 1995-11-16 2007-03-05 Activation of mutated RAC-PK
US13/021,048 US20110275102A1 (en) 1995-11-16 2011-02-04 Activation of mutated rac-pk

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9526083.2A GB9526083D0 (en) 1995-12-20 1995-12-20 Method
GBGB9610272.8A GB9610272D0 (en) 1996-05-16 1996-05-16 Method
GB9610272.8 1996-07-18
GB9615066.9 1996-07-18
GB9526083.2 1996-07-18
GBGB9615066.9A GB9615066D0 (en) 1996-07-18 1996-07-18 Method

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09091763 A-371-Of-International 1998-06-19
US09/845,667 Continuation US20020065221A1 (en) 1995-11-16 2001-04-30 Control of protein synthesis, and screening method for agents

Publications (2)

Publication Number Publication Date
WO1997022360A2 WO1997022360A2 (fr) 1997-06-26
WO1997022360A3 true WO1997022360A3 (fr) 1997-07-31

Family

ID=27268041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/003186 WO1997022360A2 (fr) 1995-11-16 1996-12-20 Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques

Country Status (5)

Country Link
EP (1) EP0868195A2 (fr)
JP (1) JP2000502097A (fr)
AU (1) AU1200497A (fr)
CA (1) CA2241080A1 (fr)
WO (1) WO1997022360A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9525702D0 (en) * 1995-12-15 1996-02-14 Ciba Geigy Ag Process for activating a kinase
US6057117A (en) * 1996-04-04 2000-05-02 Chiron Corporation Identification and use of selective inhibitors of glycogen synthase kinase 3
US6153618A (en) * 1996-10-11 2000-11-28 Chiron Corporation Inhibitors of glycogen synthase 3 kinase
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
CA2298854A1 (fr) * 1997-09-26 1999-04-08 Onyx Pharmaceuticals, Inc. Compositions et techniques permettant d'identifier les inhibiteurs de la kinase de la pkb
US6682920B1 (en) 1997-09-26 2004-01-27 Onyx Pharmaceuticals, Inc. Compositions and methods for identifying PKB kinase inhibitors
SE9801530D0 (sv) * 1998-04-30 1998-04-30 Pharmacia & Upjohn Ab Method for screening
WO1999064062A1 (fr) * 1998-06-08 1999-12-16 Pharmacia & Upjohn Ab Nouvelle utilisation therapeutique d'amplificateurs de l'activite de la proteine kinase b (picb)
AU777546C (en) * 1999-11-23 2005-05-19 Regeneron Pharmaceuticals, Inc. Methods of inhibiting atrophy or promoting hypertrophy
CZ2003555A3 (en) 2000-07-27 2004-03-17 F. Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
AU2001287914A1 (en) * 2000-09-22 2002-04-02 University Of Dundee The Protein kinase regulation
IL144583A0 (en) * 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
CA2480880C (fr) 2002-04-08 2011-03-22 Merck & Co., Inc. Inhibiteurs de l'activite de akt
AU2003226271B2 (en) 2002-04-08 2007-10-18 Merck Sharp & Dohme Corp. Fused quinoxaline derivatives as inhibitors of Akt activity
US20050182256A1 (en) 2002-04-08 2005-08-18 Duggan Mark E. Inhibitors of akt activity
EP1496896A4 (fr) 2002-04-08 2007-10-31 Merck & Co Inc Inhibiteurs de l'activite akt
GB0213614D0 (en) 2002-06-13 2002-07-24 Novartis Forschungsstiftlung Z Purified PKB Kinae and uses thereof
AU2003284981B2 (en) 2002-10-30 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
JP4616831B2 (ja) 2003-04-24 2011-01-19 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
EP1620411B1 (fr) 2003-04-24 2010-03-17 Merck Sharp & Dohme Corp. Inhibiteurs de l'activite de l'akt
AU2004233835B2 (en) 2003-04-24 2010-02-25 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7638530B2 (en) 2003-04-24 2009-12-29 Merck & Co., Inc. Inhibitors of Akt activity
EP1809282B1 (fr) 2004-10-18 2013-01-09 Amgen, Inc Composes de thiadiazole et leurs procedes d'utilisation
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
EP2173728A2 (fr) 2007-07-17 2010-04-14 Amgen Inc. Modulateurs hétérocycliques de pkb
WO2009125798A1 (fr) * 2008-04-09 2009-10-15 萬有製薬株式会社 Procédé d'identification par criblage d'une substance pharmaceutique candidate pour le traitement du cancer par activation de la voie de signalisation hedgehog
JP7022746B2 (ja) 2016-10-24 2022-02-18 ノヴォ ノルディスク アー／エス インスリン製剤のためのバイオアッセイ

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
B. BURGERING ET AL.: "Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.", NATURE, vol. 376, no. 6541, 17 August 1995 (1995-08-17), LONDON, GB, pages 599 - 602, XP002032104 *
D. ALESSI ET AL.: "Mechanism of activation of protein kinase B by insulin and IGF-1.", THE EMBO JOURNAL, vol. 15, no. 23, 2 December 1996 (1996-12-02), OXFORD, GB, pages 6541 - 6551, XP002032108 *
D. ALESSI ET AL.: "Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.", FEBS LETTERS, vol. 399, no. 3, 16 December 1996 (1996-12-16), AMSTERDAM, NL, pages 333 - 338, XP002032109 *
D. CROSS ET AL.: "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.", NATURE, vol. 378, no. 6559, 21 December 1995 (1995-12-21), LONDON, GB, pages 785 - 789, XP002025954 *
E. SIEGFRIED ET AL.: "Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3.", NATURE, vol. 345, no. 6278, 28 June 1990 (1990-06-28), LONDON, GB, pages 825 - 829, XP002032106 *
H. KONISHI ET AL.: "Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C gamma.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 205, no. 1, 30 November 1994 (1994-11-30), DULUTH, MN, USA, pages 817 - 825, XP002032107 *
T. FRANKE ET AL.: "The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.", CELL, vol. 81, no. 5, 2 June 1995 (1995-06-02), CAMBRIDGE, MA, USA, pages 727 - 736, XP002032105 *

Also Published As

Publication number Publication date
EP0868195A2 (fr) 1998-10-07
AU1200497A (en) 1997-07-14
CA2241080A1 (fr) 1997-06-26
WO1997022360A2 (fr) 1997-06-26
JP2000502097A (ja) 2000-02-22

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